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Protein

Ras-related protein Rab-17

Gene

Rab17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development. May also play a role in cell migration.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 33GTPBy similarity8
Nucleotide bindingi73 – 77GTPBy similarity5
Nucleotide bindingi132 – 135GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-17
Gene namesi
Name:Rab17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:104640 Rab17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi77Q → L: Probable constitutively active mutant unable to hydrolyze GTP; increases dendrite number and length. 1 Publication1
Mutagenesisi211 – 212CC → AA: Loss of association with membranes and redistribution to the cytosol. 1 Publication2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211921 – 214Ras-related protein Rab-17Add BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineCombined sources1
Lipidationi211S-geranylgeranyl cysteine1 Publication1
Lipidationi212S-geranylgeranyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiP35292
PeptideAtlasiP35292
PRIDEiP35292

PTM databases

iPTMnetiP35292
PhosphoSitePlusiP35292

Expressioni

Tissue specificityi

Expressed in kidney, liver, and intestine mainly by epithelial cells. Expressed in hippocampus (at protein level).2 Publications

Developmental stagei

Expression starts at E5 and gradually increases from P5 to adulthood (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000026304 Expressed in 134 organ(s), highest expression level in jejunum
CleanExiMM_RAB17
ExpressionAtlasiP35292 baseline and differential
GenevisibleiP35292 MM

Interactioni

Protein-protein interaction databases

BioGridi202535, 2 interactors
IntActiP35292, 27 interactors
MINTiP35292
STRINGi10090.ENSMUSP00000027529

Structurei

3D structure databases

ProteinModelPortaliP35292
SMRiP35292
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi47 – 55Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0092 Eukaryota
ENOG410YCCP LUCA
GeneTreeiENSGT00760000119101
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP35292
KOiK07909
OMAiSVCHLYY
OrthoDBiEOG091G0KZI
PhylomeDBiP35292
TreeFamiTF300199

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P35292-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQAAGLPQA STASGQPYVS KLVLLGSSSV GKTSLALRYM KQDFSNVLPT
60 70 80 90 100
VGCAFFTKVL DLGSSSLKLE IWDTAGQEKY QSVCHLYFRG ANAALLVYDI
110 120 130 140 150
TRKDSFHKAQ QWLEDLEKEF QPGEVVVMLV GNKTDLGEER EVTFQEGKEF
160 170 180 190 200
AESKSLLFME TSAKLNYQVS EIFNTVAQEL LQRAGDTGSS RPQEGEAVAL
210
NQEPPIRQRQ CCAR
Length:214
Mass (Da):23,640
Last modified:February 1, 1994 - v1
Checksum:i11052D3EC730EFAB
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YVQ6D3YVQ6_MOUSE
Ras-related protein Rab-17
Rab17
145Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19V → L in BAC35842 (PubMed:15489334).Curated1
Sequence conflicti57T → K in BAB26452 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70804 mRNA Translation: CAA50071.1
AK009707 mRNA Translation: BAB26452.1
AK075591 mRNA Translation: BAC35842.1
BC013170 mRNA Translation: AAH13170.1
BC051071 mRNA Translation: AAH51071.1
M79307 mRNA Translation: AAK14831.1
CCDSiCCDS15156.1
PIRiA46434
RefSeqiNP_001153197.2, NM_001159725.2
NP_033024.1, NM_008998.4
XP_006529326.1, XM_006529263.2
UniGeneiMm.279780

Genome annotation databases

EnsembliENSMUST00000027529; ENSMUSP00000027529; ENSMUSG00000026304
ENSMUST00000131428; ENSMUSP00000122178; ENSMUSG00000026304
GeneIDi19329
KEGGimmu:19329
UCSCiuc007bzn.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70804 mRNA Translation: CAA50071.1
AK009707 mRNA Translation: BAB26452.1
AK075591 mRNA Translation: BAC35842.1
BC013170 mRNA Translation: AAH13170.1
BC051071 mRNA Translation: AAH51071.1
M79307 mRNA Translation: AAK14831.1
CCDSiCCDS15156.1
PIRiA46434
RefSeqiNP_001153197.2, NM_001159725.2
NP_033024.1, NM_008998.4
XP_006529326.1, XM_006529263.2
UniGeneiMm.279780

3D structure databases

ProteinModelPortaliP35292
SMRiP35292
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202535, 2 interactors
IntActiP35292, 27 interactors
MINTiP35292
STRINGi10090.ENSMUSP00000027529

PTM databases

iPTMnetiP35292
PhosphoSitePlusiP35292

Proteomic databases

PaxDbiP35292
PeptideAtlasiP35292
PRIDEiP35292

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027529; ENSMUSP00000027529; ENSMUSG00000026304
ENSMUST00000131428; ENSMUSP00000122178; ENSMUSG00000026304
GeneIDi19329
KEGGimmu:19329
UCSCiuc007bzn.2 mouse

Organism-specific databases

CTDi64284
MGIiMGI:104640 Rab17

Phylogenomic databases

eggNOGiKOG0092 Eukaryota
ENOG410YCCP LUCA
GeneTreeiENSGT00760000119101
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP35292
KOiK07909
OMAiSVCHLYY
OrthoDBiEOG091G0KZI
PhylomeDBiP35292
TreeFamiTF300199

Enzyme and pathway databases

ReactomeiR-MMU-8873719 RAB geranylgeranylation

Miscellaneous databases

PROiPR:P35292
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026304 Expressed in 134 organ(s), highest expression level in jejunum
CleanExiMM_RAB17
ExpressionAtlasiP35292 baseline and differential
GenevisibleiP35292 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB17_MOUSE
AccessioniPrimary (citable) accession number: P35292
Secondary accession number(s): Q921D2, Q9D723
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 7, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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