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Protein

Sepiapterin reductase

Gene

SPR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=14.3 µM for sepiapterin1 Publication
  2. KM=10 µM for NADPH1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei170SubstrateBy similarity1
    Binding sitei174NADPBy similarity1
    Binding sitei199Substrate; via amide nitrogenBy similarity1
    Binding sitei257SubstrateBy similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi14 – 20NADP1 Publication7
    Nucleotide bindingi42 – 43NADP1 Publication2
    Nucleotide bindingi69 – 70NADP1 Publication2
    Nucleotide bindingi201 – 206NADP1 Publication6

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • aldo-keto reductase (NADP) activity Source: UniProtKB
    • NADP binding Source: UniProtKB
    • sepiapterin reductase activity Source: UniProtKB

    GO - Biological processi

    • cofactor metabolic process Source: Reactome
    • nitric oxide biosynthetic process Source: UniProtKB
    • oxidation-reduction process Source: UniProtKB
    • regulation of nitric-oxide synthase activity Source: Reactome
    • tetrahydrobiopterin biosynthetic process Source: GO_Central

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    LigandNADP

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS03979-MONOMER

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
    R-HSA-203615 eNOS activation

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    P35270

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Sepiapterin reductase (EC:1.1.1.153)
    Short name:
    SPR
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SPR
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000116096.5

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:11257 SPR

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    182125 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P35270

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Dystonia, DOPA-responsive, due to sepiapterin reductase deficiency (DRDSPRD)3 Publications
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA form of DOPA-responsive dystonia. In the majority of cases, patients manifest progressive psychomotor retardation, dystonia and spasticity. Cognitive anomalies are also often present. The disease is due to severe dopamine and serotonin deficiencies in the central nervous system caused by a defect in BH4 synthesis. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures.
    See also OMIM:612716
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_058007150R → G in DRDSPRD. 2 PublicationsCorresponds to variant dbSNP:rs104893665EnsemblClinVar.1
    Natural variantiVAR_058008163P → L in DRDSPRD. 1 PublicationCorresponds to variant dbSNP:rs104893666EnsemblClinVar.1

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi213S → A: Abolishes phosphorylation by CaMK2. No effect on kinetic parameters. 1 Publication1

    Keywords - Diseasei

    Disease mutation, Dystonia

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    6697

    GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

    More...
    GeneReviewsi
    SPR

    MalaCards human disease database

    More...
    MalaCardsi
    SPR
    MIMi612716 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000116096

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    70594 Dopa-responsive dystonia due to sepiapterin reductase deficiency

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA36087

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL3988583

    Drug and drug target database

    More...
    DrugBanki
    DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
    DB03886 Biopterin
    DB04275 N-Acetyl Serotonin
    DB02637 Oxaloacetate Ion

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    SPR

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    464801

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000721491 – 261Sepiapterin reductaseAdd BLAST261

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
    Modified residuei32PhosphoserineBy similarity1
    Modified residuei103PhosphoserineCombined sources1
    Modified residuei213Phosphoserine; by CaMK2; in vitro1 Publication1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    In vitro phosphorylation of Ser-213 by CaMK2 does not change kinetic parameters.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P35270

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P35270

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P35270

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P35270

    PeptideAtlas

    More...
    PeptideAtlasi
    P35270

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P35270

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    55020

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P35270

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P35270

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000116096 Expressed in 200 organ(s), highest expression level in mucosa of transverse colon

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_SPR

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P35270 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA039505

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    112575, 48 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P35270, 2 interactors

    Molecular INTeraction database

    More...
    MINTi
    P35270

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000234454

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P35270

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1261
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1Z6ZX-ray2.50A/B/C/D/E/F5-261[»]
    4HWKX-ray2.40A/B/C/D1-261[»]
    4J7UX-ray2.44A/B/C/D1-261[»]
    4J7XX-ray2.60A/B/F/J1-261[»]
    4XWYX-ray2.35A/B/C/D1-261[»]
    4Z3KX-ray2.35A/B/C/D1-261[»]

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    P35270

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P35270

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P35270

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni157 – 158Substrate bindingBy similarity2

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the sepiapterin reductase family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1204 Eukaryota
    ENOG4111PZG LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00440000033609

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG006973

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P35270

    KEGG Orthology (KO)

    More...
    KOi
    K00072

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    TFKSGAH

    Database of Orthologous Groups

    More...
    OrthoDBi
    1089743at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P35270

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF326358

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR036291 NAD(P)-bd_dom_sf
    IPR002347 SDR_fam
    IPR006393 Sepiapterin_red

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00106 adh_short, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00081 GDHRDH

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF51735 SSF51735, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR01500 sepiapter_red, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P35270-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MEGGLGRAVC LLTGASRGFG RTLAPLLASL LSPGSVLVLS ARNDEALRQL
    60 70 80 90 100
    EAELGAERSG LRVVRVPADL GAEAGLQQLL GALRELPRPK GLQRLLLINN
    110 120 130 140 150
    AGSLGDVSKG FVDLSDSTQV NNYWALNLTS MLCLTSSVLK AFPDSPGLNR
    160 170 180 190 200
    TVVNISSLCA LQPFKGWALY CAGKAARDML FQVLALEEPN VRVLNYAPGP
    210 220 230 240 250
    LDTDMQQLAR ETSVDPDMRK GLQELKAKGK LVDCKVSAQK LLSLLEKDEF
    260
    KSGAHVDFYD K
    Length:261
    Mass (Da):28,048
    Last modified:February 1, 1994 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C9BF76212826F47
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10C → R in BAD96662 (Ref. 4) Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_058007150R → G in DRDSPRD. 2 PublicationsCorresponds to variant dbSNP:rs104893665EnsemblClinVar.1
    Natural variantiVAR_058008163P → L in DRDSPRD. 1 PublicationCorresponds to variant dbSNP:rs104893666EnsemblClinVar.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    M76231 mRNA Translation: AAA60314.1
    AK291856 mRNA Translation: BAF84545.1
    AK222942 mRNA Translation: BAD96662.1
    AC092630 Genomic DNA Translation: AAY15035.1
    CH471053 Genomic DNA Translation: EAW99757.1
    CH471053 Genomic DNA Translation: EAW99758.1
    BC017310 mRNA Translation: AAH17310.1
    AB017547 Genomic DNA Translation: BAA34534.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS1920.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    JQ1176

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_003115.1, NM_003124.4

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.301540

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000234454; ENSP00000234454; ENSG00000116096

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    6697

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:6697

    UCSC genome browser

    More...
    UCSCi
    uc002sik.3 human

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    M76231 mRNA Translation: AAA60314.1
    AK291856 mRNA Translation: BAF84545.1
    AK222942 mRNA Translation: BAD96662.1
    AC092630 Genomic DNA Translation: AAY15035.1
    CH471053 Genomic DNA Translation: EAW99757.1
    CH471053 Genomic DNA Translation: EAW99758.1
    BC017310 mRNA Translation: AAH17310.1
    AB017547 Genomic DNA Translation: BAA34534.1
    CCDSiCCDS1920.1
    PIRiJQ1176
    RefSeqiNP_003115.1, NM_003124.4
    UniGeneiHs.301540

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1Z6ZX-ray2.50A/B/C/D/E/F5-261[»]
    4HWKX-ray2.40A/B/C/D1-261[»]
    4J7UX-ray2.44A/B/C/D1-261[»]
    4J7XX-ray2.60A/B/F/J1-261[»]
    4XWYX-ray2.35A/B/C/D1-261[»]
    4Z3KX-ray2.35A/B/C/D1-261[»]
    ProteinModelPortaliP35270
    SMRiP35270
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi112575, 48 interactors
    IntActiP35270, 2 interactors
    MINTiP35270
    STRINGi9606.ENSP00000234454

    Chemistry databases

    BindingDBiP35270
    ChEMBLiCHEMBL3988583
    DrugBankiDB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
    DB03886 Biopterin
    DB04275 N-Acetyl Serotonin
    DB02637 Oxaloacetate Ion

    PTM databases

    iPTMnetiP35270
    PhosphoSitePlusiP35270

    Polymorphism and mutation databases

    BioMutaiSPR
    DMDMi464801

    Proteomic databases

    EPDiP35270
    jPOSTiP35270
    MaxQBiP35270
    PaxDbiP35270
    PeptideAtlasiP35270
    PRIDEiP35270
    ProteomicsDBi55020

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    6697
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000234454; ENSP00000234454; ENSG00000116096
    GeneIDi6697
    KEGGihsa:6697
    UCSCiuc002sik.3 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    6697
    DisGeNETi6697
    EuPathDBiHostDB:ENSG00000116096.5

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    SPR
    GeneReviewsiSPR
    HGNCiHGNC:11257 SPR
    HPAiHPA039505
    MalaCardsiSPR
    MIMi182125 gene
    612716 phenotype
    neXtProtiNX_P35270
    OpenTargetsiENSG00000116096
    Orphaneti70594 Dopa-responsive dystonia due to sepiapterin reductase deficiency
    PharmGKBiPA36087

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1204 Eukaryota
    ENOG4111PZG LUCA
    GeneTreeiENSGT00440000033609
    HOVERGENiHBG006973
    InParanoidiP35270
    KOiK00072
    OMAiTFKSGAH
    OrthoDBi1089743at2759
    PhylomeDBiP35270
    TreeFamiTF326358

    Enzyme and pathway databases

    BioCyciMetaCyc:HS03979-MONOMER
    ReactomeiR-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
    R-HSA-203615 eNOS activation
    SIGNORiP35270

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    SPR human
    EvolutionaryTraceiP35270

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    Sepiapterin_reductase

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    6697

    Protein Ontology

    More...
    PROi
    PR:P35270

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000116096 Expressed in 200 organ(s), highest expression level in mucosa of transverse colon
    CleanExiHS_SPR
    GenevisibleiP35270 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR036291 NAD(P)-bd_dom_sf
    IPR002347 SDR_fam
    IPR006393 Sepiapterin_red
    PfamiView protein in Pfam
    PF00106 adh_short, 1 hit
    PRINTSiPR00081 GDHRDH
    SUPFAMiSSF51735 SSF51735, 1 hit
    TIGRFAMsiTIGR01500 sepiapter_red, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPRE_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35270
    Secondary accession number(s): A8K741
    , D6W5H2, Q53GI9, Q9UBB1
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: January 16, 2019
    This is version 188 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
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