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UniProtKB - P35247 (SFTPD_HUMAN)

Entry version 219 (25 May 2022)
Sequence version 3 (11 Jan 2011)
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Protein

Pulmonary surfactant-associated protein D

Gene

SFTPD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.

1 Publication

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processGaseous exchange, Immunity, Innate immunity
LigandCalcium, Lectin

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P35247

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-166016, Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168179, Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-391160, Signal regulatory protein family interactions
R-HSA-5683826, Surfactant metabolism
R-HSA-5686938, Regulation of TLR by endogenous ligand
R-HSA-5688849, Defective CSF2RB causes SMDP5
R-HSA-5688890, Defective CSF2RA causes SMDP4

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P35247

SIGNOR Signaling Network Open Resource

More...SIGNORi		P35247

Protein family/group databases

UniLectin database of carbohydrate-binding proteins

More...UniLectini		P35247

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pulmonary surfactant-associated protein D
Short name:
PSP-D
Short name:
SP-D
Alternative name(s):
Collectin-7
Lung surfactant protein D
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SFTPD
Synonyms:COLEC7, PSPD, SFTP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10803, SFTPD

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		178635, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P35247

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000133661

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Extracellular matrix, Secreted, Surface film

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6441

Open Targets

More...OpenTargetsi		ENSG00000133661

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35715

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P35247, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2176857

Drug and drug target database

More...DrugBanki		DB02379, Beta-D-Glucose

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SFTPD

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373510

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20By similarityAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001746521 – 375Pulmonary surfactant-associated protein DAdd BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei35S-nitrosocysteineBy similarity1
Modified residuei40S-nitrosocysteineBy similarity1
Modified residuei784-hydroxyprolineBy similarity1
Modified residuei875-hydroxylysineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei964-hydroxyprolineBy similarity1
Modified residuei995-hydroxylysineBy similarity1
Modified residuei1714-hydroxyprolineBy similarity1
Modified residuei1774-hydroxyprolineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi281 ↔ 373
Disulfide bondi351 ↔ 365

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The N-terminus is blocked.
Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.By similarity
S-nitrosylation at Cys-35 and Cys-40 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, S-nitrosylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P35247

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P35247

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P35247

PeptideAtlas

More...PeptideAtlasi		P35247

PRoteomics IDEntifications database

More...PRIDEi		P35247

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55012

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P35247, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P35247

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P35247

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in lung, brain, pancreas and adipose tissue (mainly mature adipocytes).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000133661, Expressed in visceral pleura and 136 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P35247, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P35247, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000133661, Tissue enriched (lung)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Oligomeric complex of 4 set of homotrimers.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112339, 8 interactors

Protein interaction database and analysis system

More...IntActi		P35247, 6 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000361366

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P35247, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1375
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P35247

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P35247

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P35247

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 222Collagen-likeAdd BLAST177
Domaini260 – 375C-type lectinPROSITE-ProRule annotationAdd BLAST116

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni45 – 221DisorderedSequence analysisAdd BLAST177

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili223 – 252Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi49 – 63Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi101 – 117Pro residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SFTPD family.Curated

Keywords - Domaini

Coiled coil, Collagen, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4297, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155748

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_049894_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P35247

Identification of Orthologs from Complete Genome Data

More...OMAi		EMFTNGK

Database of Orthologous Groups

More...OrthoDBi		1341167at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P35247

TreeFam database of animal gene trees

More...TreeFami		TF330481

Family and domain databases

Conserved Domains Database

More...CDDi		cd03591, CLECT_collectin_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR008160, Collagen
IPR033990, Collectin_CTLD
IPR016187, CTDL_fold
IPR015097, Surfac_D-trimer

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01391, Collagen, 2 hits
PF00059, Lectin_C, 1 hit
PF09006, Surfac_D-trimer, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00034, CLECT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56436, SSF56436, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00615, C_TYPE_LECTIN_1, 1 hit
PS50041, C_TYPE_LECTIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P35247-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLFLLSALV LLTQPLGYLE AEMKTYSHRT MPSACTLVMC SSVESGLPGR 
        60         70         80         90        100
DGRDGREGPR GEKGDPGLPG AAGQAGMPGQ AGPVGPKGDN GSVGEPGPKG 
       110        120        130        140        150
DTGPSGPPGP PGVPGPAGRE GPLGKQGNIG PQGKPGPKGE AGPKGEVGAP 
       160        170        180        190        200
GMQGSAGARG LAGPKGERGV PGERGVPGNT GAAGSAGAMG PQGSPGARGP 
       210        220        230        240        250
PGLKGDKGIP GDKGAKGESG LPDVASLRQQ VEALQGQVQH LQAAFSQYKK 
       260        270        280        290        300
VELFPNGQSV GEKIFKTAGF VKPFTEAQLL CTQAGGQLAS PRSAAENAAL 
       310        320        330        340        350
QQLVVAKNEA AFLSMTDSKT EGKFTYPTGE SLVYSNWAPG EPNDDGGSED 
       360        370 
CVEIFTNGKW NDRACGEKRL VVCEF
Length:375
Mass (Da):37,728
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i298917699FC40F6A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T0M2Q5T0M2_HUMAN
Pulmonary surfactant-associated pro...
SFTPD
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti22E → G in AAH22318 (PubMed:15489334).Curated1
Sequence conflicti59P → F AA sequence (PubMed:8424457).Curated1
Sequence conflicti122P → A in AAB59450 (PubMed:8428971).Curated1
Sequence conflicti240H → P AA sequence (PubMed:8424457).Curated1
Sequence conflicti341E → K in AAH22318 (PubMed:15489334).Curated1
Sequence conflicti369R → S in CAG46746 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02093731M → T4 PublicationsCorresponds to variant dbSNP:rs721917EnsemblClinVar.1
Natural variantiVAR_020938123L → V2 PublicationsCorresponds to variant dbSNP:rs17878336EnsemblClinVar.1
Natural variantiVAR_020939180T → A4 PublicationsCorresponds to variant dbSNP:rs2243639EnsemblClinVar.1
Natural variantiVAR_020940290S → T2 PublicationsCorresponds to variant dbSNP:rs3088308EnsemblClinVar.1
Natural variantiVAR_020941309E → K1 PublicationCorresponds to variant dbSNP:rs4469829EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X65018 mRNA Translation: CAA46152.1
L05485, L05483, L05484 Genomic DNA Translation: AAB59450.1
CR541948 mRNA Translation: CAG46746.1
AY216721 Genomic DNA Translation: AAO22991.1
AL512662 Genomic DNA No translation available.
BC022318 mRNA Translation: AAH22318.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7362.1

Protein sequence database of the Protein Information Resource

More...PIRi		A45225

NCBI Reference Sequences

More...RefSeqi		NP_003010.4, NM_003019.4
XP_011538389.1, XM_011540087.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000372292.8; ENSP00000361366.3; ENSG00000133661.17

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6441

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6441

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000372292.8; ENSP00000361366.3; NM_003019.5; NP_003010.4

UCSC genome browser

More...UCSCi		uc001kbh.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs
Functional Glycomics Gateway - Glycan Binding

Pulmonary surfactant protein SP-D

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65018 mRNA Translation: CAA46152.1
L05485, L05483, L05484 Genomic DNA Translation: AAB59450.1
CR541948 mRNA Translation: CAG46746.1
AY216721 Genomic DNA Translation: AAO22991.1
AL512662 Genomic DNA No translation available.
BC022318 mRNA Translation: AAH22318.1
CCDSiCCDS7362.1
PIRiA45225
RefSeqiNP_003010.4, NM_003019.4
XP_011538389.1, XM_011540087.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B08X-ray2.30A/B/C218-375[»]
1M7LNMR-A/B/C220-257[»]
1PW9X-ray1.60A/B/C199-375[»]
1PWBX-ray1.40A/B/C199-375[»]
2GGUX-ray1.90A/B/C223-375[»]
2GGXX-ray1.90A/B/C223-375[»]
2ORJX-ray1.80A/B/C223-375[»]
2ORKX-ray1.89A/B/C223-375[»]
2OS9X-ray1.70A/B/C223-375[»]
2RIAX-ray1.80A/B/C223-375[»]
2RIBX-ray1.80A/B/C223-375[»]
2RICX-ray1.80A/B/C223-375[»]
2RIDX-ray1.80A/B/C223-375[»]
2RIEX-ray1.60A/B/C223-375[»]
3DBZX-ray1.80A/B/C223-375[»]
3G81X-ray1.80A/B/C223-375[»]
3G83X-ray1.90A/B/C223-375[»]
3G84X-ray2.30A/B/C223-375[»]
3IKNX-ray1.60A/B/C199-375[»]
3IKPX-ray1.75A/B/C199-375[»]
3IKQX-ray2.25A/B/C199-375[»]
3IKRX-ray1.65A/B/C199-375[»]
4E52X-ray1.70A/B/C201-375[»]
4M17X-ray2.10A/B/C/D/E/F/G/H/I/J/K/L229-375[»]
4M18X-ray3.20A/B/C/D/E/F/G/H/I/J/K/L229-375[»]
5OXRX-ray1.75A/B/C201-375[»]
5OXSX-ray1.65A/B/C201-375[»]
AlphaFoldDBiP35247
SMRiP35247
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112339, 8 interactors
IntActiP35247, 6 interactors
STRINGi9606.ENSP00000361366

Chemistry databases

ChEMBLiCHEMBL2176857
DrugBankiDB02379, Beta-D-Glucose

Protein family/group databases

UniLectiniP35247

PTM databases

GlyGeniP35247, 1 site
iPTMnetiP35247
PhosphoSitePlusiP35247

Genetic variation databases

BioMutaiSFTPD
DMDMi317373510

Proteomic databases

EPDiP35247
MassIVEiP35247
PaxDbiP35247
PeptideAtlasiP35247
PRIDEiP35247
ProteomicsDBi55012

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3886, 543 antibodies from 38 providers

The DNASU plasmid repository

More...DNASUi		6441

Genome annotation databases

EnsembliENST00000372292.8; ENSP00000361366.3; ENSG00000133661.17
GeneIDi6441
KEGGihsa:6441
MANE-SelectiENST00000372292.8; ENSP00000361366.3; NM_003019.5; NP_003010.4
UCSCiuc001kbh.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6441
DisGeNETi6441

GeneCards: human genes, protein and diseases

More...GeneCardsi		SFTPD
HGNCiHGNC:10803, SFTPD
HPAiENSG00000133661, Tissue enriched (lung)
MIMi178635, gene
neXtProtiNX_P35247
OpenTargetsiENSG00000133661
PharmGKBiPA35715
VEuPathDBiHostDB:ENSG00000133661

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4297, Eukaryota
GeneTreeiENSGT00940000155748
HOGENOMiCLU_049894_3_0_1
InParanoidiP35247
OMAiEMFTNGK
OrthoDBi1341167at2759
PhylomeDBiP35247
TreeFamiTF330481

Enzyme and pathway databases

PathwayCommonsiP35247
ReactomeiR-HSA-166016, Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168179, Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-391160, Signal regulatory protein family interactions
R-HSA-5683826, Surfactant metabolism
R-HSA-5686938, Regulation of TLR by endogenous ligand
R-HSA-5688849, Defective CSF2RB causes SMDP5
R-HSA-5688890, Defective CSF2RA causes SMDP4
SignaLinkiP35247
SIGNORiP35247

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6441, 9 hits in 1069 CRISPR screens
EvolutionaryTraceiP35247

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Surfactant_protein_D

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6441
PharosiP35247, Tbio

Protein Ontology

More...PROi		PR:P35247
RNActiP35247, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000133661, Expressed in visceral pleura and 136 other tissues
ExpressionAtlasiP35247, baseline and differential
GenevisibleiP35247, HS

Family and domain databases

CDDicd03591, CLECT_collectin_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR008160, Collagen
IPR033990, Collectin_CTLD
IPR016187, CTDL_fold
IPR015097, Surfac_D-trimer
PfamiView protein in Pfam
PF01391, Collagen, 2 hits
PF00059, Lectin_C, 1 hit
PF09006, Surfac_D-trimer, 1 hit
SMARTiView protein in SMART
SM00034, CLECT, 1 hit
SUPFAMiSSF56436, SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615, C_TYPE_LECTIN_1, 1 hit
PS50041, C_TYPE_LECTIN_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSFTPD_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35247
Secondary accession number(s): Q5T0M3
, Q6FH08, Q86YK9, Q8TCD8, Q9UCJ2, Q9UCJ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 11, 2011
Last modified: May 25, 2022
This is version 219 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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