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Protein

Interleukin-13

Gene

IL13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity).By similarity2 Publications

Caution

It is uncertain whether Met-1 or Met-15 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-9012546 Interleukin-18 signaling
SignaLinkiP35225
SIGNORiP35225

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-13
Short name:
IL-13
Gene namesi
Name:IL13
Synonyms:NC30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000169194.9
HGNCiHGNC:5973 IL13
MIMi147683 gene
neXtProtiNX_P35225

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Allergic rhinitis (ALRH)
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure.
See also OMIM:607154

Organism-specific databases

DisGeNETi3596
MalaCardsiIL13
MIMi607154 phenotype
PharmGKBiPA199

Chemistry databases

ChEMBLiCHEMBL3580486
DrugBankiDB05305 Cintredekin Besudotox

Polymorphism and mutation databases

BioMutaiIL13
DMDMi239938644

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 351 PublicationAdd BLAST35
ChainiPRO_000001554736 – 146Interleukin-13Add BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi62 ↔ 902 Publications
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi78 ↔ 1042 Publications
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35225
PeptideAtlasiP35225
PRIDEiP35225
ProteomicsDBi54990

Expressioni

Gene expression databases

BgeeiENSG00000169194 Expressed in 95 organ(s), highest expression level in left testis
CleanExiHS_IL13
ExpressionAtlasiP35225 baseline and differential
GenevisibleiP35225 HS

Organism-specific databases

HPAiHPA042421

Interactioni

Subunit structurei

Interacts with IL13RA2.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-3224N
IntActiP35225, 3 interactors
STRINGi9606.ENSP00000304915

Structurei

Secondary structure

1146
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP35225
SMRiP35225
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35225

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCI3 Eukaryota
ENOG4111BX2 LUCA
HOGENOMiHOG000113028
HOVERGENiHBG006140
InParanoidiP35225
KOiK05435
OrthoDBiEOG091G10SR
PhylomeDBiP35225
TreeFamiTF336383

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020470 IL-13
IPR001325 IL-4/IL-13
IPR018096 IL-4/IL-13_CS
PANTHERiPTHR45413 PTHR45413, 1 hit
PfamiView protein in Pfam
PF03487 IL13, 1 hit
PRINTSiPR01929 INTRLEUKIN13
SMARTiView protein in SMART
SM00190 IL4_13, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00838 INTERLEUKIN_4_13, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

P35225-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHPLLNPLLL ALGLMALLLT TVIALTCLGG FASPGPVPPS TALRELIEEL
60 70 80 90 100
VNITQNQKAP LCNGSMVWSI NLTAGMYCAA LESLINVSGC SAIEKTQRML
110 120 130 140
SGFCPHKVSA GQFSSLHVRD TKIEVAQFVK DLLLHLKKLF REGRFN
Length:146
Mass (Da):15,816
Last modified:June 16, 2009 - v2
Checksum:iBE2D46CCF913D129
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WW07A0A087WW07_HUMAN
Interleukin-13
IL13
144Annotation score:

Sequence cautioni

The sequence AAA36107 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAA83738 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAB01681 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAC03535 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAK53823 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA48824 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → R in CAA48824 (PubMed:8097324).Curated1
Sequence conflicti26T → A no nucleotide entry (PubMed:1408833).Curated1
Sequence conflicti32A → D no nucleotide entry (PubMed:1408833).Curated1
Sequence conflicti51V → S no nucleotide entry (PubMed:1408833).Curated1
Sequence conflicti56N → T no nucleotide entry (PubMed:1408833).Curated1
Sequence conflicti59A → R in AAA83738 (PubMed:7721105).Curated1
Sequence conflicti101S → G in AAC03535 (Ref. 8) Curated1
Sequence conflicti112Missing in AAA83738 (PubMed:7721105).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010037144R → Q Associated with increased risk for asthma development; at homozygosity associated with higher levels of serum total IgE in some allergic rhinitis patients. 6 PublicationsCorresponds to variant dbSNP:rs20541Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69079 mRNA Translation: CAA48823.1
X69079 mRNA Translation: CAA48824.1 Different initiation.
L06801 mRNA Translation: AAA36107.1 Different initiation.
U10307 Genomic DNA Translation: AAA83738.1 Different initiation.
U31120 Genomic DNA Translation: AAB01681.1 Different initiation.
AF377331 Genomic DNA Translation: AAK53823.1 Different initiation.
AC004039 Genomic DNA No translation available.
BC096139 mRNA Translation: AAH96139.1
AF043334 mRNA Translation: AAC03535.1 Different initiation.
CCDSiCCDS4157.1
PIRiI38060 A47481
RefSeqiNP_002179.2, NM_002188.2
UniGeneiHs.845

Genome annotation databases

EnsembliENST00000304506; ENSP00000304915; ENSG00000169194
GeneIDi3596
KEGGihsa:3596
UCSCiuc003kxj.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-13 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69079 mRNA Translation: CAA48823.1
X69079 mRNA Translation: CAA48824.1 Different initiation.
L06801 mRNA Translation: AAA36107.1 Different initiation.
U10307 Genomic DNA Translation: AAA83738.1 Different initiation.
U31120 Genomic DNA Translation: AAB01681.1 Different initiation.
AF377331 Genomic DNA Translation: AAK53823.1 Different initiation.
AC004039 Genomic DNA No translation available.
BC096139 mRNA Translation: AAH96139.1
AF043334 mRNA Translation: AAC03535.1 Different initiation.
CCDSiCCDS4157.1
PIRiI38060 A47481
RefSeqiNP_002179.2, NM_002188.2
UniGeneiHs.845

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GA3NMR-A35-146[»]
1IJZNMR-A35-146[»]
1IK0NMR-A35-146[»]
1J9Umodel-A38-146[»]
3BPOX-ray3.00A34-146[»]
3G6DX-ray3.20A35-146[»]
3ITRmodel-A38-146[»]
3ITSmodel-A38-146[»]
3L5WX-ray2.00I/J35-146[»]
3L5XX-ray1.90A35-146[»]
3LB6X-ray3.05A/B15-146[»]
4I77X-ray1.90Z35-146[»]
4PS4X-ray2.80A35-146[»]
5E4EX-ray3.00A34-146[»]
5L6YX-ray1.99C35-146[»]
ProteinModelPortaliP35225
SMRiP35225
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3224N
IntActiP35225, 3 interactors
STRINGi9606.ENSP00000304915

Chemistry databases

ChEMBLiCHEMBL3580486
DrugBankiDB05305 Cintredekin Besudotox

Polymorphism and mutation databases

BioMutaiIL13
DMDMi239938644

Proteomic databases

PaxDbiP35225
PeptideAtlasiP35225
PRIDEiP35225
ProteomicsDBi54990

Protocols and materials databases

DNASUi3596
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304506; ENSP00000304915; ENSG00000169194
GeneIDi3596
KEGGihsa:3596
UCSCiuc003kxj.2 human

Organism-specific databases

CTDi3596
DisGeNETi3596
EuPathDBiHostDB:ENSG00000169194.9
GeneCardsiIL13
H-InvDBiHIX0031957
HGNCiHGNC:5973 IL13
HPAiHPA042421
MalaCardsiIL13
MIMi147683 gene
607154 phenotype
neXtProtiNX_P35225
PharmGKBiPA199
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JCI3 Eukaryota
ENOG4111BX2 LUCA
HOGENOMiHOG000113028
HOVERGENiHBG006140
InParanoidiP35225
KOiK05435
OrthoDBiEOG091G10SR
PhylomeDBiP35225
TreeFamiTF336383

Enzyme and pathway databases

ReactomeiR-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-9012546 Interleukin-18 signaling
SignaLinkiP35225
SIGNORiP35225

Miscellaneous databases

ChiTaRSiIL13 human
EvolutionaryTraceiP35225
GeneWikiiInterleukin_13
GenomeRNAii3596
PROiPR:P35225
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169194 Expressed in 95 organ(s), highest expression level in left testis
CleanExiHS_IL13
ExpressionAtlasiP35225 baseline and differential
GenevisibleiP35225 HS

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020470 IL-13
IPR001325 IL-4/IL-13
IPR018096 IL-4/IL-13_CS
PANTHERiPTHR45413 PTHR45413, 1 hit
PfamiView protein in Pfam
PF03487 IL13, 1 hit
PRINTSiPR01929 INTRLEUKIN13
SMARTiView protein in SMART
SM00190 IL4_13, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00838 INTERLEUKIN_4_13, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL13_HUMAN
AccessioniPrimary (citable) accession number: P35225
Secondary accession number(s): O43644, Q4VB52, Q9UDC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 16, 2009
Last modified: September 12, 2018
This is version 190 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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