Rab6a

Functionⁱ

Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Involved in COPI-independent retrograde transport from the Golgi to the ER (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	20 – 28	GTPBy similarity	9
Nucleotide bindingⁱ	68 – 72	GTPBy similarity	5
Nucleotide bindingⁱ	126 – 129	GTPBy similarity	4
Nucleotide bindingⁱ	156 – 158	GTPBy similarity	3

GO - Molecular functionⁱ

ATPase activator activity Source: MGI
ATPase binding Source: MGI
GTPase activity Source: UniProtKB
GTP binding Source: UniProtKB
myosin V binding Source: MGI
protein domain specific binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antigen processing and presentation Source: MGI
early endosome to Golgi transport Source: MGI
intracellular protein transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
intra-Golgi vesicle-mediated transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
peptidyl-cysteine methylation
Source: MGI
Inferred from sequence orthologyⁱ
- 11121396
protein localization to Golgi apparatus Source: UniProtKB
Rab protein signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
retrograde transport, endosome to Golgi
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
retrograde vesicle-mediated transport, Golgi to ER Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	ER-Golgi transport, Protein transport, Transport
Ligand	GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6798695 Neutrophil degranulation R-MMU-6811436 COPI-independent Golgi-to-ER retrograde traffic R-MMU-6811440 Retrograde transport at the Trans-Golgi-Network R-MMU-8854214 TBC/RABGAPs R-MMU-8873719 RAB geranylgeranylation R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Reactomeⁱ

R-MMU-6798695 Neutrophil degranulation
R-MMU-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-MMU-6811440 Retrograde transport at the Trans-Golgi-Network
R-MMU-8854214 TBC/RABGAPs
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-related protein Rab-6A Short name: Rab-6
Gene namesⁱ	Name:Rab6a Synonyms:Rab6 ORF Names:MNCb-1660
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:894313 Rab6a

Keywords - Cellular componentⁱ

Golgi apparatus, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	22	Q → V: Loss of binding to rabkinesin-6. 1 Publication	1
Mutagenesisⁱ	27	T → N: Loss of binding to rabkinesin-6; when associated with L-73. 1 Publication	1
Mutagenesisⁱ	46	I → E: Loss of binding to rabkinesin-6. 1 Publication	1
Mutagenesisⁱ	72	Q → L: Loss of binding to rabkinesin-6; when associated with N-28. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000121113	2 – 208	Ras-related protein Rab-6AAdd BLAST		207

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineBy similarity	1
Modified residueⁱ	184	PhosphoserineCombined sources	1
Lipidationⁱ	206	S-geranylgeranyl cysteineBy similarity	1
Modified residueⁱ	208	Cysteine methyl esterBy similarity	1
Lipidationⁱ	208	S-geranylgeranyl cysteineBy similarity	1

Post-translational modificationⁱ

Prenylated.By similarity

Keywords - PTMⁱ

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDⁱ	P35279
PaxDbⁱ	P35279
PeptideAtlas More...PeptideAtlasⁱ	P35279
PRIDEⁱ	P35279
TopDownProteomicsⁱ	P35279-1 [P35279-1]

PTM databases

iPTMnetⁱ	P35279
PhosphoSitePlusⁱ	P35279

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000030704 Expressed in 305 organ(s), highest expression level in cerebral cortex
CleanExⁱ	MM_RAB6
ExpressionAtlasⁱ	P35279 baseline and differential
Genevisibleⁱ	P35279 MM

Interactionⁱ

Subunit structureⁱ

Interacts with RIC1 and RGP1; the interactions are direct with a preference for RAB6A-GDP. Interacts with VSP52 and RABGAP1. Interacts with GCC2 (via its GRIP domain). Interacts with RAB6IP1 (via its RUN 1 domain). Interacts with RAB6KIFL. Interacts with BICD1. Interacts with BICD2. Interacts with TMF1. Interacts (GTP-bound) with DYNLRB1; the interaction is direct (By similarity). Interacts with SCYL1BP1. Interacts with BICDL1; leads to its accumulation in the pericentrosomal region. Interacts with PIFO. Interacts (GTP-bound) with APBA1/MINT1 isoform 3, also called Mint1_826.By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Bicd2	Q921C5	3	EBI-444674,EBI-642984
Bicdl1	A0JNT9	6	EBI-444674,EBI-7893170
SYTL5	Q8TDW5	2	EBI-444674,EBI-2939487	From Homo sapiens.

GO - Molecular functionⁱ

ATPase binding Source: MGI
myosin V binding Source: MGI
protein domain specific binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	202550, 3 interactors
Database of interacting proteins More...DIPⁱ	DIP-120N
IntActⁱ	P35279, 27 interactors
Molecular INTeraction database More...MINTⁱ	P35279
STRINGⁱ	10090.ENSMUSP00000032946

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P35279
SMRⁱ	P35279
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	42 – 50	Effector regionBy similarity		9

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0094 Eukaryota ENOG410XPBI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144073
HOGENOMⁱ	HOG000233968
HOVERGENⁱ	HBG009351
InParanoidⁱ	P35279
KEGG Orthology (KO) More...KOⁱ	K07893
OMAⁱ	VPEASQC
PhylomeDBⁱ	P35279
TreeFamⁱ	TF300803

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P35279-1) [UniParc]FASTA Add to basket

Also known as: Rab-6a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF 
        60         70         80         90        100
LSKTMYLEDR TVRLQLWDTA GQERFRSLIP SYIRDSTVAV VVYDITNVNS 
       110        120        130        140        150
FQQTTKWIDD VRTERGSDVI IMLVGNKTDL ADKRQVSIEE GERKAKELNV 
       160        170        180        190        200
MFIETSAKAG YNVKQLFRRV AAALPGMEST QDRSREDMID IKLEKPQEQP 

VNEGGCSC

Length:208

Mass (Da):23,590

Last modified:January 23, 2007 - v4

Checksum:ⁱDD08CC2914668FD4

GO

Isoform 2 (identifier: P35279-2) [UniParc]FASTA Add to basket

Also known as: Rab-6a', Rab6C

The sequence of this isoform differs from the canonical sequence as follows:
62-88: VRLQLWDTAGQERFRSLIPSYIRDSTV → IRLQLWDTAGQERFRSLIPSYIRDSAA

« Hide

        10         20         30         40         50
MSAGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF 
        60         70         80         90        100
LSKTMYLEDR TIRLQLWDTA GQERFRSLIP SYIRDSAAAV VVYDITNVNS 
       110        120        130        140        150
FQQTTKWIDD VRTERGSDVI IMLVGNKTDL ADKRQVSIEE GERKAKELNV 
       160        170        180        190        200
MFIETSAKAG YNVKQLFRRV AAALPGMEST QDRSREDMID IKLEKPQEQP 

VNEGGCSC

Show »

Length:208

Mass (Da):23,546

Checksum:ⁱCBE04CA13D0A48C1

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D3YV69	D3YV69_MOUSE		Ras-related protein Rab-6A Ras-related protein Rab-6A	Rab6a	175	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_005528	62 – 88	VRLQL…RDSTV → IRLQLWDTAGQERFRSLIPS YIRDSAA in isoform 2. 2 PublicationsAdd BLAST		27

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB041575 mRNA Translation: BAA95059.1 AK051246 mRNA Translation: BAC34572.1 AK083262 mRNA Translation: BAC38834.1 AK084131 mRNA Translation: BAC39121.1 AK160134 mRNA Translation: BAE35649.1 AK160866 mRNA Translation: BAE36058.1 AK169842 mRNA Translation: BAE41406.1 BC019118 mRNA Translation: AAH19118.1 BC026915 mRNA Translation: AAH26915.1 M79313 mRNA Translation: AAK14837.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS21503.1 [P35279-1] CCDS52323.1 [P35279-2]
PIRⁱ	A38883
NCBI Reference Sequences More...RefSeqⁱ	NP_001157135.1, NM_001163663.1 [P35279-2] NP_077249.1, NM_024287.4 [P35279-1]
UniGeneⁱ	Mm.28650

Genome annotation databases

Ensemblⁱ	ENSMUST00000032946; ENSMUSP00000032946; ENSMUSG00000030704 [P35279-1] ENSMUST00000098252; ENSMUSP00000095852; ENSMUSG00000030704 [P35279-2]
GeneIDⁱ	19346
KEGGⁱ	mmu:19346
UCSC genome browser More...UCSCⁱ	uc009ini.2 mouse [P35279-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P35279	Ras-related protein Rab-6A		RAT		208	UniRef100_P35279
RAB6, member RAS oncogene family, isoform CRA_a		MOUSE		208
P35279-2	RAB6, member RAS oncogene family, isoform CRA_c		MOUSE		208	UniRef100_Q3U4W5
RCG39700, isoform CRA_d		RAT		208
Ras-related protein Rab-6A		MOUSE		175

Protein	Similar proteins		Species	Score	Length	Source
P35279	Ras-related protein Rab-6A	)	HUMAN		208	UniRef90_P20340
Ras-related protein Rab-6A		PONAB		208
Ras-related protein Rab-6A		RAT		208
RAB6A isoform 3		PANTR		208
Uncharacterized protein		PANPA		208
+69
P35279-2	Ras-related protein Rab-6A		CHICK		208	UniRef90_Q1KME6
Ras-related protein Rab-6A isoform A		ALLMI		208
Uncharacterized protein		LATCH		210
Uncharacterized protein		CALSU		209
Uncharacterized protein		FICAL		208
+161

Protein	Similar proteins		Species	Score	Length	Source
P35279	Ras-related protein Rab-6A	)	HUMAN		208	UniRef50_P20340
Ras-related protein Rab-6A		PONAB		208
Ras-related protein Rab-6A		RAT		208
GTP-binding protein YPT6		YEAST		215
Ras-related protein Rab-6A		CHICK		208
+576

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB041575 mRNA Translation: BAA95059.1 AK051246 mRNA Translation: BAC34572.1 AK083262 mRNA Translation: BAC38834.1 AK084131 mRNA Translation: BAC39121.1 AK160134 mRNA Translation: BAE35649.1 AK160866 mRNA Translation: BAE36058.1 AK169842 mRNA Translation: BAE41406.1 BC019118 mRNA Translation: AAH19118.1 BC026915 mRNA Translation: AAH26915.1 M79313 mRNA Translation: AAK14837.1
CCDSⁱ	CCDS21503.1 [P35279-1] CCDS52323.1 [P35279-2]
PIRⁱ	A38883
RefSeqⁱ	NP_001157135.1, NM_001163663.1 [P35279-2] NP_077249.1, NM_024287.4 [P35279-1]
UniGeneⁱ	Mm.28650

3D structure databases

ProteinModelPortalⁱ	P35279
SMRⁱ	P35279
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	202550, 3 interactors
DIPⁱ	DIP-120N
IntActⁱ	P35279, 27 interactors
MINTⁱ	P35279
STRINGⁱ	10090.ENSMUSP00000032946

PTM databases

iPTMnetⁱ	P35279
PhosphoSitePlusⁱ	P35279

Proteomic databases

EPDⁱ	P35279
PaxDbⁱ	P35279
PeptideAtlasⁱ	P35279
PRIDEⁱ	P35279
TopDownProteomicsⁱ	P35279-1 [P35279-1]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000032946; ENSMUSP00000032946; ENSMUSG00000030704 [P35279-1] ENSMUST00000098252; ENSMUSP00000095852; ENSMUSG00000030704 [P35279-2]
GeneIDⁱ	19346
KEGGⁱ	mmu:19346
UCSCⁱ	uc009ini.2 mouse [P35279-1]

Organism-specific databases

CTDⁱ	5870
MGIⁱ	MGI:894313 Rab6a

Phylogenomic databases

eggNOGⁱ	KOG0094 Eukaryota ENOG410XPBI LUCA
GeneTreeⁱ	ENSGT00910000144073
HOGENOMⁱ	HOG000233968
HOVERGENⁱ	HBG009351
InParanoidⁱ	P35279
KOⁱ	K07893
OMAⁱ	VPEASQC
PhylomeDBⁱ	P35279
TreeFamⁱ	TF300803

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6798695 Neutrophil degranulation R-MMU-6811436 COPI-independent Golgi-to-ER retrograde traffic R-MMU-6811440 Retrograde transport at the Trans-Golgi-Network R-MMU-8854214 TBC/RABGAPs R-MMU-8873719 RAB geranylgeranylation R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Reactomeⁱ

R-MMU-6798695 Neutrophil degranulation
R-MMU-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-MMU-6811440 Retrograde transport at the Trans-Golgi-Network
R-MMU-8854214 TBC/RABGAPs
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSⁱ	Rab6a mouse
Protein Ontology More...PROⁱ	PR:P35279
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000030704 Expressed in 305 organ(s), highest expression level in cerebral cortex
CleanExⁱ	MM_RAB6
ExpressionAtlasⁱ	P35279 baseline and differential
Genevisibleⁱ	P35279 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RAB6A_MOUSE
Accessionⁱ	P35279Primary (citable) accession number: P35279 Secondary accession number(s): Q542M6 , Q8R2Z7, Q8VEE5, Q9JJD4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 176 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P35279 (RAB6A_MOUSE)

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Ras-related protein Rab-6A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Cytosol

Golgi apparatus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ