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UniProtKB - P35226 (BMI1_HUMAN)

Entry version 216 (25 May 2022)
Sequence version 2 (13 Aug 2002)
Previous versions | rss
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Protein

Polycomb complex protein BMI-1

Gene

BMI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:26151332, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:27827373).

The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358).

In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:26151332, PubMed:21772249).

8 Publications

Miscellaneous

The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri18 – 57RING-typePROSITE-ProRule annotationAdd BLAST40

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P35226

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2559580, Oxidative Stress Induced Senescence
R-HSA-3108214, SUMOylation of DNA damage response and repair proteins
R-HSA-3899300, SUMOylation of transcription cofactors
R-HSA-4551638, SUMOylation of chromatin organization proteins
R-HSA-4570464, SUMOylation of RNA binding proteins
R-HSA-4655427, SUMOylation of DNA methylation proteins
R-HSA-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8943724, Regulation of PTEN gene transcription
R-HSA-8953750, Transcriptional Regulation by E2F6

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P35226

SIGNOR Signaling Network Open Resource

More...SIGNORi		P35226

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polycomb complex protein BMI-1
Alternative name(s):
Polycomb group RING finger protein 4
RING finger protein 51
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BMI1
Synonyms:PCGF4, RNF51
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1066, BMI1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		164831, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P35226

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000168283

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi62K → A: Strongly decreases histone H2A ubiquitination; when associated with A-64. 1 Publication1
Mutagenesisi64R → A: Mildly decreases histone H2A ubiquitination. Strongly decreases histone H2A ubiquitination; when associated with A-62. 2 Publications1
Mutagenesisi73K → N: Increases stimulation of RNF2 ubiquitin ligase activity; when associated with E-77. 1 Publication1
Mutagenesisi77D → E: Increases stimulation of RNF2 ubiquitin ligase activity; when associated with N-73. 1 Publication1
Mutagenesisi165R → E: Decreases affinity for PHC2. Abolishes interaction with PHC2; when associated with E-174. 1 Publication1
Mutagenesisi170M → E: Strongly decreases affinity for PHC2. 1 Publication1
Mutagenesisi174H → E: Strongly decreases affinity for PHC2. Abolishes interaction with PHC2; when associated with E-165. 1 Publication1

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...DisGeNETi		100532731
648

Open Targets

More...OpenTargetsi		ENSG00000168283

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25376

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P35226, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4295749

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		BMI1

Domain mapping of disease mutations (DMDM)

More...DMDMi		22258801

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000559871 – 326Polycomb complex protein BMI-1Add BLAST326

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Monoubiquitinated (By similarity). May be polyubiquitinated; which does not lead to proteasomal degradation.By similarity1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P35226

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P35226

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P35226

MaxQB - The MaxQuant DataBase

More...MaxQBi		P35226

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P35226

PeptideAtlas

More...PeptideAtlasi		P35226

PRoteomics IDEntifications database

More...PRIDEi		P35226

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54991

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P35226, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P35226

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P35226

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated by oxidative stress.By similarity

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000168283, Expressed in brain and 247 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P35226, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P35226, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000168283, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a PRC1-like complex (PubMed:12167701, PubMed:15386022, PubMed:19636380, PubMed:21282530, PubMed:26151332, PubMed:21772249, PubMed:25355358).

Identified in a PRC1-like HPRC-H complex with CBX2, CBX4, CBX8, PHC1, PHC2, PHC3 RING1 and RNF2 (PubMed:12167701).

Interacts with RNF2/RING2 (PubMed:16714294, PubMed:21772249, PubMed:25355358).

Interacts with RING1 (By similarity).

Part of a complex that contains RNF2, UB2D3 and BMI1, where RNF2 and BMI1 form a tight heterodimer, and UB2D3 interacts only with RNF2 (PubMed:21772249, PubMed:25355358). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358).

Interacts with CBX7 and CBX8 (PubMed:19636380).

Interacts with SPOP (PubMed:15897469).

Part of a complex consisting of BMI1, CUL3 and SPOP (PubMed:15897469).

Interacts with E4F1 (PubMed:16882984).

Interacts with PHC2 (PubMed:9121482, PubMed:9199346, PubMed:27827373).

Interacts with zinc finger protein ZNF277 (By similarity). May be part of a complex including at least ZNF277, BMI1 and RNF2/RING2 (By similarity).

By similarity13 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107116, 477 interactors
1529410, 16 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P35226

Database of interacting proteins

More...DIPi		DIP-41879N

Protein interaction database and analysis system

More...IntActi		P35226, 961 interactors

Molecular INTeraction database

More...MINTi		P35226

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000365851

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P35226, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1326
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P35226

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P35226

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P35226

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni162 – 182Interaction with PHC21 PublicationAdd BLAST21
Regioni164 – 228Interaction with E4F11 PublicationAdd BLAST65
Regioni236 – 326DisorderedSequence analysisAdd BLAST91

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi81 – 95Nuclear localization signalSequence analysisAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi244 – 276Polar residuesSequence analysisAdd BLAST33
Compositional biasi283 – 326Polar residuesSequence analysisAdd BLAST44

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri18 – 57RING-typePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2660, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156042

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_046427_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P35226

Identification of Orthologs from Complete Genome Data

More...OMAi		DIDARYL

Database of Orthologous Groups

More...OrthoDBi		1344247at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P35226

TreeFam database of animal gene trees

More...TreeFami		TF324206

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00450

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032443, RAWUL
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16207, RAWUL, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00184, RING, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P35226-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHRTTRIKIT ELNPHLMCVL CGGYFIDATT IIECLHSFCK TCIVRYLETS 
        60         70         80         90        100
KYCPICDVQV HKTRPLLNIR SDKTLQDIVY KLVPGLFKNE MKRRRDFYAA 
       110        120        130        140        150
HPSADAANGS NEDRGEVADE DKRIITDDEI ISLSIEFFDQ NRLDRKVNKD 
       160        170        180        190        200
KEKSKEEVND KRYLRCPAAM TVMHLRKFLR SKMDIPNTFQ IDVMYEEEPL 
       210        220        230        240        250
KDYYTLMDIA YIYTWRRNGP LPLKYRVRPT CKRMKISHQR DGLTNAGELE 
       260        270        280        290        300
SDSGSDKANS PAGGIPSTSS CLPSPSTPVQ SPHPQFPHIS STMNGTSNSP 
       310        320 
SGNHQSSFAN RPRKSSVNGS SATSSG
Length:326
Mass (Da):36,949
Last modified:August 13, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i030A7D396BADA543
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T8Z2Q5T8Z2_HUMAN
Polycomb complex protein BMI-1
BMI1
184Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T8Z4Q5T8Z4_HUMAN
Polycomb complex protein BMI-1
BMI1
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T8Z6Q5T8Z6_HUMAN
Polycomb complex protein BMI-1
BMI1
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti109G → S in AAB27059 (PubMed:8390036).Curated1
Sequence conflicti265I → V in AAA19873 (PubMed:8268912).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05208718C → Y. Corresponds to variant dbSNP:rs1042059Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L13689 mRNA Translation: AAA19873.1
AK313235 mRNA Translation: BAG36046.1
AL158211 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86148.1
CH471072 Genomic DNA Translation: EAW86150.1
CH471072 Genomic DNA Translation: EAW86151.1
CH471072 Genomic DNA Translation: EAW86154.1
BC011652 mRNA Translation: AAH11652.1
AH004292 mRNA Translation: AAB27059.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7138.1

Protein sequence database of the Protein Information Resource

More...PIRi		I54339

NCBI Reference Sequences

More...RefSeqi		NP_001190991.1, NM_001204062.1
NP_005171.4, NM_005180.8

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000376663.8; ENSP00000365851.3; ENSG00000168283.14

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100532731
648

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:100532731
hsa:648

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000376663.8; ENSP00000365851.3; NM_005180.9; NP_005171.4

UCSC genome browser

More...UCSCi		uc001irh.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13689 mRNA Translation: AAA19873.1
AK313235 mRNA Translation: BAG36046.1
AL158211 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86148.1
CH471072 Genomic DNA Translation: EAW86150.1
CH471072 Genomic DNA Translation: EAW86151.1
CH471072 Genomic DNA Translation: EAW86154.1
BC011652 mRNA Translation: AAH11652.1
AH004292 mRNA Translation: AAB27059.1
CCDSiCCDS7138.1
PIRiI54339
RefSeqiNP_001190991.1, NM_001204062.1
NP_005171.4, NM_005180.8

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H0DX-ray2.50A5-101[»]
2NA1NMR-A121-235[»]
3RPGX-ray2.65B1-109[»]
4R8PX-ray3.28K/M2-109[»]
5FR6X-ray2.51A121-235[»]
6WI7X-ray1.70A1-104[»]
6WI8X-ray3.09A/B1-104[»]
7ND1NMR-H4-104[»]
AlphaFoldDBiP35226
SMRiP35226
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107116, 477 interactors
1529410, 16 interactors
CORUMiP35226
DIPiDIP-41879N
IntActiP35226, 961 interactors
MINTiP35226
STRINGi9606.ENSP00000365851

Chemistry databases

ChEMBLiCHEMBL4295749

PTM databases

GlyGeniP35226, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP35226
PhosphoSitePlusiP35226

Genetic variation databases

BioMutaiBMI1
DMDMi22258801

Proteomic databases

EPDiP35226
jPOSTiP35226
MassIVEiP35226
MaxQBiP35226
PaxDbiP35226
PeptideAtlasiP35226
PRIDEiP35226
ProteomicsDBi54991

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4554, 942 antibodies from 46 providers

The DNASU plasmid repository

More...DNASUi		648

Genome annotation databases

EnsembliENST00000376663.8; ENSP00000365851.3; ENSG00000168283.14
GeneIDi100532731
648
KEGGihsa:100532731
hsa:648
MANE-SelectiENST00000376663.8; ENSP00000365851.3; NM_005180.9; NP_005171.4
UCSCiuc001irh.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		100532731
648
DisGeNETi100532731
648

GeneCards: human genes, protein and diseases

More...GeneCardsi		BMI1
HGNCiHGNC:1066, BMI1
HPAiENSG00000168283, Low tissue specificity
MIMi164831, gene
neXtProtiNX_P35226
OpenTargetsiENSG00000168283
PharmGKBiPA25376
VEuPathDBiHostDB:ENSG00000168283

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2660, Eukaryota
GeneTreeiENSGT00940000156042
HOGENOMiCLU_046427_0_0_1
InParanoidiP35226
OMAiDIDARYL
OrthoDBi1344247at2759
PhylomeDBiP35226
TreeFamiTF324206

Enzyme and pathway databases

PathwayCommonsiP35226
ReactomeiR-HSA-2559580, Oxidative Stress Induced Senescence
R-HSA-3108214, SUMOylation of DNA damage response and repair proteins
R-HSA-3899300, SUMOylation of transcription cofactors
R-HSA-4551638, SUMOylation of chromatin organization proteins
R-HSA-4570464, SUMOylation of RNA binding proteins
R-HSA-4655427, SUMOylation of DNA methylation proteins
R-HSA-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8943724, Regulation of PTEN gene transcription
R-HSA-8953750, Transcriptional Regulation by E2F6
SignaLinkiP35226
SIGNORiP35226

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		100532731, 17 hits in 606 CRISPR screens
648, 44 hits in 1113 CRISPR screens
EvolutionaryTraceiP35226

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		BMI1
PharosiP35226, Tbio

Protein Ontology

More...PROi		PR:P35226
RNActiP35226, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000168283, Expressed in brain and 247 other tissues
ExpressionAtlasiP35226, baseline and differential
GenevisibleiP35226, HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
IDEALiIID00450
InterProiView protein in InterPro
IPR032443, RAWUL
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS
PfamiView protein in Pfam
PF16207, RAWUL, 1 hit
SMARTiView protein in SMART
SM00184, RING, 1 hit
PROSITEiView protein in PROSITE
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBMI1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35226
Secondary accession number(s): Q16030, Q5T8Z3, Q96F37
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: August 13, 2002
Last modified: May 25, 2022
This is version 216 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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