RFC2

Functionⁱ

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	76 – 83	ATPSequence analysis		8

GO - Molecular functionⁱ

ATP binding
Source: ProtInc
Traceable author statementⁱ
- 1313560
DNA binding Source: InterPro
enzyme binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

DNA damage response, detection of DNA damage Source: Reactome
DNA repair Source: GO_Central
DNA replication Source: Reactome
error-free translesion synthesis Source: Reactome
error-prone translesion synthesis Source: Reactome
nucleotide-excision repair, DNA gap filling Source: Reactome
nucleotide-excision repair, DNA incision Source: Reactome
nucleotide-excision repair, DNA incision, 5'-to lesion Source: Reactome
positive regulation of DNA-directed DNA polymerase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 12930902
telomere maintenance via semi-conservative replication Source: Reactome
transcription-coupled nucleotide-excision repair Source: Reactome
translesion synthesis Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	DNA replication
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-110312 Translesion synthesis by REV1 R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex R-HSA-110320 Translesion Synthesis by POLH R-HSA-174411 Polymerase switching on the C-strand of the telomere R-HSA-176187 Activation of ATR in response to replication stress R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair R-HSA-5655862 Translesion synthesis by POLK R-HSA-5656121 Translesion synthesis by POLI R-HSA-5656169 Termination of translesion DNA synthesis R-HSA-5685938 HDR through Single Strand Annealing (SSA) R-HSA-5685942 HDR through Homologous Recombination (HRR) R-HSA-5693607 Processing of DNA double-strand break ends R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696400 Dual Incision in GG-NER R-HSA-6782135 Dual incision in TC-NER R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation R-HSA-69091 Polymerase switching R-HSA-69473 G2/M DNA damage checkpoint

Reactomeⁱ

R-HSA-110312 Translesion synthesis by REV1
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex
R-HSA-110320 Translesion Synthesis by POLH
R-HSA-174411 Polymerase switching on the C-strand of the telomere
R-HSA-176187 Activation of ATR in response to replication stress
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-HSA-5655862 Translesion synthesis by POLK
R-HSA-5656121 Translesion synthesis by POLI
R-HSA-5656169 Termination of translesion DNA synthesis
R-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5685942 HDR through Homologous Recombination (HRR)
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-HSA-5696400 Dual Incision in GG-NER
R-HSA-6782135 Dual incision in TC-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-69091 Polymerase switching
R-HSA-69473 G2/M DNA damage checkpoint

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Replication factor C subunit 2 Alternative name(s): Activator 1 40 kDa subunit Short name: A1 40 kDa subunit Activator 1 subunit 2 Replication factor C 40 kDa subunit Short name: RF-C 40 kDa subunit Short name: RFC40
Gene namesⁱ	Name:RFC2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000049541.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9970 RFC2
MIMⁱ	600404 gene
neXtProtⁱ	NX_P35250

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

RFC2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region (PubMed:11003705).1 Publication

Keywords - Diseaseⁱ

Williams-Beuren syndrome

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5982
MalaCards human disease database More...MalaCardsⁱ	RFC2
MIMⁱ	194050 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000049541
Orphanetⁱ	904 Williams syndrome
PharmGKBⁱ	PA34339

Polymorphism and mutation databases

DMDMⁱ	2507300

DMDMⁱ

2507300

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000121766	1 – 354	Replication factor C subunit 2Add BLAST		354

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	18	PhosphoserineCombined sources	1
Modified residueⁱ	30	PhosphoserineCombined sources	1
Modified residueⁱ	163	N6-acetyllysineCombined sources	1
Modified residueⁱ	304	N6-acetyllysineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P35250
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P35250
PaxDbⁱ	P35250
PeptideAtlas More...PeptideAtlasⁱ	P35250
PRIDEⁱ	P35250
ProteomicsDBⁱ	55014 55015 [P35250-2]

PTM databases

iPTMnetⁱ	P35250
PhosphoSitePlusⁱ	P35250

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000049541
CleanExⁱ	HS_RFC2
ExpressionAtlasⁱ	P35250 baseline and differential
Genevisibleⁱ	P35250 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA029493

HPAⁱ

HPA029493

Interactionⁱ

Subunit structureⁱ

Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not stimulated by PCNA. RFC2 also interacts with PRKAR1A; the complex may be involved in cell survival (PubMed:15655353). Interacts with DDX11 (PubMed:18499658).2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
PRKAR1A	P10644	7	EBI-476409,EBI-476431
RFC1	P35251	4	EBI-476409,EBI-476616
RFC4	P35249	8	EBI-476409,EBI-476655

Show more details

GO - Molecular functionⁱ

enzyme binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111914, 69 interactors
ComplexPortalⁱ	CPX-415 DNA replication factor C complex
CORUMⁱ	P35250
Database of interacting proteins More...DIPⁱ	DIP-34367N
IntActⁱ	P35250, 36 interactors
Molecular INTeraction database More...MINTⁱ	P35250
STRINGⁱ	9606.ENSP00000055077

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P35250
SMRⁱ	P35250
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the activator 1 small subunits family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0991 Eukaryota COG0470 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000075050
HOGENOMⁱ	HOG000224155
HOVERGENⁱ	HBG002053
InParanoidⁱ	P35250
KEGG Orthology (KO) More...KOⁱ	K10755
OMAⁱ	QSTWSGF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CKT
PhylomeDBⁱ	P35250
TreeFamⁱ	TF300585

Family and domain databases

InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR003959 ATPase_AAA_core IPR008921 DNA_pol3_clamp-load_cplx_C IPR027417 P-loop_NTPase IPR013748 Rep_factorC_C
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00004 AAA, 1 hit PF08542 Rep_fac_C, 1 hit
SMARTⁱ	View protein in SMART SM00382 AAA, 1 hit
SUPFAMⁱ	SSF48019 SSF48019, 1 hit SSF52540 SSF52540, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: P35250-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVEAVCGGA GEVEAQDSDP APAFSKAPGS AGHYELPWVE KYRPVKLNEI 
        60         70         80         90        100
VGNEDTVSRL EVFAREGNVP NIIIAGPPGT GKTTSILCLA RALLGPALKD 
       110        120        130        140        150
AMLELNASND RGIDVVRNKI KMFAQQKVTL PKGRHKIIIL DEADSMTDGA 
       160        170        180        190        200
QQALRRTMEI YSKTTRFALA CNASDKIIEP IQSRCAVLRY TKLTDAQILT 
       210        220        230        240        250
RLMNVIEKER VPYTDDGLEA IIFTAQGDMR QALNNLQSTF SGFGFINSEN 
       260        270        280        290        300
VFKVCDEPHP LLVKEMIQHC VNANIDEAYK ILAHLWHLGY SPEDIIGNIF 
       310        320        330        340        350
RVCKTFQMAE YLKLEFIKEI GYTHMKIAEG VNSLLQMAGL LARLCQKTMA 

PVAS

Length:354

Mass (Da):39,157

Last modified:November 1, 1997 - v3

Checksum:ⁱB50AC8EEF89F64A9

GO

Isoform 2 (identifier: P35250-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
111-144: Missing.

« Hide

        10         20         30         40         50
MEVEAVCGGA GEVEAQDSDP APAFSKAPGS AGHYELPWVE KYRPVKLNEI 
        60         70         80         90        100
VGNEDTVSRL EVFAREGNVP NIIIAGPPGT GKTTSILCLA RALLGPALKD 
       110        120        130        140        150
AMLELNASND SMTDGAQQAL RRTMEIYSKT TRFALACNAS DKIIEPIQSR 
       160        170        180        190        200
CAVLRYTKLT DAQILTRLMN VIEKERVPYT DDGLEAIIFT AQGDMRQALN 
       210        220        230        240        250
NLQSTFSGFG FINSENVFKV CDEPHPLLVK EMIQHCVNAN IDEAYKILAH 
       260        270        280        290        300
LWHLGYSPED IIGNIFRVCK TFQMAEYLKL EFIKEIGYTH MKIAEGVNSL 
       310        320
LQMAGLLARL CQKTMAPVAS

Note: No experimental confirmation available.

Show »

Length:320

Mass (Da):35,244

Checksum:ⁱD6E72DD28EA014E8

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	244	G → L AA sequence (PubMed:1313560).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_023126	232	A → V1 PublicationCorresponds to variant dbSNP:rs3135684Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_005660	111 – 144	Missing in isoform 2. 1 PublicationAdd BLAST		34

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M87338 mRNA Translation: AAB09786.1 AF045555 Genomic DNA Translation: AAC04860.1 AF483622 Genomic DNA Translation: AAL82503.1 AC005081 Genomic DNA Translation: AAP22334.1 AB451243 mRNA Translation: BAG70057.1 CH471200 Genomic DNA Translation: EAW69607.1 CH471200 Genomic DNA Translation: EAW69608.1 BC002813 mRNA Translation: AAH02813.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5567.1 [P35250-2] CCDS5568.1 [P35250-1]
PIRⁱ	A42700
NCBI Reference Sequences More...RefSeqⁱ	NP_001265720.1, NM_001278791.1 NP_001265721.1, NM_001278792.1 NP_001265722.1, NM_001278793.1 NP_002905.2, NM_002914.4 [P35250-2] NP_852136.1, NM_181471.2 [P35250-1]
UniGeneⁱ	Hs.647062

Genome annotation databases

Ensemblⁱ	ENST00000055077; ENSP00000055077; ENSG00000049541 [P35250-1] ENST00000352131; ENSP00000275627; ENSG00000049541 [P35250-2]
GeneIDⁱ	5982
KEGGⁱ	hsa:5982
UCSC genome browser More...UCSCⁱ	uc003uaj.5 human [P35250-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P35250	UPI0001EE9255		HUMAN		253
UPI00063C0282		Florida manatee		368
UPI0007A6B2FB		MINNA		368
UPI0007DA6D3B		CRIGR		366
Replication factor C subunit 2		CANLF		364
+84
P35250-2	Replication factor C subunit 2		PONAB		306
UPI0003EDE641		LEPWE		334
UPI00063C415B		ODORO		334
UPI0008130F74		MANJA		333
UPI0003AE596C		CANLF		330
+27

Protein	Similar proteins		Species	Score	Length
P35250	UPI0001EE9255		HUMAN		253
UPI00063C0282		Florida manatee		368
UPI0007A6B2FB		MINNA		368
UPI0007DA6D3B		CRIGR		366
Replication factor C subunit 2		CANLF		364
+355
P35250-2	Replication factor C subunit 2		PONAB		306
UPI0003EDE641		LEPWE		334
UPI00063C415B		ODORO		334
UPI0008130F74		MANJA		333
UPI0003AE596C		CANLF		330
+70

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M87338 mRNA Translation: AAB09786.1 AF045555 Genomic DNA Translation: AAC04860.1 AF483622 Genomic DNA Translation: AAL82503.1 AC005081 Genomic DNA Translation: AAP22334.1 AB451243 mRNA Translation: BAG70057.1 CH471200 Genomic DNA Translation: EAW69607.1 CH471200 Genomic DNA Translation: EAW69608.1 BC002813 mRNA Translation: AAH02813.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5567.1 [P35250-2] CCDS5568.1 [P35250-1]
PIRⁱ	A42700
NCBI Reference Sequences More...RefSeqⁱ	NP_001265720.1, NM_001278791.1 NP_001265721.1, NM_001278792.1 NP_001265722.1, NM_001278793.1 NP_002905.2, NM_002914.4 [P35250-2] NP_852136.1, NM_181471.2 [P35250-1]
UniGeneⁱ	Hs.647062

3D structure databases

ProteinModelPortalⁱ	P35250
SMRⁱ	P35250
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111914, 69 interactors
ComplexPortalⁱ	CPX-415 DNA replication factor C complex
CORUMⁱ	P35250
Database of interacting proteins More...DIPⁱ	DIP-34367N
IntActⁱ	P35250, 36 interactors
Molecular INTeraction database More...MINTⁱ	P35250
STRINGⁱ	9606.ENSP00000055077

PTM databases

iPTMnetⁱ	P35250
PhosphoSitePlusⁱ	P35250

Polymorphism and mutation databases

DMDMⁱ	2507300

DMDMⁱ

2507300

Proteomic databases

EPDⁱ	P35250
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P35250
PaxDbⁱ	P35250
PeptideAtlas More...PeptideAtlasⁱ	P35250
PRIDEⁱ	P35250
ProteomicsDBⁱ	55014 55015 [P35250-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5982
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000055077; ENSP00000055077; ENSG00000049541 [P35250-1] ENST00000352131; ENSP00000275627; ENSG00000049541 [P35250-2]
GeneIDⁱ	5982
KEGGⁱ	hsa:5982
UCSC genome browser More...UCSCⁱ	uc003uaj.5 human [P35250-1]

Organism-specific databases

CTDⁱ	5982
DisGeNET More...DisGeNETⁱ	5982
EuPathDBⁱ	HostDB:ENSG00000049541.10
GeneCardsⁱ	RFC2
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9970 RFC2
Human Protein Atlas More...HPAⁱ	HPA029493
MalaCards human disease database More...MalaCardsⁱ	RFC2
MIMⁱ	194050 phenotype 600404 gene
neXtProtⁱ	NX_P35250
Open Targets More...OpenTargetsⁱ	ENSG00000049541
Orphanetⁱ	904 Williams syndrome
PharmGKBⁱ	PA34339
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0991 Eukaryota COG0470 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000075050
HOGENOMⁱ	HOG000224155
HOVERGENⁱ	HBG002053
InParanoidⁱ	P35250
KEGG Orthology (KO) More...KOⁱ	K10755
OMAⁱ	QSTWSGF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CKT
PhylomeDBⁱ	P35250
TreeFamⁱ	TF300585

Enzyme and pathway databases

Reactomeⁱ	R-HSA-110312 Translesion synthesis by REV1 R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex R-HSA-110320 Translesion Synthesis by POLH R-HSA-174411 Polymerase switching on the C-strand of the telomere R-HSA-176187 Activation of ATR in response to replication stress R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair R-HSA-5655862 Translesion synthesis by POLK R-HSA-5656121 Translesion synthesis by POLI R-HSA-5656169 Termination of translesion DNA synthesis R-HSA-5685938 HDR through Single Strand Annealing (SSA) R-HSA-5685942 HDR through Homologous Recombination (HRR) R-HSA-5693607 Processing of DNA double-strand break ends R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696400 Dual Incision in GG-NER R-HSA-6782135 Dual incision in TC-NER R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation R-HSA-69091 Polymerase switching R-HSA-69473 G2/M DNA damage checkpoint

Reactomeⁱ

R-HSA-110312 Translesion synthesis by REV1
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex
R-HSA-110320 Translesion Synthesis by POLH
R-HSA-174411 Polymerase switching on the C-strand of the telomere
R-HSA-176187 Activation of ATR in response to replication stress
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-HSA-5655862 Translesion synthesis by POLK
R-HSA-5656121 Translesion synthesis by POLI
R-HSA-5656169 Termination of translesion DNA synthesis
R-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5685942 HDR through Homologous Recombination (HRR)
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-HSA-5696400 Dual Incision in GG-NER
R-HSA-6782135 Dual incision in TC-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-69091 Polymerase switching
R-HSA-69473 G2/M DNA damage checkpoint

Miscellaneous databases

ChiTaRSⁱ	RFC2 human
GeneWikiⁱ	RFC2
GenomeRNAiⁱ	5982
Protein Ontology More...PROⁱ	PR:P35250
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000049541
CleanExⁱ	HS_RFC2
ExpressionAtlasⁱ	P35250 baseline and differential
Genevisibleⁱ	P35250 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR003959 ATPase_AAA_core IPR008921 DNA_pol3_clamp-load_cplx_C IPR027417 P-loop_NTPase IPR013748 Rep_factorC_C
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00004 AAA, 1 hit PF08542 Rep_fac_C, 1 hit
SMARTⁱ	View protein in SMART SM00382 AAA, 1 hit
SUPFAMⁱ	SSF48019 SSF48019, 1 hit SSF52540 SSF52540, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RFC2_HUMAN
Accessionⁱ	P35250Primary (citable) accession number: P35250 Secondary accession number(s): B5BU07 , D3DXG3, P32846, Q9BU93
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
	Last sequence update:	November 1, 1997
	Last modified:	June 20, 2018
	This is version 189 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P35250 (RFC2_HUMAN)

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Replication factor C subunit 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ