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UniProtKB - P35244 (RFA3_HUMAN)

Entry version 195 (25 May 2022)
Sequence version 1 (01 Feb 1994)
Previous versions | rss
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Protein

Replication protein A 14 kDa subunit

Gene

RPA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682).

In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808).

It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716).

Plays also a role in base excision repair (BER), probably through interaction with UNG (PubMed:9765279).

Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA3 has its own single-stranded DNA-binding activity and may be responsible for polarity of the binding of the complex to DNA (PubMed:19010961).

As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105).

1 Publication6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA recombination, DNA repair, DNA replication

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P35244

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-110312, Translesion synthesis by REV1
R-HSA-110314, Recognition of DNA damage by PCNA-containing replication complex
R-HSA-110320, Translesion Synthesis by POLH
R-HSA-174437, Removal of the Flap Intermediate from the C-strand
R-HSA-176187, Activation of ATR in response to replication stress
R-HSA-3371453, Regulation of HSF1-mediated heat shock response
R-HSA-3371511, HSF1 activation
R-HSA-5358565, Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-HSA-5358606, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
R-HSA-5651801, PCNA-Dependent Long Patch Base Excision Repair
R-HSA-5655862, Translesion synthesis by POLK
R-HSA-5656121, Translesion synthesis by POLI
R-HSA-5656169, Termination of translesion DNA synthesis
R-HSA-5685938, HDR through Single Strand Annealing (SSA)
R-HSA-5685942, HDR through Homologous Recombination (HRR)
R-HSA-5693607, Processing of DNA double-strand break ends
R-HSA-5693616, Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-5696395, Formation of Incision Complex in GG-NER
R-HSA-5696397, Gap-filling DNA repair synthesis and ligation in GG-NER
R-HSA-5696400, Dual Incision in GG-NER
R-HSA-6782135, Dual incision in TC-NER
R-HSA-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-6783310, Fanconi Anemia Pathway
R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation
R-HSA-68962, Activation of the pre-replicative complex
R-HSA-69166, Removal of the Flap Intermediate
R-HSA-69473, G2/M DNA damage checkpoint
R-HSA-912446, Meiotic recombination

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P35244

SIGNOR Signaling Network Open Resource

More...SIGNORi		P35244

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Replication protein A 14 kDa subunit
Short name:
RP-A p14
Alternative name(s):
Replication factor A protein 3
Short name:
RF-A protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPA3
Synonyms:REPA3, RPA14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10291, RPA3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		179837, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P35244

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000106399

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6119

Open Targets

More...OpenTargetsi		ENSG00000106399

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34653

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P35244, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RPA3

Domain mapping of disease mutations (DMDM)

More...DMDMi		464608

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000972762 – 121Replication protein A 14 kDa subunitAdd BLAST120

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylvalineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki23Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki39Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by RFWD3 at stalled replication forks in response to DNA damage: ubiquitination by RFWD3 does not lead to degradation by the proteasome and promotes removal of the RPA complex from stalled replication forks, promoting homologous recombination (PubMed:26474068).1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P35244

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P35244

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P35244

MaxQB - The MaxQuant DataBase

More...MaxQBi		P35244

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P35244

PeptideAtlas

More...PeptideAtlasi		P35244

PRoteomics IDEntifications database

More...PRIDEi		P35244

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55011

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P35244

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P35244

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P35244

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P35244

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000106399, Expressed in bronchial epithelial cell and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P35244, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P35244, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000106399, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the canonical replication protein A complex (RPA), a heterotrimer composed of RPA1, RPA2 and RPA3. Also component of the aRPA, the alternative replication protein A complex, a trimeric complex similar to the replication protein A complex/RPA but where RPA1 and RPA3 are associated with RPA4 instead of RPA2.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112039, 465 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1878, Replication protein A complex, RPA2 variant
CPX-1879, Replication protein A complex, RPA4 variant

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P35244

Database of interacting proteins

More...DIPi		DIP-24190N

Protein interaction database and analysis system

More...IntActi		P35244, 72 interactors

Molecular INTeraction database

More...MINTi		P35244

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000223129

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P35244, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1121
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P35244

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P35244

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P35244

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the replication factor A protein 3 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S203, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000008029

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P35244

Identification of Orthologs from Complete Genome Data

More...OMAi		INRPVCF

Database of Orthologous Groups

More...OrthoDBi		1594928at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P35244

TreeFam database of animal gene trees

More...TreeFami		TF105243

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.50.140, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00040

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012340, NA-bd_OB-fold
IPR013970, Rfa2

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08661, Rep_fac-A_3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50249, SSF50249, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P35244-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDMMDLPRS RINAGMLAQF IDKPVCFVGR LEKIHPTGKM FILSDGEGKN 
        60         70         80         90        100
GTIELMEPLD EEISGIVEVV GRVTAKATIL CTSYVQFKED SHPFDLGLYN 
       110        120 
EAVKIIHDFP QFYPLGIVQH D
Length:121
Mass (Da):13,569
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3FD99851959FB498
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MC59B5MC59_HUMAN
Replication protein A 14 kDa subuni...
RPA3 hCG_17407
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L07493 mRNA Translation: AAA58350.1
BT007320 mRNA Translation: AAP35984.1
DQ003136 Genomic DNA Translation: AAX84517.1
AC004948 Genomic DNA Translation: AAQ96878.1
BC005264 mRNA Translation: AAH05264.1
BC009868 mRNA Translation: AAH09868.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5356.1

Protein sequence database of the Protein Information Resource

More...PIRi		A46008

NCBI Reference Sequences

More...RefSeqi		NP_002938.1, NM_002947.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000223129.8; ENSP00000223129.4; ENSG00000106399.11
ENST00000396682.6; ENSP00000379914.2; ENSG00000106399.11

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6119

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6119

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000223129.8; ENSP00000223129.4; NM_002947.5; NP_002938.1

UCSC genome browser

More...UCSCi		uc003sri.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07493 mRNA Translation: AAA58350.1
BT007320 mRNA Translation: AAP35984.1
DQ003136 Genomic DNA Translation: AAX84517.1
AC004948 Genomic DNA Translation: AAQ96878.1
BC005264 mRNA Translation: AAH05264.1
BC009868 mRNA Translation: AAH09868.1
CCDSiCCDS5356.1
PIRiA46008
RefSeqiNP_002938.1, NM_002947.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1L1OX-ray2.80A/D1-121[»]
1QUQX-ray2.50B/D1-121[»]
2PI2X-ray2.00E/F/G/H1-121[»]
2PQAX-ray2.50B/D1-121[»]
2Z6KX-ray3.00C/D1-121[»]
3KDFX-ray1.98A/C1-121[»]
AlphaFoldDBiP35244
SMRiP35244
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112039, 465 interactors
ComplexPortaliCPX-1878, Replication protein A complex, RPA2 variant
CPX-1879, Replication protein A complex, RPA4 variant
CORUMiP35244
DIPiDIP-24190N
IntActiP35244, 72 interactors
MINTiP35244
STRINGi9606.ENSP00000223129

PTM databases

iPTMnetiP35244
MetOSiteiP35244
PhosphoSitePlusiP35244

Genetic variation databases

BioMutaiRPA3
DMDMi464608

Proteomic databases

EPDiP35244
jPOSTiP35244
MassIVEiP35244
MaxQBiP35244
PaxDbiP35244
PeptideAtlasiP35244
PRIDEiP35244
ProteomicsDBi55011
TopDownProteomicsiP35244

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1308, 301 antibodies from 30 providers

The DNASU plasmid repository

More...DNASUi		6119

Genome annotation databases

EnsembliENST00000223129.8; ENSP00000223129.4; ENSG00000106399.11
ENST00000396682.6; ENSP00000379914.2; ENSG00000106399.11
GeneIDi6119
KEGGihsa:6119
MANE-SelectiENST00000223129.8; ENSP00000223129.4; NM_002947.5; NP_002938.1
UCSCiuc003sri.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6119
DisGeNETi6119

GeneCards: human genes, protein and diseases

More...GeneCardsi		RPA3
HGNCiHGNC:10291, RPA3
HPAiENSG00000106399, Low tissue specificity
MIMi179837, gene
neXtProtiNX_P35244
OpenTargetsiENSG00000106399
PharmGKBiPA34653
VEuPathDBiHostDB:ENSG00000106399

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S203, Eukaryota
GeneTreeiENSGT00390000008029
InParanoidiP35244
OMAiINRPVCF
OrthoDBi1594928at2759
PhylomeDBiP35244
TreeFamiTF105243

Enzyme and pathway databases

PathwayCommonsiP35244
ReactomeiR-HSA-110312, Translesion synthesis by REV1
R-HSA-110314, Recognition of DNA damage by PCNA-containing replication complex
R-HSA-110320, Translesion Synthesis by POLH
R-HSA-174437, Removal of the Flap Intermediate from the C-strand
R-HSA-176187, Activation of ATR in response to replication stress
R-HSA-3371453, Regulation of HSF1-mediated heat shock response
R-HSA-3371511, HSF1 activation
R-HSA-5358565, Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-HSA-5358606, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
R-HSA-5651801, PCNA-Dependent Long Patch Base Excision Repair
R-HSA-5655862, Translesion synthesis by POLK
R-HSA-5656121, Translesion synthesis by POLI
R-HSA-5656169, Termination of translesion DNA synthesis
R-HSA-5685938, HDR through Single Strand Annealing (SSA)
R-HSA-5685942, HDR through Homologous Recombination (HRR)
R-HSA-5693607, Processing of DNA double-strand break ends
R-HSA-5693616, Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-5696395, Formation of Incision Complex in GG-NER
R-HSA-5696397, Gap-filling DNA repair synthesis and ligation in GG-NER
R-HSA-5696400, Dual Incision in GG-NER
R-HSA-6782135, Dual incision in TC-NER
R-HSA-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-6783310, Fanconi Anemia Pathway
R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation
R-HSA-68962, Activation of the pre-replicative complex
R-HSA-69166, Removal of the Flap Intermediate
R-HSA-69473, G2/M DNA damage checkpoint
R-HSA-912446, Meiotic recombination
SignaLinkiP35244
SIGNORiP35244

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6119, 807 hits in 1034 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RPA3, human
EvolutionaryTraceiP35244

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RPA3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6119
PharosiP35244, Tbio

Protein Ontology

More...PROi		PR:P35244
RNActiP35244, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000106399, Expressed in bronchial epithelial cell and 237 other tissues
ExpressionAtlasiP35244, baseline and differential
GenevisibleiP35244, HS

Family and domain databases

Gene3Di2.40.50.140, 1 hit
IDEALiIID00040
InterProiView protein in InterPro
IPR012340, NA-bd_OB-fold
IPR013970, Rfa2
PfamiView protein in Pfam
PF08661, Rep_fac-A_3, 1 hit
SUPFAMiSSF50249, SSF50249, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRFA3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35244
Secondary accession number(s): Q549U6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 25, 2022
This is version 195 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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