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Protein

Ras-related protein Rab-23

Gene

Rab23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes (By similarity). Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity.By similarity5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 23GTPBy similarity8
Nucleotide bindingi64 – 68GTPBy similarity5
Nucleotide bindingi121 – 124GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-23
Alternative name(s):
Protein open brain
Rab-15
Gene namesi
Name:Rab23
Synonyms:Opb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:99833 Rab23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Endosome, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Rab23 are the cause of the open brain phenotype. Mice suffer from exencephaly and severe malformations of the spinal cord and the dorsal root ganglia, leading to complete embryonic lethality. In addition, mice display poorly developed eyes and polydactyly.

Disruption phenotypei

Complete embryonic lethality, due to defects in neural tube closure. Mice suffer from exencephaly and severe malformations of the spinal cord and the dorsal root ganglia. In addition, mice display poorly developed eyes and polydactyly.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212121 – 234Ras-related protein Rab-23Add BLAST234
PropeptideiPRO_0000370772235 – 237Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei186PhosphoserineBy similarity1
Modified residuei187PhosphoserineBy similarity1
Modified residuei234Cysteine methyl esterSequence analysis1
Lipidationi234S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiP35288
MaxQBiP35288
PaxDbiP35288
PeptideAtlasiP35288
PRIDEiP35288

PTM databases

iPTMnetiP35288
PhosphoSitePlusiP35288

Expressioni

Tissue specificityi

Detected in brain neurons (at protein level). Forebrain and midbrain.2 Publications

Gene expression databases

CleanExiMM_RAB23

Interactioni

Subunit structurei

Interacts with SUFU.By similarity

Protein-protein interaction databases

DIPiDIP-60517N
IntActiP35288, 1 interactor
STRINGi10090.ENSMUSP00000085625

Structurei

Secondary structure

1237
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP35288
SMRiP35288
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35288

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 46Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG4252 Eukaryota
ENOG4110BDM LUCA
HOGENOMiHOG000233968
HOVERGENiHBG100144
InParanoidiP35288
PhylomeDBiP35288

Family and domain databases

CDDicd04106 Rab23_like, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR034114 Rab23
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P35288-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLEEDMEVAI KMVVVGNGAV GKSSMIQRYC KGIFTKDYKK TIGVDFLERQ
60 70 80 90 100
IQVNDEDVRL MLWDTAGQEE FDAITKAYYR GAQACVLVFS TTDRESFEAI
110 120 130 140 150
SSWREKVVAE VGDIPTALVQ NKIDLLDDSC IKNEEAEGLA KRLKLRFYRT
160 170 180 190 200
SVKEDLNVSE VFKYLAEKHL QKLKQQITED PEQTHSSSNK IGVFNASVGS
210 220 230
HLGQNSSSLN GGDVINLRPN KQRTKRTRNP FSSCSVP
Length:237
Mass (Da):26,678
Last modified:October 1, 1996 - v2
Checksum:iAA1F2B25BAECD3E6
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9D4I9Q9D4I9_MOUSE
RAB23, member RAS oncogene family, ...
Rab23 mCG_10410
237Annotation score:
M0QWL7M0QWL7_MOUSE
Ras-related protein Rab-23
Rab23
64Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22821 mRNA Translation: CAA80474.1
BC025578 mRNA Translation: AAH25578.1
M79305 mRNA Translation: AAK14829.1
CCDSiCCDS35532.1
PIRiI48729 S40244
JH0645
UniGeneiMm.86744

Genome annotation databases

UCSCiuc007anv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22821 mRNA Translation: CAA80474.1
BC025578 mRNA Translation: AAH25578.1
M79305 mRNA Translation: AAK14829.1
CCDSiCCDS35532.1
PIRiI48729 S40244
JH0645
UniGeneiMm.86744

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z22X-ray2.06A7-172[»]
1Z2AX-ray1.90A7-172[»]
ProteinModelPortaliP35288
SMRiP35288
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60517N
IntActiP35288, 1 interactor
STRINGi10090.ENSMUSP00000085625

PTM databases

iPTMnetiP35288
PhosphoSitePlusiP35288

Proteomic databases

EPDiP35288
MaxQBiP35288
PaxDbiP35288
PeptideAtlasiP35288
PRIDEiP35288

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc007anv.1 mouse

Organism-specific databases

MGIiMGI:99833 Rab23

Phylogenomic databases

eggNOGiKOG4252 Eukaryota
ENOG4110BDM LUCA
HOGENOMiHOG000233968
HOVERGENiHBG100144
InParanoidiP35288
PhylomeDBiP35288

Miscellaneous databases

EvolutionaryTraceiP35288
PROiPR:P35288
SOURCEiSearch...

Gene expression databases

CleanExiMM_RAB23

Family and domain databases

CDDicd04106 Rab23_like, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR034114 Rab23
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB23_MOUSE
AccessioniPrimary (citable) accession number: P35288
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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