SFTPD

Functionⁱ

Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.1 Publication

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

GO - Molecular functionⁱ

carbohydrate binding
Source: UniProtKB
Traceable author statementⁱ
- 10485905
identical protein binding Source: Ensembl
lipopolysaccharide binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
monosaccharide binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular protein metabolic process Source: Reactome
defense response to bacterium
Source: UniProtKB
Traceable author statementⁱ
- 9751757
induction of bacterial agglutination
Source: AgBase
Inferred from mutant phenotypeⁱ
- 28228557
innate immune response
Source: UniProtKB
Traceable author statementⁱ
- 10485905
lung alveolus development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 9751757
macrophage chemotaxis
Source: UniProtKB
Traceable author statementⁱ
- 10485905
negative regulation by host of symbiont molecular function
Source: AgBase
Inferred from direct assayⁱ
- 28228557
negative regulation of interleukin-2 biosynthetic process
Source: UniProtKB
Traceable author statementⁱ
- 10485905
negative regulation of T cell proliferation
Source: UniProtKB
Traceable author statementⁱ
- 10485905
positive regulation of phagocytosis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
reactive oxygen species metabolic process
Source: UniProtKB
Traceable author statementⁱ
- 10485905
receptor-mediated endocytosis
Source: UniProtKB
Traceable author statementⁱ
- 10485905
regulation of adhesion of symbiont to host epithelial cell
Source: AgBase
Inferred from direct assayⁱ
- 28228557
regulation of cytokine production
Source: UniProtKB
Non-traceable author statementⁱ
- 9751757
regulation of immune response Source: Reactome
respiratory gaseous exchange Source: UniProtKB-KW
surfactant homeostasis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 9751757
toll-like receptor signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Gaseous exchange, Immunity, Innate immunity
Ligand	Calcium, Lectin

Enzyme and pathway databases

Reactomeⁱ	R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-391160 Signal regulatory protein family interactions R-HSA-5683826 Surfactant metabolism R-HSA-5686938 Regulation of TLR by endogenous ligand R-HSA-5687868 Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF) R-HSA-5688849 Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) R-HSA-5688890 Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)
SIGNORⁱ	P35247

Reactomeⁱ

R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-391160 Signal regulatory protein family interactions
R-HSA-5683826 Surfactant metabolism
R-HSA-5686938 Regulation of TLR by endogenous ligand
R-HSA-5687868 Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF)
R-HSA-5688849 Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)
R-HSA-5688890 Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)

SIGNORⁱ

P35247

Protein family/group databases

UniLectinⁱ	P35247

UniLectinⁱ

P35247

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Pulmonary surfactant-associated protein D Short name: PSP-D Short name: SP-D Alternative name(s): Collectin-7 Lung surfactant protein D
Gene namesⁱ	Name:SFTPD Synonyms:COLEC7, PSPD, SFTP4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000133661.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10803 SFTPD
MIMⁱ	178635 gene
neXtProtⁱ	NX_P35247

Keywords - Cellular componentⁱ

Extracellular matrix, Secreted, Surface film

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6441
Open Targets More...OpenTargetsⁱ	ENSG00000133661
PharmGKBⁱ	PA35715

Chemistry databases

ChEMBLⁱ	CHEMBL2176857
Drug and drug target database More...DrugBankⁱ	DB02379 Beta-D-Glucose

Polymorphism and mutation databases

BioMutaⁱ	SFTPD
DMDMⁱ	317373510

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	By similarityAdd BLAST		20
ChainⁱPRO_0000017465	21 – 375	Pulmonary surfactant-associated protein DAdd BLAST		355

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	35	S-nitrosocysteineBy similarity	1
Modified residueⁱ	40	S-nitrosocysteineBy similarity	1
Modified residueⁱ	78	4-hydroxyprolineBy similarity	1
Modified residueⁱ	87	5-hydroxylysineBy similarity	1
Glycosylationⁱ	90	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	96	4-hydroxyprolineBy similarity	1
Modified residueⁱ	99	5-hydroxylysineBy similarity	1
Modified residueⁱ	171	4-hydroxyprolineBy similarity	1
Modified residueⁱ	177	4-hydroxyprolineBy similarity	1
Disulfide bondⁱ	281 ↔ 373
Disulfide bondⁱ	351 ↔ 365

Post-translational modificationⁱ

The N-terminus is blocked.

Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.By similarity

S-nitrosylation at Cys-35 and Cys-40 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Hydroxylation, S-nitrosylation

Proteomic databases

EPDⁱ	P35247
PaxDbⁱ	P35247
PeptideAtlas More...PeptideAtlasⁱ	P35247
PRIDEⁱ	P35247
ProteomicsDBⁱ	55012

PTM databases

iPTMnetⁱ	P35247
PhosphoSitePlusⁱ	P35247

Expressionⁱ

Tissue specificityⁱ

Expressed in lung, brain, pancreas and adipose tissue (mainly mature adipocytes).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000133661 Expressed in 116 organ(s), highest expression level in visceral pleura
CleanExⁱ	HS_SFTPD
ExpressionAtlasⁱ	P35247 baseline and differential
Genevisibleⁱ	P35247 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB004578 HPA044582 HPA056768

HPAⁱ

CAB004578
HPA044582
HPA056768

Interactionⁱ

Subunit structureⁱ

Oligomeric complex of 4 set of homotrimers.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
UPK1A	O00322	3	EBI-11316157,EBI-14031976

With

Entry

#Exp.

IntAct

Notes

UPK1A

O00322

3

EBI-11316157,EBI-14031976

GO - Molecular functionⁱ

identical protein binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112339, 4 interactors
IntActⁱ	P35247, 3 interactors
STRINGⁱ	9606.ENSP00000361366

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	226 – 253	Combined sources	28
Turnⁱ	254 – 256	Combined sources	3
Beta strandⁱ	257 – 260	Combined sources	4
Beta strandⁱ	263 – 273	Combined sources	11
Helixⁱ	274 – 283	Combined sources	10
Beta strandⁱ	286 – 288	Combined sources	3
Helixⁱ	294 – 307	Combined sources	14
Beta strandⁱ	311 – 316	Combined sources	6
Beta strandⁱ	318 – 320	Combined sources	3
Beta strandⁱ	323 – 325	Combined sources	3
Helixⁱ	345 – 347	Combined sources	3
Beta strandⁱ	351 – 354	Combined sources	4
Beta strandⁱ	360 – 363	Combined sources	4
Beta strandⁱ	367 – 375	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	P35247
SMRⁱ	P35247
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P35247

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	46 – 222	Collagen-likeAdd BLAST		177
Domainⁱ	260 – 375	C-type lectinPROSITE-ProRule annotationAdd BLAST		116

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	223 – 252	Sequence analysisAdd BLAST		30

Sequence similaritiesⁱ

Belongs to the SFTPD family.Curated

Keywords - Domainⁱ

Coiled coil, Collagen, Repeat, Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IS48 Eukaryota ENOG4110NRD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00700000104102
HOVERGENⁱ	HBG108270
InParanoidⁱ	P35247
KEGG Orthology (KO) More...KOⁱ	K10068
OMAⁱ	QNKAAFL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MYV
PhylomeDBⁱ	P35247
TreeFamⁱ	TF330481

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03591 CLECT_collectin_like, 1 hit
Gene3Dⁱ	3.10.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR001304 C-type_lectin-like IPR016186 C-type_lectin-like/link_sf IPR018378 C-type_lectin_CS IPR008160 Collagen IPR033990 Collectin_CTLD IPR016187 CTDL_fold IPR015097 Surfac_D-trimer
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01391 Collagen, 2 hits PF00059 Lectin_C, 1 hit PF09006 Surfac_D-trimer, 1 hit
SMARTⁱ	View protein in SMART SM00034 CLECT, 1 hit
SUPFAMⁱ	SSF56436 SSF56436, 1 hit
PROSITEⁱ	View protein in PROSITE PS00615 C_TYPE_LECTIN_1, 1 hit PS50041 C_TYPE_LECTIN_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P35247-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLLFLLSALV LLTQPLGYLE AEMKTYSHRT MPSACTLVMC SSVESGLPGR 
        60         70         80         90        100
DGRDGREGPR GEKGDPGLPG AAGQAGMPGQ AGPVGPKGDN GSVGEPGPKG 
       110        120        130        140        150
DTGPSGPPGP PGVPGPAGRE GPLGKQGNIG PQGKPGPKGE AGPKGEVGAP 
       160        170        180        190        200
GMQGSAGARG LAGPKGERGV PGERGVPGNT GAAGSAGAMG PQGSPGARGP 
       210        220        230        240        250
PGLKGDKGIP GDKGAKGESG LPDVASLRQQ VEALQGQVQH LQAAFSQYKK 
       260        270        280        290        300
VELFPNGQSV GEKIFKTAGF VKPFTEAQLL CTQAGGQLAS PRSAAENAAL 
       310        320        330        340        350
QQLVVAKNEA AFLSMTDSKT EGKFTYPTGE SLVYSNWAPG EPNDDGGSED 
       360        370 
CVEIFTNGKW NDRACGEKRL VVCEF

Length:375

Mass (Da):37,728

Last modified:January 11, 2011 - v3

Checksum:ⁱ298917699FC40F6A

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q5T0M2	Q5T0M2_HUMAN		Pulmonary surfactant-associated pro... Pulmonary surfactant-associated protein D	SFTPD	218	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	22	E → G in AAH22318 (PubMed:15489334).Curated	1
Sequence conflictⁱ	59	P → F AA sequence (PubMed:8424457).Curated	1
Sequence conflictⁱ	122	P → A in AAB59450 (PubMed:8428971).Curated	1
Sequence conflictⁱ	240	H → P AA sequence (PubMed:8424457).Curated	1
Sequence conflictⁱ	341	E → K in AAH22318 (PubMed:15489334).Curated	1
Sequence conflictⁱ	369	R → S in CAG46746 (Ref. 3) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_020937	31	M → T4 PublicationsCorresponds to variant dbSNP:rs721917EnsemblClinVar.	1
Natural variantⁱVAR_020938	123	L → V2 PublicationsCorresponds to variant dbSNP:rs17878336EnsemblClinVar.	1
Natural variantⁱVAR_020939	180	T → A4 PublicationsCorresponds to variant dbSNP:rs2243639EnsemblClinVar.	1
Natural variantⁱVAR_020940	290	S → T2 PublicationsCorresponds to variant dbSNP:rs3088308EnsemblClinVar.	1
Natural variantⁱVAR_020941	309	E → K1 PublicationCorresponds to variant dbSNP:rs4469829EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X65018 mRNA Translation: CAA46152.1 L05485, L05483, L05484 Genomic DNA Translation: AAB59450.1 CR541948 mRNA Translation: CAG46746.1 AY216721 Genomic DNA Translation: AAO22991.1 AL512662 Genomic DNA No translation available. BC022318 mRNA Translation: AAH22318.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7362.1
PIRⁱ	A45225
NCBI Reference Sequences More...RefSeqⁱ	NP_003010.4, NM_003019.4 XP_011538389.1, XM_011540087.1
UniGeneⁱ	Hs.253495

Genome annotation databases

Ensemblⁱ	ENST00000372292; ENSP00000361366; ENSG00000133661
GeneIDⁱ	6441
KEGGⁱ	hsa:6441
UCSC genome browser More...UCSCⁱ	uc001kbh.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P35247	Pulmonary surfactant-associated protein D		MACMU		375	UniRef90_P35247
Uncharacterized protein		RHIRO		414
Uncharacterized protein		RHIBE		414
Uncharacterized protein		COLAP		378
Uncharacterized protein		MACFA		375
+23

Protein	Similar proteins		Species	Score	Length	Source
P35247	Pulmonary surfactant-associated protein D		MACMU		375	UniRef50_P35247
Pulmonary surfactant-associated protein D		MOUSE		374
Pulmonary surfactant-associated protein D		RAT		374
Pulmonary surfactant-associated protein D		BOVIN		369
Pulmonary surfactant-associated protein D	)	PIG		378
+200

Cross-referencesⁱ

Web resourcesⁱ

SeattleSNPs

Functional Glycomics Gateway - Glycan Binding

Pulmonary surfactant protein SP-D

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X65018 mRNA Translation: CAA46152.1 L05485, L05483, L05484 Genomic DNA Translation: AAB59450.1 CR541948 mRNA Translation: CAG46746.1 AY216721 Genomic DNA Translation: AAO22991.1 AL512662 Genomic DNA No translation available. BC022318 mRNA Translation: AAH22318.1
CCDSⁱ	CCDS7362.1
PIRⁱ	A45225
RefSeqⁱ	NP_003010.4, NM_003019.4 XP_011538389.1, XM_011540087.1
UniGeneⁱ	Hs.253495

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1B08	X-ray	2.30	A/B/C	218-375	[»]
	1M7L	NMR	-	A/B/C	220-257	[»]
	1PW9	X-ray	1.60	A/B/C	199-375	[»]
	1PWB	X-ray	1.40	A/B/C	199-375	[»]
	2GGU	X-ray	1.90	A/B/C	223-375	[»]
	2GGX	X-ray	1.90	A/B/C	223-375	[»]
	2ORJ	X-ray	1.80	A/B/C	223-375	[»]
	2ORK	X-ray	1.89	A/B/C	223-375	[»]
	2OS9	X-ray	1.70	A/B/C	223-375	[»]
	2RIA	X-ray	1.80	A/B/C	223-375	[»]
	2RIB	X-ray	1.80	A/B/C	223-375	[»]
	2RIC	X-ray	1.80	A/B/C	223-375	[»]
	2RID	X-ray	1.80	A/B/C	223-375	[»]
	2RIE	X-ray	1.60	A/B/C	223-375	[»]
	3DBZ	X-ray	1.80	A/B/C	223-375	[»]
	3G81	X-ray	1.80	A/B/C	223-375	[»]
	3G83	X-ray	1.90	A/B/C	223-375	[»]
	3G84	X-ray	2.30	A/B/C	223-375	[»]
	3IKN	X-ray	1.60	A/B/C	199-375	[»]
	3IKP	X-ray	1.75	A/B/C	199-375	[»]
	3IKQ	X-ray	2.25	A/B/C	199-375	[»]
	3IKR	X-ray	1.65	A/B/C	199-375	[»]
	4E52	X-ray	1.70	A/B/C	201-375	[»]
	4M17	X-ray	2.10	A/B/C/D/E/F/G/H/I/J/K/L	229-375	[»]
	4M18	X-ray	3.20	A/B/C/D/E/F/G/H/I/J/K/L	229-375	[»]
	5OXR	X-ray	1.75	A/B/C	201-375	[»]
	5OXS	X-ray	1.65	A/B/C	201-375	[»]
ProteinModelPortalⁱ	P35247
SMRⁱ	P35247
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112339, 4 interactors
IntActⁱ	P35247, 3 interactors
STRINGⁱ	9606.ENSP00000361366

Chemistry databases

ChEMBLⁱ	CHEMBL2176857
DrugBankⁱ	DB02379 Beta-D-Glucose

Protein family/group databases

UniLectinⁱ	P35247

UniLectinⁱ

P35247

PTM databases

iPTMnetⁱ	P35247
PhosphoSitePlusⁱ	P35247

Polymorphism and mutation databases

BioMutaⁱ	SFTPD
DMDMⁱ	317373510

Proteomic databases

EPDⁱ	P35247
PaxDbⁱ	P35247
PeptideAtlasⁱ	P35247
PRIDEⁱ	P35247
ProteomicsDBⁱ	55012

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6441
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000372292; ENSP00000361366; ENSG00000133661
GeneIDⁱ	6441
KEGGⁱ	hsa:6441
UCSCⁱ	uc001kbh.4 human

Organism-specific databases

CTDⁱ	6441
DisGeNETⁱ	6441
EuPathDBⁱ	HostDB:ENSG00000133661.15
GeneCardsⁱ	SFTPD
H-InvDBⁱ	HIX0008974
HGNCⁱ	HGNC:10803 SFTPD
HPAⁱ	CAB004578 HPA044582 HPA056768
MIMⁱ	178635 gene
neXtProtⁱ	NX_P35247
OpenTargetsⁱ	ENSG00000133661
PharmGKBⁱ	PA35715
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IS48 Eukaryota ENOG4110NRD LUCA
GeneTreeⁱ	ENSGT00700000104102
HOVERGENⁱ	HBG108270
InParanoidⁱ	P35247
KOⁱ	K10068
OMAⁱ	QNKAAFL
OrthoDBⁱ	EOG091G0MYV
PhylomeDBⁱ	P35247
TreeFamⁱ	TF330481

Enzyme and pathway databases

Reactomeⁱ	R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-391160 Signal regulatory protein family interactions R-HSA-5683826 Surfactant metabolism R-HSA-5686938 Regulation of TLR by endogenous ligand R-HSA-5687868 Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF) R-HSA-5688849 Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) R-HSA-5688890 Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)
SIGNORⁱ	P35247

Reactomeⁱ

R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-391160 Signal regulatory protein family interactions
R-HSA-5683826 Surfactant metabolism
R-HSA-5686938 Regulation of TLR by endogenous ligand
R-HSA-5687868 Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF)
R-HSA-5688849 Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)
R-HSA-5688890 Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)

SIGNORⁱ

P35247

Miscellaneous databases

EvolutionaryTraceⁱ	P35247
GeneWikiⁱ	Surfactant_protein_D
GenomeRNAiⁱ	6441
Protein Ontology More...PROⁱ	PR:P35247
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000133661 Expressed in 116 organ(s), highest expression level in visceral pleura
CleanExⁱ	HS_SFTPD
ExpressionAtlasⁱ	P35247 baseline and differential
Genevisibleⁱ	P35247 HS

Family and domain databases

CDDⁱ	cd03591 CLECT_collectin_like, 1 hit
Gene3Dⁱ	3.10.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR001304 C-type_lectin-like IPR016186 C-type_lectin-like/link_sf IPR018378 C-type_lectin_CS IPR008160 Collagen IPR033990 Collectin_CTLD IPR016187 CTDL_fold IPR015097 Surfac_D-trimer
Pfamⁱ	View protein in Pfam PF01391 Collagen, 2 hits PF00059 Lectin_C, 1 hit PF09006 Surfac_D-trimer, 1 hit
SMARTⁱ	View protein in SMART SM00034 CLECT, 1 hit
SUPFAMⁱ	SSF56436 SSF56436, 1 hit
PROSITEⁱ	View protein in PROSITE PS00615 C_TYPE_LECTIN_1, 1 hit PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SFTPD_HUMAN
Accessionⁱ	P35247Primary (citable) accession number: P35247 Secondary accession number(s): Q5T0M3 , Q6FH08, Q86YK9, Q8TCD8, Q9UCJ2, Q9UCJ3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
	Last sequence update:	January 11, 2011
	Last modified:	November 7, 2018
	This is version 197 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - P35247 (SFTPD_HUMAN)

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Pulmonary surfactant-associated protein D

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endoplasmic reticulum

Endosome

Extracellular region or secreted

Lysosome

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ