Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ras-related protein Rab-5C

Gene

Rab5c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi28 – 36GTPBy similarity9
Nucleotide bindingi47 – 53GTPBy similarity7
Nucleotide bindingi76 – 80GTPBy similarity5
Nucleotide bindingi134 – 137GTPBy similarity4
Nucleotide bindingi164 – 166GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

  • endosome organization Source: MGI
  • intracellular protein transport Source: GO_Central
  • plasma membrane to endosome transport Source: MGI
  • Rab protein signal transduction Source: GO_Central
  • regulation of endocytosis Source: MGI

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-432722 Golgi Associated Vesicle Biogenesis
R-MMU-6798695 Neutrophil degranulation
R-MMU-8856828 Clathrin-mediated endocytosis
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-5C
Gene namesi
Name:Rab5c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:105306 Rab5c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211111 – 216Ras-related protein Rab-5CAdd BLAST216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi213S-geranylgeranyl cysteineBy similarity1
Lipidationi214S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

EPDiP35278
PaxDbiP35278
PeptideAtlasiP35278
PRIDEiP35278

PTM databases

iPTMnetiP35278
PhosphoSitePlusiP35278
SwissPalmiP35278

Expressioni

Gene expression databases

BgeeiENSMUSG00000019173 Expressed in 283 organ(s), highest expression level in stomach
CleanExiMM_RAB5C
ExpressionAtlasiP35278 baseline and differential
GenevisibleiP35278 MM

Interactioni

Subunit structurei

Interacts with EEA1 and INCA1.By similarity

Protein-protein interaction databases

BioGridi202549, 114 interactors
DIPiDIP-56521N
IntActiP35278, 138 interactors
MINTiP35278
STRINGi10090.ENSMUSP00000102987

Structurei

Secondary structure

1216
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP35278
SMRiP35278
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35278

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi50 – 58Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0092 Eukaryota
ENOG410YCCP LUCA
GeneTreeiENSGT00760000119101
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP35278
KOiK07889
OMAiQTTVKFE

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P35278-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGRGGAARP NGPAAGNKIC QFKLVLLGES AVGKSSLVLR FVKGQFHEYQ
60 70 80 90 100
ESTIGAAFLT QTVCLDDTTV KFEIWDTAGQ ERYHSLAPMY YRGAQAAIVV
110 120 130 140 150
YDITNTDTFA RAKNWVKELQ RQASPNIVIA LAGNKADLAS KRAVEFQEAQ
160 170 180 190 200
AYADDNSLLF METSAKTAMN VNEIFMAIAK KLPKNEPQNA AGAPGRTRGV
210
DLQESNPASR SQCCSN
Length:216
Mass (Da):23,413
Last modified:October 31, 2003 - v2
Checksum:iAA5658239D8D77ED
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8C266Q8C266_MOUSE
Ras-related protein Rab-5C
Rab5c
234Annotation score:
A2A5F5A2A5F5_MOUSE
Ras-related protein Rab-5C
Rab5c
83Annotation score:
A2A5F6A2A5F6_MOUSE
Ras-related protein Rab-5C
Rab5c
34Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC023027 mRNA Translation: AAH23027.1
BC027378 mRNA Translation: AAH27378.1
BC029678 mRNA Translation: AAH29678.1
M79312 mRNA Translation: AAK14836.1
CCDSiCCDS36333.1
PIRiJH0641
RefSeqiNP_077776.2, NM_024456.5
UniGeneiMm.29829

Genome annotation databases

EnsembliENSMUST00000107364; ENSMUSP00000102987; ENSMUSG00000019173
GeneIDi19345
KEGGimmu:19345
UCSCiuc007lme.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC023027 mRNA Translation: AAH23027.1
BC027378 mRNA Translation: AAH27378.1
BC029678 mRNA Translation: AAH29678.1
M79312 mRNA Translation: AAK14836.1
CCDSiCCDS36333.1
PIRiJH0641
RefSeqiNP_077776.2, NM_024456.5
UniGeneiMm.29829

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HUQX-ray1.80A19-182[»]
1Z07X-ray1.81A19-182[»]
1Z0DX-ray2.20A/C19-183[»]
ProteinModelPortaliP35278
SMRiP35278
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202549, 114 interactors
DIPiDIP-56521N
IntActiP35278, 138 interactors
MINTiP35278
STRINGi10090.ENSMUSP00000102987

PTM databases

iPTMnetiP35278
PhosphoSitePlusiP35278
SwissPalmiP35278

Proteomic databases

EPDiP35278
PaxDbiP35278
PeptideAtlasiP35278
PRIDEiP35278

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107364; ENSMUSP00000102987; ENSMUSG00000019173
GeneIDi19345
KEGGimmu:19345
UCSCiuc007lme.2 mouse

Organism-specific databases

CTDi5878
MGIiMGI:105306 Rab5c

Phylogenomic databases

eggNOGiKOG0092 Eukaryota
ENOG410YCCP LUCA
GeneTreeiENSGT00760000119101
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP35278
KOiK07889
OMAiQTTVKFE

Enzyme and pathway databases

ReactomeiR-MMU-432722 Golgi Associated Vesicle Biogenesis
R-MMU-6798695 Neutrophil degranulation
R-MMU-8856828 Clathrin-mediated endocytosis
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

EvolutionaryTraceiP35278
PROiPR:P35278
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019173 Expressed in 283 organ(s), highest expression level in stomach
CleanExiMM_RAB5C
ExpressionAtlasiP35278 baseline and differential
GenevisibleiP35278 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB5C_MOUSE
AccessioniPrimary (citable) accession number: P35278
Secondary accession number(s): Q8R1V8, Q8R2N8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 31, 2003
Last modified: November 7, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again