UniProtKB - P35279 (RAB6A_MOUSE)
Ras-related protein Rab-6A
Rab6a
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 20 – 28 | GTPBy similarity | 9 | |
Nucleotide bindingi | 68 – 72 | GTPBy similarity | 5 | |
Nucleotide bindingi | 126 – 129 | GTPBy similarity | 4 | |
Nucleotide bindingi | 156 – 158 | GTPBy similarity | 3 |
GO - Molecular functioni
- ATPase activator activity Source: MGI
- ATPase binding Source: MGI
- GTPase activity Source: UniProtKB
- GTP binding Source: UniProtKB
- myosin V binding Source: MGI
- protein domain specific binding Source: MGI
GO - Biological processi
- antigen processing and presentation Source: MGI
- early endosome to Golgi transport Source: MGI
- intracellular protein transport Source: GO_Central
- intra-Golgi vesicle-mediated transport Source: GO_Central
- peptidyl-cysteine methylation Source: MGI
- protein localization to Golgi apparatus Source: UniProtKB
- retrograde transport, endosome to Golgi Source: GO_Central
- retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: UniProtKB
Keywordsi
Biological process | ER-Golgi transport, Protein transport, Transport |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-6798695, Neutrophil degranulation R-MMU-6811436, COPI-independent Golgi-to-ER retrograde traffic R-MMU-6811438, Intra-Golgi traffic R-MMU-6811440, Retrograde transport at the Trans-Golgi-Network R-MMU-8854214, TBC/RABGAPs R-MMU-8873719, RAB geranylgeranylation R-MMU-8876198, RAB GEFs exchange GTP for GDP on RABs |
Names & Taxonomyi
Protein namesi | Recommended name: Ras-related protein Rab-6AShort name: Rab-6 |
Gene namesi | Name:Rab6a Synonyms:Rab6 ORF Names:MNCb-1660 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:894313, Rab6a |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane By similarity; Lipid-anchor By similarity
Note: BICD2 facilitates its targeting to Golgi apparatus membrane.By similarity
Cytosol
- cytosol Source: MGI
Golgi apparatus
- Golgi apparatus Source: MGI
- Golgi membrane Source: UniProtKB
- trans-Golgi network Source: MGI
Other locations
- cytoplasmic vesicle Source: MGI
- endomembrane system Source: GO_Central
- endosome to plasma membrane transport vesicle Source: MGI
- membrane Source: MGI
- presynapse Source: MGI
Keywords - Cellular componenti
Golgi apparatus, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 22 | Q → V: Loss of binding to rabkinesin-6. 1 Publication | 1 | |
Mutagenesisi | 27 | T → N: Loss of binding to rabkinesin-6; when associated with L-73. 1 Publication | 1 | |
Mutagenesisi | 46 | I → E: Loss of binding to rabkinesin-6. 1 Publication | 1 | |
Mutagenesisi | 72 | Q → L: Loss of binding to rabkinesin-6; when associated with N-28. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000121113 | 2 – 208 | Ras-related protein Rab-6AAdd BLAST | 207 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 184 | PhosphoserineCombined sources | 1 | |
Lipidationi | 206 | S-geranylgeranyl cysteineBy similarity | 1 | |
Modified residuei | 208 | Cysteine methyl esterBy similarity | 1 | |
Lipidationi | 208 | S-geranylgeranyl cysteineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Lipoprotein, Methylation, Phosphoprotein, PrenylationProteomic databases
EPDi | P35279 |
jPOSTi | P35279 |
PaxDbi | P35279 |
PeptideAtlasi | P35279 |
PRIDEi | P35279 |
TopDownProteomicsi | P35279-1 [P35279-1] |
PTM databases
iPTMneti | P35279 |
PhosphoSitePlusi | P35279 |
SwissPalmi | P35279 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000030704, Expressed in cerebral cortex and 317 other tissues |
Genevisiblei | P35279, MM |
Interactioni
Subunit structurei
Interacts with RIC1 and RGP1; the interactions are direct with a preference for RAB6A-GDP.
Interacts with VSP52 and RABGAP1.
Interacts with GCC2 (via its GRIP domain).
Interacts with RAB6IP1 (via its RUN 1 domain).
Interacts with RAB6KIFL.
Interacts with BICD1.
Interacts with BICD2.
Interacts with TMF1.
Interacts (GTP-bound) with DYNLRB1; the interaction is direct (By similarity).
Interacts with SCYL1BP1.
Interacts with BICDL1; leads to its accumulation in the pericentrosomal region.
Interacts with PIFO.
Interacts (GTP-bound) with APBA1/MINT1 isoform 3, also called Mint1_826.
By similarity4 PublicationsBinary interactionsi
Hide detailsP35279
With | #Exp. | IntAct |
---|---|---|
Bicd2 [Q921C5] | 3 | EBI-444674,EBI-642984 |
Bicdl1 [A0JNT9] | 6 | EBI-444674,EBI-7893170 |
SYTL5 [Q8TDW5] from Homo sapiens. | 2 | EBI-444674,EBI-2939487 |
GO - Molecular functioni
- ATPase binding Source: MGI
- myosin V binding Source: MGI
- protein domain specific binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 202550, 9 interactors |
DIPi | DIP-120N |
IntActi | P35279, 27 interactors |
MINTi | P35279 |
STRINGi | 10090.ENSMUSP00000032946 |
Miscellaneous databases
RNActi | P35279, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 42 – 50 | Effector regionBy similarity | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0094, Eukaryota |
GeneTreei | ENSGT00940000154769 |
HOGENOMi | CLU_041217_10_2_1 |
InParanoidi | P35279 |
OMAi | SKAMYLE |
PhylomeDBi | P35279 |
TreeFami | TF300803 |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSAGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF
60 70 80 90 100
LSKTMYLEDR TVRLQLWDTA GQERFRSLIP SYIRDSTVAV VVYDITNVNS
110 120 130 140 150
FQQTTKWIDD VRTERGSDVI IMLVGNKTDL ADKRQVSIEE GERKAKELNV
160 170 180 190 200
MFIETSAKAG YNVKQLFRRV AAALPGMEST QDRSREDMID IKLEKPQEQP
VNEGGCSC
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3YV69 | D3YV69_MOUSE | Ras-related protein Rab-6A | Rab6a | 175 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005528 | 62 – 88 | VRLQL…RDSTV → IRLQLWDTAGQERFRSLIPS YIRDSAA in isoform 2. 2 PublicationsAdd BLAST | 27 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB041575 mRNA Translation: BAA95059.1 AK051246 mRNA Translation: BAC34572.1 AK083262 mRNA Translation: BAC38834.1 AK084131 mRNA Translation: BAC39121.1 AK160134 mRNA Translation: BAE35649.1 AK160866 mRNA Translation: BAE36058.1 AK169842 mRNA Translation: BAE41406.1 BC019118 mRNA Translation: AAH19118.1 BC026915 mRNA Translation: AAH26915.1 M79313 mRNA Translation: AAK14837.1 |
CCDSi | CCDS21503.1 [P35279-1] CCDS52323.1 [P35279-2] |
PIRi | A38883 |
RefSeqi | NP_001157135.1, NM_001163663.1 [P35279-2] NP_077249.1, NM_024287.4 [P35279-1] |
Genome annotation databases
Ensembli | ENSMUST00000032946; ENSMUSP00000032946; ENSMUSG00000030704 [P35279-1] ENSMUST00000098252; ENSMUSP00000095852; ENSMUSG00000030704 [P35279-2] |
GeneIDi | 19346 |
KEGGi | mmu:19346 |
UCSCi | uc009ini.2, mouse [P35279-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB041575 mRNA Translation: BAA95059.1 AK051246 mRNA Translation: BAC34572.1 AK083262 mRNA Translation: BAC38834.1 AK084131 mRNA Translation: BAC39121.1 AK160134 mRNA Translation: BAE35649.1 AK160866 mRNA Translation: BAE36058.1 AK169842 mRNA Translation: BAE41406.1 BC019118 mRNA Translation: AAH19118.1 BC026915 mRNA Translation: AAH26915.1 M79313 mRNA Translation: AAK14837.1 |
CCDSi | CCDS21503.1 [P35279-1] CCDS52323.1 [P35279-2] |
PIRi | A38883 |
RefSeqi | NP_001157135.1, NM_001163663.1 [P35279-2] NP_077249.1, NM_024287.4 [P35279-1] |
3D structure databases
SMRi | P35279 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 202550, 9 interactors |
DIPi | DIP-120N |
IntActi | P35279, 27 interactors |
MINTi | P35279 |
STRINGi | 10090.ENSMUSP00000032946 |
PTM databases
iPTMneti | P35279 |
PhosphoSitePlusi | P35279 |
SwissPalmi | P35279 |
Proteomic databases
EPDi | P35279 |
jPOSTi | P35279 |
PaxDbi | P35279 |
PeptideAtlasi | P35279 |
PRIDEi | P35279 |
TopDownProteomicsi | P35279-1 [P35279-1] |
Protocols and materials databases
ABCDi | P35279, 39 sequenced antibodies |
Antibodypediai | 4093, 281 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000032946; ENSMUSP00000032946; ENSMUSG00000030704 [P35279-1] ENSMUST00000098252; ENSMUSP00000095852; ENSMUSG00000030704 [P35279-2] |
GeneIDi | 19346 |
KEGGi | mmu:19346 |
UCSCi | uc009ini.2, mouse [P35279-1] |
Organism-specific databases
CTDi | 5870 |
MGIi | MGI:894313, Rab6a |
Phylogenomic databases
eggNOGi | KOG0094, Eukaryota |
GeneTreei | ENSGT00940000154769 |
HOGENOMi | CLU_041217_10_2_1 |
InParanoidi | P35279 |
OMAi | SKAMYLE |
PhylomeDBi | P35279 |
TreeFami | TF300803 |
Enzyme and pathway databases
Reactomei | R-MMU-6798695, Neutrophil degranulation R-MMU-6811436, COPI-independent Golgi-to-ER retrograde traffic R-MMU-6811438, Intra-Golgi traffic R-MMU-6811440, Retrograde transport at the Trans-Golgi-Network R-MMU-8854214, TBC/RABGAPs R-MMU-8873719, RAB geranylgeranylation R-MMU-8876198, RAB GEFs exchange GTP for GDP on RABs |
Miscellaneous databases
BioGRID-ORCSi | 19346, 6 hits in 17 CRISPR screens |
ChiTaRSi | Rab6a, mouse |
PROi | PR:P35279 |
RNActi | P35279, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030704, Expressed in cerebral cortex and 317 other tissues |
Genevisiblei | P35279, MM |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RAB6A_MOUSE | |
Accessioni | P35279Primary (citable) accession number: P35279 Secondary accession number(s): Q542M6 Q9JJD4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 189 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families