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Protein

Intercellular adhesion molecule 2

Gene

Icam2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: GO_Central
  • cell-cell adhesion Source: InterPro

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-216083 Integrin cell surface interactions
R-MMU-5621575 CD209 (DC-SIGN) signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Intercellular adhesion molecule 2
Short name:
ICAM-2
Alternative name(s):
Lymphocyte function-associated AG-1 counter-receptor
CD_antigen: CD102
Gene namesi
Name:Icam2
Synonyms:Icam-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96394 Icam2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 222ExtracellularSequence analysisAdd BLAST200
Transmembranei223 – 247HelicalSequence analysisAdd BLAST25
Topological domaini248 – 277CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Cell projection, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi253 – 255RRR → GGA: Loss of interaction with EZR, MSN and RDX and co-localization to microvilli. 1 Publication3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000001479123 – 277Intercellular adhesion molecule 2Add BLAST255

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi46 ↔ 91By similarity
Disulfide bondi50 ↔ 95By similarity
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi134 ↔ 189By similarity
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP35330
MaxQBiP35330
PaxDbiP35330
PRIDEiP35330

PTM databases

iPTMnetiP35330
PhosphoSitePlusiP35330
SwissPalmiP35330

Expressioni

Tissue specificityi

Expressed in endothelial cells and leukocytes. High levels found in lung.

Gene expression databases

BgeeiENSMUSG00000001029 Expressed in 195 organ(s), highest expression level in right lung lobe
CleanExiMM_ICAM2
ExpressionAtlasiP35330 baseline and differential
GenevisibleiP35330 MM

Interactioni

Subunit structurei

Interacts with RDX, EZR and MSN.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RdxP260432EBI-1035485,EBI-647737

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-29094N
IntActiP35330, 1 interactor
STRINGi10090.ENSMUSP00000001055

Structurei

Secondary structure

1277
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP35330
SMRiP35330
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35330

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 98Ig-like C2-type 1Add BLAST60
Domaini127 – 196Ig-like C2-type 2Add BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni250 – 277Required for interaction with EZR, MSN and RDX and co-localization to microvilli1 PublicationAdd BLAST28

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. ICAM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH57 Eukaryota
ENOG410Z9H1 LUCA
GeneTreeiENSGT00530000063246
HOGENOMiHOG000049136
HOVERGENiHBG052075
InParanoidiP35330
KOiK06523
OMAiPTWVAVG
OrthoDBiEOG091G022Y
PhylomeDBiP35330
TreeFamiTF333745

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR015653 ICAM2
IPR013768 ICAM_N
IPR003987 ICAM_VCAM_N
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
PANTHERiPTHR13771:SF3 PTHR13771:SF3, 1 hit
PfamiView protein in Pfam
PF03921 ICAM_N, 1 hit
PRINTSiPR01472 ICAMVCAM1
SUPFAMiSSF48726 SSF48726, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P35330-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSFACWSLS LLILFYSPGS GEKAFEVYIW SEKQIVEATE SWKINCSTNC
60 70 80 90 100
AAPDMGGLET PTNKIMLEEH PQGKWKQFLV SNVSKDTVFF CHFTCSGKQH
110 120 130 140 150
SESLNIRVYQ PPAQVTLKLQ PPRVFVGEDF TIECTVSPVQ PLERLTLSLL
160 170 180 190 200
RGRETLKNQT FGGAETVPQE ATATFNSTAL KKDGLNFSCQ AELDLRPHGG
210 220 230 240 250
YIIRSISEYQ ILEVYEPMQD NQMVIIIVVV SILLFLFVTS VLLCFIFGQH
260 270
WHRRRTGTYG VLAAWRRLPR AFRARPV
Length:277
Mass (Da):31,390
Last modified:February 1, 1994 - v1
Checksum:iCBB2FFBCF207DA48
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E8M9G5E8M9_MOUSE
Intercellular adhesion molecule 2
Icam2
162Annotation score:
B1ARJ2B1ARJ2_MOUSE
Intercellular adhesion molecule 2
Icam2
138Annotation score:
G3UWJ5G3UWJ5_MOUSE
Intercellular adhesion molecule 2
Icam2
180Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti272F → S in BAB25266 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65493 mRNA Translation: CAA46474.1
X65490, X65491, X65492 Genomic DNA Translation: CAA46473.1
AK007801 mRNA Translation: BAB25266.1
BC039128 mRNA Translation: AAH39128.1
BC039970 mRNA Translation: AAH39970.1
CCDSiCCDS25555.1
PIRiA46510
RefSeqiNP_034624.1, NM_010494.2
XP_006532366.1, XM_006532303.1
UniGeneiMm.394

Genome annotation databases

EnsembliENSMUST00000001055; ENSMUSP00000001055; ENSMUSG00000001029
GeneIDi15896
KEGGimmu:15896
UCSCiuc007lyx.1 mouse

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

ICAM-2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65493 mRNA Translation: CAA46474.1
X65490, X65491, X65492 Genomic DNA Translation: CAA46473.1
AK007801 mRNA Translation: BAB25266.1
BC039128 mRNA Translation: AAH39128.1
BC039970 mRNA Translation: AAH39970.1
CCDSiCCDS25555.1
PIRiA46510
RefSeqiNP_034624.1, NM_010494.2
XP_006532366.1, XM_006532303.1
UniGeneiMm.394

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J19X-ray2.40B253-268[»]
ProteinModelPortaliP35330
SMRiP35330
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29094N
IntActiP35330, 1 interactor
STRINGi10090.ENSMUSP00000001055

PTM databases

iPTMnetiP35330
PhosphoSitePlusiP35330
SwissPalmiP35330

Proteomic databases

EPDiP35330
MaxQBiP35330
PaxDbiP35330
PRIDEiP35330

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001055; ENSMUSP00000001055; ENSMUSG00000001029
GeneIDi15896
KEGGimmu:15896
UCSCiuc007lyx.1 mouse

Organism-specific databases

CTDi3384
MGIiMGI:96394 Icam2

Phylogenomic databases

eggNOGiENOG410IH57 Eukaryota
ENOG410Z9H1 LUCA
GeneTreeiENSGT00530000063246
HOGENOMiHOG000049136
HOVERGENiHBG052075
InParanoidiP35330
KOiK06523
OMAiPTWVAVG
OrthoDBiEOG091G022Y
PhylomeDBiP35330
TreeFamiTF333745

Enzyme and pathway databases

ReactomeiR-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-216083 Integrin cell surface interactions
R-MMU-5621575 CD209 (DC-SIGN) signaling

Miscellaneous databases

EvolutionaryTraceiP35330
PROiPR:P35330
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001029 Expressed in 195 organ(s), highest expression level in right lung lobe
CleanExiMM_ICAM2
ExpressionAtlasiP35330 baseline and differential
GenevisibleiP35330 MM

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR015653 ICAM2
IPR013768 ICAM_N
IPR003987 ICAM_VCAM_N
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
PANTHERiPTHR13771:SF3 PTHR13771:SF3, 1 hit
PfamiView protein in Pfam
PF03921 ICAM_N, 1 hit
PRINTSiPR01472 ICAMVCAM1
SUPFAMiSSF48726 SSF48726, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiICAM2_MOUSE
AccessioniPrimary (citable) accession number: P35330
Secondary accession number(s): Q9D8Q4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 7, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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