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Protein

B-cell receptor CD22

Gene

Cd22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei124Sialic acidBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • CD4 receptor binding Source: ARUK-UCL
  • coreceptor activity Source: MGI
  • protein phosphatase binding Source: ARUK-UCL
  • sialic acid binding Source: ARUK-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandLectin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
B-cell receptor CD22
Alternative name(s):
B-lymphocyte cell adhesion molecule
Short name:
BL-CAM
Sialic acid-binding Ig-like lectin 2
Short name:
Siglec-2
T-cell surface antigen Leu-14
CD_antigen: CD22
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cd22
Synonyms:Lyb-8, Siglec2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:88322 Cd22

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 702ExtracellularSequence analysisAdd BLAST681
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei703 – 721HelicalSequence analysisAdd BLAST19
Topological domaini722 – 862CytoplasmicSequence analysisAdd BLAST141

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi822Y → F: Abolishes binding to GRB2. 1 Publication1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1075279

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001487422 – 862B-cell receptor CD22Add BLAST841

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi41 ↔ 171PROSITE-ProRule annotation
Disulfide bondi46 ↔ 106PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi165 ↔ 229PROSITE-ProRule annotation
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi265N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi272 ↔ 324PROSITE-ProRule annotation
Glycosylationi275N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi368 ↔ 411PROSITE-ProRule annotation
Glycosylationi378N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi408N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi457 ↔ 499PROSITE-ProRule annotation
Glycosylationi460N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi544 ↔ 586PROSITE-ProRule annotation
Glycosylationi561N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi589N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi631 ↔ 674PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei740PhosphoserineCombined sources1
Modified residuei741PhosphoserineCombined sources1
Modified residuei744PhosphoserineCombined sources1
Modified residuei777Phosphotyrosine1 Publication1
Modified residuei822Phosphotyrosine1 Publication1
Modified residuei837Phosphotyrosine1 Publication1
Modified residuei857Phosphotyrosine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues by LYN.Curated
Phosphorylation of Tyr-777 and Tyr-837 are involved in binding to SYK. Phosphorylation of Tyr-822 is involved in binding to GRB2. Phosphorylation of Tyr-857 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P35329

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P35329

PRoteomics IDEntifications database

More...
PRIDEi
P35329

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P35329

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P35329

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

B-lymphocytes.

Gene expression databases

CleanEx database of gene expression profiles

More...
CleanExi
MM_CD22

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with LYN, SYK, PIK3R1/PIK3R2, PLCG1, SHC1, INPP5D and GRB2 upon phosphorylation. May form a complex with INPP5D/SHIP, GRB2 and SHC1. Interacts with PTPN6/SHP-1 upon phosphorylation (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
198581, 5 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P35329

Protein interaction database and analysis system

More...
IntActi
P35329, 13 interactors

Molecular INTeraction database

More...
MINTi
P35329

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000019248

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P35329

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P35329

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P35329

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 142Ig-like V-typeAdd BLAST121
Domaini147 – 244Ig-like C2-type 1Add BLAST98
Domaini251 – 341Ig-like C2-type 2Add BLAST91
Domaini346 – 429Ig-like C2-type 3Add BLAST84
Domaini434 – 515Ig-like C2-type 4Add BLAST82
Domaini520 – 597Ig-like C2-type 5Add BLAST78
Domaini608 – 691Ig-like C2-type 6Add BLAST84

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi775 – 780ITIM motif 16
Motifi835 – 840ITIM motif 26
Motifi855 – 860ITIM motif 36

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IUGI Eukaryota
ENOG410YH8H LUCA

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG005272

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P35329

KEGG Orthology (KO)

More...
KOi
K06467

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P35329

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08205 C2-set_2, 1 hit
PF13895 Ig_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 7 hits
SM00408 IGc2, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P35329-1) [UniParc]FASTAAdd to basket
Also known as: CD22-beta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRVHYLWLLL ILGHAASAQY SSANDWTVDH PQTLFAWEGA CIRIPCKYKT
60 70 80 90 100
PLPKARLDNI LLFQNYEFDK ATKKFKGTVL YNKAEPELYP PKQRRVTFLG
110 120 130 140 150
NSIDNCTLKI HPIRANDSGN LGLRMTAGTE RWMEPIHLNV SEKPFQPYIQ
160 170 180 190 200
MPSEIRESQS VTLTCGLNFS CFEYDILLQW FLEDSKITSV TPSVTSITSS
210 220 230 240 250
VTSSIKNVYT ESKLTFQPKW TDHGKSVKCQ VQHSSEVLSE RTVRLDVKYT
260 270 280 290 300
PKLEIKVNPT EVEKNNSVTM TCRVNSSNPK LRTVAVSWFK DGRPLEDQEL
310 320 330 340 350
EQEQQMSKLI LHSVTKDMRG KYRCQASNDI GPGESEEVEL TVHYAPEPSR
360 370 380 390 400
VHIYPSPAEE GQSVELICES LASPSATNYT WYHNRKPIPG DTQEKLRIPK
410 420 430 440 450
VSPWHAGNYS CLAENRLGHG KIDQEAKLDV HYAPKAVTTV IQSFTPILEG
460 470 480 490 500
DSVTLVCRYN SSNPDVTSYR WNPQGSGSVL KPGVLRIQKV TWDSMPVSCA
510 520 530 540 550
ACNHKCSWAL PVILNVHYAP RDVKVLKVSP ASEIRAGQRV LLQCDFAESN
560 570 580 590 600
PAEVRFFWKK NGSLVQEGRY LSFGSVSPED SGNYNCMVNN SIGETLSQAW
610 620 630 640 650
NLQVLYAPRR LRVSISPGDH VMEGKKATLS CESDANPPIS QYTWFDSSGQ
660 670 680 690 700
DLHSSGQKLR LEPLEVQHTG SYRCKGTNGI GTGESPPSTL TVYYSPETIG
710 720 730 740 750
KRVALGLGFC LTICILAIWG MKIQKKWKQN RSQQGLQENS SGQSFFVRNK
760 770 780 790 800
KARRTPLSEG PQSQGCYNPA MDDTVSYAIL RFPESDMHNA GDAGTPATQA
810 820 830 840 850
PPPNNSDSVT YSVIQKRPMG DYENVNPSCP EDESIHYSEL VQFGAGKRPQ
860
AKEDVDYVTL KH
Length:862
Mass (Da):96,582
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA7662D6E87038E83
GO
Isoform 2 (identifier: P35329-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-115: Missing.

Show »
Length:800
Mass (Da):89,333
Checksum:i394094553D0F14E6
GO
Isoform 3 (identifier: P35329-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     100-133: Missing.

Show »
Length:828
Mass (Da):92,857
Checksum:i6C84F4BE3F0B6045
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UP36Q3UP36_MOUSE
B-cell receptor CD22
Cd22
868Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WR96A0A087WR96_MOUSE
B-cell receptor CD22
Cd22
353Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1SSS3A0A1L1SSS3_MOUSE
B-cell receptor CD22
Cd22
663Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WR31A0A087WR31_MOUSE
B-cell receptor CD22
Cd22
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WQ27A0A087WQ27_MOUSE
B-cell receptor CD22
Cd22
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WST4A0A087WST4_MOUSE
B-cell receptor CD22
Cd22
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WQV3A0A087WQV3_MOUSE
B-cell receptor CD22
Cd22
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti87E → G in CAB85611 (PubMed:10975807).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti15A → V in strain: BALB/c, C57BL/6, BXSB and MRL. 1
Natural varianti19Q → R in strain: BALB/c, C57BL/6, BXSB and MRL. 1
Natural varianti76K → T in strain: BALB/c, C57BL/6 and MRL. 1
Natural varianti83 – 86KAEP → ATKTEKDPES in strain: BALB/c, C57BL/6, BXSB and MRL. 4
Natural varianti90 – 91PP → LS in strain: BALB/c. 2
Natural varianti94R → G in strain: BALB/c. 1
Natural varianti102S → R in strain: BALB/c, C57BL/6, BXSB and MRL. 1
Natural varianti112 – 114PIR → LIH in strain: BXSB. 3
Natural varianti173E → G in strain: BALB/c, C57BL/6 and MRL. 1
Natural varianti179Q → K in strain: BALB/c, C57BL/6 and MRL. 1
Natural varianti186K → E in strain: BALB/c, C57BL/6 and MRL. 1
Natural varianti190V → I in strain: BALB/c, C57BL/6 and MRL. 1
Natural varianti192P → S in strain: BALB/c, C57BL/6 and MRL. 1
Natural varianti236E → K in strain: BALB/c, C57BL/6 and MRL. 1
Natural varianti241R → C in strain: BALB/c. 1
Natural varianti244R → H in strain: BALB/c and MRL. 1
Natural varianti273R → Q in strain: BXSB. 1
Natural varianti380T → I in strain: BXSB. 1
Natural varianti387P → H in strain: BXSB. 1
Natural varianti403P → L in strain: BXSB. 1
Natural varianti419H → R in strain: BXSB. 1
Natural varianti423D → G in strain: BXSB. 1
Natural varianti482P → S in strain: BXSB. 1
Natural varianti548E → K in strain: BXSB. 1
Natural varianti616S → I in strain: BALB/c. 1
Natural varianti620H → R in strain: BXSB. 1
Natural varianti714C → F in strain: BALB/c. 1
Natural varianti787M → T in strain: BALB/c, C57BL/6, BXSB and MRL. 1
Natural varianti790A → T in strain: C57BL/6. 1
Natural varianti808S → T in strain: BALB/c, BXSB and MRL. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00253254 – 115Missing in isoform 2. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_002533100 – 133Missing in isoform 3. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L16928 mRNA Translation: AAA02562.1
AF115401 mRNA Translation: AAD30392.1
AF115400 mRNA Translation: AAD30391.1
AF102134 mRNA Translation: AAF02417.1
AJ250676 mRNA Translation: CAB85609.1
AJ250677 mRNA Translation: CAB85610.1
AJ250678 mRNA Translation: CAB85611.1
AJ250679 mRNA Translation: CAB85612.1
AJ250680 mRNA Translation: CAB85613.1
AJ250682 mRNA Translation: CAB85615.1
AJ250683 mRNA Translation: CAB85616.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A46512
I49583

NCBI Reference Sequences

More...
RefSeqi
NP_001036782.1, NM_001043317.2
NP_033975.3, NM_009845.3
XP_006539556.1, XM_006539493.1
XP_006539557.1, XM_006539494.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.260994

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
12483

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:12483

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Siglec-2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16928 mRNA Translation: AAA02562.1
AF115401 mRNA Translation: AAD30392.1
AF115400 mRNA Translation: AAD30391.1
AF102134 mRNA Translation: AAF02417.1
AJ250676 mRNA Translation: CAB85609.1
AJ250677 mRNA Translation: CAB85610.1
AJ250678 mRNA Translation: CAB85611.1
AJ250679 mRNA Translation: CAB85612.1
AJ250680 mRNA Translation: CAB85613.1
AJ250682 mRNA Translation: CAB85615.1
AJ250683 mRNA Translation: CAB85616.1
PIRiA46512
I49583
RefSeqiNP_001036782.1, NM_001043317.2
NP_033975.3, NM_009845.3
XP_006539556.1, XM_006539493.1
XP_006539557.1, XM_006539494.2
UniGeneiMm.260994

3D structure databases

ProteinModelPortaliP35329
SMRiP35329
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198581, 5 interactors
CORUMiP35329
IntActiP35329, 13 interactors
MINTiP35329
STRINGi10090.ENSMUSP00000019248

Chemistry databases

BindingDBiP35329
ChEMBLiCHEMBL1075279

PTM databases

iPTMnetiP35329
PhosphoSitePlusiP35329

Proteomic databases

MaxQBiP35329
PaxDbiP35329
PRIDEiP35329

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi12483
KEGGimmu:12483

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
933
MGIiMGI:88322 Cd22

Phylogenomic databases

eggNOGiENOG410IUGI Eukaryota
ENOG410YH8H LUCA
HOVERGENiHBG005272
InParanoidiP35329
KOiK06467
PhylomeDBiP35329

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P35329

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

CleanExiMM_CD22

Family and domain databases

Gene3Di2.60.40.10, 6 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 7 hits
SM00408 IGc2, 5 hits
SUPFAMiSSF48726 SSF48726, 7 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD22_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35329
Secondary accession number(s): Q9JHL2
, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: December 5, 2018
This is version 171 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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