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Entry version 207 (25 May 2022)
Sequence version 1 (01 Feb 1994)
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Protein

Sepiapterin reductase

Gene

SPR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 1.1 sec(-1) with sepiapterin as substrate (PubMed:10350607). kcat is 1.1 sec(-1) with NADPH as substrate (PubMed:10350607).1 Publication
  1. KM=14.3 µM for sepiapterin2 Publications
  2. KM=10 µM for NADPH2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei170SubstrateBy similarity1
Binding sitei174NADPBy similarity1
Binding sitei199Substrate; via amide nitrogenBy similarity1
Binding sitei257SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi14 – 20NADP1 Publication7
Nucleotide bindingi42 – 43NADP1 Publication2
Nucleotide bindingi69 – 70NADP1 Publication2
Nucleotide bindingi201 – 206NADP1 Publication6

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.1.1.153, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P35270

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1474151, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-HSA-203615, eNOS activation

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P35270

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P35270

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P35270

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sepiapterin reductase (EC:1.1.1.1532 Publications)
Short name:
SPR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11257, SPR

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
182125, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P35270

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000116096

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Dystonia, DOPA-responsive, due to sepiapterin reductase deficiency (DRDSPRD)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of DOPA-responsive dystonia. In the majority of cases, patients manifest progressive psychomotor retardation, dystonia and spasticity. Cognitive anomalies are also often present. The disease is due to severe dopamine and serotonin deficiencies in the central nervous system caused by a defect in BH4 synthesis. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_085775119 – 261Missing in DRDSPRD. 1 PublicationAdd BLAST143
Natural variantiVAR_058007150R → G in DRDSPRD; loss of sepiapterin reductase activity. 2 PublicationsCorresponds to variant dbSNP:rs104893665EnsemblClinVar.1
Natural variantiVAR_058008163P → L in DRDSPRD. 1 PublicationCorresponds to variant dbSNP:rs104893666EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi213S → A: Abolishes phosphorylation by CaMK2. No effect on kinetic parameters. 1 Publication1

Keywords - Diseasei

Disease variant, Dystonia

Organism-specific databases

DisGeNET

More...
DisGeNETi
6697

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
SPR

MalaCards human disease database

More...
MalaCardsi
SPR
MIMi612716, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000116096

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
70594, Dopa-responsive dystonia due to sepiapterin reductase deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36087

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P35270, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3988583

Drug and drug target database

More...
DrugBanki
DB03886, Biopterin
DB04275, N-acetylserotonin
DB03461, Nicotinamide adenine dinucleotide phosphate
DB02637, Oxaloacetate Ion

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
3020

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPR

Domain mapping of disease mutations (DMDM)

More...
DMDMi
464801

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000721491 – 261Sepiapterin reductaseAdd BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei32PhosphoserineBy similarity1
Modified residuei103PhosphoserineCombined sources1
Modified residuei213Phosphoserine; by CaMK2; in vitro1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

In vitro phosphorylation of Ser-213 by CaMK2 does not change kinetic parameters.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P35270

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P35270

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P35270

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P35270

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P35270

PeptideAtlas

More...
PeptideAtlasi
P35270

PRoteomics IDEntifications database

More...
PRIDEi
P35270

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
55020

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P35270

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P35270

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000116096, Expressed in mucosa of transverse colon and 216 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P35270, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000116096, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
112575, 85 interactors

Protein interaction database and analysis system

More...
IntActi
P35270, 5 interactors

Molecular INTeraction database

More...
MINTi
P35270

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000234454

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P35270

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P35270, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
P35270

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P35270

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P35270

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni157 – 158Substrate bindingBy similarity2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sepiapterin reductase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1204, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00440000033609

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010194_2_11_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P35270

Identification of Orthologs from Complete Genome Data

More...
OMAi
PYKGWSA

Database of Orthologous Groups

More...
OrthoDBi
1089743at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P35270

TreeFam database of animal gene trees

More...
TreeFami
TF326358

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036291, NAD(P)-bd_dom_sf
IPR002347, SDR_fam
IPR006393, Sepiapterin_red

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00106, adh_short, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00081, GDHRDH

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735, SSF51735, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01500, sepiapter_red, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P35270-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGGLGRAVC LLTGASRGFG RTLAPLLASL LSPGSVLVLS ARNDEALRQL
60 70 80 90 100
EAELGAERSG LRVVRVPADL GAEAGLQQLL GALRELPRPK GLQRLLLINN
110 120 130 140 150
AGSLGDVSKG FVDLSDSTQV NNYWALNLTS MLCLTSSVLK AFPDSPGLNR
160 170 180 190 200
TVVNISSLCA LQPFKGWALY CAGKAARDML FQVLALEEPN VRVLNYAPGP
210 220 230 240 250
LDTDMQQLAR ETSVDPDMRK GLQELKAKGK LVDCKVSAQK LLSLLEKDEF
260
KSGAHVDFYD K
Length:261
Mass (Da):28,048
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C9BF76212826F47
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10C → R in BAD96662 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_085775119 – 261Missing in DRDSPRD. 1 PublicationAdd BLAST143
Natural variantiVAR_058007150R → G in DRDSPRD; loss of sepiapterin reductase activity. 2 PublicationsCorresponds to variant dbSNP:rs104893665EnsemblClinVar.1
Natural variantiVAR_058008163P → L in DRDSPRD. 1 PublicationCorresponds to variant dbSNP:rs104893666EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M76231 mRNA Translation: AAA60314.1
AK291856 mRNA Translation: BAF84545.1
AK222942 mRNA Translation: BAD96662.1
AC092630 Genomic DNA Translation: AAY15035.1
CH471053 Genomic DNA Translation: EAW99757.1
CH471053 Genomic DNA Translation: EAW99758.1
BC017310 mRNA Translation: AAH17310.1
AB017547 Genomic DNA Translation: BAA34534.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1920.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JQ1176

NCBI Reference Sequences

More...
RefSeqi
NP_003115.1, NM_003124.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000234454.6; ENSP00000234454.5; ENSG00000116096.6

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6697

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6697

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...
MANE-Selecti
ENST00000234454.6; ENSP00000234454.5; NM_003124.5; NP_003115.1

UCSC genome browser

More...
UCSCi
uc002sik.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76231 mRNA Translation: AAA60314.1
AK291856 mRNA Translation: BAF84545.1
AK222942 mRNA Translation: BAD96662.1
AC092630 Genomic DNA Translation: AAY15035.1
CH471053 Genomic DNA Translation: EAW99757.1
CH471053 Genomic DNA Translation: EAW99758.1
BC017310 mRNA Translation: AAH17310.1
AB017547 Genomic DNA Translation: BAA34534.1
CCDSiCCDS1920.1
PIRiJQ1176
RefSeqiNP_003115.1, NM_003124.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z6ZX-ray2.50A/B/C/D/E/F5-261[»]
4HWKX-ray2.40A/B/C/D1-261[»]
4J7UX-ray2.44A/B/C/D1-261[»]
4J7XX-ray2.60A/B/F/J1-261[»]
4XWYX-ray2.35A/B/C/D1-261[»]
4Z3KX-ray2.35A/B/C/D1-261[»]
6I6CX-ray1.72A/B1-261[»]
6I6FX-ray1.94A/B1-261[»]
6I6PX-ray1.62A/B1-261[»]
6I6TX-ray1.79A/B1-261[»]
6I6VX-ray1.43A/B1-261[»]
6I79X-ray1.63A/B1-261[»]
6USNX-ray2.77A/B/C/D1-261[»]
7DSFX-ray1.80A/B1-261[»]
AlphaFoldDBiP35270
SMRiP35270
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112575, 85 interactors
IntActiP35270, 5 interactors
MINTiP35270
STRINGi9606.ENSP00000234454

Chemistry databases

BindingDBiP35270
ChEMBLiCHEMBL3988583
DrugBankiDB03886, Biopterin
DB04275, N-acetylserotonin
DB03461, Nicotinamide adenine dinucleotide phosphate
DB02637, Oxaloacetate Ion
GuidetoPHARMACOLOGYi3020

PTM databases

iPTMnetiP35270
PhosphoSitePlusiP35270

Genetic variation databases

BioMutaiSPR
DMDMi464801

Proteomic databases

EPDiP35270
jPOSTiP35270
MassIVEiP35270
MaxQBiP35270
PaxDbiP35270
PeptideAtlasiP35270
PRIDEiP35270
ProteomicsDBi55020

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
31290, 354 antibodies from 30 providers

The DNASU plasmid repository

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DNASUi
6697

Genome annotation databases

EnsembliENST00000234454.6; ENSP00000234454.5; ENSG00000116096.6
GeneIDi6697
KEGGihsa:6697
MANE-SelectiENST00000234454.6; ENSP00000234454.5; NM_003124.5; NP_003115.1
UCSCiuc002sik.3, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6697
DisGeNETi6697

GeneCards: human genes, protein and diseases

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GeneCardsi
SPR
GeneReviewsiSPR
HGNCiHGNC:11257, SPR
HPAiENSG00000116096, Low tissue specificity
MalaCardsiSPR
MIMi182125, gene
612716, phenotype
neXtProtiNX_P35270
OpenTargetsiENSG00000116096
Orphaneti70594, Dopa-responsive dystonia due to sepiapterin reductase deficiency
PharmGKBiPA36087
VEuPathDBiHostDB:ENSG00000116096

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1204, Eukaryota
GeneTreeiENSGT00440000033609
HOGENOMiCLU_010194_2_11_1
InParanoidiP35270
OMAiPYKGWSA
OrthoDBi1089743at2759
PhylomeDBiP35270
TreeFamiTF326358

Enzyme and pathway databases

BRENDAi1.1.1.153, 2681
PathwayCommonsiP35270
ReactomeiR-HSA-1474151, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-HSA-203615, eNOS activation
SABIO-RKiP35270
SignaLinkiP35270
SIGNORiP35270

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
6697, 15 hits in 1080 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SPR, human
EvolutionaryTraceiP35270

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Sepiapterin_reductase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6697
PharosiP35270, Tchem

Protein Ontology

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PROi
PR:P35270
RNActiP35270, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000116096, Expressed in mucosa of transverse colon and 216 other tissues
GenevisibleiP35270, HS

Family and domain databases

InterProiView protein in InterPro
IPR036291, NAD(P)-bd_dom_sf
IPR002347, SDR_fam
IPR006393, Sepiapterin_red
PfamiView protein in Pfam
PF00106, adh_short, 1 hit
PRINTSiPR00081, GDHRDH
SUPFAMiSSF51735, SSF51735, 1 hit
TIGRFAMsiTIGR01500, sepiapter_red, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPRE_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35270
Secondary accession number(s): A8K741
, D6W5H2, Q53GI9, Q9UBB1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 25, 2022
This is version 207 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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