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Protein

Ras-related protein Rab-22A

Gene

Rab22a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in endocytosis and intracellular protein transport (PubMed:19759177, PubMed:27718357). Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (By similarity).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 20GTP9
Nucleotide bindingi60 – 64GTP5
Nucleotide bindingi118 – 121GTP4
Nucleotide bindingi148 – 150GTP3

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processEndocytosis, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-22A
Short name:
Rab-22
Alternative name(s):
Rab-14
Gene namesi
Name:Rab22a
Synonyms:Rab22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:105072 Rab22a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasmic vesicle, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi64Q → L: Constitutively active. Disrupts general recycling of receptors in embryonic fibroblasts. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212101 – 194Ras-related protein Rab-22AAdd BLAST194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi193S-geranylgeranyl cysteineBy similarity1
Lipidationi194S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

EPDiP35285
PaxDbiP35285
PeptideAtlasiP35285
PRIDEiP35285

PTM databases

iPTMnetiP35285
PhosphoSitePlusiP35285

Expressioni

Tissue specificityi

Detected in brain and heart, and at lower levels in lung and spleen.1 Publication

Gene expression databases

BgeeiENSMUSG00000027519 Expressed in 277 organ(s), highest expression level in humerus cartilage element
CleanExiMM_RAB22A
ExpressionAtlasiP35285 baseline and differential
GenevisibleiP35285 MM

Interactioni

Subunit structurei

Binds EEA1 (By similarity). Interacts (in its GTP-bound form) with RINL (By similarity). Interacts directly with ZFYVE20 (PubMed:16034420). Interacts (in its GTP-bound form) with RABGEF1 (PubMed:19759177).By similarity2 Publications

Protein-protein interaction databases

BioGridi202539, 1 interactor
DIPiDIP-60516N
IntActiP35285, 35 interactors
MINTiP35285
STRINGi10090.ENSMUSP00000029024

Structurei

Secondary structure

1194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP35285
SMRiP35285
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35285

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi34 – 42Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0092 Eukaryota
ENOG410YCCP LUCA
GeneTreeiENSGT00760000119101
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP35285
KOiK07891
OMAiKCDLSDA
OrthoDBiEOG091G0HKN
PhylomeDBiP35285
TreeFamiTF331262

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P35285-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALRELKVCL LGDTGVGKSS IVWRFVEDSF DPNINPTIGA SFMTKTVQYQ
60 70 80 90 100
NELHKFLIWD TAGQERFRAL APMYYRGSAA AIIVYDITKE ETFSTLKNWV
110 120 130 140 150
RELRQHGPPS IVVAIAGNKC DLTDVREVME RDAKDYADSI HAIFVETSAK
160 170 180 190
NAININELFI EISRRIPSTD ANPASGGKGF KLRRQPSEPK RSCC
Length:194
Mass (Da):21,802
Last modified:April 26, 2004 - v2
Checksum:i1799B676CA9091F7
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RFT6D6RFT6_MOUSE
Ras-related protein Rab-22A
Rab22a
68Annotation score:
A2ARZ7A2ARZ7_MOUSE
RAB22A, member RAS oncogene family,...
Rab22a mCG_13765
187Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54H → R in AAK14828 (PubMed:1555775).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ311124 mRNA Translation: CAC41378.1
AK031667 mRNA Translation: BAC27501.1
AK146594 mRNA Translation: BAE27289.1
AK150617 mRNA Translation: BAE29707.1
BC006596 mRNA Translation: AAH06596.1
M79304 mRNA Translation: AAK14828.1
CCDSiCCDS38352.1
PIRiJH0644
RefSeqiNP_077756.2, NM_024436.3
UniGeneiMm.275304

Genome annotation databases

EnsembliENSMUST00000029024; ENSMUSP00000029024; ENSMUSG00000027519
GeneIDi19334
KEGGimmu:19334
UCSCiuc008oed.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ311124 mRNA Translation: CAC41378.1
AK031667 mRNA Translation: BAC27501.1
AK146594 mRNA Translation: BAE27289.1
AK150617 mRNA Translation: BAE29707.1
BC006596 mRNA Translation: AAH06596.1
M79304 mRNA Translation: AAK14828.1
CCDSiCCDS38352.1
PIRiJH0644
RefSeqiNP_077756.2, NM_024436.3
UniGeneiMm.275304

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YVDX-ray1.93A3-169[»]
1Z0JX-ray1.32A2-169[»]
ProteinModelPortaliP35285
SMRiP35285
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202539, 1 interactor
DIPiDIP-60516N
IntActiP35285, 35 interactors
MINTiP35285
STRINGi10090.ENSMUSP00000029024

PTM databases

iPTMnetiP35285
PhosphoSitePlusiP35285

Proteomic databases

EPDiP35285
PaxDbiP35285
PeptideAtlasiP35285
PRIDEiP35285

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029024; ENSMUSP00000029024; ENSMUSG00000027519
GeneIDi19334
KEGGimmu:19334
UCSCiuc008oed.1 mouse

Organism-specific databases

CTDi57403
MGIiMGI:105072 Rab22a

Phylogenomic databases

eggNOGiKOG0092 Eukaryota
ENOG410YCCP LUCA
GeneTreeiENSGT00760000119101
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP35285
KOiK07891
OMAiKCDLSDA
OrthoDBiEOG091G0HKN
PhylomeDBiP35285
TreeFamiTF331262

Enzyme and pathway databases

ReactomeiR-MMU-8873719 RAB geranylgeranylation

Miscellaneous databases

EvolutionaryTraceiP35285
PROiPR:P35285
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027519 Expressed in 277 organ(s), highest expression level in humerus cartilage element
CleanExiMM_RAB22A
ExpressionAtlasiP35285 baseline and differential
GenevisibleiP35285 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRB22A_MOUSE
AccessioniPrimary (citable) accession number: P35285
Secondary accession number(s): Q3UCA7, Q91VD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: April 26, 2004
Last modified: November 7, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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