Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nitric oxide synthase, inducible

Gene

NOS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109).By similarity4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Regulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and effects may be exerted at the level of translational/post-translational modification and directly on the catalytic activity (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi110Zinc1
Metal bindingi115Zinc1
Metal bindingi200Iron (heme axial ligand)1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi623 – 654FMNPROSITE-ProRule annotationAdd BLAST32
Nucleotide bindingi767 – 778FADBy similarityAdd BLAST12
Nucleotide bindingi903 – 913FADBy similarityAdd BLAST11
Nucleotide bindingi978 – 996NADPBy similarityAdd BLAST19
Nucleotide bindingi1076 – 1091NADPBy similarityAdd BLAST16

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • arginine binding Source: BHF-UCL
  • calmodulin binding Source: UniProtKB-KW
  • flavin adenine dinucleotide binding Source: BHF-UCL
  • FMN binding Source: BHF-UCL
  • heme binding Source: BHF-UCL
  • metal ion binding Source: UniProtKB-KW
  • NADP binding Source: BHF-UCL
  • NADPH-hemoprotein reductase activity Source: GO_Central
  • nitric-oxide synthase activity Source: UniProtKB
  • oxidoreductase activity Source: GO_Central
  • protein homodimerization activity Source: BHF-UCL
  • signaling receptor binding Source: UniProtKB
  • tetrahydrobiopterin binding Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Oxidoreductase
LigandCalcium, FAD, Flavoprotein, FMN, Heme, Iron, Metal-binding, NADP, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS00205-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.14.13.39 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-392154 Nitric oxide stimulates guanylate cyclase
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-9033241 Peroxisomal protein import

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P35228

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P35228

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nitric oxide synthase, inducible (EC:1.14.13.39)
Alternative name(s):
Hepatocyte NOS
Short name:
HEP-NOS
Inducible NO synthase
Short name:
Inducible NOS
Short name:
iNOS
NOS type II
Peptidyl-cysteine S-nitrosylase NOS2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOS2
Synonyms:NOS2A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000007171.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7873 NOS2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
163730 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P35228

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi27N → A: Loss of interaction with SPSB1 and SPSB4. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
4843

MalaCards human disease database

More...
MalaCardsi
NOS2
MIMi611162 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000007171

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164724093

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4481

Drug and drug target database

More...
DrugBanki
DB01997 3-Bromo-7-Nitroindazole
DB08214 4-(1H-IMIDAZOL-1-YL)PHENOL
DB07002 4-({4-[(4-methoxypyridin-2-yl)amino]piperidin-1-yl}carbonyl)benzonitrile
DB01835 4r-Fluoro-N6-Ethanimidoyl-L-Lysine
DB04534 5-Nitroindazole
DB03100 6-Nitroindazole
DB02207 7-Nitroindazole
DB05252 ACCLAIM
DB02533 Aminoguanidine
DB01234 Dexamethasone
DB00997 Doxorubicin
DB07306 ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE
DB07388 ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE
DB02234 Ethylisothiourea
DB05214 KD7040
DB00125 L-Arginine
DB00155 L-Citrulline
DB03953 L-Thiocitrulline
DB01110 Miconazole
DB02044 N-(3-(Aminomethyl)Benzyl)Acetamidine
DB03449 N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine
DB07389 N-[2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL]-4-CYANOBENZAMIDE
DB03144 N-Omega-Hydroxy-L-Arginine
DB02644 N-Omega-Propyl-L-Arginine
DB02539 S-Ethylisothiourea
DB02462 Thiocoumarin
DB08814 Triflusal

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1250

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NOS2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1352513

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001709301 – 1153Nitric oxide synthase, inducibleAdd BLAST1153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei234Phosphoserine; by PKASequence analysis1
Modified residuei575PhosphotyrosineBy similarity1
Modified residuei578Phosphoserine; by PKASequence analysis1
Modified residuei892Phosphoserine; by PKASequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Polyubiquitinated; mediated by SPSB1, SPSB2 and SPSB4, leading to proteasomal degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P35228

PeptideAtlas

More...
PeptideAtlasi
P35228

PRoteomics IDEntifications database

More...
PRIDEi
P35228

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54993
54994 [P35228-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P35228

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P35228

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P35228

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By endotoxins and cytokines. Induced by IFNG/IFN-gamma acting synergistically with bacterial lipopolysaccharides (LPS), TNF or IL1B/interleukin-1 beta (PubMed:7528267). Down-regulated by zinc due to inhibition of NF-kappa-B transactivation activity (PubMed:25180171). By oxidatively-modified low-densitity lipoprotein (LDL(ox)) (PubMed:25417112).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000007171 Expressed in 91 organ(s), highest expression level in cartilage tissue

CleanEx database of gene expression profiles

More...
CleanExi
HS_NOS2

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P35228 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002014

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:10409685, PubMed:10074942). Interacts with SLC9A3R1 (PubMed:12080081). Interacts with GAPDH; induced by oxidatively-modified low-densitity lipoprotein (LDL(ox)) (PubMed:25417112). Interacts with S100A8 and S100A9 to form the iNOS-S100A8/9 transnitrosylase complex (PubMed:25417112). Interacts with SPSB1, SPSB2 and SPSB4 (PubMed:21199876). Interacts with ELOC and CUL5 in the presence of SPSB1 or SPSB2 or SPSB4 (PubMed:21199876).5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
GAPDHP044068EBI-6662224,EBI-354056

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110906, 147 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-52 iNOS-S100A8/A9 complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P35228

Database of interacting proteins

More...
DIPi
DIP-59359N

Protein interaction database and analysis system

More...
IntActi
P35228, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000327251

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P35228

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11153
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P35228

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P35228

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P35228

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini539 – 677Flavodoxin-likePROSITE-ProRule annotationAdd BLAST139
Domaini730 – 970FAD-binding FR-typePROSITE-ProRule annotationAdd BLAST241

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni509 – 529Calmodulin-bindingSequence analysisAdd BLAST21

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi23 – 27DINNN-motif; mediates interaction with SPSB1, SPSB2 and SPSB41 Publication5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NOS family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1158 Eukaryota
COG0369 LUCA
COG4362 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159752

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000159

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P35228

KEGG Orthology (KO)

More...
KOi
K13241

Identification of Orthologs from Complete Genome Data

More...
OMAi
DGPAPHQ

Database of Orthologous Groups

More...
OrthoDBi
EOG091G10Z0

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P35228

TreeFam database of animal gene trees

More...
TreeFami
TF324410

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.990.10, 1 hit
3.40.50.360, 1 hit
3.40.50.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003097 CysJ-like_FAD-binding
IPR017927 FAD-bd_FR_type
IPR001094 Flavdoxin-like
IPR008254 Flavodoxin/NO_synth
IPR001709 Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR029039 Flavoprotein-like_sf
IPR039261 FNR_nucleotide-bd
IPR023173 NADPH_Cyt_P450_Rdtase_alpha
IPR012144 NOS_euk
IPR004030 NOS_N
IPR036119 NOS_N_sf
IPR001433 OxRdtase_FAD/NAD-bd
IPR017938 Riboflavin_synthase-like_b-brl

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00667 FAD_binding_1, 1 hit
PF00258 Flavodoxin_1, 1 hit
PF00175 NAD_binding_1, 1 hit
PF02898 NO_synthase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000333 NOS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00369 FLAVODOXIN
PR00371 FPNCR

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52218 SSF52218, 1 hit
SSF52343 SSF52343, 1 hit
SSF56512 SSF56512, 1 hit
SSF63380 SSF63380, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51384 FAD_FR, 1 hit
PS50902 FLAVODOXIN_LIKE, 1 hit
PS60001 NOS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P35228-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MACPWKFLFK TKFHQYAMNG EKDINNNVEK APCATSSPVT QDDLQYHNLS
60 70 80 90 100
KQQNESPQPL VETGKKSPES LVKLDATPLS SPRHVRIKNW GSGMTFQDTL
110 120 130 140 150
HHKAKGILTC RSKSCLGSIM TPKSLTRGPR DKPTPPDELL PQAIEFVNQY
160 170 180 190 200
YGSFKEAKIE EHLARVEAVT KEIETTGTYQ LTGDELIFAT KQAWRNAPRC
210 220 230 240 250
IGRIQWSNLQ VFDARSCSTA REMFEHICRH VRYSTNNGNI RSAITVFPQR
260 270 280 290 300
SDGKHDFRVW NAQLIRYAGY QMPDGSIRGD PANVEFTQLC IDLGWKPKYG
310 320 330 340 350
RFDVVPLVLQ ANGRDPELFE IPPDLVLEVA MEHPKYEWFR ELELKWYALP
360 370 380 390 400
AVANMLLEVG GLEFPGCPFN GWYMGTEIGV RDFCDVQRYN ILEEVGRRMG
410 420 430 440 450
LETHKLASLW KDQAVVEINI AVLHSFQKQN VTIMDHHSAA ESFMKYMQNE
460 470 480 490 500
YRSRGGCPAD WIWLVPPMSG SITPVFHQEM LNYVLSPFYY YQVEAWKTHV
510 520 530 540 550
WQDEKRRPKR REIPLKVLVK AVLFACMLMR KTMASRVRVT ILFATETGKS
560 570 580 590 600
EALAWDLGAL FSCAFNPKVV CMDKYRLSCL EEERLLLVVT STFGNGDCPG
610 620 630 640 650
NGEKLKKSLF MLKELNNKFR YAVFGLGSSM YPRFCAFAHD IDQKLSHLGA
660 670 680 690 700
SQLTPMGEGD ELSGQEDAFR SWAVQTFKAA CETFDVRGKQ HIQIPKLYTS
710 720 730 740 750
NVTWDPHHYR LVQDSQPLDL SKALSSMHAK NVFTMRLKSR QNLQSPTSSR
760 770 780 790 800
ATILVELSCE DGQGLNYLPG EHLGVCPGNQ PALVQGILER VVDGPTPHQT
810 820 830 840 850
VRLEALDESG SYWVSDKRLP PCSLSQALTY FLDITTPPTQ LLLQKLAQVA
860 870 880 890 900
TEEPERQRLE ALCQPSEYSK WKFTNSPTFL EVLEEFPSLR VSAGFLLSQL
910 920 930 940 950
PILKPRFYSI SSSRDHTPTE IHLTVAVVTY HTRDGQGPLH HGVCSTWLNS
960 970 980 990 1000
LKPQDPVPCF VRNASGFHLP EDPSHPCILI GPGTGIAPFR SFWQQRLHDS
1010 1020 1030 1040 1050
QHKGVRGGRM TLVFGCRRPD EDHIYQEEML EMAQKGVLHA VHTAYSRLPG
1060 1070 1080 1090 1100
KPKVYVQDIL RQQLASEVLR VLHKEPGHLY VCGDVRMARD VAHTLKQLVA
1110 1120 1130 1140 1150
AKLKLNEEQV EDYFFQLKSQ KRYHEDIFGA VFPYEAKKDR VAVQPSSLEM

SAL
Length:1,153
Mass (Da):131,117
Last modified:February 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i47671E5385CB3A52
GO
Isoform 2 (identifier: P35228-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     264-288: Missing.
     298-311: Missing.

Show »
Length:1,114
Mass (Da):126,749
Checksum:iC1F9624774435571
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YDS4A0A2R8YDS4_HUMAN
Nitric oxide synthase
NOS2
1,152Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti23D → G in AAA56666 (PubMed:7522054).Curated1
Sequence conflicti154F → L in AAA56666 (PubMed:7522054).Curated1
Sequence conflicti177G → V in AAA56666 (PubMed:7522054).Curated1
Sequence conflicti266R → H in AAC19133 (PubMed:9160867).Curated1
Sequence conflicti423L → I in AAA59171 (PubMed:7682706).Curated1
Sequence conflicti439A → T in AAC19133 (PubMed:9160867).Curated1
Sequence conflicti552A → G in AAI44127 (PubMed:15489334).Curated1
Sequence conflicti676T → I in AAB60366 (PubMed:7544004).Curated1
Sequence conflicti800T → A in AAA56666 (PubMed:7522054).Curated1
Sequence conflicti805A → D in AAA59171 (PubMed:7682706).Curated1
Sequence conflicti831 – 832FL → SP in AAA59171 (PubMed:7682706).Curated2
Sequence conflicti913S → P in AAA56666 (PubMed:7522054).Curated1
Sequence conflicti933R → G in AAA59171 (PubMed:7682706).Curated1
Sequence conflicti933R → G in AAB60366 (PubMed:7544004).Curated1
Sequence conflicti966G → A in AAA59171 (PubMed:7682706).Curated1
Sequence conflicti966G → A in AAB60366 (PubMed:7544004).Curated1
Sequence conflicti987A → V in AAA59171 (PubMed:7682706).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Note: Genetic variations in NOS2 are involved in resistance to malaria [MIMi:611162].1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024548221R → W1 PublicationCorresponds to variant dbSNP:rs3730017Ensembl.1
Natural variantiVAR_022127608S → L Polymorphism; found in patients with very early onset inflammatory bowel disease; increases NOS2 activity. 4 PublicationsCorresponds to variant dbSNP:rs2297518Ensembl.1
Natural variantiVAR_036302679A → S in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs769900089Ensembl.1
Natural variantiVAR_025020747T → A1 PublicationCorresponds to variant dbSNP:rs28944173Ensembl.1
Natural variantiVAR_0250211009R → C1 PublicationCorresponds to variant dbSNP:rs28944201Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003582264 – 288Missing in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_003583298 – 311Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L24553 mRNA Translation: AAA36375.1
L09210 mRNA Translation: AAA59171.1
X73029 mRNA Translation: CAA51512.1
U05810 mRNA Translation: AAA56666.1
U31511 mRNA Translation: AAB49041.1
D26525 mRNA Translation: BAA05531.1
U20141 mRNA Translation: AAB60366.1
AF068236 mRNA Translation: AAC19133.1
AB022318 mRNA Translation: BAA37123.1
DQ060518 Genomic DNA Translation: AAY43131.1
EU332854 Genomic DNA Translation: ABY87543.1
BC130283 mRNA Translation: AAI30284.1
BC144126 mRNA Translation: AAI44127.1
S75615 mRNA Translation: AAD14179.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11223.1 [P35228-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A49676

NCBI Reference Sequences

More...
RefSeqi
NP_000616.3, NM_000625.4 [P35228-1]
XP_011523161.1, XM_011524859.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.709191

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000313735; ENSP00000327251; ENSG00000007171 [P35228-1]
ENST00000621962; ENSP00000482291; ENSG00000007171 [P35228-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4843

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4843

UCSC genome browser

More...
UCSCi
uc002gzu.4 human [P35228-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
Wikipedia

Nitric oxide synthase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24553 mRNA Translation: AAA36375.1
L09210 mRNA Translation: AAA59171.1
X73029 mRNA Translation: CAA51512.1
U05810 mRNA Translation: AAA56666.1
U31511 mRNA Translation: AAB49041.1
D26525 mRNA Translation: BAA05531.1
U20141 mRNA Translation: AAB60366.1
AF068236 mRNA Translation: AAC19133.1
AB022318 mRNA Translation: BAA37123.1
DQ060518 Genomic DNA Translation: AAY43131.1
EU332854 Genomic DNA Translation: ABY87543.1
BC130283 mRNA Translation: AAI30284.1
BC144126 mRNA Translation: AAI44127.1
S75615 mRNA Translation: AAD14179.1
CCDSiCCDS11223.1 [P35228-1]
PIRiA49676
RefSeqiNP_000616.3, NM_000625.4 [P35228-1]
XP_011523161.1, XM_011524859.2
UniGeneiHs.709191

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NSIX-ray2.55A/B/C/D74-504[»]
2LL6NMR-B515-531[»]
2NSIX-ray3.00A/B/C/D74-504[»]
3E7GX-ray2.20A/B/C/D82-505[»]
3EJ8X-ray2.55A/B/C/D82-505[»]
3HR4X-ray2.50A/C/E/G503-715[»]
4CX7X-ray3.16A/B/C/D74-504[»]
4NOSX-ray2.25A/B/C/D82-508[»]
5TP6NMR-B507-531[»]
5XN3X-ray1.34B23-28[»]
ProteinModelPortaliP35228
SMRiP35228
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110906, 147 interactors
ComplexPortaliCPX-52 iNOS-S100A8/A9 complex
CORUMiP35228
DIPiDIP-59359N
IntActiP35228, 6 interactors
STRINGi9606.ENSP00000327251

Chemistry databases

BindingDBiP35228
ChEMBLiCHEMBL4481
DrugBankiDB01997 3-Bromo-7-Nitroindazole
DB08214 4-(1H-IMIDAZOL-1-YL)PHENOL
DB07002 4-({4-[(4-methoxypyridin-2-yl)amino]piperidin-1-yl}carbonyl)benzonitrile
DB01835 4r-Fluoro-N6-Ethanimidoyl-L-Lysine
DB04534 5-Nitroindazole
DB03100 6-Nitroindazole
DB02207 7-Nitroindazole
DB05252 ACCLAIM
DB02533 Aminoguanidine
DB01234 Dexamethasone
DB00997 Doxorubicin
DB07306 ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE
DB07388 ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE
DB02234 Ethylisothiourea
DB05214 KD7040
DB00125 L-Arginine
DB00155 L-Citrulline
DB03953 L-Thiocitrulline
DB01110 Miconazole
DB02044 N-(3-(Aminomethyl)Benzyl)Acetamidine
DB03449 N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine
DB07389 N-[2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL]-4-CYANOBENZAMIDE
DB03144 N-Omega-Hydroxy-L-Arginine
DB02644 N-Omega-Propyl-L-Arginine
DB02539 S-Ethylisothiourea
DB02462 Thiocoumarin
DB08814 Triflusal
GuidetoPHARMACOLOGYi1250

PTM databases

iPTMnetiP35228
PhosphoSitePlusiP35228
SwissPalmiP35228

Polymorphism and mutation databases

BioMutaiNOS2
DMDMi1352513

Proteomic databases

PaxDbiP35228
PeptideAtlasiP35228
PRIDEiP35228
ProteomicsDBi54993
54994 [P35228-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313735; ENSP00000327251; ENSG00000007171 [P35228-1]
ENST00000621962; ENSP00000482291; ENSG00000007171 [P35228-2]
GeneIDi4843
KEGGihsa:4843
UCSCiuc002gzu.4 human [P35228-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4843
DisGeNETi4843
EuPathDBiHostDB:ENSG00000007171.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NOS2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0027239
HGNCiHGNC:7873 NOS2
HPAiCAB002014
MalaCardsiNOS2
MIMi163730 gene
611162 phenotype
neXtProtiNX_P35228
OpenTargetsiENSG00000007171
PharmGKBiPA164724093

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1158 Eukaryota
COG0369 LUCA
COG4362 LUCA
GeneTreeiENSGT00940000159752
HOVERGENiHBG000159
InParanoidiP35228
KOiK13241
OMAiDGPAPHQ
OrthoDBiEOG091G10Z0
PhylomeDBiP35228
TreeFamiTF324410

Enzyme and pathway databases

BioCyciMetaCyc:HS00205-MONOMER
BRENDAi1.14.13.39 2681
ReactomeiR-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-392154 Nitric oxide stimulates guanylate cyclase
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-9033241 Peroxisomal protein import
SignaLinkiP35228
SIGNORiP35228

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NOS2 human
EvolutionaryTraceiP35228

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Nitric_oxide_synthase_2_(inducible)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4843

Protein Ontology

More...
PROi
PR:P35228

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000007171 Expressed in 91 organ(s), highest expression level in cartilage tissue
CleanExiHS_NOS2
GenevisibleiP35228 HS

Family and domain databases

Gene3Di1.20.990.10, 1 hit
3.40.50.360, 1 hit
3.40.50.80, 1 hit
InterProiView protein in InterPro
IPR003097 CysJ-like_FAD-binding
IPR017927 FAD-bd_FR_type
IPR001094 Flavdoxin-like
IPR008254 Flavodoxin/NO_synth
IPR001709 Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR029039 Flavoprotein-like_sf
IPR039261 FNR_nucleotide-bd
IPR023173 NADPH_Cyt_P450_Rdtase_alpha
IPR012144 NOS_euk
IPR004030 NOS_N
IPR036119 NOS_N_sf
IPR001433 OxRdtase_FAD/NAD-bd
IPR017938 Riboflavin_synthase-like_b-brl
PfamiView protein in Pfam
PF00667 FAD_binding_1, 1 hit
PF00258 Flavodoxin_1, 1 hit
PF00175 NAD_binding_1, 1 hit
PF02898 NO_synthase, 1 hit
PIRSFiPIRSF000333 NOS, 1 hit
PRINTSiPR00369 FLAVODOXIN
PR00371 FPNCR
SUPFAMiSSF52218 SSF52218, 1 hit
SSF52343 SSF52343, 1 hit
SSF56512 SSF56512, 1 hit
SSF63380 SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS51384 FAD_FR, 1 hit
PS50902 FLAVODOXIN_LIKE, 1 hit
PS60001 NOS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOS2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35228
Secondary accession number(s): A1L3U5
, B7ZLY2, O60757, O94994, Q16263, Q16692, Q4TTS5, Q9UD42
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1996
Last modified: December 5, 2018
This is version 216 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again