UniProtKB - P35247 (SFTPD_HUMAN)
Pulmonary surfactant-associated protein D
SFTPD
Functioni
Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.
1 PublicationMiscellaneous
GO - Molecular functioni
- carbohydrate binding Source: UniProtKB
- identical protein binding Source: Ensembl
GO - Biological processi
- defense response to bacterium Source: UniProtKB
- induction of bacterial agglutination Source: AgBase
- innate immune response Source: UniProtKB
- lung alveolus development Source: UniProtKB
- macrophage chemotaxis Source: UniProtKB
- negative regulation by host of symbiont catalytic activity Source: AgBase
- negative regulation of interleukin-2 production Source: UniProtKB
- negative regulation of T cell proliferation Source: UniProtKB
- positive regulation of phagocytosis Source: GO_Central
- reactive oxygen species metabolic process Source: UniProtKB
- receptor-mediated endocytosis Source: UniProtKB
- regulation of adhesion of symbiont to host epithelial cell Source: AgBase
- regulation of cytokine production Source: UniProtKB
- respiratory gaseous exchange by respiratory system Source: UniProtKB-KW
- surfactant homeostasis Source: UniProtKB
Keywordsi
Biological process | Gaseous exchange, Immunity, Innate immunity |
Ligand | Calcium, Lectin |
Enzyme and pathway databases
PathwayCommonsi | P35247 |
Reactomei | R-HSA-166016, Toll Like Receptor 4 (TLR4) Cascade R-HSA-168179, Toll Like Receptor TLR1:TLR2 Cascade R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-391160, Signal regulatory protein family interactions R-HSA-5683826, Surfactant metabolism R-HSA-5686938, Regulation of TLR by endogenous ligand R-HSA-5688849, Defective CSF2RB causes SMDP5 R-HSA-5688890, Defective CSF2RA causes SMDP4 |
SignaLinki | P35247 |
SIGNORi | P35247 |
Protein family/group databases
UniLectini | P35247 |
Names & Taxonomyi
Protein namesi | Recommended name: Pulmonary surfactant-associated protein DShort name: PSP-D Short name: SP-D Alternative name(s): Collectin-7 Lung surfactant protein D |
Gene namesi | Name:SFTPD Synonyms:COLEC7, PSPD, SFTP4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10803, SFTPD |
MIMi | 178635, gene |
neXtProti | NX_P35247 |
VEuPathDBi | HostDB:ENSG00000133661 |
Subcellular locationi
Extracellular region or secreted
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: Reactome
- rough endoplasmic reticulum Source: GO_Central
Endosome
- multivesicular body Source: GO_Central
Extracellular region or secreted
- extracellular region Source: UniProtKB
- extracellular space Source: GO_Central
Lysosome
- lysosome Source: UniProtKB
Other locations
- clathrin-coated endocytic vesicle Source: Reactome
- collagen trimer Source: UniProtKB-KW
- endocytic vesicle Source: UniProtKB
Keywords - Cellular componenti
Extracellular matrix, Secreted, Surface filmPathology & Biotechi
Organism-specific databases
DisGeNETi | 6441 |
OpenTargetsi | ENSG00000133661 |
PharmGKBi | PA35715 |
Miscellaneous databases
Pharosi | P35247, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2176857 |
DrugBanki | DB02379, Beta-D-Glucose |
Genetic variation databases
BioMutai | SFTPD |
DMDMi | 317373510 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | By similarityAdd BLAST | 20 | |
ChainiPRO_0000017465 | 21 – 375 | Pulmonary surfactant-associated protein DAdd BLAST | 355 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 35 | S-nitrosocysteineBy similarity | 1 | |
Modified residuei | 40 | S-nitrosocysteineBy similarity | 1 | |
Modified residuei | 78 | 4-hydroxyprolineBy similarity | 1 | |
Modified residuei | 87 | 5-hydroxylysineBy similarity | 1 | |
Glycosylationi | 90 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 96 | 4-hydroxyprolineBy similarity | 1 | |
Modified residuei | 99 | 5-hydroxylysineBy similarity | 1 | |
Modified residuei | 171 | 4-hydroxyprolineBy similarity | 1 | |
Modified residuei | 177 | 4-hydroxyprolineBy similarity | 1 | |
Disulfide bondi | 281 ↔ 373 | |||
Disulfide bondi | 351 ↔ 365 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Hydroxylation, S-nitrosylationProteomic databases
EPDi | P35247 |
MassIVEi | P35247 |
PaxDbi | P35247 |
PeptideAtlasi | P35247 |
PRIDEi | P35247 |
ProteomicsDBi | 55012 |
PTM databases
GlyGeni | P35247, 1 site |
iPTMneti | P35247 |
PhosphoSitePlusi | P35247 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000133661, Expressed in visceral pleura and 136 other tissues |
ExpressionAtlasi | P35247, baseline and differential |
Genevisiblei | P35247, HS |
Organism-specific databases
HPAi | ENSG00000133661, Tissue enriched (lung) |
Interactioni
Subunit structurei
Oligomeric complex of 4 set of homotrimers.
Binary interactionsi
P35247
With | #Exp. | IntAct |
---|---|---|
ACE2 [Q9BYF1] | 2 | EBI-11316157,EBI-7730807 |
UPK1A [O00322] | 3 | EBI-11316157,EBI-14031976 |
S [P0DTC2] from Severe acute respiratory syndrome coronavirus 2. | 3 | EBI-11316157,EBI-25474821 |
Pulmonary surfactant-associated protein D (PRO_0000017465)
With | #Exp. | IntAct |
---|---|---|
S [P0DTC2] from Severe acute respiratory syndrome coronavirus 2. | 11 | EBI-27021977,EBI-25474821 |
GO - Molecular functioni
- identical protein binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 112339, 8 interactors |
IntActi | P35247, 6 interactors |
STRINGi | 9606.ENSP00000361366 |
Miscellaneous databases
RNActi | P35247, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P35247 |
SMRi | P35247 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P35247 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 46 – 222 | Collagen-likeAdd BLAST | 177 | |
Domaini | 260 – 375 | C-type lectinPROSITE-ProRule annotationAdd BLAST | 116 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 45 – 221 | DisorderedSequence analysisAdd BLAST | 177 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 223 – 252 | Sequence analysisAdd BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 49 – 63 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 101 – 117 | Pro residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Collagen, Repeat, SignalPhylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00940000155748 |
HOGENOMi | CLU_049894_3_0_1 |
InParanoidi | P35247 |
OMAi | EMFTNGK |
OrthoDBi | 1341167at2759 |
PhylomeDBi | P35247 |
TreeFami | TF330481 |
Family and domain databases
CDDi | cd03591, CLECT_collectin_like, 1 hit |
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR018378, C-type_lectin_CS IPR008160, Collagen IPR033990, Collectin_CTLD IPR016187, CTDL_fold IPR015097, Surfac_D-trimer |
Pfami | View protein in Pfam PF01391, Collagen, 2 hits PF00059, Lectin_C, 1 hit PF09006, Surfac_D-trimer, 1 hit |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS00615, C_TYPE_LECTIN_1, 1 hit PS50041, C_TYPE_LECTIN_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MLLFLLSALV LLTQPLGYLE AEMKTYSHRT MPSACTLVMC SSVESGLPGR
60 70 80 90 100
DGRDGREGPR GEKGDPGLPG AAGQAGMPGQ AGPVGPKGDN GSVGEPGPKG
110 120 130 140 150
DTGPSGPPGP PGVPGPAGRE GPLGKQGNIG PQGKPGPKGE AGPKGEVGAP
160 170 180 190 200
GMQGSAGARG LAGPKGERGV PGERGVPGNT GAAGSAGAMG PQGSPGARGP
210 220 230 240 250
PGLKGDKGIP GDKGAKGESG LPDVASLRQQ VEALQGQVQH LQAAFSQYKK
260 270 280 290 300
VELFPNGQSV GEKIFKTAGF VKPFTEAQLL CTQAGGQLAS PRSAAENAAL
310 320 330 340 350
QQLVVAKNEA AFLSMTDSKT EGKFTYPTGE SLVYSNWAPG EPNDDGGSED
360 370
CVEIFTNGKW NDRACGEKRL VVCEF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5T0M2 | Q5T0M2_HUMAN | Pulmonary surfactant-associated pro... | SFTPD | 218 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 22 | E → G in AAH22318 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 59 | P → F AA sequence (PubMed:8424457).Curated | 1 | |
Sequence conflicti | 122 | P → A in AAB59450 (PubMed:8428971).Curated | 1 | |
Sequence conflicti | 240 | H → P AA sequence (PubMed:8424457).Curated | 1 | |
Sequence conflicti | 341 | E → K in AAH22318 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 369 | R → S in CAG46746 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020937 | 31 | M → T4 PublicationsCorresponds to variant dbSNP:rs721917EnsemblClinVar. | 1 | |
Natural variantiVAR_020938 | 123 | L → V2 PublicationsCorresponds to variant dbSNP:rs17878336EnsemblClinVar. | 1 | |
Natural variantiVAR_020939 | 180 | T → A4 PublicationsCorresponds to variant dbSNP:rs2243639EnsemblClinVar. | 1 | |
Natural variantiVAR_020940 | 290 | S → T2 PublicationsCorresponds to variant dbSNP:rs3088308EnsemblClinVar. | 1 | |
Natural variantiVAR_020941 | 309 | E → K1 PublicationCorresponds to variant dbSNP:rs4469829EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X65018 mRNA Translation: CAA46152.1 L05485, L05483, L05484 Genomic DNA Translation: AAB59450.1 CR541948 mRNA Translation: CAG46746.1 AY216721 Genomic DNA Translation: AAO22991.1 AL512662 Genomic DNA No translation available. BC022318 mRNA Translation: AAH22318.1 |
CCDSi | CCDS7362.1 |
PIRi | A45225 |
RefSeqi | NP_003010.4, NM_003019.4 XP_011538389.1, XM_011540087.1 |
Genome annotation databases
Ensembli | ENST00000372292.8; ENSP00000361366.3; ENSG00000133661.17 |
GeneIDi | 6441 |
KEGGi | hsa:6441 |
MANE-Selecti | ENST00000372292.8; ENSP00000361366.3; NM_003019.5; NP_003010.4 |
UCSCi | uc001kbh.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
Functional Glycomics Gateway - Glycan Binding Pulmonary surfactant protein SP-D |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X65018 mRNA Translation: CAA46152.1 L05485, L05483, L05484 Genomic DNA Translation: AAB59450.1 CR541948 mRNA Translation: CAG46746.1 AY216721 Genomic DNA Translation: AAO22991.1 AL512662 Genomic DNA No translation available. BC022318 mRNA Translation: AAH22318.1 |
CCDSi | CCDS7362.1 |
PIRi | A45225 |
RefSeqi | NP_003010.4, NM_003019.4 XP_011538389.1, XM_011540087.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1B08 | X-ray | 2.30 | A/B/C | 218-375 | [»] | |
1M7L | NMR | - | A/B/C | 220-257 | [»] | |
1PW9 | X-ray | 1.60 | A/B/C | 199-375 | [»] | |
1PWB | X-ray | 1.40 | A/B/C | 199-375 | [»] | |
2GGU | X-ray | 1.90 | A/B/C | 223-375 | [»] | |
2GGX | X-ray | 1.90 | A/B/C | 223-375 | [»] | |
2ORJ | X-ray | 1.80 | A/B/C | 223-375 | [»] | |
2ORK | X-ray | 1.89 | A/B/C | 223-375 | [»] | |
2OS9 | X-ray | 1.70 | A/B/C | 223-375 | [»] | |
2RIA | X-ray | 1.80 | A/B/C | 223-375 | [»] | |
2RIB | X-ray | 1.80 | A/B/C | 223-375 | [»] | |
2RIC | X-ray | 1.80 | A/B/C | 223-375 | [»] | |
2RID | X-ray | 1.80 | A/B/C | 223-375 | [»] | |
2RIE | X-ray | 1.60 | A/B/C | 223-375 | [»] | |
3DBZ | X-ray | 1.80 | A/B/C | 223-375 | [»] | |
3G81 | X-ray | 1.80 | A/B/C | 223-375 | [»] | |
3G83 | X-ray | 1.90 | A/B/C | 223-375 | [»] | |
3G84 | X-ray | 2.30 | A/B/C | 223-375 | [»] | |
3IKN | X-ray | 1.60 | A/B/C | 199-375 | [»] | |
3IKP | X-ray | 1.75 | A/B/C | 199-375 | [»] | |
3IKQ | X-ray | 2.25 | A/B/C | 199-375 | [»] | |
3IKR | X-ray | 1.65 | A/B/C | 199-375 | [»] | |
4E52 | X-ray | 1.70 | A/B/C | 201-375 | [»] | |
4M17 | X-ray | 2.10 | A/B/C/D/E/F/G/H/I/J/K/L | 229-375 | [»] | |
4M18 | X-ray | 3.20 | A/B/C/D/E/F/G/H/I/J/K/L | 229-375 | [»] | |
5OXR | X-ray | 1.75 | A/B/C | 201-375 | [»] | |
5OXS | X-ray | 1.65 | A/B/C | 201-375 | [»] | |
AlphaFoldDBi | P35247 | |||||
SMRi | P35247 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112339, 8 interactors |
IntActi | P35247, 6 interactors |
STRINGi | 9606.ENSP00000361366 |
Chemistry databases
ChEMBLi | CHEMBL2176857 |
DrugBanki | DB02379, Beta-D-Glucose |
Protein family/group databases
UniLectini | P35247 |
PTM databases
GlyGeni | P35247, 1 site |
iPTMneti | P35247 |
PhosphoSitePlusi | P35247 |
Genetic variation databases
BioMutai | SFTPD |
DMDMi | 317373510 |
Proteomic databases
EPDi | P35247 |
MassIVEi | P35247 |
PaxDbi | P35247 |
PeptideAtlasi | P35247 |
PRIDEi | P35247 |
ProteomicsDBi | 55012 |
Protocols and materials databases
Antibodypediai | 3886, 543 antibodies from 38 providers |
DNASUi | 6441 |
Genome annotation databases
Ensembli | ENST00000372292.8; ENSP00000361366.3; ENSG00000133661.17 |
GeneIDi | 6441 |
KEGGi | hsa:6441 |
MANE-Selecti | ENST00000372292.8; ENSP00000361366.3; NM_003019.5; NP_003010.4 |
UCSCi | uc001kbh.4, human |
Organism-specific databases
CTDi | 6441 |
DisGeNETi | 6441 |
GeneCardsi | SFTPD |
HGNCi | HGNC:10803, SFTPD |
HPAi | ENSG00000133661, Tissue enriched (lung) |
MIMi | 178635, gene |
neXtProti | NX_P35247 |
OpenTargetsi | ENSG00000133661 |
PharmGKBi | PA35715 |
VEuPathDBi | HostDB:ENSG00000133661 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00940000155748 |
HOGENOMi | CLU_049894_3_0_1 |
InParanoidi | P35247 |
OMAi | EMFTNGK |
OrthoDBi | 1341167at2759 |
PhylomeDBi | P35247 |
TreeFami | TF330481 |
Enzyme and pathway databases
PathwayCommonsi | P35247 |
Reactomei | R-HSA-166016, Toll Like Receptor 4 (TLR4) Cascade R-HSA-168179, Toll Like Receptor TLR1:TLR2 Cascade R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-391160, Signal regulatory protein family interactions R-HSA-5683826, Surfactant metabolism R-HSA-5686938, Regulation of TLR by endogenous ligand R-HSA-5688849, Defective CSF2RB causes SMDP5 R-HSA-5688890, Defective CSF2RA causes SMDP4 |
SignaLinki | P35247 |
SIGNORi | P35247 |
Miscellaneous databases
BioGRID-ORCSi | 6441, 9 hits in 1069 CRISPR screens |
EvolutionaryTracei | P35247 |
GeneWikii | Surfactant_protein_D |
GenomeRNAii | 6441 |
Pharosi | P35247, Tbio |
PROi | PR:P35247 |
RNActi | P35247, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000133661, Expressed in visceral pleura and 136 other tissues |
ExpressionAtlasi | P35247, baseline and differential |
Genevisiblei | P35247, HS |
Family and domain databases
CDDi | cd03591, CLECT_collectin_like, 1 hit |
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR018378, C-type_lectin_CS IPR008160, Collagen IPR033990, Collectin_CTLD IPR016187, CTDL_fold IPR015097, Surfac_D-trimer |
Pfami | View protein in Pfam PF01391, Collagen, 2 hits PF00059, Lectin_C, 1 hit PF09006, Surfac_D-trimer, 1 hit |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS00615, C_TYPE_LECTIN_1, 1 hit PS50041, C_TYPE_LECTIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SFTPD_HUMAN | |
Accessioni | P35247Primary (citable) accession number: P35247 Secondary accession number(s): Q5T0M3 Q9UCJ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | January 11, 2011 | |
Last modified: | May 25, 2022 | |
This is version 219 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families