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Protein

Interleukin-13

Gene

IL13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity).By similarity2 Publications

Caution

It is uncertain whether Met-1 or Met-15 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-9012546 Interleukin-18 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P35225

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P35225

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-13
Short name:
IL-13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL13
Synonyms:NC30
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000169194.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5973 IL13

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
147683 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P35225

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Allergic rhinitis (ALRH)
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure.
See also OMIM:607154

Organism-specific databases

DisGeNET

More...
DisGeNETi
3596

MalaCards human disease database

More...
MalaCardsi
IL13
MIMi607154 phenotype

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA199

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3580486

Drug and drug target database

More...
DrugBanki
DB05305 Cintredekin Besudotox

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IL13

Domain mapping of disease mutations (DMDM)

More...
DMDMi
239938644

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 351 PublicationAdd BLAST35
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001554736 – 146Interleukin-13Add BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi62 ↔ 902 Publications
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi78 ↔ 1042 Publications
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P35225

PeptideAtlas

More...
PeptideAtlasi
P35225

PRoteomics IDEntifications database

More...
PRIDEi
P35225

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54990

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000169194 Expressed in 95 organ(s), highest expression level in left testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_IL13

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P35225 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P35225 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042421

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with IL13RA2.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-3224N

Protein interaction database and analysis system

More...
IntActi
P35225, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000304915

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1146
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P35225

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P35225

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P35225

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JCI3 Eukaryota
ENOG4111BX2 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113028

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006140

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P35225

KEGG Orthology (KO)

More...
KOi
K05435

Database of Orthologous Groups

More...
OrthoDBi
EOG091G10SR

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P35225

TreeFam database of animal gene trees

More...
TreeFami
TF336383

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020470 IL-13
IPR001325 IL-4/IL-13
IPR018096 IL-4/IL-13_CS

The PANTHER Classification System

More...
PANTHERi
PTHR45413 PTHR45413, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03487 IL13, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01929 INTRLEUKIN13

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00190 IL4_13, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47266 SSF47266, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00838 INTERLEUKIN_4_13, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P35225-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHPLLNPLLL ALGLMALLLT TVIALTCLGG FASPGPVPPS TALRELIEEL
60 70 80 90 100
VNITQNQKAP LCNGSMVWSI NLTAGMYCAA LESLINVSGC SAIEKTQRML
110 120 130 140
SGFCPHKVSA GQFSSLHVRD TKIEVAQFVK DLLLHLKKLF REGRFN
Length:146
Mass (Da):15,816
Last modified:June 16, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBE2D46CCF913D129
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WW07A0A087WW07_HUMAN
Interleukin-13
IL13
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA36107 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAA83738 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAB01681 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAC03535 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAK53823 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA48824 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1M → R in CAA48824 (PubMed:8097324).Curated1
Sequence conflicti26T → A no nucleotide entry (PubMed:1408833).Curated1
Sequence conflicti32A → D no nucleotide entry (PubMed:1408833).Curated1
Sequence conflicti51V → S no nucleotide entry (PubMed:1408833).Curated1
Sequence conflicti56N → T no nucleotide entry (PubMed:1408833).Curated1
Sequence conflicti59A → R in AAA83738 (PubMed:7721105).Curated1
Sequence conflicti101S → G in AAC03535 (Ref. 8) Curated1
Sequence conflicti112Missing in AAA83738 (PubMed:7721105).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_010037144R → Q Associated with increased risk for asthma development; at homozygosity associated with higher levels of serum total IgE in some allergic rhinitis patients. 6 PublicationsCorresponds to variant dbSNP:rs20541Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X69079 mRNA Translation: CAA48823.1
X69079 mRNA Translation: CAA48824.1 Different initiation.
L06801 mRNA Translation: AAA36107.1 Different initiation.
U10307 Genomic DNA Translation: AAA83738.1 Different initiation.
U31120 Genomic DNA Translation: AAB01681.1 Different initiation.
AF377331 Genomic DNA Translation: AAK53823.1 Different initiation.
AC004039 Genomic DNA No translation available.
BC096139 mRNA Translation: AAH96139.1
AF043334 mRNA Translation: AAC03535.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4157.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I38060 A47481

NCBI Reference Sequences

More...
RefSeqi
NP_002179.2, NM_002188.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.845

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000304506; ENSP00000304915; ENSG00000169194

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3596

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3596

UCSC genome browser

More...
UCSCi
uc003kxj.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Interleukin-13 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69079 mRNA Translation: CAA48823.1
X69079 mRNA Translation: CAA48824.1 Different initiation.
L06801 mRNA Translation: AAA36107.1 Different initiation.
U10307 Genomic DNA Translation: AAA83738.1 Different initiation.
U31120 Genomic DNA Translation: AAB01681.1 Different initiation.
AF377331 Genomic DNA Translation: AAK53823.1 Different initiation.
AC004039 Genomic DNA No translation available.
BC096139 mRNA Translation: AAH96139.1
AF043334 mRNA Translation: AAC03535.1 Different initiation.
CCDSiCCDS4157.1
PIRiI38060 A47481
RefSeqiNP_002179.2, NM_002188.2
UniGeneiHs.845

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GA3NMR-A35-146[»]
1IJZNMR-A35-146[»]
1IK0NMR-A35-146[»]
1J9Umodel-A38-146[»]
3BPOX-ray3.00A34-146[»]
3G6DX-ray3.20A35-146[»]
3ITRmodel-A38-146[»]
3ITSmodel-A38-146[»]
3L5WX-ray2.00I/J35-146[»]
3L5XX-ray1.90A35-146[»]
3LB6X-ray3.05A/B15-146[»]
4I77X-ray1.90Z35-146[»]
4PS4X-ray2.80A35-146[»]
5E4EX-ray3.00A34-146[»]
5L6YX-ray1.99C35-146[»]
ProteinModelPortaliP35225
SMRiP35225
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3224N
IntActiP35225, 3 interactors
STRINGi9606.ENSP00000304915

Chemistry databases

ChEMBLiCHEMBL3580486
DrugBankiDB05305 Cintredekin Besudotox

Polymorphism and mutation databases

BioMutaiIL13
DMDMi239938644

Proteomic databases

PaxDbiP35225
PeptideAtlasiP35225
PRIDEiP35225
ProteomicsDBi54990

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3596
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304506; ENSP00000304915; ENSG00000169194
GeneIDi3596
KEGGihsa:3596
UCSCiuc003kxj.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3596
DisGeNETi3596
EuPathDBiHostDB:ENSG00000169194.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IL13

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0031957
HGNCiHGNC:5973 IL13
HPAiHPA042421
MalaCardsiIL13
MIMi147683 gene
607154 phenotype
neXtProtiNX_P35225
PharmGKBiPA199

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JCI3 Eukaryota
ENOG4111BX2 LUCA
HOGENOMiHOG000113028
HOVERGENiHBG006140
InParanoidiP35225
KOiK05435
OrthoDBiEOG091G10SR
PhylomeDBiP35225
TreeFamiTF336383

Enzyme and pathway databases

ReactomeiR-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-9012546 Interleukin-18 signaling
SignaLinkiP35225
SIGNORiP35225

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IL13 human
EvolutionaryTraceiP35225

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Interleukin_13

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3596

Protein Ontology

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PROi
PR:P35225

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000169194 Expressed in 95 organ(s), highest expression level in left testis
CleanExiHS_IL13
ExpressionAtlasiP35225 baseline and differential
GenevisibleiP35225 HS

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020470 IL-13
IPR001325 IL-4/IL-13
IPR018096 IL-4/IL-13_CS
PANTHERiPTHR45413 PTHR45413, 1 hit
PfamiView protein in Pfam
PF03487 IL13, 1 hit
PRINTSiPR01929 INTRLEUKIN13
SMARTiView protein in SMART
SM00190 IL4_13, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00838 INTERLEUKIN_4_13, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL13_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35225
Secondary accession number(s): O43644, Q4VB52, Q9UDC7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 16, 2009
Last modified: November 7, 2018
This is version 191 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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