Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pulmonary surfactant-associated protein D

Gene

Sftpd

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

GO - Molecular functioni

  • identical protein binding Source: RGD
  • lipopolysaccharide binding Source: RGD
  • monosaccharide binding Source: RGD

GO - Biological processi

  • innate immune response Source: UniProtKB-KW
  • lung alveolus development Source: UniProtKB
  • negative regulation of interleukin-2 production Source: RGD
  • negative regulation of phagocytosis Source: RGD
  • negative regulation of T cell proliferation Source: RGD
  • opsonization Source: RGD
  • positive regulation of phagocytosis Source: RGD
  • regulation of liquid surface tension Source: RGD
  • respiratory gaseous exchange Source: UniProtKB-KW
  • response to corticosteroid Source: RGD
  • response to glucocorticoid Source: RGD
  • response to growth factor Source: RGD
  • response to hyperoxia Source: RGD
  • surfactant homeostasis Source: RGD

Keywordsi

Biological processGaseous exchange, Immunity, Innate immunity
LigandCalcium, Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Pulmonary surfactant-associated protein D
Short name:
PSP-D
Short name:
SP-D
Alternative name(s):
CP4
Lung surfactant protein D
Gene namesi
Name:Sftpd
Synonyms:Sftp4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3667 Sftpd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted, Surface film

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000001746720 – 374Pulmonary surfactant-associated protein DAdd BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34S-nitrosocysteine1 Publication1
Modified residuei39S-nitrosocysteine1 Publication1
Modified residuei77Hydroxyproline1 Publication1
Modified residuei865-hydroxylysine1 Publication1
Glycosylationi89N-linked (GlcNAc...) asparagine1
Modified residuei95Hydroxyproline1 Publication1
Modified residuei985-hydroxylysine1 Publication1
Modified residuei109PhosphoserineCombined sources1
Modified residuei170Hydroxyproline1 Publication1
Modified residuei176Hydroxyproline1 Publication1
Disulfide bondi280 ↔ 372PROSITE-ProRule annotation
Disulfide bondi350 ↔ 364PROSITE-ProRule annotation

Post-translational modificationi

S-nitrosylation at Cys-34 and Cys-39 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Phosphoprotein, S-nitrosylation

Proteomic databases

PRIDEiP35248

PTM databases

iPTMnetiP35248
PhosphoSitePlusiP35248

Interactioni

Subunit structurei

Oligomeric complex of 4 set of homotrimers.

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-11328301,EBI-11328301

GO - Molecular functioni

  • identical protein binding Source: RGD

Protein-protein interaction databases

BioGridi247389, 1 interactor
DIPiDIP-46337N
IntActiP35248, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliP35248
SMRiP35248
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 221Collagen-likeAdd BLAST177
Domaini259 – 374C-type lectinPROSITE-ProRule annotationAdd BLAST116

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili222 – 253Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the SFTPD family.Curated

Keywords - Domaini

Coiled coil, Collagen, Repeat, Signal

Phylogenomic databases

HOVERGENiHBG108270
InParanoidiP35248
KOiK10068
PhylomeDBiP35248

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR008160 Collagen
IPR016187 CTDL_fold
IPR015097 Surfac_D-trimer
PfamiView protein in Pfam
PF01391 Collagen, 2 hits
PF00059 Lectin_C, 1 hit
PF09006 Surfac_D-trimer, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35248-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHFLSMLVL LVQPLGDLGA EMKTLSQRSI TNTCTLVLCS PTENGLPGRD
60 70 80 90 100
GRDGREGPRG EKGDPGLPGP MGLSGLPGPR GPVGPKGENG SAGEPGPKGE
110 120 130 140 150
RGLVGPPGSP GISGPAGKEG PSGKQGNIGP QGKPGPKGEA GPKGEVGAPG
160 170 180 190 200
MQGSAGAKGP AGPKGERGAP GEQGAPGNAG AAGPAGPAGP QGAPGSRGPP
210 220 230 240 250
GLKGDRGAPG DRGIKGESGL PDSAALRQQM EALNGKLQRL EAAFSRYKKA
260 270 280 290 300
ALFPDGQSVG DKIFRAANSE EPFEDAKEMC RQAGGQLASP RSATENAAVQ
310 320 330 340 350
QLVTAHSKAA FLSMTDVGTE GKFTYPTGEA LVYSNWAPGE PNNNGGAENC
360 370
VEIFTNGQWN DKACGEQRLV ICEF
Length:374
Mass (Da):37,561
Last modified:February 1, 1994 - v1
Checksum:iDB2BB5E399DB4A3C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89N → E AA sequence (PubMed:2675969).Curated1
Sequence conflicti164K → C AA sequence (PubMed:2675969).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81231 mRNA Translation: AAA42170.1
PIRiA42046
RefSeqiNP_037010.1, NM_012878.2
UniGeneiRn.11348

Genome annotation databases

GeneIDi25350
KEGGirno:25350

Similar proteinsi

Entry informationi

Entry nameiSFTPD_RAT
AccessioniPrimary (citable) accession number: P35248
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 20, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health