PHB

Functionⁱ

Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.1 Publication

GO - Molecular functionⁱ

complement component C3a binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17070910
complement component C3b binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17070910
DNA-binding transcription factor activity, RNA polymerase II-specific Source: Ensembl
enzyme binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 23921388
histone deacetylase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 16964284
proteinase activated receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 24732013
protein C-terminus binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19906925
transcription regulatory region DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 18487222

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

animal organ regeneration Source: Ensembl
cellular response to interleukin-6
Source: BHF-UCL
Inferred from direct assayⁱ
- 17324931
DNA biosynthetic process Source: UniProtKB-KW
histone deacetylation
Source: UniProtKB
Inferred from direct assayⁱ
- 12466959
mitochondrial calcium ion transmembrane transport Source: Reactome
mitochondrion organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17008324
negative regulation of androgen receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 16964284
negative regulation of apoptotic process Source: Ensembl
negative regulation of cell growth
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12065415
negative regulation of cell proliferation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18487222
negative regulation of ERK1 and ERK2 cascade
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24732013
negative regulation of glucocorticoid receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 16964284
negative regulation of protein catabolic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24732013
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 12566959
negative regulation of transcription by competitive promoter binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 18487222
negative regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 16964284
osteoblast differentiation
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 16210410
ovarian follicle atresia Source: Ensembl
ovarian follicle development Source: Ensembl
positive regulation of cell death
Source: ParkinsonsUK-UCL
Inferred from genetic interactionⁱ
- 26310625
positive regulation of complement activation
Source: UniProtKB
Inferred from direct assayⁱ
- 17070910
positive regulation of ERK1 and ERK2 cascade
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22417827
positive regulation of gene expression
Source: ParkinsonsUK-UCL
Inferred from genetic interactionⁱ
- 26310625
positive regulation of G protein-coupled receptor signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24732013
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 14500729
progesterone receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 16964284
protein stabilization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17008324
regulation of apoptotic process
Source: UniProtKB
Traceable author statementⁱ
- 16130169
regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 14500729
response to ethanol Source: Ensembl
response to immobilization stress Source: Ensembl
response to peptide hormone Source: Ensembl
signal transduction
Source: UniProtKB
Traceable author statementⁱ
- 16130169

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	DNA synthesis

Biological process

DNA synthesis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5673000 RAF activation R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants R-HSA-6802949 Signaling by RAS mutants R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-8949664 Processing of SMDT1

Reactomeⁱ

R-HSA-5673000 RAF activation
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-8949664 Processing of SMDT1

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Prohibitin
Gene namesⁱ	Name:PHB
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000167085.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8912 PHB
MIMⁱ	176705 gene
neXtProtⁱ	NX_P35232

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5245
MalaCards human disease database More...MalaCardsⁱ	PHB
Open Targets More...OpenTargetsⁱ	ENSG00000167085
PharmGKBⁱ	PA33251

Polymorphism and mutation databases

DMDMⁱ	464371

DMDMⁱ

464371

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000213878	2 – 272	ProhibitinAdd BLAST		271

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	91	PhosphothreonineCombined sources	1
Modified residueⁱ	128	N6-acetyllysineBy similarity	1
Modified residueⁱ	186	N6-acetyllysineBy similarity	1
Modified residueⁱ	202	N6-acetyllysine; alternateCombined sources	1
Modified residueⁱ	202	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	249	PhosphotyrosineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P35232
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P35232
PaxDbⁱ	P35232
PeptideAtlas More...PeptideAtlasⁱ	P35232
PRIDEⁱ	P35232
ProteomicsDBⁱ	54995
TopDownProteomicsⁱ	P35232-1 [P35232-1]

2D gel databases

DOSAC-COBS 2D-PAGE database More...DOSAC-COBS-2DPAGEⁱ	P35232
USC-OGP 2-DE database More...OGPⁱ	P35232
REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00017334 P35232
SWISS-2DPAGEⁱ	P35232
UCD-2DPAGEⁱ	P35232

PTM databases

iPTMnetⁱ	P35232
PhosphoSitePlusⁱ	P35232
SwissPalmⁱ	P35232

Expressionⁱ

Tissue specificityⁱ

Widely expressed in different tissues.

Developmental stageⁱ

Levels of expression in fibroblasts decrease heterogeneously during cellular aging.1 Publication

Inductionⁱ

Expression increases approximately 3-fold upon entry into G1 phase compared with other phases of the cell cycle. Also induced following inhibition of mitochondrial protein synthesis by thiamphenicol.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000167085 Expressed in 231 organ(s), highest expression level in mucosa of transverse colon
CleanExⁱ	HS_PHB
ExpressionAtlasⁱ	P35232 baseline and differential
Genevisibleⁱ	P35232 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA003280

HPAⁱ

HPA003280

Interactionⁱ

Subunit structureⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
LONRF3	Q496Y0	2	EBI-354213,EBI-2690768
SKP2	Q13309-2	2	EBI-354213,EBI-7791408
TP53	P04637	6	EBI-354213,EBI-366083
XPO1	O14980	2	EBI-354213,EBI-355867

GO - Molecular functionⁱ

complement component C3a binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17070910
complement component C3b binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17070910
enzyme binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 23921388
histone deacetylase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 16964284
proteinase activated receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 24732013
protein C-terminus binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19906925

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111264, 158 interactors
CORUMⁱ	P35232
Database of interacting proteins More...DIPⁱ	DIP-24248N
IntActⁱ	P35232, 105 interactors
Molecular INTeraction database More...MINTⁱ	P35232
STRINGⁱ	9606.ENSP00000300408

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P35232
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	177 – 211	Sequence analysisAdd BLAST		35

Sequence similaritiesⁱ

Belongs to the prohibitin family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG3083 Eukaryota COG0330 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074770
HOGENOMⁱ	HOG000205692
HOVERGENⁱ	HBG004457
InParanoidⁱ	P35232
KEGG Orthology (KO) More...KOⁱ	K17080
OMAⁱ	RTRIRDN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IHW
PhylomeDBⁱ	P35232
TreeFamⁱ	TF300095

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03401 SPFH_prohibitin, 1 hit
InterProⁱ	View protein in InterPro IPR001107 Band_7 IPR036013 Band_7/SPFH_dom_sf IPR000163 Prohibitin
PANTHERⁱ	PTHR23222 PTHR23222, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01145 Band_7, 1 hit
PRINTSⁱ	PR00679 PROHIBITIN
SMARTⁱ	View protein in SMART SM00244 PHB, 1 hit
SUPFAMⁱ	SSF117892 SSF117892, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P35232-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAKVFESIG KFGLALAVAG GVVNSALYNV DAGHRAVIFD RFRGVQDIVV 
        60         70         80         90        100
GEGTHFLIPW VQKPIIFDCR SRPRNVPVIT GSKDLQNVNI TLRILFRPVA 
       110        120        130        140        150
SQLPRIFTSI GEDYDERVLP SITTEILKSV VARFDAGELI TQRELVSRQV 
       160        170        180        190        200
SDDLTERAAT FGLILDDVSL THLTFGKEFT EAVEAKQVAQ QEAERARFVV 
       210        220        230        240        250
EKAEQQKKAA IISAEGDSKA AELIANSLAT AGDGLIELRK LEAAEDIAYQ 
       260        270 
LSRSRNITYL PAGQSVLLQL PQ

Length:272

Mass (Da):29,804

Last modified:February 1, 1994 - v1

Checksum:ⁱ915494273E342C76

GO

Isoform 2 (identifier: P35232-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
140-256: Missing.

« Hide

        10         20         30         40         50
MAAKVFESIG KFGLALAVAG GVVNSALYNV DAGHRAVIFD RFRGVQDIVV 
        60         70         80         90        100
GEGTHFLIPW VQKPIIFDCR SRPRNVPVIT GSKDLQNVNI TLRILFRPVA 
       110        120        130        140        150
SQLPRIFTSI GEDYDERVLP SITTEILKSV VARFDAGELI TYLPAGQSVL 

LQLPQ

Note: No experimental confirmation available.

Show »

Length:155

Mass (Da):17,018

Checksum:ⁱFDFDE03209523798

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JW96	C9JW96_HUMAN	Prohibitin Prohibitin	PHB	246	Annotation score:
E9PCW0	E9PCW0_HUMAN	Prohibitin Prohibitin	PHB	216	Annotation score:
C9JZ20	C9JZ20_HUMAN	Prohibitin Prohibitin	PHB	201	Annotation score:
E7ESE2	E7ESE2_HUMAN	Prohibitin Prohibitin	PHB	202	Annotation score:
D6RBK0	D6RBK0_HUMAN	Prohibitin Prohibitin	PHB	124	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_006479	88	V → A in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121918373Ensembl.		1
Natural variantⁱVAR_006480	105	R → H in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121918372Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054922	140 – 256	Missing in isoform 2. 1 PublicationAdd BLAST		117

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S85655 mRNA Translation: AAB21614.1 L14272 Genomic DNA Translation: AAO18340.1 BT007411 mRNA Translation: AAP36079.1 AK302258 mRNA Translation: BAG63609.1 AC091180 Genomic DNA No translation available. BC013401 mRNA Translation: AAH13401.1 BC095460 mRNA Translation: AAH95460.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11548.1 [P35232-1] CCDS62244.1 [P35232-2]
PIRⁱ	I52690
NCBI Reference Sequences More...RefSeqⁱ	NP_001268425.1, NM_001281496.1 [P35232-1] NP_001268426.1, NM_001281497.1 [P35232-2] NP_001268644.1, NM_001281715.1 [P35232-1] NP_002625.1, NM_002634.3 [P35232-1] XP_016880252.1, XM_017024763.1 [P35232-1]
UniGeneⁱ	Hs.514303

Genome annotation databases

Ensemblⁱ	ENST00000300408; ENSP00000300408; ENSG00000167085 [P35232-1] ENST00000511832; ENSP00000425035; ENSG00000167085 [P35232-2] ENST00000614445; ENSP00000479488; ENSG00000167085 [P35232-1] ENST00000617874; ENSP00000484113; ENSG00000167085 [P35232-1]
GeneIDⁱ	5245
KEGGⁱ	hsa:5245
UCSC genome browser More...UCSCⁱ	uc002iox.3 human [P35232-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P35232	Prohibitin		BOVIN		272	UniRef100_P35232
Prohibitin		MYOBR		367
Uncharacterized protein		CHLSB		271
Prohibitin (Fragment)		MUSPF		270
Prohibitin (Fragment)		RHEPE		26
+53
P35232-2	PHB isoform 3		PANTR		155	UniRef100_A0A2I3TIG9
Uncharacterized protein		PROCO		155
Uncharacterized protein		MACMU		155
Prohibitin		CALJA		155
Uncharacterized protein		COLAP		155
+12

Protein	Similar proteins		Species	Score	Length	Source
P35232	Prohibitin		BOVIN		272	UniRef90_P35232
Prohibitin		MYOBR		367
Uncharacterized protein		CHLSB		271
Prohibitin (Fragment)		MUSPF		270
Prohibitin (Fragment)		RHEPE		26
+58
P35232-2	Uncharacterized protein		RHIRO		155	UniRef90_A0A2K6QMI1
PHB isoform 3		PANTR		155
Uncharacterized protein		PROCO		155
Uncharacterized protein		MACMU		155
Prohibitin		CALJA		155
+44

Protein	Similar proteins		Species	Score	Length	Source
P35232	Prohibitin		BOVIN		272	UniRef50_P35232
Prohibitin		MOUSE		272
Prohibitin		RAT		272
Prohibitin		CHICK		272
Prohibitin		MYOBR		367
+218
P35232-2	Uncharacterized protein		RHIRO		155	UniRef50_A0A2K6QMI1
Uncharacterized protein		SAIBB		155
PHB isoform 3		PANTR		155
Uncharacterized protein		PROCO		155
Uncharacterized protein		MACMU		155
+94

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S85655 mRNA Translation: AAB21614.1 L14272 Genomic DNA Translation: AAO18340.1 BT007411 mRNA Translation: AAP36079.1 AK302258 mRNA Translation: BAG63609.1 AC091180 Genomic DNA No translation available. BC013401 mRNA Translation: AAH13401.1 BC095460 mRNA Translation: AAH95460.1
CCDSⁱ	CCDS11548.1 [P35232-1] CCDS62244.1 [P35232-2]
PIRⁱ	I52690
RefSeqⁱ	NP_001268425.1, NM_001281496.1 [P35232-1] NP_001268426.1, NM_001281497.1 [P35232-2] NP_001268644.1, NM_001281715.1 [P35232-1] NP_002625.1, NM_002634.3 [P35232-1] XP_016880252.1, XM_017024763.1 [P35232-1]
UniGeneⁱ	Hs.514303

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1LU7	model	-	A	1-272	[»]
ProteinModelPortalⁱ	P35232
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111264, 158 interactors
CORUMⁱ	P35232
DIPⁱ	DIP-24248N
IntActⁱ	P35232, 105 interactors
MINTⁱ	P35232
STRINGⁱ	9606.ENSP00000300408

PTM databases

iPTMnetⁱ	P35232
PhosphoSitePlusⁱ	P35232
SwissPalmⁱ	P35232

Polymorphism and mutation databases

DMDMⁱ	464371

DMDMⁱ

464371

2D gel databases

DOSAC-COBS-2DPAGEⁱ	P35232
OGPⁱ	P35232
REPRODUCTION-2DPAGEⁱ	IPI00017334 P35232
SWISS-2DPAGEⁱ	P35232
UCD-2DPAGEⁱ	P35232

Proteomic databases

EPDⁱ	P35232
MaxQBⁱ	P35232
PaxDbⁱ	P35232
PeptideAtlasⁱ	P35232
PRIDEⁱ	P35232
ProteomicsDBⁱ	54995
TopDownProteomicsⁱ	P35232-1 [P35232-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5245
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000300408; ENSP00000300408; ENSG00000167085 [P35232-1] ENST00000511832; ENSP00000425035; ENSG00000167085 [P35232-2] ENST00000614445; ENSP00000479488; ENSG00000167085 [P35232-1] ENST00000617874; ENSP00000484113; ENSG00000167085 [P35232-1]
GeneIDⁱ	5245
KEGGⁱ	hsa:5245
UCSCⁱ	uc002iox.3 human [P35232-1]

Organism-specific databases

CTDⁱ	5245
DisGeNETⁱ	5245
EuPathDBⁱ	HostDB:ENSG00000167085.11
GeneCardsⁱ	PHB
HGNCⁱ	HGNC:8912 PHB
HPAⁱ	HPA003280
MalaCardsⁱ	PHB
MIMⁱ	176705 gene
neXtProtⁱ	NX_P35232
OpenTargetsⁱ	ENSG00000167085
PharmGKBⁱ	PA33251
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3083 Eukaryota COG0330 LUCA
GeneTreeⁱ	ENSGT00550000074770
HOGENOMⁱ	HOG000205692
HOVERGENⁱ	HBG004457
InParanoidⁱ	P35232
KOⁱ	K17080
OMAⁱ	RTRIRDN
OrthoDBⁱ	EOG091G0IHW
PhylomeDBⁱ	P35232
TreeFamⁱ	TF300095

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5673000 RAF activation R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants R-HSA-6802949 Signaling by RAS mutants R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-8949664 Processing of SMDT1

Reactomeⁱ

R-HSA-5673000 RAF activation
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-8949664 Processing of SMDT1

Miscellaneous databases

GeneWikiⁱ	Prohibitin
GenomeRNAiⁱ	5245
Protein Ontology More...PROⁱ	PR:P35232
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000167085 Expressed in 231 organ(s), highest expression level in mucosa of transverse colon
CleanExⁱ	HS_PHB
ExpressionAtlasⁱ	P35232 baseline and differential
Genevisibleⁱ	P35232 HS

Family and domain databases

CDDⁱ	cd03401 SPFH_prohibitin, 1 hit
InterProⁱ	View protein in InterPro IPR001107 Band_7 IPR036013 Band_7/SPFH_dom_sf IPR000163 Prohibitin
PANTHERⁱ	PTHR23222 PTHR23222, 1 hit
Pfamⁱ	View protein in Pfam PF01145 Band_7, 1 hit
PRINTSⁱ	PR00679 PROHIBITIN
SMARTⁱ	View protein in SMART SM00244 PHB, 1 hit
SUPFAMⁱ	SSF117892 SSF117892, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PHB_HUMAN
Accessionⁱ	P35232Primary (citable) accession number: P35232 Secondary accession number(s): B4DY47, Q4VBQ0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
	Last sequence update:	February 1, 1994
	Last modified:	November 7, 2018
	This is version 184 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P35232 (PHB_HUMAN)

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Prohibitin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Endosome

Extracellular region or secreted

Mitochondrion

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ