Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60S ribosomal protein L22

Gene

RPL22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Binds to Epstein-Barr virus small RNAs and to heparin.

GO - Molecular functioni

  • heparin binding Source: UniProtKB-KW
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding, Ribonucleoprotein, Ribosomal protein, RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIGNORiP35268

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L22
Alternative name(s):
EBER-associated protein
Short name:
EAP
Epstein-Barr virus small RNA-associated protein
Heparin-binding protein HBp15
Large ribosomal subunit protein eL221 Publication
Gene namesi
Name:RPL22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116251.9
HGNCiHGNC:10315 RPL22
MIMi180474 gene
neXtProtiNX_P35268

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6146
OpenTargetsiENSG00000116251
PharmGKBiPA34688

Polymorphism and mutation databases

BioMutaiRPL22

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00002155012 – 12860S ribosomal protein L22Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62PhosphothreonineBy similarity1
Modified residuei66PhosphoserineCombined sources1
Modified residuei69N6-succinyllysineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP35268
MaxQBiP35268
PaxDbiP35268
PeptideAtlasiP35268
PRIDEiP35268
ProteomicsDBi55018
TopDownProteomicsiP35268

2D gel databases

SWISS-2DPAGEiP35268

PTM databases

iPTMnetiP35268
PhosphoSitePlusiP35268
SwissPalmiP35268

Expressioni

Gene expression databases

BgeeiENSG00000116251 Expressed in 230 organ(s), highest expression level in left ovary
CleanExiHS_RPL22
ExpressionAtlasiP35268 baseline and differential
GenevisibleiP35268 HS

Organism-specific databases

HPAiHPA068294

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi112066, 209 interactors
CORUMiP35268
IntActiP35268, 63 interactors
MINTiP35268
STRINGi9606.ENSP00000346088

Structurei

3D structure databases

ProteinModelPortaliP35268
SMRiP35268
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi120 – 128Asp/Glu-rich (highly acidic)9

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3434 Eukaryota
ENOG4111UVJ LUCA
GeneTreeiENSGT00390000003719
HOGENOMiHOG000198396
HOVERGENiHBG004373
InParanoidiP35268
KOiK02891
OMAiYQLRFYN
OrthoDBiEOG091G0POE
PhylomeDBiP35268
TreeFamiTF313018

Family and domain databases

Gene3Di3.30.1360.210, 1 hit
InterProiView protein in InterPro
IPR002671 Ribosomal_L22e
IPR038526 Ribosomal_L22e_sf
PANTHERiPTHR10064 PTHR10064, 1 hit
PfamiView protein in Pfam
PF01776 Ribosomal_L22e, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P35268-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPVKKLVVK GGKKKKQVLK FTLDCTHPVE DGIMDAANFE QFLQERIKVN
60 70 80 90 100
GKAGNLGGGV VTIERSKSKI TVTSEVPFSK RYLKYLTKKY LKKNNLRDWL
110 120
RVVANSKESY ELRYFQINQD EEEEEDED
Length:128
Mass (Da):14,787
Last modified:January 23, 2007 - v2
Checksum:i0F3ED8BE70C9F962
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ELC4K7ELC4_HUMAN
60S ribosomal protein L22
RPL22
79Annotation score:
K7ERI7K7ERI7_HUMAN
60S ribosomal protein L22
RPL22 hCG_2009685
95Annotation score:
K7EKS7K7EKS7_HUMAN
60S ribosomal protein L22
RPL22
53Annotation score:
K7EMH1K7EMH1_HUMAN
60S ribosomal protein L22
RPL22
89Annotation score:
K7EJT5K7EJT5_HUMAN
60S ribosomal protein L22
RPL22
47Annotation score:
K7EP65K7EP65_HUMAN
60S ribosomal protein L22
RPL22
48Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59357 mRNA Translation: CAA42007.1
D17652 mRNA Translation: BAA04545.1
AK311749 mRNA Translation: BAG34692.1
CR456873 mRNA Translation: CAG33154.1
AL031847 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71518.1
BC035566 mRNA Translation: AAH35566.1
BC058887 mRNA Translation: AAH58887.1
BC066314 mRNA Translation: AAH66314.1
CCDSiCCDS58.1
PIRiJC2120
RefSeqiNP_000974.1, NM_000983.3
UniGeneiHs.515329
Hs.554762

Genome annotation databases

EnsembliENST00000234875; ENSP00000346088; ENSG00000116251
GeneIDi6146
KEGGihsa:6146
UCSCiuc001amd.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59357 mRNA Translation: CAA42007.1
D17652 mRNA Translation: BAA04545.1
AK311749 mRNA Translation: BAG34692.1
CR456873 mRNA Translation: CAG33154.1
AL031847 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71518.1
BC035566 mRNA Translation: AAH35566.1
BC058887 mRNA Translation: AAH58887.1
BC066314 mRNA Translation: AAH66314.1
CCDSiCCDS58.1
PIRiJC2120
RefSeqiNP_000974.1, NM_000983.3
UniGeneiHs.515329
Hs.554762

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LU1-128[»]
4V6Xelectron microscopy5.00CU1-128[»]
5AJ0electron microscopy3.50AU1-128[»]
5LKSelectron microscopy3.60LU1-128[»]
5T2Celectron microscopy3.60O1-128[»]
6EK0electron microscopy2.90LU1-128[»]
ProteinModelPortaliP35268
SMRiP35268
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112066, 209 interactors
CORUMiP35268
IntActiP35268, 63 interactors
MINTiP35268
STRINGi9606.ENSP00000346088

PTM databases

iPTMnetiP35268
PhosphoSitePlusiP35268
SwissPalmiP35268

Polymorphism and mutation databases

BioMutaiRPL22

2D gel databases

SWISS-2DPAGEiP35268

Proteomic databases

EPDiP35268
MaxQBiP35268
PaxDbiP35268
PeptideAtlasiP35268
PRIDEiP35268
ProteomicsDBi55018
TopDownProteomicsiP35268

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000234875; ENSP00000346088; ENSG00000116251
GeneIDi6146
KEGGihsa:6146
UCSCiuc001amd.4 human

Organism-specific databases

CTDi6146
DisGeNETi6146
EuPathDBiHostDB:ENSG00000116251.9
GeneCardsiRPL22
HGNCiHGNC:10315 RPL22
HPAiHPA068294
MIMi180474 gene
neXtProtiNX_P35268
OpenTargetsiENSG00000116251
PharmGKBiPA34688
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3434 Eukaryota
ENOG4111UVJ LUCA
GeneTreeiENSGT00390000003719
HOGENOMiHOG000198396
HOVERGENiHBG004373
InParanoidiP35268
KOiK02891
OMAiYQLRFYN
OrthoDBiEOG091G0POE
PhylomeDBiP35268
TreeFamiTF313018

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIGNORiP35268

Miscellaneous databases

ChiTaRSiRPL22 human
GeneWikiiRPL22
GenomeRNAii6146
PROiPR:P35268
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116251 Expressed in 230 organ(s), highest expression level in left ovary
CleanExiHS_RPL22
ExpressionAtlasiP35268 baseline and differential
GenevisibleiP35268 HS

Family and domain databases

Gene3Di3.30.1360.210, 1 hit
InterProiView protein in InterPro
IPR002671 Ribosomal_L22e
IPR038526 Ribosomal_L22e_sf
PANTHERiPTHR10064 PTHR10064, 1 hit
PfamiView protein in Pfam
PF01776 Ribosomal_L22e, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRL22_HUMAN
AccessioniPrimary (citable) accession number: P35268
Secondary accession number(s): B2R495, Q6IBD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 181 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again