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Protein

Ras-related protein Rab-3D

Gene

Rab3d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity). May be involved in the insulin-induced exocytosis of glut4-containing vesicles in adipocytes.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 37GTPBy similarity9
Nucleotide bindingi48 – 54GTPBy similarity7
Nucleotide bindingi77 – 81GTPBy similarity5
Nucleotide bindingi135 – 138GTPBy similarity4
Nucleotide bindingi165 – 167GTPBy similarity3

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW
  • GTP-dependent protein binding Source: MGI
  • myosin V binding Source: MGI

GO - Biological processi

Keywordsi

Biological processExocytosis, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-3D
Gene namesi
Name:Rab3d
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:97844 Rab3d

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001210892 – 219Ras-related protein Rab-3DAdd BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei190PhosphoserineBy similarity1
Lipidationi217S-geranylgeranyl cysteineBy similarity1
Modified residuei219Cysteine methyl esterBy similarity1
Lipidationi219S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiP35276
PaxDbiP35276
PeptideAtlasiP35276
PRIDEiP35276

PTM databases

iPTMnetiP35276
PhosphoSitePlusiP35276

Expressioni

Tissue specificityi

Predominantly expressed in the adipocyte tissue, but is also expressed in several other organs including skin, spleen, heart and lung.

Gene expression databases

BgeeiENSMUSG00000019066 Expressed in 234 organ(s), highest expression level in lacrimal gland
CleanExiMM_RAB3D
ExpressionAtlasiP35276 baseline and differential
GenevisibleiP35276 MM

Interactioni

Subunit structurei

Interacts with RIMS1, RIMS2, RPH3A, RPH3AL and RAB3IP.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202545, 6 interactors
IntActiP35276, 14 interactors
MINTiP35276
STRINGi10090.ENSMUSP00000111008

Structurei

3D structure databases

ProteinModelPortaliP35276
SMRiP35276
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi51 – 59Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0093 Eukaryota
ENOG410ZZXQ LUCA
GeneTreeiENSGT00890000139330
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP35276
KOiK07884
OMAiKGPTLGD
OrthoDBiEOG091G0J64
PhylomeDBiP35276
TreeFamiTF313199

Family and domain databases

CDDicd01865 Rab3, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR037872 Rab3
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P35276-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASASEPPAS PRDAADQNFD YMFKLLLIGN SSVGKTSFLF RYADDSFTPA
60 70 80 90 100
FVSTVGIDFK VKTVYRHDKR IKLQIWDTAG QERYRTITTA YYRGAMGFLL
110 120 130 140 150
MYDIANQESF TAVQDWATQI KTYSWDNAQV ILVGNKCDLE DERVVPAEDG
160 170 180 190 200
RRLADDLGFE FFEASAKENI NVKQVFERLV DIICDKMNES LEPSSSPGSN
210
GKGPALGDTP PPQPSSCSC
Length:219
Mass (Da):24,416
Last modified:February 1, 1994 - v1
Checksum:i438115B0B5710648
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YWL1D3YWL1_MOUSE
Ras-related protein Rab-3D
Rab3d
106Annotation score:
D3YW33D3YW33_MOUSE
RAB3D, member RAS oncogene family, ...
Rab3d mCG_14029
136Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89777 mRNA Translation: AAA40026.1
AF263365 mRNA Translation: AAF82769.1
AF263366 Genomic DNA Translation: AAF82770.1
BC010779 mRNA Translation: AAH10779.1
BC020010 mRNA Translation: AAH20010.1
CCDSiCCDS22912.1
PIRiA45384
RefSeqiNP_001311460.1, NM_001324531.1
NP_114080.2, NM_031874.5
XP_011240724.1, XM_011242422.2
XP_011240725.1, XM_011242423.2
UniGeneiMm.260157

Genome annotation databases

EnsembliENSMUST00000115351; ENSMUSP00000111008; ENSMUSG00000019066
ENSMUST00000122211; ENSMUSP00000113322; ENSMUSG00000019066
GeneIDi19340
KEGGimmu:19340
UCSCiuc009omu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89777 mRNA Translation: AAA40026.1
AF263365 mRNA Translation: AAF82769.1
AF263366 Genomic DNA Translation: AAF82770.1
BC010779 mRNA Translation: AAH10779.1
BC020010 mRNA Translation: AAH20010.1
CCDSiCCDS22912.1
PIRiA45384
RefSeqiNP_001311460.1, NM_001324531.1
NP_114080.2, NM_031874.5
XP_011240724.1, XM_011242422.2
XP_011240725.1, XM_011242423.2
UniGeneiMm.260157

3D structure databases

ProteinModelPortaliP35276
SMRiP35276
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202545, 6 interactors
IntActiP35276, 14 interactors
MINTiP35276
STRINGi10090.ENSMUSP00000111008

PTM databases

iPTMnetiP35276
PhosphoSitePlusiP35276

Proteomic databases

EPDiP35276
PaxDbiP35276
PeptideAtlasiP35276
PRIDEiP35276

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115351; ENSMUSP00000111008; ENSMUSG00000019066
ENSMUST00000122211; ENSMUSP00000113322; ENSMUSG00000019066
GeneIDi19340
KEGGimmu:19340
UCSCiuc009omu.1 mouse

Organism-specific databases

CTDi9545
MGIiMGI:97844 Rab3d

Phylogenomic databases

eggNOGiKOG0093 Eukaryota
ENOG410ZZXQ LUCA
GeneTreeiENSGT00890000139330
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP35276
KOiK07884
OMAiKGPTLGD
OrthoDBiEOG091G0J64
PhylomeDBiP35276
TreeFamiTF313199

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-8873719 RAB geranylgeranylation

Miscellaneous databases

ChiTaRSiRab3d mouse
PROiPR:P35276
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019066 Expressed in 234 organ(s), highest expression level in lacrimal gland
CleanExiMM_RAB3D
ExpressionAtlasiP35276 baseline and differential
GenevisibleiP35276 MM

Family and domain databases

CDDicd01865 Rab3, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR037872 Rab3
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB3D_MOUSE
AccessioniPrimary (citable) accession number: P35276
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 7, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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