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Entry version 146 (12 Aug 2020)
Sequence version 1 (01 Feb 1994)
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Protein

Small proline-rich protein 2A

Gene

SPRR2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processKeratinization

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P35326

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6809371, Formation of the cornified envelope

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P35326

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Small proline-rich protein 2A
Short name:
SPR-2A
Alternative name(s):
2-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPRR2A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000241794.1

Human Gene Nomenclature Database

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HGNCi
HGNC:11261, SPRR2A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
182267, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P35326

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6700

Open Targets

More...
OpenTargetsi
ENSG00000241794

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36090

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P35326, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPRR2A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001500081 – 72Small proline-rich protein 2AAdd BLAST72

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P35326

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P35326

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P35326

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P35326

PeptideAtlas

More...
PeptideAtlasi
P35326

PRoteomics IDEntifications database

More...
PRIDEi
P35326

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
55024

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P35326

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P35326

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

During squamous differentiation of epidermal keratinocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000241794, Expressed in gingiva and 109 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P35326, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000241794, Group enriched (esophagus, lymphoid tissue, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
112578, 12 interactors

Protein interaction database and analysis system

More...
IntActi
P35326, 15 interactors

Molecular INTeraction database

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MINTi
P35326

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000376423

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P35326, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati21 – 2919
Repeati30 – 3829
Repeati39 – 4739

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni21 – 473 X 9 AA tandem repeats of P-K-C-P-[EQ]-P-C-P-PAdd BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cornifin (SPRR) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502TEHF, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183516

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_192372_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P35326

Identification of Orthologs from Complete Genome Data

More...
OMAi
CPEPCPH

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026075, SPRR/LCE
IPR029142, SPRR2

The PANTHER Classification System

More...
PANTHERi
PTHR23263, PTHR23263, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14820, SPRR2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P35326-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYQQQQCKQ PCQPPPVCPT PKCPEPCPPP KCPEPCPPPK CPQPCPPQQC
60 70
QQKYPPVTPS PPCQSKYPPK SK
Length:72
Mass (Da):7,965
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i28B452D0F8B6344A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X53064 Genomic DNA Translation: CAA37239.1
AL356867 Genomic DNA No translation available.
AK311939 mRNA Translation: BAG34880.1
CH471121 Genomic DNA Translation: EAW53346.1
CH471121 Genomic DNA Translation: EAW53347.1
BC096108 mRNA Translation: AAH96108.1
BC096109 mRNA Translation: AAH96109.1
BC096110 mRNA Translation: AAH96110.1
BC096111 mRNA Translation: AAH96111.1
BC128049 mRNA Translation: AAI28050.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1034.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S12712

NCBI Reference Sequences

More...
RefSeqi
NP_005979.1, NM_005988.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000392653; ENSP00000376423; ENSG00000241794

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6700

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6700

UCSC genome browser

More...
UCSCi
uc001fbd.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53064 Genomic DNA Translation: CAA37239.1
AL356867 Genomic DNA No translation available.
AK311939 mRNA Translation: BAG34880.1
CH471121 Genomic DNA Translation: EAW53346.1
CH471121 Genomic DNA Translation: EAW53347.1
BC096108 mRNA Translation: AAH96108.1
BC096109 mRNA Translation: AAH96109.1
BC096110 mRNA Translation: AAH96110.1
BC096111 mRNA Translation: AAH96111.1
BC128049 mRNA Translation: AAI28050.1
CCDSiCCDS1034.1
PIRiS12712
RefSeqiNP_005979.1, NM_005988.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi112578, 12 interactors
IntActiP35326, 15 interactors
MINTiP35326
STRINGi9606.ENSP00000376423

PTM databases

iPTMnetiP35326
PhosphoSitePlusiP35326

Polymorphism and mutation databases

BioMutaiSPRR2A

Proteomic databases

EPDiP35326
MassIVEiP35326
MaxQBiP35326
PaxDbiP35326
PeptideAtlasiP35326
PRIDEiP35326
ProteomicsDBi55024

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
54240, 120 antibodies

Genome annotation databases

EnsembliENST00000392653; ENSP00000376423; ENSG00000241794
GeneIDi6700
KEGGihsa:6700
UCSCiuc001fbd.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6700
DisGeNETi6700
EuPathDBiHostDB:ENSG00000241794.1

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SPRR2A
HGNCiHGNC:11261, SPRR2A
HPAiENSG00000241794, Group enriched (esophagus, lymphoid tissue, tongue)
MIMi182267, gene
neXtProtiNX_P35326
OpenTargetsiENSG00000241794
PharmGKBiPA36090

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502TEHF, Eukaryota
GeneTreeiENSGT00950000183516
HOGENOMiCLU_192372_0_0_1
InParanoidiP35326
OMAiCPEPCPH

Enzyme and pathway databases

PathwayCommonsiP35326
ReactomeiR-HSA-6809371, Formation of the cornified envelope
SIGNORiP35326

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
6700, 8 hits in 148 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SPRR2A, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SPRR2A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6700
PharosiP35326, Tbio

Protein Ontology

More...
PROi
PR:P35326
RNActiP35326, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000241794, Expressed in gingiva and 109 other tissues
GenevisibleiP35326, HS

Family and domain databases

InterProiView protein in InterPro
IPR026075, SPRR/LCE
IPR029142, SPRR2
PANTHERiPTHR23263, PTHR23263, 1 hit
PfamiView protein in Pfam
PF14820, SPRR2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPR2A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35326
Secondary accession number(s): B2R4T3, D3DV35, Q5T529
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: August 12, 2020
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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