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Protein

Ras-related protein Rab-21

Gene

Rab21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration. During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Involved in neurite growth (By similarity).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 32GTPBy similarity9
Nucleotide bindingi72 – 76GTPBy similarity5
Nucleotide bindingi130 – 133GTPBy similarity4
Nucleotide bindingi160 – 162GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-21
Alternative name(s):
Rab-12
Gene namesi
Name:Rab21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:894308 Rab21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi31T → N: Defects in GTP-binding. Decrease in integrin-binding. 1 Publication1
Mutagenesisi76Q → L: Defects in GTP hydrolysis. Increase in integrin-binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001212062 – 219Ras-related protein Rab-21Add BLAST218
PropeptideiPRO_0000370769220 – 222Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Lipidationi218S-geranylgeranyl cysteineBy similarity1
Modified residuei219Cysteine methyl esterSequence analysis1
Lipidationi219S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP35282
PaxDbiP35282
PeptideAtlasiP35282
PRIDEiP35282

PTM databases

iPTMnetiP35282
PhosphoSitePlusiP35282
SwissPalmiP35282

Expressioni

Gene expression databases

BgeeiENSMUSG00000020132
CleanExiMM_RAB21
ExpressionAtlasiP35282 baseline and differential
GenevisibleiP35282 MM

Interactioni

Subunit structurei

Interacts with the cytoplasmic tail of integrins ITGA1, ITGA2, ITGA5, ITGA6, ITGA11 and ITGB1; this interaction is dependent upon its GDP/GTP cycle. Interacts with ANKRD27 (By similarity).By similarity1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiP35282, 34 interactors
MINTiP35282
STRINGi10090.ENSMUSP00000020343

Structurei

3D structure databases

ProteinModelPortaliP35282
SMRiP35282
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi46 – 54Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0088 Eukaryota
ENOG410XQT5 LUCA
GeneTreeiENSGT00760000119101
HOVERGENiHBG009351
InParanoidiP35282
KOiK07890
OMAiTDQDSFQ
OrthoDBiEOG091G0HKN
TreeFamiTF300199

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35282-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAGGGAAA AAGRAYSFKV VLLGEGCVGK TSLVLRYCEN KFNDKHITTL
60 70 80 90 100
QASFLTKKLN IGGKRVNLAI WDTAGQERFH ALGPIYYRDS NGAILVYDVT
110 120 130 140 150
DEDSFQKVKN WVKELRKMLG NEICLCIVGN KIDLEKERHV SIQEAESYAE
160 170 180 190 200
SVGAKHYHTS AKQNKGIEEL FLDLCKRMIE TAQVDERAKG NGSSQAGAAR
210 220
RGVQIIDDEP QAQSSGGCCS SG
Length:222
Mass (Da):24,106
Last modified:January 23, 2007 - v4
Checksum:i7FB005C28E8D6954
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC055042 mRNA Translation: AAH55042.1
M79302 mRNA Translation: AAK14826.1
CCDSiCCDS24177.1
PIRiA38879
RefSeqiNP_077774.1, NM_024454.1
UniGeneiMm.21936

Genome annotation databases

EnsembliENSMUST00000020343; ENSMUSP00000020343; ENSMUSG00000020132
GeneIDi216344
KEGGimmu:216344
UCSCiuc007haz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRAB21_MOUSE
AccessioniPrimary (citable) accession number: P35282
Secondary accession number(s): Q7TPN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 153 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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