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Protein

Regenerating islet-derived protein 3-beta

Gene

Reg3b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Bactericidal C-type lectin which acts against several intestinal Gram-positive and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial
Biological processAcute phase, Inflammatory response
LigandLectin

Enzyme and pathway databases

ReactomeiR-MMU-6803157 Antimicrobial peptides

Names & Taxonomyi

Protein namesi
Recommended name:
Regenerating islet-derived protein 3-beta
Short name:
REG-3-beta
Alternative name(s):
Pancreatitis-associated protein 1
Regenerating islet-derived protein III-beta
Short name:
Reg III-beta
Cleaved into the following 2 chains:
Gene namesi
Name:Reg3b
Synonyms:Pap, Pap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:97478 Reg3b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Overexpressed during the acute phase of pancreatitis.

Disruption phenotypei

Mice are more susceptible to salmonellosis, but not listeriosis.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_000001743227 – 175Regenerating islet-derived protein 3-beta 16.5 kDa formAdd BLAST149
PropeptideiPRO_000042274727 – 37By similarityAdd BLAST11
ChainiPRO_000042274838 – 175Regenerating islet-derived protein 3-beta 15 kDa formAdd BLAST138

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 51PROSITE-ProRule annotation
Disulfide bondi68 ↔ 171PROSITE-ProRule annotation
Disulfide bondi146 ↔ 163PROSITE-ProRule annotation

Post-translational modificationi

Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP35230
PaxDbiP35230
PeptideAtlasiP35230
PRIDEiP35230

Expressioni

Tissue specificityi

Constitutively expressed in the small intestine, moderately in colon and at an extremely low level in healthy pancreas.

Inductioni

Up-regulated in the intestine by S.typhimurium infection (at protein level). Appears in pancreatic juice after induction of pancreatic inflammation.1 Publication

Gene expression databases

BgeeiENSMUSG00000071356 Expressed in 74 organ(s), highest expression level in ileum
CleanExiMM_REG3B
ExpressionAtlasiP35230 baseline and differential
GenevisibleiP35230 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094667

Structurei

3D structure databases

ProteinModelPortaliP35230
SMRiP35230
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 172C-type lectinPROSITE-ProRule annotationAdd BLAST126

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi114 – 116EPNBy similarity3

Domaini

The EPN motif is essential for recognition of the peptidoglycan carbohydrate backbone and for efficient bacterial killing with Glu-114 playing a key role in peptidoglycan binding and bactericidal activity.By similarity

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104249
HOGENOMiHOG000010281
HOVERGENiHBG004151
InParanoidiP35230
OMAiYANIWIG
OrthoDBiEOG091G0MDY
PhylomeDBiP35230

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P35230-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPPTACSVM SWMLLSCLML LSQVQGEDSL KNIPSARISC PKGSQAYGSY
60 70 80 90 100
CYALFQIPQT WFDAELACQK RPGGHLVSVL NSAEASFLSS MVKRTGNSYQ
110 120 130 140 150
YTWIGLHDPT LGAEPNGGGW EWSNNDVMNY FNWERNPSTA LDRAFCGSLS
160 170
RASGFLKWRD MTCEVKLPYV CKFTG
Length:175
Mass (Da):19,476
Last modified:February 1, 1994 - v1
Checksum:i44B3101171E79775
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SVX1A0A0N4SVX1_MOUSE
Regenerating islet-derived protein ...
Reg3b
140Annotation score:
A0A0N4SWI2A0A0N4SWI2_MOUSE
Regenerating islet-derived protein ...
Reg3b
143Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13509 mRNA Translation: BAA02727.1
D63359 mRNA Translation: BAA18928.1
D63360 Genomic DNA Translation: BAA18929.1
BC027525 mRNA Translation: AAH27525.1
CCDSiCCDS20253.1
PIRiS29822
RefSeqiNP_035166.1, NM_011036.1
UniGeneiMm.2553

Genome annotation databases

EnsembliENSMUST00000096904; ENSMUSP00000094667; ENSMUSG00000071356
GeneIDi18489
KEGGimmu:18489
UCSCiuc009cjw.1 mouse

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Pancreatitis-associated protein 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13509 mRNA Translation: BAA02727.1
D63359 mRNA Translation: BAA18928.1
D63360 Genomic DNA Translation: BAA18929.1
BC027525 mRNA Translation: AAH27525.1
CCDSiCCDS20253.1
PIRiS29822
RefSeqiNP_035166.1, NM_011036.1
UniGeneiMm.2553

3D structure databases

ProteinModelPortaliP35230
SMRiP35230
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094667

Proteomic databases

MaxQBiP35230
PaxDbiP35230
PeptideAtlasiP35230
PRIDEiP35230

Protocols and materials databases

DNASUi18489
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096904; ENSMUSP00000094667; ENSMUSG00000071356
GeneIDi18489
KEGGimmu:18489
UCSCiuc009cjw.1 mouse

Organism-specific databases

CTDi18489
MGIiMGI:97478 Reg3b

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104249
HOGENOMiHOG000010281
HOVERGENiHBG004151
InParanoidiP35230
OMAiYANIWIG
OrthoDBiEOG091G0MDY
PhylomeDBiP35230

Enzyme and pathway databases

ReactomeiR-MMU-6803157 Antimicrobial peptides

Miscellaneous databases

PROiPR:P35230
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000071356 Expressed in 74 organ(s), highest expression level in ileum
CleanExiMM_REG3B
ExpressionAtlasiP35230 baseline and differential
GenevisibleiP35230 MM

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiREG3B_MOUSE
AccessioniPrimary (citable) accession number: P35230
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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