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UniProtKB - P35247 (SFTPD_HUMAN)

Protein

Pulmonary surfactant-associated protein D

Gene

SFTPD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.1 Publication

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB
  • identical protein binding Source: Ensembl
  • lipopolysaccharide binding Source: GO_Central
  • monosaccharide binding Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processGaseous exchange, Immunity, Innate immunity
LigandCalcium, Lectin

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-391160 Signal regulatory protein family interactions
R-HSA-5683826 Surfactant metabolism
R-HSA-5686938 Regulation of TLR by endogenous ligand
R-HSA-5687868 Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF)
R-HSA-5688849 Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)
R-HSA-5688890 Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)

SIGNOR Signaling Network Open Resource

More...SIGNORi		P35247

Protein family/group databases

UniLectin database of carbohydrate-binding proteins

More...UniLectini		P35247

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pulmonary surfactant-associated protein D
Short name:
PSP-D
Short name:
SP-D
Alternative name(s):
Collectin-7
Lung surfactant protein D
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SFTPD
Synonyms:COLEC7, PSPD, SFTP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000133661.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:10803 SFTPD

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		178635 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P35247

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted, Surface film

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6441

Open Targets

More...OpenTargetsi		ENSG00000133661

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35715

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2176857

Drug and drug target database

More...DrugBanki		DB02379 Beta-D-Glucose

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SFTPD

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373510

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20By similarityAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001746521 – 375Pulmonary surfactant-associated protein DAdd BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei35S-nitrosocysteineBy similarity1
Modified residuei40S-nitrosocysteineBy similarity1
Modified residuei784-hydroxyprolineBy similarity1
Modified residuei875-hydroxylysineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei964-hydroxyprolineBy similarity1
Modified residuei995-hydroxylysineBy similarity1
Modified residuei1714-hydroxyprolineBy similarity1
Modified residuei1774-hydroxyprolineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi281 ↔ 373
Disulfide bondi351 ↔ 365

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The N-terminus is blocked.
Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.By similarity
S-nitrosylation at Cys-35 and Cys-40 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, S-nitrosylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P35247

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P35247

PeptideAtlas

More...PeptideAtlasi		P35247

PRoteomics IDEntifications database

More...PRIDEi		P35247

ProteomicsDB human proteome resource

More...ProteomicsDBi		55012

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P35247

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P35247

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in lung, brain, pancreas and adipose tissue (mainly mature adipocytes).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000133661 Expressed in 116 organ(s), highest expression level in visceral pleura

CleanEx database of gene expression profiles

More...CleanExi		HS_SFTPD

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P35247 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P35247 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB004578
HPA044582
HPA056768

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Oligomeric complex of 4 set of homotrimers.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
UPK1AO003223EBI-11316157,EBI-14031976

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		112339, 4 interactors

Protein interaction database and analysis system

More...IntActi		P35247, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000361366

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1375
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B08X-ray2.30A/B/C218-375[»]
1M7LNMR-A/B/C220-257[»]
1PW9X-ray1.60A/B/C199-375[»]
1PWBX-ray1.40A/B/C199-375[»]
2GGUX-ray1.90A/B/C223-375[»]
2GGXX-ray1.90A/B/C223-375[»]
2ORJX-ray1.80A/B/C223-375[»]
2ORKX-ray1.89A/B/C223-375[»]
2OS9X-ray1.70A/B/C223-375[»]
2RIAX-ray1.80A/B/C223-375[»]
2RIBX-ray1.80A/B/C223-375[»]
2RICX-ray1.80A/B/C223-375[»]
2RIDX-ray1.80A/B/C223-375[»]
2RIEX-ray1.60A/B/C223-375[»]
3DBZX-ray1.80A/B/C223-375[»]
3G81X-ray1.80A/B/C223-375[»]
3G83X-ray1.90A/B/C223-375[»]
3G84X-ray2.30A/B/C223-375[»]
3IKNX-ray1.60A/B/C199-375[»]
3IKPX-ray1.75A/B/C199-375[»]
3IKQX-ray2.25A/B/C199-375[»]
3IKRX-ray1.65A/B/C199-375[»]
4E52X-ray1.70A/B/C201-375[»]
4M17X-ray2.10A/B/C/D/E/F/G/H/I/J/K/L229-375[»]
4M18X-ray3.20A/B/C/D/E/F/G/H/I/J/K/L229-375[»]
5OXRX-ray1.75A/B/C201-375[»]
5OXSX-ray1.65A/B/C201-375[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P35247

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P35247

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P35247

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 222Collagen-likeAdd BLAST177
Domaini260 – 375C-type lectinPROSITE-ProRule annotationAdd BLAST116

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili223 – 252Sequence analysisAdd BLAST30

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SFTPD family.Curated

Keywords - Domaini

Coiled coil, Collagen, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IS48 Eukaryota
ENOG4110NRD LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155748

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG108270

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P35247

KEGG Orthology (KO)

More...KOi		K10068

Identification of Orthologs from Complete Genome Data

More...OMAi		QNKAAFL

Database of Orthologous Groups

More...OrthoDBi		1341167at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P35247

TreeFam database of animal gene trees

More...TreeFami		TF330481

Family and domain databases

Conserved Domains Database

More...CDDi		cd03591 CLECT_collectin_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR008160 Collagen
IPR033990 Collectin_CTLD
IPR016187 CTDL_fold
IPR015097 Surfac_D-trimer

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01391 Collagen, 2 hits
PF00059 Lectin_C, 1 hit
PF09006 Surfac_D-trimer, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00034 CLECT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56436 SSF56436, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P35247-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLFLLSALV LLTQPLGYLE AEMKTYSHRT MPSACTLVMC SSVESGLPGR 
        60         70         80         90        100
DGRDGREGPR GEKGDPGLPG AAGQAGMPGQ AGPVGPKGDN GSVGEPGPKG 
       110        120        130        140        150
DTGPSGPPGP PGVPGPAGRE GPLGKQGNIG PQGKPGPKGE AGPKGEVGAP 
       160        170        180        190        200
GMQGSAGARG LAGPKGERGV PGERGVPGNT GAAGSAGAMG PQGSPGARGP 
       210        220        230        240        250
PGLKGDKGIP GDKGAKGESG LPDVASLRQQ VEALQGQVQH LQAAFSQYKK 
       260        270        280        290        300
VELFPNGQSV GEKIFKTAGF VKPFTEAQLL CTQAGGQLAS PRSAAENAAL 
       310        320        330        340        350
QQLVVAKNEA AFLSMTDSKT EGKFTYPTGE SLVYSNWAPG EPNDDGGSED 
       360        370 
CVEIFTNGKW NDRACGEKRL VVCEF
Length:375
Mass (Da):37,728
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i298917699FC40F6A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T0M2Q5T0M2_HUMAN
Pulmonary surfactant-associated pro...
SFTPD
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti22E → G in AAH22318 (PubMed:15489334).Curated1
Sequence conflicti59P → F AA sequence (PubMed:8424457).Curated1
Sequence conflicti122P → A in AAB59450 (PubMed:8428971).Curated1
Sequence conflicti240H → P AA sequence (PubMed:8424457).Curated1
Sequence conflicti341E → K in AAH22318 (PubMed:15489334).Curated1
Sequence conflicti369R → S in CAG46746 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02093731M → T4 PublicationsCorresponds to variant dbSNP:rs721917EnsemblClinVar.1
Natural variantiVAR_020938123L → V2 PublicationsCorresponds to variant dbSNP:rs17878336EnsemblClinVar.1
Natural variantiVAR_020939180T → A4 PublicationsCorresponds to variant dbSNP:rs2243639EnsemblClinVar.1
Natural variantiVAR_020940290S → T2 PublicationsCorresponds to variant dbSNP:rs3088308EnsemblClinVar.1
Natural variantiVAR_020941309E → K1 PublicationCorresponds to variant dbSNP:rs4469829EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X65018 mRNA Translation: CAA46152.1
L05485, L05483, L05484 Genomic DNA Translation: AAB59450.1
CR541948 mRNA Translation: CAG46746.1
AY216721 Genomic DNA Translation: AAO22991.1
AL512662 Genomic DNA No translation available.
BC022318 mRNA Translation: AAH22318.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7362.1

Protein sequence database of the Protein Information Resource

More...PIRi		A45225

NCBI Reference Sequences

More...RefSeqi		NP_003010.4, NM_003019.4
XP_011538389.1, XM_011540087.1

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.253495

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000372292; ENSP00000361366; ENSG00000133661

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6441

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6441

UCSC genome browser

More...UCSCi		uc001kbh.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs
Functional Glycomics Gateway - Glycan Binding

Pulmonary surfactant protein SP-D

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65018 mRNA Translation: CAA46152.1
L05485, L05483, L05484 Genomic DNA Translation: AAB59450.1
CR541948 mRNA Translation: CAG46746.1
AY216721 Genomic DNA Translation: AAO22991.1
AL512662 Genomic DNA No translation available.
BC022318 mRNA Translation: AAH22318.1
CCDSiCCDS7362.1
PIRiA45225
RefSeqiNP_003010.4, NM_003019.4
XP_011538389.1, XM_011540087.1
UniGeneiHs.253495

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B08X-ray2.30A/B/C218-375[»]
1M7LNMR-A/B/C220-257[»]
1PW9X-ray1.60A/B/C199-375[»]
1PWBX-ray1.40A/B/C199-375[»]
2GGUX-ray1.90A/B/C223-375[»]
2GGXX-ray1.90A/B/C223-375[»]
2ORJX-ray1.80A/B/C223-375[»]
2ORKX-ray1.89A/B/C223-375[»]
2OS9X-ray1.70A/B/C223-375[»]
2RIAX-ray1.80A/B/C223-375[»]
2RIBX-ray1.80A/B/C223-375[»]
2RICX-ray1.80A/B/C223-375[»]
2RIDX-ray1.80A/B/C223-375[»]
2RIEX-ray1.60A/B/C223-375[»]
3DBZX-ray1.80A/B/C223-375[»]
3G81X-ray1.80A/B/C223-375[»]
3G83X-ray1.90A/B/C223-375[»]
3G84X-ray2.30A/B/C223-375[»]
3IKNX-ray1.60A/B/C199-375[»]
3IKPX-ray1.75A/B/C199-375[»]
3IKQX-ray2.25A/B/C199-375[»]
3IKRX-ray1.65A/B/C199-375[»]
4E52X-ray1.70A/B/C201-375[»]
4M17X-ray2.10A/B/C/D/E/F/G/H/I/J/K/L229-375[»]
4M18X-ray3.20A/B/C/D/E/F/G/H/I/J/K/L229-375[»]
5OXRX-ray1.75A/B/C201-375[»]
5OXSX-ray1.65A/B/C201-375[»]
ProteinModelPortaliP35247
SMRiP35247
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112339, 4 interactors
IntActiP35247, 3 interactors
STRINGi9606.ENSP00000361366

Chemistry databases

ChEMBLiCHEMBL2176857
DrugBankiDB02379 Beta-D-Glucose

Protein family/group databases

UniLectiniP35247

PTM databases

iPTMnetiP35247
PhosphoSitePlusiP35247

Polymorphism and mutation databases

BioMutaiSFTPD
DMDMi317373510

Proteomic databases

EPDiP35247
PaxDbiP35247
PeptideAtlasiP35247
PRIDEiP35247
ProteomicsDBi55012

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		6441
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372292; ENSP00000361366; ENSG00000133661
GeneIDi6441
KEGGihsa:6441
UCSCiuc001kbh.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6441
DisGeNETi6441
EuPathDBiHostDB:ENSG00000133661.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		SFTPD

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0008974
HGNCiHGNC:10803 SFTPD
HPAiCAB004578
HPA044582
HPA056768
MIMi178635 gene
neXtProtiNX_P35247
OpenTargetsiENSG00000133661
PharmGKBiPA35715

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IS48 Eukaryota
ENOG4110NRD LUCA
GeneTreeiENSGT00940000155748
HOVERGENiHBG108270
InParanoidiP35247
KOiK10068
OMAiQNKAAFL
OrthoDBi1341167at2759
PhylomeDBiP35247
TreeFamiTF330481

Enzyme and pathway databases

ReactomeiR-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-391160 Signal regulatory protein family interactions
R-HSA-5683826 Surfactant metabolism
R-HSA-5686938 Regulation of TLR by endogenous ligand
R-HSA-5687868 Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF)
R-HSA-5688849 Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)
R-HSA-5688890 Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)
SIGNORiP35247

Miscellaneous databases

EvolutionaryTraceiP35247

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Surfactant_protein_D

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6441

Protein Ontology

More...PROi		PR:P35247

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000133661 Expressed in 116 organ(s), highest expression level in visceral pleura
CleanExiHS_SFTPD
ExpressionAtlasiP35247 baseline and differential
GenevisibleiP35247 HS

Family and domain databases

CDDicd03591 CLECT_collectin_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR008160 Collagen
IPR033990 Collectin_CTLD
IPR016187 CTDL_fold
IPR015097 Surfac_D-trimer
PfamiView protein in Pfam
PF01391 Collagen, 2 hits
PF00059 Lectin_C, 1 hit
PF09006 Surfac_D-trimer, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSFTPD_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35247
Secondary accession number(s): Q5T0M3
, Q6FH08, Q86YK9, Q8TCD8, Q9UCJ2, Q9UCJ3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 11, 2011
Last modified: January 16, 2019
This is version 199 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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