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UniProtKB - P35269 (T2FA_HUMAN)
Protein
General transcription factor IIF subunit 1
Gene
GTF2F1
Organism
Homo sapiens (Human)
Status
Functioni
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.
1 PublicationCaution
Was reported to have a protein kinase activity and to autophosphorylates on Ser-385 and Thr-389.1 Publication
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- phosphatase activator activity Source: UniProtKB
- promoter-specific chromatin binding Source: UniProtKB
- protein domain specific binding Source: CAFA
- protein phosphatase binding Source: CAFA
- RNA binding Source: UniProtKB
- RNA polymerase II general transcription initiation factor activity Source: ARUK-UCL
- RNA polymerase II general transcription initiation factor binding Source: BHF-UCL
- TFIIF-class transcription factor complex binding Source: GO_Central
GO - Biological processi
- negative regulation of protein binding Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: ComplexPortal
- positive regulation of transcription elongation from RNA polymerase II promoter Source: InterPro
- response to virus Source: UniProtKB
- transcription by RNA polymerase II Source: ProtInc
- transcription elongation from RNA polymerase II promoter Source: ComplexPortal
- transcription initiation from RNA polymerase II promoter Source: ARUK-UCL
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P35269 |
Reactomei | R-HSA-112382, Formation of RNA Pol II elongation complex R-HSA-113418, Formation of the Early Elongation Complex R-HSA-167152, Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167158, Formation of the HIV-1 Early Elongation Complex R-HSA-167160, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167161, HIV Transcription Initiation R-HSA-167162, RNA Polymerase II HIV Promoter Escape R-HSA-167172, Transcription of the HIV genome R-HSA-167200, Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167238, Pausing and recovery of Tat-mediated HIV elongation R-HSA-167242, Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167243, Tat-mediated HIV elongation arrest and recovery R-HSA-167246, Tat-mediated elongation of the HIV-1 transcript R-HSA-167287, HIV elongation arrest and recovery R-HSA-167290, Pausing and recovery of HIV elongation R-HSA-168325, Viral Messenger RNA Synthesis R-HSA-674695, RNA Polymerase II Pre-transcription Events R-HSA-6796648, TP53 Regulates Transcription of DNA Repair Genes R-HSA-6803529, FGFR2 alternative splicing R-HSA-6807505, RNA polymerase II transcribes snRNA genes R-HSA-72086, mRNA Capping R-HSA-72163, mRNA Splicing - Major Pathway R-HSA-72165, mRNA Splicing - Minor Pathway R-HSA-72203, Processing of Capped Intron-Containing Pre-mRNA R-HSA-73776, RNA Polymerase II Promoter Escape R-HSA-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-75953, RNA Polymerase II Transcription Initiation R-HSA-75955, RNA Polymerase II Transcription Elongation R-HSA-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-77075, RNA Pol II CTD phosphorylation and interaction with CE R-HSA-8851708, Signaling by FGFR2 IIIa TM R-HSA-9018519, Estrogen-dependent gene expression |
SignaLinki | P35269 |
SIGNORi | P35269 |
Names & Taxonomyi
Protein namesi | Recommended name: General transcription factor IIF subunit 1Alternative name(s): General transcription factor IIF 74 kDa subunit Transcription initiation factor IIF subunit alpha Short name: TFIIF-alpha Transcription initiation factor RAP74 |
Gene namesi | Name:GTF2F1 Synonyms:RAP74 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4652, GTF2F1 |
MIMi | 189968, gene |
neXtProti | NX_P35269 |
VEuPathDBi | HostDB:ENSG00000125651 |
Subcellular locationi
Nucleus
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: CAFA
- transcription factor TFIID complex Source: UniProtKB
- transcription factor TFIIF complex Source: ComplexPortal
Other locations
- cell junction Source: HPA
- intracellular membrane-bounded organelle Source: HPA
- protein-containing complex Source: CAFA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 385 | S → A: Eliminates putative kinase activity; when associated with A-389. 1 Publication | 1 | |
Mutagenesisi | 389 | T → A: Eliminates putative kinase activity; when associated with A-385. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 2962 |
OpenTargetsi | ENSG00000125651 |
PharmGKBi | PA29038 |
Miscellaneous databases
Pharosi | P35269, Tbio |
Genetic variation databases
BioMutai | GTF2F1 |
DMDMi | 46397744 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000211231 | 2 – 517 | General transcription factor IIF subunit 1Add BLAST | 516 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 156 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 217 | PhosphoserineCombined sources | 1 | |
Modified residuei | 218 | PhosphoserineCombined sources | 1 | |
Modified residuei | 221 | PhosphoserineCombined sources | 1 | |
Modified residuei | 224 | PhosphoserineCombined sources | 1 | |
Modified residuei | 331 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 377 | PhosphoserineCombined sources | 1 | |
Modified residuei | 380 | PhosphoserineCombined sources | 1 | |
Modified residuei | 381 | PhosphoserineCombined sources | 1 | |
Modified residuei | 385 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 389 | PhosphothreonineCombined sources1 Publication | 1 | |
Modified residuei | 391 | PhosphoserineCombined sources | 1 | |
Modified residuei | 407 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 431 | PhosphoserineCombined sources | 1 | |
Modified residuei | 433 | PhosphoserineCombined sources | 1 | |
Modified residuei | 436 | PhosphoserineCombined sources | 1 | |
Modified residuei | 437 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 446 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 449 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated on Ser and other residues by TAF1 and casein kinase II-like kinases.2 Publications
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P35269 |
jPOSTi | P35269 |
MassIVEi | P35269 |
MaxQBi | P35269 |
PaxDbi | P35269 |
PeptideAtlasi | P35269 |
PRIDEi | P35269 |
ProteomicsDBi | 55019 |
TopDownProteomicsi | P35269 |
PTM databases
GlyGeni | P35269, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P35269 |
MetOSitei | P35269 |
PhosphoSitePlusi | P35269 |
Expressioni
Inductioni
Up-regulated in response to enterovirus 71 (EV71) infection.1 Publication
Gene expression databases
Bgeei | ENSG00000125651, Expressed in testis and 124 other tissues |
ExpressionAtlasi | P35269, baseline and differential |
Genevisiblei | P35269, HS |
Organism-specific databases
HPAi | ENSG00000125651, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
P35269
With | #Exp. | IntAct |
---|---|---|
CTDP1 [Q9Y5B0] | 2 | EBI-457886,EBI-2807555 |
GTF2F2 [P13984] | 16 | EBI-457886,EBI-1030560 |
SRF [P11831] | 2 | EBI-457886,EBI-493034 |
TAF1 [P21675] | 3 | EBI-457886,EBI-491289 |
URI1 [O94763] | 3 | EBI-457886,EBI-357067 |
GO - Molecular functioni
- protein domain specific binding Source: CAFA
- protein phosphatase binding Source: CAFA
- RNA polymerase II general transcription initiation factor binding Source: BHF-UCL
- TFIIF-class transcription factor complex binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 109217, 156 interactors |
ComplexPortali | CPX-79, Transcription factor TFIIF complex |
CORUMi | P35269 |
DIPi | DIP-677N |
IntActi | P35269, 59 interactors |
MINTi | P35269 |
STRINGi | 9606.ENSP00000377969 |
Miscellaneous databases
RNActi | P35269, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P35269 |
SMRi | P35269 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P35269 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 178 – 466 | DisorderedSequence analysisAdd BLAST | 289 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 179 – 214 | Basic and acidic residuesSequence analysisAdd BLAST | 36 | |
Compositional biasi | 273 – 287 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 288 – 305 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 306 – 320 | Acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 321 – 345 | Basic and acidic residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 380 – 405 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 429 – 453 | Polar residuesSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the TFIIF alpha subunit family.Curated
Phylogenomic databases
eggNOGi | KOG2393, Eukaryota |
GeneTreei | ENSGT00440000038032 |
HOGENOMi | CLU_027572_2_0_1 |
InParanoidi | P35269 |
OMAi | AFYVFTH |
OrthoDBi | 893557at2759 |
PhylomeDBi | P35269 |
TreeFami | TF313850 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
IDEALi | IID00369 |
InterProi | View protein in InterPro IPR008851, TFIIF-alpha IPR011039, TFIIF_interaction IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR13011, PTHR13011, 1 hit |
Pfami | View protein in Pfam PF05793, TFIIF_alpha, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF50916, SSF50916, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P35269-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAALGPSSQN VTEYVVRVPK NTTKKYNIMA FNAADKVNFA TWNQARLERD
60 70 80 90 100
LSNKKIYQEE EMPESGAGSE FNRKLREEAR RKKYGIVLKE FRPEDQPWLL
110 120 130 140 150
RVNGKSGRKF KGIKKGGVTE NTSYYIFTQC PDGAFEAFPV HNWYNFTPLA
160 170 180 190 200
RHRTLTAEEA EEEWERRNKV LNHFSIMQQR RLKDQDQDED EEEKEKRGRR
210 220 230 240 250
KASELRIHDL EDDLEMSSDA SDASGEEGGR VPKAKKKAPL AKGGRKKKKK
260 270 280 290 300
KGSDDEAFED SDDGDFEGQE VDYMSDGSSS SQEEPESKAK APQQEEGPKG
310 320 330 340 350
VDEQSDSSEE SEEEKPPEED KEEEEEKKAP TPQEKKRRKD SSEESDSSEE
360 370 380 390 400
SDIDSEASSA LFMAKKKTPP KRERKPSGGS SRGNSRPGTP SAEGGSTSST
410 420 430 440 450
LRAAASKLEQ GKRVSEMPAA KRLRLDTGPQ SLSGKSTPQP PSGKTTPNSG
460 470 480 490 500
DVQVTEDAVR RYLTRKPMTT KDLLKKFQTK KTGLSSEQTV NVLAQILKRL
510
NPERKMINDK MHFSLKE
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QXD6 | M0QXD6_HUMAN | Transcription initiation factor IIF... | GTF2F1 | 433 | Annotation score: | ||
M0R0R9 | M0R0R9_HUMAN | Transcription initiation factor IIF... | GTF2F1 | 381 | Annotation score: | ||
M0R0Z3 | M0R0Z3_HUMAN | Transcription initiation factor IIF... | GTF2F1 | 127 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 231 | V → I in CAA45404 (PubMed:1734284).Curated | 1 | |
Sequence conflicti | 361 | L → F in CAA45408 (PubMed:1734283).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039004 | 3 | A → V. Corresponds to variant dbSNP:rs34826931Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X64037 mRNA Translation: CAA45408.1 X64002 mRNA Translation: CAA45404.1 BT007097 mRNA Translation: AAP35761.1 AK315240 mRNA Translation: BAG37667.1 CH471139 Genomic DNA Translation: EAW69098.1 BC000120 mRNA Translation: AAH00120.1 BC013007 mRNA Translation: AAH13007.1 |
CCDSi | CCDS12165.1 |
PIRi | S20248 |
RefSeqi | NP_002087.2, NM_002096.2 |
Genome annotation databases
Ensembli | ENST00000394456; ENSP00000377969; ENSG00000125651 |
GeneIDi | 2962 |
KEGGi | hsa:2962 |
MANE-Selecti | ENST00000394456.10; ENSP00000377969.3; NM_002096.3; NP_002087.2 |
UCSCi | uc002meq.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X64037 mRNA Translation: CAA45408.1 X64002 mRNA Translation: CAA45404.1 BT007097 mRNA Translation: AAP35761.1 AK315240 mRNA Translation: BAG37667.1 CH471139 Genomic DNA Translation: EAW69098.1 BC000120 mRNA Translation: AAH00120.1 BC013007 mRNA Translation: AAH13007.1 |
CCDSi | CCDS12165.1 |
PIRi | S20248 |
RefSeqi | NP_002087.2, NM_002096.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1F3U | X-ray | 1.70 | B/D/F/H | 2-172 | [»] | |
1I27 | X-ray | 1.02 | A | 449-517 | [»] | |
1J2X | X-ray | 2.00 | A | 449-517 | [»] | |
1NHA | NMR | - | A | 436-517 | [»] | |
1ONV | NMR | - | A | 436-517 | [»] | |
2K7L | NMR | - | A | 451-517 | [»] | |
5IY6 | electron microscopy | 7.20 | S | 1-517 | [»] | |
5IY7 | electron microscopy | 8.60 | S | 1-517 | [»] | |
5IY8 | electron microscopy | 7.90 | S | 1-517 | [»] | |
5IY9 | electron microscopy | 6.30 | S | 1-517 | [»] | |
5IYA | electron microscopy | 5.40 | S | 1-517 | [»] | |
5IYB | electron microscopy | 3.90 | S | 1-517 | [»] | |
5IYC | electron microscopy | 3.90 | S | 1-517 | [»] | |
5IYD | electron microscopy | 3.90 | S | 1-517 | [»] | |
6O9L | electron microscopy | 7.20 | S | 1-517 | [»] | |
7EDX | electron microscopy | 4.50 | S | 1-517 | [»] | |
7EG7 | electron microscopy | 6.20 | S | 1-517 | [»] | |
7EG8 | electron microscopy | 7.40 | S | 1-517 | [»] | |
7EG9 | electron microscopy | 3.70 | S | 1-517 | [»] | |
7EGA | electron microscopy | 4.10 | S | 1-517 | [»] | |
7EGB | electron microscopy | 3.30 | S | 1-517 | [»] | |
7EGC | electron microscopy | 3.90 | S | 1-517 | [»] | |
7ENA | electron microscopy | 4.07 | FA | 1-517 | [»] | |
7ENC | electron microscopy | 4.13 | FA | 1-517 | [»] | |
7LBM | electron microscopy | 4.80 | S | 1-517 | [»] | |
7NVR | electron microscopy | 4.50 | Q | 1-517 | [»] | |
7NVS | electron microscopy | 2.80 | Q | 1-517 | [»] | |
7NVT | electron microscopy | 2.90 | Q | 1-517 | [»] | |
7NVU | electron microscopy | 2.50 | Q | 1-517 | [»] | |
7NVY | electron microscopy | 7.30 | Q | 1-517 | [»] | |
7NVZ | electron microscopy | 7.20 | Q | 1-517 | [»] | |
7NW0 | electron microscopy | 6.60 | Q | 1-517 | [»] | |
BMRBi | P35269 | |||||
SMRi | P35269 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109217, 156 interactors |
ComplexPortali | CPX-79, Transcription factor TFIIF complex |
CORUMi | P35269 |
DIPi | DIP-677N |
IntActi | P35269, 59 interactors |
MINTi | P35269 |
STRINGi | 9606.ENSP00000377969 |
PTM databases
GlyGeni | P35269, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P35269 |
MetOSitei | P35269 |
PhosphoSitePlusi | P35269 |
Genetic variation databases
BioMutai | GTF2F1 |
DMDMi | 46397744 |
Proteomic databases
EPDi | P35269 |
jPOSTi | P35269 |
MassIVEi | P35269 |
MaxQBi | P35269 |
PaxDbi | P35269 |
PeptideAtlasi | P35269 |
PRIDEi | P35269 |
ProteomicsDBi | 55019 |
TopDownProteomicsi | P35269 |
Protocols and materials databases
Antibodypediai | 11855, 294 antibodies from 27 providers |
DNASUi | 2962 |
Genome annotation databases
Ensembli | ENST00000394456; ENSP00000377969; ENSG00000125651 |
GeneIDi | 2962 |
KEGGi | hsa:2962 |
MANE-Selecti | ENST00000394456.10; ENSP00000377969.3; NM_002096.3; NP_002087.2 |
UCSCi | uc002meq.3, human |
Organism-specific databases
CTDi | 2962 |
DisGeNETi | 2962 |
GeneCardsi | GTF2F1 |
HGNCi | HGNC:4652, GTF2F1 |
HPAi | ENSG00000125651, Low tissue specificity |
MIMi | 189968, gene |
neXtProti | NX_P35269 |
OpenTargetsi | ENSG00000125651 |
PharmGKBi | PA29038 |
VEuPathDBi | HostDB:ENSG00000125651 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2393, Eukaryota |
GeneTreei | ENSGT00440000038032 |
HOGENOMi | CLU_027572_2_0_1 |
InParanoidi | P35269 |
OMAi | AFYVFTH |
OrthoDBi | 893557at2759 |
PhylomeDBi | P35269 |
TreeFami | TF313850 |
Enzyme and pathway databases
PathwayCommonsi | P35269 |
Reactomei | R-HSA-112382, Formation of RNA Pol II elongation complex R-HSA-113418, Formation of the Early Elongation Complex R-HSA-167152, Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167158, Formation of the HIV-1 Early Elongation Complex R-HSA-167160, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167161, HIV Transcription Initiation R-HSA-167162, RNA Polymerase II HIV Promoter Escape R-HSA-167172, Transcription of the HIV genome R-HSA-167200, Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167238, Pausing and recovery of Tat-mediated HIV elongation R-HSA-167242, Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167243, Tat-mediated HIV elongation arrest and recovery R-HSA-167246, Tat-mediated elongation of the HIV-1 transcript R-HSA-167287, HIV elongation arrest and recovery R-HSA-167290, Pausing and recovery of HIV elongation R-HSA-168325, Viral Messenger RNA Synthesis R-HSA-674695, RNA Polymerase II Pre-transcription Events R-HSA-6796648, TP53 Regulates Transcription of DNA Repair Genes R-HSA-6803529, FGFR2 alternative splicing R-HSA-6807505, RNA polymerase II transcribes snRNA genes R-HSA-72086, mRNA Capping R-HSA-72163, mRNA Splicing - Major Pathway R-HSA-72165, mRNA Splicing - Minor Pathway R-HSA-72203, Processing of Capped Intron-Containing Pre-mRNA R-HSA-73776, RNA Polymerase II Promoter Escape R-HSA-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-75953, RNA Polymerase II Transcription Initiation R-HSA-75955, RNA Polymerase II Transcription Elongation R-HSA-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-77075, RNA Pol II CTD phosphorylation and interaction with CE R-HSA-8851708, Signaling by FGFR2 IIIa TM R-HSA-9018519, Estrogen-dependent gene expression |
SignaLinki | P35269 |
SIGNORi | P35269 |
Miscellaneous databases
BioGRID-ORCSi | 2962, 356 hits in 1055 CRISPR screens |
ChiTaRSi | GTF2F1, human |
EvolutionaryTracei | P35269 |
GeneWikii | GTF2F1 |
GenomeRNAii | 2962 |
Pharosi | P35269, Tbio |
PROi | PR:P35269 |
RNActi | P35269, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125651, Expressed in testis and 124 other tissues |
ExpressionAtlasi | P35269, baseline and differential |
Genevisiblei | P35269, HS |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
IDEALi | IID00369 |
InterProi | View protein in InterPro IPR008851, TFIIF-alpha IPR011039, TFIIF_interaction IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR13011, PTHR13011, 1 hit |
Pfami | View protein in Pfam PF05793, TFIIF_alpha, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF50916, SSF50916, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | T2FA_HUMAN | |
Accessioni | P35269Primary (citable) accession number: P35269 Secondary accession number(s): B2RCS0, Q9BWN0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | April 13, 2004 | |
Last modified: | February 23, 2022 | |
This is version 211 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families