Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ADM

Gene

ADM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • adrenomedullin receptor binding Source: UniProtKB
  • hormone activity Source: UniProtKB-KW
  • signaling receptor binding Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHormone

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-418555 G alpha (s) signalling events
R-HSA-419812 Calcitonin-like ligand receptors

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P35318

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ADM
Cleaved into the following 2 chains:
Adrenomedullin
Short name:
AM
Alternative name(s):
ProAM N-terminal 20 peptide
Short name:
PAMP
Short name:
ProAM-N20
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADM
Synonyms:AM
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000148926.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:259 ADM

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
103275 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P35318

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
133

Open Targets

More...
OpenTargetsi
ENSG00000148926

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24580

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2062356

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ADM

Domain mapping of disease mutations (DMDM)

More...
DMDMi
461474

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21By similarityAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000000096122 – 41Proadrenomedullin N-20 terminal peptideBy similarityAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000096245 – 92By similarityAdd BLAST48
PeptideiPRO_000000096395 – 146Adrenomedullin1 PublicationAdd BLAST52
PropeptideiPRO_0000000964148 – 185PreproAM C-terminal fragmentAdd BLAST38

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei41Arginine amide1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi110 ↔ 1151 Publication
Modified residuei146Tyrosine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P35318

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P35318

PeptideAtlas

More...
PeptideAtlasi
P35318

PRoteomics IDEntifications database

More...
PRIDEi
P35318

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55021

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P35318

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P35318

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P35318

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000148926 Expressed in 226 organ(s), highest expression level in placenta

CleanEx database of gene expression profiles

More...
CleanExi
HS_ADM

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P35318 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P35318 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB016075

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106645, 1 interactor

Protein interaction database and analysis system

More...
IntActi
P35318, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000278175

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1185
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P35318

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P35318

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P35318

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adrenomedullin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IK4C Eukaryota
ENOG41120TV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154380

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000033821

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004181

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P35318

KEGG Orthology (KO)

More...
KOi
K12333

Identification of Orthologs from Complete Genome Data

More...
OMAi
RNKISPQ

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0QFI

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P35318

TreeFam database of animal gene trees

More...
TreeFami
TF333447

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001710 Adrenomedullin
IPR021116 Calcitonin/adrenomedullin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00214 Calc_CGRP_IAPP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00801 ADRENOMEDULN

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P35318-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLVSVALMY LGSLAFLGAD TARLDVASEF RKKWNKWALS RGKRELRMSS
60 70 80 90 100
SYPTGLADVK AGPAQTLIRP QDMKGASRSP EDSSPDAARI RVKRYRQSMN
110 120 130 140 150
NFQGLRSFGC RFGTCTVQKL AHQIYQFTDK DKDNVAPRSK ISPQGYGRRR
160 170 180
RRSLPEAGPG RTLVSSKPQA HGAPAPPSGS APHFL
Length:185
Mass (Da):20,420
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i64C7D2A0B4654DFE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PQT2E9PQT2_HUMAN
ADM
ADM
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PML4E9PML4_HUMAN
ADM
ADM
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQE6E9PQE6_HUMAN
ADM
ADM
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PL83E9PL83_HUMAN
ADM
ADM
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01486150S → R1 PublicationCorresponds to variant dbSNP:rs5005Ensembl.1
Natural variantiVAR_04820585P → R. Corresponds to variant dbSNP:rs2228573Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D14874 mRNA Translation: BAA03589.1
S73906 Genomic DNA Translation: AAC60642.1
D43639 Genomic DNA Translation: BAA07756.1 Sequence problems.
CR541995 mRNA Translation: CAG46792.1
BT006902 mRNA Translation: AAP35548.1
AK312893 mRNA Translation: BAG35740.1
DQ143945 Genomic DNA Translation: AAZ38717.1
CH471064 Genomic DNA Translation: EAW68571.1
CH471064 Genomic DNA Translation: EAW68572.1
BC015961 mRNA Translation: AAH15961.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7801.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC2351 JN0684

NCBI Reference Sequences

More...
RefSeqi
NP_001115.1, NM_001124.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.441047

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000278175; ENSP00000278175; ENSG00000148926
ENST00000525063; ENSP00000435124; ENSG00000148926
ENST00000528655; ENSP00000436607; ENSG00000148926

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
133

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:133

UCSC genome browser

More...
UCSCi
uc001mil.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14874 mRNA Translation: BAA03589.1
S73906 Genomic DNA Translation: AAC60642.1
D43639 Genomic DNA Translation: BAA07756.1 Sequence problems.
CR541995 mRNA Translation: CAG46792.1
BT006902 mRNA Translation: AAP35548.1
AK312893 mRNA Translation: BAG35740.1
DQ143945 Genomic DNA Translation: AAZ38717.1
CH471064 Genomic DNA Translation: EAW68571.1
CH471064 Genomic DNA Translation: EAW68572.1
BC015961 mRNA Translation: AAH15961.1
CCDSiCCDS7801.1
PIRiJC2351 JN0684
RefSeqiNP_001115.1, NM_001124.2
UniGeneiHs.441047

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FLYNMR-A22-41[»]
2L7SNMR-A95-146[»]
4RWFX-ray1.76B119-146[»]
5V6YX-ray2.80E/F/G/H131-146[»]
ProteinModelPortaliP35318
SMRiP35318
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106645, 1 interactor
IntActiP35318, 1 interactor
STRINGi9606.ENSP00000278175

Chemistry databases

ChEMBLiCHEMBL2062356

PTM databases

iPTMnetiP35318
PhosphoSitePlusiP35318

Polymorphism and mutation databases

BioMutaiADM
DMDMi461474

Proteomic databases

EPDiP35318
PaxDbiP35318
PeptideAtlasiP35318
PRIDEiP35318
ProteomicsDBi55021

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
133
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278175; ENSP00000278175; ENSG00000148926
ENST00000525063; ENSP00000435124; ENSG00000148926
ENST00000528655; ENSP00000436607; ENSG00000148926
GeneIDi133
KEGGihsa:133
UCSCiuc001mil.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
133
DisGeNETi133
EuPathDBiHostDB:ENSG00000148926.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ADM
HGNCiHGNC:259 ADM
HPAiCAB016075
MIMi103275 gene
neXtProtiNX_P35318
OpenTargetsiENSG00000148926
PharmGKBiPA24580

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IK4C Eukaryota
ENOG41120TV LUCA
GeneTreeiENSGT00940000154380
HOGENOMiHOG000033821
HOVERGENiHBG004181
InParanoidiP35318
KOiK12333
OMAiRNKISPQ
OrthoDBiEOG091G0QFI
PhylomeDBiP35318
TreeFamiTF333447

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events
R-HSA-419812 Calcitonin-like ligand receptors
SIGNORiP35318

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ADM human
EvolutionaryTraceiP35318

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Adrenomedullin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
133
PMAP-CutDBiP35318

Protein Ontology

More...
PROi
PR:P35318

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000148926 Expressed in 226 organ(s), highest expression level in placenta
CleanExiHS_ADM
ExpressionAtlasiP35318 baseline and differential
GenevisibleiP35318 HS

Family and domain databases

InterProiView protein in InterPro
IPR001710 Adrenomedullin
IPR021116 Calcitonin/adrenomedullin
PfamiView protein in Pfam
PF00214 Calc_CGRP_IAPP, 1 hit
PRINTSiPR00801 ADRENOMEDULN

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADML_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35318
Secondary accession number(s): B2R793, D3DQV3, Q6FGW2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: December 5, 2018
This is version 171 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again