BMI1

Functionⁱ

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:26151332, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:26151332, PubMed:21772249).8 Publications

Miscellaneous

The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	18 – 57	RING-typePROSITE-ProRule annotationAdd BLAST		40

GO - Molecular functionⁱ

promoter-specific chromatin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 24623306
RING-like zinc finger domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16714294
zinc ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16714294

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chromatin silencing
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
hemopoiesis
Source: UniProtKB
Inferred from expression patternⁱ
- 15334543
histone H2A-K119 monoubiquitination
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 26151332
negative regulation of G0 to G1 transition Source: Reactome
negative regulation of gene expression, epigenetic
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24623306
negative regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19636380
positive regulation of fibroblast proliferation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17420273
positive regulation of ubiquitin-protein transferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16714294
regulation of gene expression
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17420273
segment specification
Source: ProtInc
Traceable author statementⁱ
- 7715727

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chromatin regulator, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2559580 Oxidative Stress Induced Senescence R-HSA-3108214 SUMOylation of DNA damage response and repair proteins R-HSA-3899300 SUMOylation of transcription cofactors R-HSA-4551638 SUMOylation of chromatin organization proteins R-HSA-4570464 SUMOylation of RNA binding proteins R-HSA-4655427 SUMOylation of DNA methylation proteins R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8943724 Regulation of PTEN gene transcription R-HSA-8953750 Transcriptional Regulation by E2F6
SIGNORⁱ	P35226

Reactomeⁱ

R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4655427 SUMOylation of DNA methylation proteins
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-8953750 Transcriptional Regulation by E2F6

SIGNORⁱ

P35226

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Polycomb complex protein BMI-1 Alternative name(s): Polycomb group RING finger protein 4 RING finger protein 51
Gene namesⁱ	Name:BMI1 Synonyms:PCGF4, RNF51
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168283.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1066 BMI1
MIMⁱ	164831 gene
neXtProtⁱ	NX_P35226

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	62	K → A: Strongly decreases histone H2A ubiquitination; when associated with A-64. 1 Publication	1
Mutagenesisⁱ	64	R → A: Mildly decreases histone H2A ubiquitination. Strongly decreases histone H2A ubiquitination; when associated with A-62. 2 Publications	1
Mutagenesisⁱ	73	K → N: Increases stimulation of RNF2 ubiquitin ligase activity; when associated with E-77. 1 Publication	1
Mutagenesisⁱ	77	D → E: Increases stimulation of RNF2 ubiquitin ligase activity; when associated with N-73. 1 Publication	1
Mutagenesisⁱ	165	R → E: Decreases affinity for PHC2. Abolishes interaction with PHC2; when associated with E-174. 1 Publication	1
Mutagenesisⁱ	170	M → E: Strongly decreases affinity for PHC2. 1 Publication	1
Mutagenesisⁱ	174	H → E: Strongly decreases affinity for PHC2. Abolishes interaction with PHC2; when associated with E-165. 1 Publication	1

Keywords - Diseaseⁱ

Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	100532731 648
Open Targets More...OpenTargetsⁱ	ENSG00000168283
PharmGKBⁱ	PA25376

Polymorphism and mutation databases

BioMutaⁱ	BMI1
DMDMⁱ	22258801

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000055987	1 – 326	Polycomb complex protein BMI-1Add BLAST		326

Post-translational modificationⁱ

Monoubiquitinated (By similarity). May be polyubiquitinated; which does not lead to proteasomal degradation.By similarity1 Publication

Keywords - PTMⁱ

Ubl conjugation

Proteomic databases

EPDⁱ	P35226
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P35226
PaxDbⁱ	P35226
PeptideAtlas More...PeptideAtlasⁱ	P35226
PRIDEⁱ	P35226
ProteomicsDBⁱ	54991

PTM databases

iPTMnetⁱ	P35226
PhosphoSitePlusⁱ	P35226

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000168283 Expressed in 234 organ(s), highest expression level in brain
CleanExⁱ	HS_BMI1
ExpressionAtlasⁱ	P35226 baseline and differential
Genevisibleⁱ	P35226 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB011120 HPA030471 HPA030472

HPAⁱ

CAB011120
HPA030471
HPA030472

Interactionⁱ

Subunit structureⁱ

Component of a PRC1-like complex (PubMed:12167701, PubMed:15386022, PubMed:19636380, PubMed:21282530, PubMed:26151332, PubMed:21772249, PubMed:25355358). Identified in a PRC1-like HPRC-H complex with CBX2, CBX4, CBX8, PHC1, PHC2, PHC3 RING1 and RNF2 (PubMed:12167701). Interacts with RNF2/RING2 (PubMed:16714294, PubMed:21772249, PubMed:25355358). Interacts with RING1 (By similarity). Part of a complex that contains RNF2, UB2D3 and BMI1, where RNF2 and BMI1 form a tight heterodimer, and UB2D3 interacts only with RNF2 (PubMed:21772249, PubMed:25355358). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). Interacts with CBX7 and CBX8 (PubMed:19636380). Interacts with SPOP (PubMed:15897469). Part of a complex consisting of BMI1, CUL3 and SPOP (PubMed:15897469). Interacts with E4F1 (PubMed:16882984). Interacts with PHC2 (PubMed:9121482, PubMed:9199346, PubMed:27827373).By similarity13 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CBX4	O00257	7	EBI-2341576,EBI-722425
CBX4	O00257-3	2	EBI-2341576,EBI-4392727
CBX6	O95503	5	EBI-2341576,EBI-3951758
CBX7	O95931	10	EBI-2341576,EBI-3923843
CBX8	Q9HC52	17	EBI-2341576,EBI-712912
MOV10	Q9HCE1	2	EBI-2341576,EBI-1055820
NDEL1	Q9GZM8	3	EBI-2341576,EBI-928842
PHC1	P78364	5	EBI-2341576,EBI-725403
PHC2	Q8IXK0	7	EBI-2341576,EBI-713786
PTEN	P60484	7	EBI-2341576,EBI-696162
RING1	Q06587	16	EBI-2341576,EBI-752313
RNF2	Q99496	17	EBI-2341576,EBI-722416
UBC	P0CG48	2	EBI-2341576,EBI-3390054
USP11	P51784	7	EBI-2341576,EBI-306876
USP7	Q93009	7	EBI-2341576,EBI-302474
VPS11	Q9H270	2	EBI-2341576,EBI-373380

GO - Molecular functionⁱ

RING-like zinc finger domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16714294

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107116, 393 interactors 1529410, 5 interactors
CORUMⁱ	P35226
Database of interacting proteins More...DIPⁱ	DIP-41879N
IntActⁱ	P35226, 50 interactors
Molecular INTeraction database More...MINTⁱ	P35226
STRINGⁱ	9606.ENSP00000365851

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	6 – 8	Combined sources	3
Helixⁱ	9 – 12	Combined sources	4
Helixⁱ	13 – 15	Combined sources	3
Turnⁱ	19 – 21	Combined sources	3
Beta strandⁱ	22 – 24	Combined sources	3
Beta strandⁱ	29 – 31	Combined sources	3
Turnⁱ	32 – 34	Combined sources	3
Beta strandⁱ	36 – 39	Combined sources	4
Helixⁱ	40 – 46	Combined sources	7
Turnⁱ	47 – 49	Combined sources	3
Turnⁱ	54 – 56	Combined sources	3
Helixⁱ	65 – 68	Combined sources	4
Beta strandⁱ	69 – 71	Combined sources	3
Helixⁱ	73 – 82	Combined sources	10
Helixⁱ	86 – 100	Combined sources	15
Beta strandⁱ	130 – 137	Combined sources	8
Helixⁱ	140 – 142	Combined sources	3
Helixⁱ	147 – 150	Combined sources	4
Beta strandⁱ	162 – 167	Combined sources	6
Helixⁱ	172 – 182	Combined sources	11
Beta strandⁱ	189 – 199	Combined sources	11
Helixⁱ	206 – 213	Combined sources	8
Beta strandⁱ	217 – 229	Combined sources	13

Show more details

3D structure databases

ProteinModelPortalⁱ	P35226
SMRⁱ	P35226
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P35226

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	162 – 182	Interaction with PHC21 PublicationAdd BLAST		21
Regionⁱ	164 – 228	Interaction with E4F11 PublicationAdd BLAST		65

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	81 – 95	Nuclear localization signalSequence analysisAdd BLAST		15

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	251 – 326	Pro/Ser-richAdd BLAST		76

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	18 – 57	RING-typePROSITE-ProRule annotationAdd BLAST		40

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG2660 Eukaryota ENOG410XPCN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074463
HOGENOMⁱ	HOG000231945
HOVERGENⁱ	HBG052826
InParanoidⁱ	P35226
KEGG Orthology (KO) More...KOⁱ	K11459
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09IB
PhylomeDBⁱ	P35226
TreeFamⁱ	TF324206

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR039642 E3_Ub_ligase/polycomb_RING IPR032443 RAWUL IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD IPR017907 Znf_RING_CS
PANTHERⁱ	PTHR10825 PTHR10825, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16207 RAWUL, 1 hit
SMARTⁱ	View protein in SMART SM00184 RING, 1 hit
PROSITEⁱ	View protein in PROSITE PS00518 ZF_RING_1, 1 hit PS50089 ZF_RING_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

P35226-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MHRTTRIKIT ELNPHLMCVL CGGYFIDATT IIECLHSFCK TCIVRYLETS 
        60         70         80         90        100
KYCPICDVQV HKTRPLLNIR SDKTLQDIVY KLVPGLFKNE MKRRRDFYAA 
       110        120        130        140        150
HPSADAANGS NEDRGEVADE DKRIITDDEI ISLSIEFFDQ NRLDRKVNKD 
       160        170        180        190        200
KEKSKEEVND KRYLRCPAAM TVMHLRKFLR SKMDIPNTFQ IDVMYEEEPL 
       210        220        230        240        250
KDYYTLMDIA YIYTWRRNGP LPLKYRVRPT CKRMKISHQR DGLTNAGELE 
       260        270        280        290        300
SDSGSDKANS PAGGIPSTSS CLPSPSTPVQ SPHPQFPHIS STMNGTSNSP 
       310        320 
SGNHQSSFAN RPRKSSVNGS SATSSG

Length:326

Mass (Da):36,949

Last modified:August 13, 2002 - v2

Checksum:ⁱ030A7D396BADA543

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q5T8Z2	Q5T8Z2_HUMAN	Polycomb complex protein BMI-1 Polycomb complex protein BMI-1	BMI1	184	Annotation score:
Q5T8Z6	Q5T8Z6_HUMAN	Polycomb complex protein BMI-1 Polycomb complex protein BMI-1	BMI1	105	Annotation score:
Q5T8Z4	Q5T8Z4_HUMAN	Polycomb complex protein BMI-1 Polycomb complex protein BMI-1	BMI1	150	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	109	G → S in AAB27059 (PubMed:8390036).Curated		1
Sequence conflictⁱ	265	I → V in AAA19873 (PubMed:8268912).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052087	18	C → Y. Corresponds to variant dbSNP:rs1042059Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L13689 mRNA Translation: AAA19873.1 AK313235 mRNA Translation: BAG36046.1 AL158211 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86148.1 CH471072 Genomic DNA Translation: EAW86150.1 CH471072 Genomic DNA Translation: EAW86151.1 CH471072 Genomic DNA Translation: EAW86154.1 BC011652 mRNA Translation: AAH11652.1 AH004292 mRNA Translation: AAB27059.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7138.1
PIRⁱ	I54339
NCBI Reference Sequences More...RefSeqⁱ	NP_001190991.1, NM_001204062.1 NP_005171.4, NM_005180.8
UniGeneⁱ	Hs.380403 Hs.731287

Genome annotation databases

Ensemblⁱ	ENST00000376663; ENSP00000365851; ENSG00000168283
GeneIDⁱ	100532731 648
KEGGⁱ	hsa:100532731 hsa:648
UCSC genome browser More...UCSCⁱ	uc001irh.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P35226	Polycomb complex protein BMI-1		PONAB		326	UniRef100_P35226
COMMD3-BMI1 readthrough		HUMAN		469
BMI1 isoform 1		PANTR		326
Polycomb group RING finger protein 4		MACFA		326
Uncharacterized protein		COLAP		326
+19

Protein	Similar proteins		Species	Score	Length	Source
P35226	Polycomb complex protein BMI-1		PONAB		326	UniRef90_P35226
COMMD3-BMI1 readthrough		HUMAN		469
BMI1 isoform 1		PANTR		326
Polycomb group RING finger protein 4		MACFA		326
Uncharacterized protein		COLAP		326
+26

Protein	Similar proteins		Species	Score	Length	Source
P35226	Polycomb complex protein BMI-1		PONAB		326	UniRef50_P35226
COMMD3-BMI1 readthrough		HUMAN		469
BMI1 isoform 1		PANTR		326
Polycomb group RING finger protein 4		MACFA		326
Uncharacterized protein		COLAP		326
+39

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L13689 mRNA Translation: AAA19873.1 AK313235 mRNA Translation: BAG36046.1 AL158211 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86148.1 CH471072 Genomic DNA Translation: EAW86150.1 CH471072 Genomic DNA Translation: EAW86151.1 CH471072 Genomic DNA Translation: EAW86154.1 BC011652 mRNA Translation: AAH11652.1 AH004292 mRNA Translation: AAB27059.1
CCDSⁱ	CCDS7138.1
PIRⁱ	I54339
RefSeqⁱ	NP_001190991.1, NM_001204062.1 NP_005171.4, NM_005180.8
UniGeneⁱ	Hs.380403 Hs.731287

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2H0D	X-ray	2.50	A	5-101	[»]
	2NA1	NMR	-	A	121-235	[»]
	3RPG	X-ray	2.65	B	1-109	[»]
	4R8P	X-ray	3.28	K/M	2-109	[»]
	5FR6	X-ray	2.51	A	121-235	[»]
ProteinModelPortalⁱ	P35226
SMRⁱ	P35226
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107116, 393 interactors 1529410, 5 interactors
CORUMⁱ	P35226
DIPⁱ	DIP-41879N
IntActⁱ	P35226, 50 interactors
MINTⁱ	P35226
STRINGⁱ	9606.ENSP00000365851

PTM databases

iPTMnetⁱ	P35226
PhosphoSitePlusⁱ	P35226

Polymorphism and mutation databases

BioMutaⁱ	BMI1
DMDMⁱ	22258801

Proteomic databases

EPDⁱ	P35226
MaxQBⁱ	P35226
PaxDbⁱ	P35226
PeptideAtlasⁱ	P35226
PRIDEⁱ	P35226
ProteomicsDBⁱ	54991

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	648
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000376663; ENSP00000365851; ENSG00000168283
GeneIDⁱ	100532731 648
KEGGⁱ	hsa:100532731 hsa:648
UCSCⁱ	uc001irh.4 human

Organism-specific databases

CTDⁱ	100532731 648
DisGeNETⁱ	100532731 648
EuPathDBⁱ	HostDB:ENSG00000168283.13
GeneCardsⁱ	BMI1
HGNCⁱ	HGNC:1066 BMI1
HPAⁱ	CAB011120 HPA030471 HPA030472
MIMⁱ	164831 gene
neXtProtⁱ	NX_P35226
OpenTargetsⁱ	ENSG00000168283
PharmGKBⁱ	PA25376
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2660 Eukaryota ENOG410XPCN LUCA
GeneTreeⁱ	ENSGT00550000074463
HOGENOMⁱ	HOG000231945
HOVERGENⁱ	HBG052826
InParanoidⁱ	P35226
KOⁱ	K11459
OrthoDBⁱ	EOG091G09IB
PhylomeDBⁱ	P35226
TreeFamⁱ	TF324206

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2559580 Oxidative Stress Induced Senescence R-HSA-3108214 SUMOylation of DNA damage response and repair proteins R-HSA-3899300 SUMOylation of transcription cofactors R-HSA-4551638 SUMOylation of chromatin organization proteins R-HSA-4570464 SUMOylation of RNA binding proteins R-HSA-4655427 SUMOylation of DNA methylation proteins R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8943724 Regulation of PTEN gene transcription R-HSA-8953750 Transcriptional Regulation by E2F6
SIGNORⁱ	P35226

Reactomeⁱ

R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4655427 SUMOylation of DNA methylation proteins
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-8953750 Transcriptional Regulation by E2F6

SIGNORⁱ

P35226

Miscellaneous databases

EvolutionaryTraceⁱ	P35226
GeneWikiⁱ	BMI1
Protein Ontology More...PROⁱ	PR:P35226
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000168283 Expressed in 234 organ(s), highest expression level in brain
CleanExⁱ	HS_BMI1
ExpressionAtlasⁱ	P35226 baseline and differential
Genevisibleⁱ	P35226 HS

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR039642 E3_Ub_ligase/polycomb_RING IPR032443 RAWUL IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD IPR017907 Znf_RING_CS
PANTHERⁱ	PTHR10825 PTHR10825, 1 hit
Pfamⁱ	View protein in Pfam PF16207 RAWUL, 1 hit
SMARTⁱ	View protein in SMART SM00184 RING, 1 hit
PROSITEⁱ	View protein in PROSITE PS00518 ZF_RING_1, 1 hit PS50089 ZF_RING_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BMI1_HUMAN
Accessionⁱ	P35226Primary (citable) accession number: P35226 Secondary accession number(s): Q16030, Q5T8Z3, Q96F37
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
	Last sequence update:	August 13, 2002
	Last modified:	November 7, 2018
	This is version 195 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P35226 (BMI1_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Polycomb complex protein BMI-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ