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Protein

Cornifin-A

Gene

SPRR1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.

GO - Molecular functioni

GO - Biological processi

  • cornification Source: Reactome
  • epidermis development Source: ProtInc
  • keratinocyte differentiation Source: UniProtKB
  • peptide cross-linking Source: UniProtKB

Keywordsi

Biological processKeratinization

Enzyme and pathway databases

ReactomeiR-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Cornifin-A
Alternative name(s):
19 kDa pancornulin
SPRK
Small proline-rich protein IA
Short name:
SPR-IA
Gene namesi
Name:SPRR1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000169474.4
HGNCiHGNC:11259 SPRR1A
MIMi182265 gene
neXtProtiNX_P35321

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6698
OpenTargetsiENSG00000169474
PharmGKBiPA36088

Polymorphism and mutation databases

BioMutaiSPRR1A
DMDMi215273890

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001499951 – 89Cornifin-AAdd BLAST89

Proteomic databases

EPDiP35321
PaxDbiP35321
PeptideAtlasiP35321
PRIDEiP35321
ProteomicsDBi55022

2D gel databases

UCD-2DPAGEiP35321

PTM databases

iPTMnetiP35321
PhosphoSitePlusiP35321

Expressioni

Inductioni

During squamous differentiation of epidermal keratinocytes.

Gene expression databases

BgeeiENSG00000169474 Expressed in 180 organ(s), highest expression level in ectocervix
CleanExiHS_SPRR1A
GenevisibleiP35321 HS

Organism-specific databases

HPAiCAB011237

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112576, 3 interactors
IntActiP35321, 4 interactors
MINTiP35321
STRINGi9606.ENSP00000307340

Structurei

3D structure databases

ProteinModelPortaliP35321
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati3 – 141Add BLAST12
Repeati18 – 292Add BLAST12
Repeati31 – 3818
Repeati39 – 4628
Repeati47 – 5438
Repeati55 – 6248
Repeati63 – 7058
Repeati71 – 7868

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni3 – 292 X 12 AA approximate repeatsAdd BLAST27
Regioni31 – 786 X 8 AA approximate tandem repeatsAdd BLAST48

Sequence similaritiesi

Belongs to the cornifin (SPRR) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JH2M Eukaryota
ENOG410XUVY LUCA
GeneTreeiENSGT00730000111065
HOGENOMiHOG000059526
HOVERGENiHBG079213
InParanoidiP35321
OMAiPVVPEPC
OrthoDBiEOG091G15WJ
PhylomeDBiP35321
TreeFamiTF338205

Family and domain databases

InterProiView protein in InterPro
IPR003302 Cornifin
IPR026075 SPRR/LCE
PANTHERiPTHR23263 PTHR23263, 1 hit
PTHR23263:SF108 PTHR23263:SF108, 1 hit

Sequencei

Sequence statusi: Complete.

P35321-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSQQQKQPC TPPPQPQQQQ VKQPCQPPPQ EPCIPKTKEP CHPKVPEPCH
60 70 80
PKVPEPCQPK VPEPCQPKVP EPCPSTVTPA PAQQKTKQK
Length:89
Mass (Da):9,877
Last modified:November 25, 2008 - v2
Checksum:iC79E79931794D3D4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53V → I AA sequence (PubMed:7829876).Curated1
Sequence conflicti65Missing AA sequence (PubMed:7829876).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02109742H → Q3 PublicationsCorresponds to variant dbSNP:rs1611762Ensembl.1
Natural variantiVAR_02109861V → I3 PublicationsCorresponds to variant dbSNP:rs1611764Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05187 Genomic DNA Translation: AAC26838.1
AY755659 Genomic DNA Translation: AAU88143.1
AL356867 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53355.1
CH471121 Genomic DNA Translation: EAW53356.1
BC105081 mRNA Translation: AAI05082.1
BC105083 mRNA Translation: AAI05084.1
CCDSiCCDS1032.1
PIRiI54187
RefSeqiNP_001186757.1, NM_001199828.1
NP_005978.2, NM_005987.3
UniGeneiHs.46320

Genome annotation databases

EnsembliENST00000368762; ENSP00000357751; ENSG00000169474
GeneIDi6698
KEGGihsa:6698
UCSCiuc057lan.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05187 Genomic DNA Translation: AAC26838.1
AY755659 Genomic DNA Translation: AAU88143.1
AL356867 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53355.1
CH471121 Genomic DNA Translation: EAW53356.1
BC105081 mRNA Translation: AAI05082.1
BC105083 mRNA Translation: AAI05084.1
CCDSiCCDS1032.1
PIRiI54187
RefSeqiNP_001186757.1, NM_001199828.1
NP_005978.2, NM_005987.3
UniGeneiHs.46320

3D structure databases

ProteinModelPortaliP35321
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112576, 3 interactors
IntActiP35321, 4 interactors
MINTiP35321
STRINGi9606.ENSP00000307340

PTM databases

iPTMnetiP35321
PhosphoSitePlusiP35321

Polymorphism and mutation databases

BioMutaiSPRR1A
DMDMi215273890

2D gel databases

UCD-2DPAGEiP35321

Proteomic databases

EPDiP35321
PaxDbiP35321
PeptideAtlasiP35321
PRIDEiP35321
ProteomicsDBi55022

Protocols and materials databases

DNASUi6698
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368762; ENSP00000357751; ENSG00000169474
GeneIDi6698
KEGGihsa:6698
UCSCiuc057lan.1 human

Organism-specific databases

CTDi6698
DisGeNETi6698
EuPathDBiHostDB:ENSG00000169474.4
GeneCardsiSPRR1A
H-InvDBiHIX0028873
HGNCiHGNC:11259 SPRR1A
HPAiCAB011237
MIMi182265 gene
neXtProtiNX_P35321
OpenTargetsiENSG00000169474
PharmGKBiPA36088
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JH2M Eukaryota
ENOG410XUVY LUCA
GeneTreeiENSGT00730000111065
HOGENOMiHOG000059526
HOVERGENiHBG079213
InParanoidiP35321
OMAiPVVPEPC
OrthoDBiEOG091G15WJ
PhylomeDBiP35321
TreeFamiTF338205

Enzyme and pathway databases

ReactomeiR-HSA-6809371 Formation of the cornified envelope

Miscellaneous databases

ChiTaRSiSPRR1A human
GeneWikiiSPRR1A
GenomeRNAii6698
PROiPR:P35321
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169474 Expressed in 180 organ(s), highest expression level in ectocervix
CleanExiHS_SPRR1A
GenevisibleiP35321 HS

Family and domain databases

InterProiView protein in InterPro
IPR003302 Cornifin
IPR026075 SPRR/LCE
PANTHERiPTHR23263 PTHR23263, 1 hit
PTHR23263:SF108 PTHR23263:SF108, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPR1A_HUMAN
AccessioniPrimary (citable) accession number: P35321
Secondary accession number(s): B1AN47
, D3DV31, Q2M303, Q9UDG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 25, 2008
Last modified: September 12, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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