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Protein

Recoverin

Gene

RCVRN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse.

Miscellaneous

Binds two calcium ions; one with high affinity, the other with low affinity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi74 – 851; low affinityPROSITE-ProRule annotationAdd BLAST12
Calcium bindingi110 – 1212; high affinityPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: ProtInc
  • calcium sensitive guanylate cyclase activator activity Source: ProtInc

GO - Biological processi

  • phototransduction Source: Ensembl
  • regulation of calcium ion transport Source: Ensembl
  • signal transduction Source: ProtInc
  • visual perception Source: ProtInc

Keywordsi

Biological processSensory transduction, Vision
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
SignaLinkiP35243

Names & Taxonomyi

Protein namesi
Recommended name:
Recoverin
Alternative name(s):
Cancer-associated retinopathy protein
Short name:
Protein CAR
Gene namesi
Name:RCVRN
Synonyms:RCV1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000109047.7
HGNCiHGNC:9937 RCVRN
MIMi179618 gene
neXtProtiNX_P35243

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi5957
OpenTargetsiENSG00000109047
PharmGKBiPA162400987

Chemistry databases

DrugBankiDB08231 MYRISTIC ACID

Polymorphism and mutation databases

BioMutaiRCVRN
DMDMi464600

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000737592 – 200RecoverinAdd BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP35243
PeptideAtlasiP35243
PRIDEiP35243
ProteomicsDBi55010

PTM databases

iPTMnetiP35243
PhosphoSitePlusiP35243

Expressioni

Tissue specificityi

Retina and pineal gland.

Gene expression databases

BgeeiENSG00000109047
CleanExiHS_RCVRN
GenevisibleiP35243 HS

Organism-specific databases

HPAiCAB022363
HPA015783

Interactioni

Protein-protein interaction databases

BioGridi111890, 14 interactors
IntActiP35243, 5 interactors
STRINGi9606.ENSP00000226193

Structurei

Secondary structure

1200
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 20Combined sources10
Helixi25 – 38Combined sources14
Beta strandi42 – 45Combined sources4
Helixi46 – 55Combined sources10
Helixi63 – 73Combined sources11
Beta strandi79 – 82Combined sources4
Helixi83 – 93Combined sources11
Beta strandi96 – 99Combined sources4
Helixi102 – 109Combined sources8
Beta strandi114 – 117Combined sources4
Helixi119 – 132Combined sources14
Helixi135 – 139Combined sources5
Turni143 – 145Combined sources3
Helixi148 – 158Combined sources11
Helixi169 – 178Combined sources10
Helixi180 – 186Combined sources7

3D structure databases

ProteinModelPortaliP35243
SMRiP35243
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35243

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 60EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini61 – 96EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini97 – 132EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini147 – 182EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the recoverin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0044 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118820
HOGENOMiHOG000233019
HOVERGENiHBG108179
InParanoidiP35243
KOiK13764
OMAiKECPSGR
OrthoDBiEOG091G11T4
PhylomeDBiP35243
TreeFamiTF300009

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35243-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNSKSGALS KEILEELQLN TKFSEEELCS WYQSFLKDCP TGRITQQQFQ
60 70 80 90 100
SIYAKFFPDT DPKAYAQHVF RSFDSNLDGT LDFKEYVIAL HMTTAGKTNQ
110 120 130 140 150
KLEWAFSLYD VDGNGTISKN EVLEIVMAIF KMITPEDVKL LPDDENTPEK
160 170 180 190 200
RAEKIWKYFG KNDDDKLTEK EFIEGTLANK EILRLIQFEP QKVKEKMKNA
Length:200
Mass (Da):23,130
Last modified:January 23, 2007 - v2
Checksum:i7B1FA91EF19E6122
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S43855 mRNA Translation: AAB23163.1
S45545 mRNA Translation: AAB23392.1
S62028 mRNA Translation: AAB26894.1
AB001838 mRNA Translation: BAA19460.1
BT009838 mRNA Translation: AAP88840.1
AK314129 mRNA Translation: BAG36819.1
AB593156 mRNA Translation: BAJ84088.1
CH471108 Genomic DNA Translation: EAW90014.1
BC001720 mRNA Translation: AAH01720.1
CCDSiCCDS11151.1
PIRiJC1227
RefSeqiNP_002894.1, NM_002903.2
UniGeneiHs.80539

Genome annotation databases

EnsembliENST00000226193; ENSP00000226193; ENSG00000109047
GeneIDi5957
KEGGihsa:5957
UCSCiuc002gme.2 human

Similar proteinsi

Entry informationi

Entry nameiRECO_HUMAN
AccessioniPrimary (citable) accession number: P35243
Secondary accession number(s): Q53XL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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