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Protein

Pulmonary surfactant-associated protein D

Gene

SFTPD

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

GO - Molecular functioni

  • lipopolysaccharide binding Source: GO_Central
  • monosaccharide binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processGaseous exchange, Immunity, Innate immunity
LigandCalcium, Lectin

Enzyme and pathway databases

ReactomeiR-BTA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-BTA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-BTA-391160 Signal regulatory protein family interactions
R-BTA-5683826 Surfactant metabolism
R-BTA-5686938 Regulation of TLR by endogenous ligand

Names & Taxonomyi

Protein namesi
Recommended name:
Pulmonary surfactant-associated protein D
Short name:
PSP-D
Short name:
SP-D
Alternative name(s):
Lung surfactant protein D
Gene namesi
Name:SFTPD
Synonyms:SFTP4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 28

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted, Surface film

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000001746421 – 369Pulmonary surfactant-associated protein DAdd BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35S-nitrosocysteineBy similarity1
Modified residuei40S-nitrosocysteineBy similarity1
Modified residuei784-hydroxyprolineBy similarity1
Modified residuei875-hydroxylysineBy similarity1
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei964-hydroxyprolineBy similarity1
Modified residuei995-hydroxylysineBy similarity1
Modified residuei1654-hydroxyprolineBy similarity1
Modified residuei1714-hydroxyprolineBy similarity1
Disulfide bondi275 ↔ 367PROSITE-ProRule annotation
Disulfide bondi345 ↔ 359PROSITE-ProRule annotation

Post-translational modificationi

Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.By similarity
S-nitrosylation at Cys-35 and Cys-40 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, S-nitrosylation

Proteomic databases

PaxDbiP35246
PRIDEiP35246

Expressioni

Gene expression databases

BgeeiENSBTAG00000046421 Expressed in 3 organ(s), highest expression level in lung

Interactioni

Subunit structurei

Oligomeric complex of 4 set of homotrimers.

Protein-protein interaction databases

BioGridi159354, 2 interactors
STRINGi9913.ENSBTAP00000008579

Structurei

3D structure databases

ProteinModelPortaliP35246
SMRiP35246
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 216Collagen-likeAdd BLAST171
Domaini254 – 369C-type lectinPROSITE-ProRule annotationAdd BLAST116

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili217 – 248Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the SFTPD family.Curated

Keywords - Domaini

Coiled coil, Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104102
HOGENOMiHOG000085660
HOVERGENiHBG108270
InParanoidiP35246
KOiK10068
OMAiQNKAAFL
OrthoDBiEOG091G0MYV
TreeFamiTF330481

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR008160 Collagen
IPR016187 CTDL_fold
IPR015097 Surfac_D-trimer
PfamiView protein in Pfam
PF01391 Collagen, 2 hits
PF00059 Lectin_C, 1 hit
PF09006 Surfac_D-trimer, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35246-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLLPLSVLL LLTQPWRSLG AEMKIYSQKT MANACTLVMC SPPEDGLPGR
60 70 80 90 100
DGRDGREGPR GEKGDPGSPG PAGRAGMPGP AGPIGLKGDN GSAGEPGPKG
110 120 130 140 150
DTGPPGPPGM PGPAGREGPS GKQGSMGPPG TPGPKGDTGP KGGVGAPGIQ
160 170 180 190 200
GSPGPAGLKG ERGAPGEPGA PGRAGAPGPA GAIGPQGPSG ARGPPGLKGD
210 220 230 240 250
RGTPGERGAK GESGLAEVNA LRQRVGILEG QLQRLQNAFS QYKKAMLFPN
260 270 280 290 300
GRSVGEKIFK TEGSEKTFQD AQQICTQAGG QLPSPRSAAE NEALTQLATA
310 320 330 340 350
QNKAAFLSMS DTRKEGTFIY PTGEPLVYSN WAPQEPNNDG GSENCVEIFP
360
NGKWNDKVCG EQRLVICEF
Length:369
Mass (Da):37,405
Last modified:June 27, 2006 - v2
Checksum:i4A74B7593508AE5D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti262E → V in CAA53510 (PubMed:8436402).Curated1
Sequence conflicti288A → G in CAA53510 (PubMed:8436402).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75911 mRNA Translation: CAA53510.1
AJ548848, AJ548849, AJ548850 Genomic DNA Translation: CAD69922.1
PIRiS33603
RefSeqiNP_851369.1, NM_181026.2
UniGeneiBt.33887

Genome annotation databases

EnsembliENSBTAT00000008579; ENSBTAP00000008579; ENSBTAG00000046421
GeneIDi282072
KEGGibta:282072

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75911 mRNA Translation: CAA53510.1
AJ548848, AJ548849, AJ548850 Genomic DNA Translation: CAD69922.1
PIRiS33603
RefSeqiNP_851369.1, NM_181026.2
UniGeneiBt.33887

3D structure databases

ProteinModelPortaliP35246
SMRiP35246
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi159354, 2 interactors
STRINGi9913.ENSBTAP00000008579

Proteomic databases

PaxDbiP35246
PRIDEiP35246

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000008579; ENSBTAP00000008579; ENSBTAG00000046421
GeneIDi282072
KEGGibta:282072

Organism-specific databases

CTDi6441

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104102
HOGENOMiHOG000085660
HOVERGENiHBG108270
InParanoidiP35246
KOiK10068
OMAiQNKAAFL
OrthoDBiEOG091G0MYV
TreeFamiTF330481

Enzyme and pathway databases

ReactomeiR-BTA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-BTA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-BTA-391160 Signal regulatory protein family interactions
R-BTA-5683826 Surfactant metabolism
R-BTA-5686938 Regulation of TLR by endogenous ligand

Gene expression databases

BgeeiENSBTAG00000046421 Expressed in 3 organ(s), highest expression level in lung

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR008160 Collagen
IPR016187 CTDL_fold
IPR015097 Surfac_D-trimer
PfamiView protein in Pfam
PF01391 Collagen, 2 hits
PF00059 Lectin_C, 1 hit
PF09006 Surfac_D-trimer, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSFTPD_BOVIN
AccessioniPrimary (citable) accession number: P35246
Secondary accession number(s): Q863A1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 27, 2006
Last modified: November 7, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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