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Protein

Catenin alpha-1

Gene

CTNNA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-375170 CDO in myogenesis
R-HSA-418990 Adherens junctions interactions
R-HSA-5218920 VEGFR2 mediated vascular permeability
R-HSA-5626467 RHO GTPases activate IQGAPs

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P35221

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Catenin alpha-1
Alternative name(s):
Alpha E-catenin
Cadherin-associated protein
Renal carcinoma antigen NY-REN-13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CTNNA1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000044115.20

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2509 CTNNA1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
116805 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P35221

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Germline CTNNA1 truncating mutations have been detected in patients with hereditary diffuse gastric cancer (HDGC) and may play a role in disease susceptibility. Diffuse gastric cancer is a malignant disease characterized by poorly differentiated infiltrating lesions resulting in thickening of the stomach. Malignant tumors start in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body.2 Publications
Macular dystrophy, patterned, 2 (MDPT2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of retinal patterned dystrophy, a heterogeneous group of macular disorders caused by abnormal accumulation of lipofuscin in the retinal pigment epithelium. Lipofuscin distribution can show various shapes that define different types of macular dystrophy, including reticular (fishnet-like) dystrophy, macroreticular (spider-shaped) dystrophy and butterfly-shaped pigment dystrophy. MDPT2 is an autosomal dominant form characterized by bilateral accumulation of pigment in the macular area that resembles the wings of a butterfly.
See also OMIM:608970
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07658654R → C in MDPT2; no effect on VCL-binding. 1 PublicationCorresponds to variant dbSNP:rs781520852Ensembl.1
Natural variantiVAR_076587307E → K in MDPT2; no effect on VCL-binding. 1 PublicationCorresponds to variant dbSNP:rs869320697EnsemblClinVar.1
Natural variantiVAR_076588318L → S in MDPT2; no effect on VCL-binding. 1 PublicationCorresponds to variant dbSNP:rs869320696EnsemblClinVar.1
Natural variantiVAR_076589431I → M in MDPT2; no effect on VCL-binding. 1 PublicationCorresponds to variant dbSNP:rs755215402EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi641S → A: Abolishes phosphorylation by CK2. No effect on phosphorylation by CK1. 1 Publication1
Mutagenesisi641S → D: Enhances phosphorylation by CK1. 1 Publication1
Mutagenesisi652 – 658SRTSVQT → ARTAVQA: Abolishes phosphorylation by CK1. No effect on phosphorylation by CK2. 1 Publication7
Mutagenesisi652S → A: Abolishes phosphorylation by CK1. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
1495

MalaCards human disease database

More...
MalaCardsi
CTNNA1
MIMi608970 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000044115

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
99001 Butterfly-shaped pigment dystrophy
26106 Hereditary diffuse gastric cancer

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27008

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CTNNA1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
461853

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000642612 – 906Catenin alpha-1Add BLAST905

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylthreonine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki57Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei264PhosphoserineCombined sources1
Modified residuei268PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Modified residuei297PhosphoserineCombined sources1
Modified residuei634PhosphothreonineCombined sources1
Modified residuei641Phosphoserine; by CK2Combined sources1 Publication1
Modified residuei645PhosphothreonineCombined sources1
Modified residuei652Phosphoserine; by CK1Combined sources1 Publication1
Modified residuei655Phosphoserine; by CK11 Publication1
Modified residuei658Phosphothreonine; by CK11 Publication1
Cross-linki797Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei851PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated.1 Publication
Phosphorylation seems to contribute to the strength of cell-cell adhesion rather than to the basic capacity for cell-cell adhesion.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P35221

MaxQB - The MaxQuant DataBase

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MaxQBi
P35221

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P35221

PeptideAtlas

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PeptideAtlasi
P35221

PRoteomics IDEntifications database

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PRIDEi
P35221

ProteomicsDB human proteome resource

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ProteomicsDBi
54986
54987 [P35221-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P35221

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P35221

SwissPalm database of S-palmitoylation events

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SwissPalmi
P35221

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed ubiquitously in normal tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000044115 Expressed in 237 organ(s), highest expression level in corpus callosum

CleanEx database of gene expression profiles

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CleanExi
HS_CTNNA1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P35221 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P35221 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB021089
HPA046119
HPA063535

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer; the monomer preferentially binds to CTNNB1 and the homodimer to actin. Binds AFDN and F-actin. Possible component of an E-cadherin/ catenin adhesion complex together with E-cadherin/CDH1 and beta-catenin/CTNNB1 or gamma-catenin/JUP; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Alternatively, the CTNNA1-containing complex may be linked to F-actin by other proteins such as LIMA1. Interacts with ARHGAP21 and with AJUBA. Interacts with LIMA1 (By similarity). Interacts with vinculin/VCL (PubMed:26691986). Component of an cadherin:catenin adhesion complex composed of at least of CDH26, beta-catenin/CTNNB1, alpha-catenin/CTNNA1 and p120 catenin/CTNND1 (PubMed:28051089).By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107876, 94 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P35221

Database of interacting proteins

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DIPi
DIP-515N

Protein interaction database and analysis system

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IntActi
P35221, 77 interactors

Molecular INTeraction database

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MINTi
P35221

STRING: functional protein association networks

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STRINGi
9606.ENSP00000304669

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1906
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P35221

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P35221

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P35221

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 228Involved in homodimerizationAdd BLAST227
Regioni97 – 148Interaction with JUP and CTNNB11 PublicationAdd BLAST52
Regioni325 – 394Interaction with alpha-actininAdd BLAST70

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the vinculin/alpha-catenin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3681 Eukaryota
ENOG410XSRU LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153356

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000280724

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000069

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P35221

KEGG Orthology (KO)

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KOi
K05691

Identification of Orthologs from Complete Genome Data

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OMAi
ADMSDVY

Database of Orthologous Groups

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OrthoDBi
EOG091G01KR

Database for complete collections of gene phylogenies

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PhylomeDBi
P35221

TreeFam database of animal gene trees

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TreeFami
TF313686

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036723 Alpha-catenin/vinculin-like_sf
IPR001033 Alpha_catenin
IPR030047 CTNNA1
IPR006077 Vinculin/catenin
IPR000633 Vinculin_CS

The PANTHER Classification System

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PANTHERi
PTHR18914 PTHR18914, 1 hit
PTHR18914:SF24 PTHR18914:SF24, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01044 Vinculin, 2 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00805 ALPHACATENIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47220 SSF47220, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00663 VINCULIN_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 28 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P35221-1) [UniParc]FASTAAdd to basket
Also known as: CTNNA1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAVHAGNIN FKWDPKSLEI RTLAVERLLE PLVTQVTTLV NTNSKGPSNK
60 70 80 90 100
KRGRSKKAHV LAASVEQATE NFLEKGDKIA KESQFLKEEL VAAVEDVRKQ
110 120 130 140 150
GDLMKAAAGE FADDPCSSVK RGNMVRAARA LLSAVTRLLI LADMADVYKL
160 170 180 190 200
LVQLKVVEDG ILKLRNAGNE QDLGIQYKAL KPEVDKLNIM AAKRQQELKD
210 220 230 240 250
VGHRDQMAAA RGILQKNVPI LYTASQACLQ HPDVAAYKAN RDLIYKQLQQ
260 270 280 290 300
AVTGISNAAQ ATASDDASQH QGGGGGELAY ALNNFDKQII VDPLSFSEER
310 320 330 340 350
FRPSLEERLE SIISGAALMA DSSCTRDDRR ERIVAECNAV RQALQDLLSE
360 370 380 390 400
YMGNAGRKER SDALNSAIDK MTKKTRDLRR QLRKAVMDHV SDSFLETNVP
410 420 430 440 450
LLVLIEAAKN GNEKEVKEYA QVFREHANKL IEVANLACSI SNNEEGVKLV
460 470 480 490 500
RMSASQLEAL CPQVINAALA LAAKPQSKLA QENMDLFKEQ WEKQVRVLTD
510 520 530 540 550
AVDDITSIDD FLAVSENHIL EDVNKCVIAL QEKDVDGLDR TAGAIRGRAA
560 570 580 590 600
RVIHVVTSEM DNYEPGVYTE KVLEATKLLS NTVMPRFTEQ VEAAVEALSS
610 620 630 640 650
DPAQPMDENE FIDASRLVYD GIRDIRKAVL MIRTPEELDD SDFETEDFDV
660 670 680 690 700
RSRTSVQTED DQLIAGQSAR AIMAQLPQEQ KAKIAEQVAS FQEEKSKLDA
710 720 730 740 750
EVSKWDDSGN DIIVLAKQMC MIMMEMTDFT RGKGPLKNTS DVISAAKKIA
760 770 780 790 800
EAGSRMDKLG RTIADHCPDS ACKQDLLAYL QRIALYCHQL NICSKVKAEV
810 820 830 840 850
QNLGGELVVS GVDSAMSLIQ AAKNLMNAVV QTVKASYVAS TKYQKSQGMA
860 870 880 890 900
SLNLPAVSWK MKAPEKKPLV KREKQDETQT KIKRASQKKH VNPVQALSEF

KAMDSI
Length:906
Mass (Da):100,071
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7AAE6F5DDBAF5099
GO
Isoform 2 (identifier: P35221-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     811-811: G → GNCDTCGALQGLKGWPPPLCLATHW

Show »
Length:930
Mass (Da):102,635
Checksum:i6EDF38C221CA2FA0
GO
Isoform 3 (identifier: P35221-3) [UniParc]FASTAAdd to basket
Also known as: CTNNA1b

The sequence of this isoform differs from the canonical sequence as follows:
     1-370: Missing.

Note: Expressed at high levels in the nervous system. Lacks the beta-catenin interaction domain.
Show »
Length:536
Mass (Da):59,550
Checksum:i887A39433621F5DB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 28 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3XAM7G3XAM7_HUMAN
Catenin (Cadherin-associated protei...
CTNNA1 hCG_1782385
841Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIB1E5RIB1_HUMAN
Catenin alpha-1
CTNNA1
215Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJ41E5RJ41_HUMAN
Catenin alpha-1
CTNNA1
161Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGY6E5RGY6_HUMAN
Catenin alpha-1
CTNNA1
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RG03E5RG03_HUMAN
Catenin alpha-1
CTNNA1
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHV7E5RHV7_HUMAN
Catenin alpha-1
CTNNA1
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIE0E5RIE0_HUMAN
Catenin alpha-1
CTNNA1
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFK9E5RFK9_HUMAN
Catenin alpha-1
CTNNA1
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJL0E5RJL0_HUMAN
Catenin alpha-1
CTNNA1
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGY7E5RGY7_HUMAN
Catenin alpha-1
CTNNA1
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti92A → V in AAA86430 (PubMed:7945318).Curated1
Sequence conflicti92A → V in AAA18949 (PubMed:7945318).Curated1
Sequence conflicti129R → P in AAA18949 (PubMed:7945318).Curated1
Sequence conflicti175I → N in AAA86430 (PubMed:7945318).Curated1
Sequence conflicti175I → N in AAA18949 (PubMed:7945318).Curated1
Sequence conflicti216K → S in AAA86430 (PubMed:7945318).Curated1
Sequence conflicti216K → S in AAA18949 (PubMed:7945318).Curated1
Sequence conflicti342Q → K in BAA03530 (PubMed:8404069).Curated1
Sequence conflicti344 – 348LQDLL → CRTCV in AAA86430 (PubMed:7945318).Curated5
Sequence conflicti460L → G in AAA86430 (PubMed:7945318).Curated1
Sequence conflicti460L → G in AAA18949 (PubMed:7945318).Curated1
Sequence conflicti469L → TW in AAA86430 (PubMed:7945318).Curated1
Sequence conflicti469L → TW in AAA18949 (PubMed:7945318).Curated1
Sequence conflicti473A → P in AAA86430 (PubMed:7945318).Curated1
Sequence conflicti473A → P in AAA18949 (PubMed:7945318).Curated1
Sequence conflicti653R → E in AAA86430 (PubMed:7945318).Curated1
Sequence conflicti653R → E in AAA18949 (PubMed:7945318).Curated1
Sequence conflicti685A → R in AAA86430 (PubMed:7945318).Curated1
Sequence conflicti685A → R in AAA18949 (PubMed:7945318).Curated1
Sequence conflicti764A → R in AAA86430 (PubMed:7945318).Curated1
Sequence conflicti764A → R in AAA18949 (PubMed:7945318).Curated1
Sequence conflicti789Q → H in BAA03530 (PubMed:8404069).Curated1
Sequence conflicti859W → M in AAA86430 (PubMed:7945318).Curated1
Sequence conflicti859W → M in AAA18949 (PubMed:7945318).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07658654R → C in MDPT2; no effect on VCL-binding. 1 PublicationCorresponds to variant dbSNP:rs781520852Ensembl.1
Natural variantiVAR_022303179A → V1 PublicationCorresponds to variant dbSNP:rs28363394EnsemblClinVar.1
Natural variantiVAR_022304219P → S1 PublicationCorresponds to variant dbSNP:rs28363406Ensembl.1
Natural variantiVAR_076587307E → K in MDPT2; no effect on VCL-binding. 1 PublicationCorresponds to variant dbSNP:rs869320697EnsemblClinVar.1
Natural variantiVAR_076588318L → S in MDPT2; no effect on VCL-binding. 1 PublicationCorresponds to variant dbSNP:rs869320696EnsemblClinVar.1
Natural variantiVAR_076589431I → M in MDPT2; no effect on VCL-binding. 1 PublicationCorresponds to variant dbSNP:rs755215402EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0478101 – 370Missing in isoform 3. 2 PublicationsAdd BLAST370
Alternative sequenceiVSP_017494811G → GNCDTCGALQGLKGWPPPLC LATHW in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D14705 mRNA Translation: BAA03530.1
D13866 mRNA Translation: BAA02979.1
L23805 mRNA Translation: AAA86430.1
U03100 mRNA Translation: AAA18949.1
HQ589335 mRNA Translation: AEF32483.1
AF102803
, AF102787, AF102788, AF102789, AF102790, AF102791, AF102792, AF102793, AF102794, AF102795, AF102796, AF102797, AF102798, AF102799, AF102800, AF102801, AF102802 Genomic DNA Translation: AAC99459.1
AY884207 Genomic DNA Translation: AAW56940.1
AC010453 Genomic DNA No translation available.
AC011405 Genomic DNA No translation available.
AC034243 Genomic DNA No translation available.
AC113340 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW62124.1
BC000385 mRNA Translation: AAH00385.1
BC031262 mRNA Translation: AAH31262.1
L22080 mRNA Translation: AAA35502.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34243.1 [P35221-1]
CCDS75315.1 [P35221-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC2542
JN0607

NCBI Reference Sequences

More...
RefSeqi
NP_001277236.1, NM_001290307.2
NP_001277238.1, NM_001290309.2
NP_001277239.1, NM_001290310.2
NP_001277241.1, NM_001290312.1 [P35221-3]
NP_001310911.1, NM_001323982.1 [P35221-1]
NP_001310912.1, NM_001323983.1 [P35221-1]
NP_001310913.1, NM_001323984.1 [P35221-1]
NP_001310916.1, NM_001323987.1 [P35221-3]
NP_001310917.1, NM_001323988.1 [P35221-3]
NP_001310918.1, NM_001323989.1 [P35221-3]
NP_001310919.1, NM_001323990.1 [P35221-3]
NP_001310920.1, NM_001323991.1 [P35221-3]
NP_001310921.1, NM_001323992.1 [P35221-3]
NP_001310922.1, NM_001323993.1 [P35221-3]
NP_001310923.1, NM_001323994.1 [P35221-3]
NP_001310924.1, NM_001323995.1 [P35221-3]
NP_001310925.1, NM_001323996.1 [P35221-3]
NP_001310926.1, NM_001323997.1 [P35221-3]
NP_001310927.1, NM_001323998.1 [P35221-3]
NP_001310928.1, NM_001323999.1 [P35221-3]
NP_001310929.1, NM_001324000.1 [P35221-3]
NP_001894.2, NM_001903.4 [P35221-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.445981

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000302763; ENSP00000304669; ENSG00000044115 [P35221-1]
ENST00000540387; ENSP00000438476; ENSG00000044115 [P35221-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1495

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1495

UCSC genome browser

More...
UCSCi
uc003ldh.4 human [P35221-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14705 mRNA Translation: BAA03530.1
D13866 mRNA Translation: BAA02979.1
L23805 mRNA Translation: AAA86430.1
U03100 mRNA Translation: AAA18949.1
HQ589335 mRNA Translation: AEF32483.1
AF102803
, AF102787, AF102788, AF102789, AF102790, AF102791, AF102792, AF102793, AF102794, AF102795, AF102796, AF102797, AF102798, AF102799, AF102800, AF102801, AF102802 Genomic DNA Translation: AAC99459.1
AY884207 Genomic DNA Translation: AAW56940.1
AC010453 Genomic DNA No translation available.
AC011405 Genomic DNA No translation available.
AC034243 Genomic DNA No translation available.
AC113340 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW62124.1
BC000385 mRNA Translation: AAH00385.1
BC031262 mRNA Translation: AAH31262.1
L22080 mRNA Translation: AAA35502.1
CCDSiCCDS34243.1 [P35221-1]
CCDS75315.1 [P35221-3]
PIRiJC2542
JN0607
RefSeqiNP_001277236.1, NM_001290307.2
NP_001277238.1, NM_001290309.2
NP_001277239.1, NM_001290310.2
NP_001277241.1, NM_001290312.1 [P35221-3]
NP_001310911.1, NM_001323982.1 [P35221-1]
NP_001310912.1, NM_001323983.1 [P35221-1]
NP_001310913.1, NM_001323984.1 [P35221-1]
NP_001310916.1, NM_001323987.1 [P35221-3]
NP_001310917.1, NM_001323988.1 [P35221-3]
NP_001310918.1, NM_001323989.1 [P35221-3]
NP_001310919.1, NM_001323990.1 [P35221-3]
NP_001310920.1, NM_001323991.1 [P35221-3]
NP_001310921.1, NM_001323992.1 [P35221-3]
NP_001310922.1, NM_001323993.1 [P35221-3]
NP_001310923.1, NM_001323994.1 [P35221-3]
NP_001310924.1, NM_001323995.1 [P35221-3]
NP_001310925.1, NM_001323996.1 [P35221-3]
NP_001310926.1, NM_001323997.1 [P35221-3]
NP_001310927.1, NM_001323998.1 [P35221-3]
NP_001310928.1, NM_001323999.1 [P35221-3]
NP_001310929.1, NM_001324000.1 [P35221-3]
NP_001894.2, NM_001903.4 [P35221-1]
UniGeneiHs.445981

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H6GX-ray2.20A/B377-632[»]
4EHPX-ray2.66B277-382[»]
4IGGX-ray3.66A/B82-906[»]
ProteinModelPortaliP35221
SMRiP35221
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107876, 94 interactors
CORUMiP35221
DIPiDIP-515N
IntActiP35221, 77 interactors
MINTiP35221
STRINGi9606.ENSP00000304669

PTM databases

iPTMnetiP35221
PhosphoSitePlusiP35221
SwissPalmiP35221

Polymorphism and mutation databases

BioMutaiCTNNA1
DMDMi461853

Proteomic databases

EPDiP35221
MaxQBiP35221
PaxDbiP35221
PeptideAtlasiP35221
PRIDEiP35221
ProteomicsDBi54986
54987 [P35221-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1495
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302763; ENSP00000304669; ENSG00000044115 [P35221-1]
ENST00000540387; ENSP00000438476; ENSG00000044115 [P35221-3]
GeneIDi1495
KEGGihsa:1495
UCSCiuc003ldh.4 human [P35221-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1495
DisGeNETi1495
EuPathDBiHostDB:ENSG00000044115.20

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CTNNA1
HGNCiHGNC:2509 CTNNA1
HPAiCAB021089
HPA046119
HPA063535
MalaCardsiCTNNA1
MIMi116805 gene
608970 phenotype
neXtProtiNX_P35221
OpenTargetsiENSG00000044115
Orphaneti99001 Butterfly-shaped pigment dystrophy
26106 Hereditary diffuse gastric cancer
PharmGKBiPA27008

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3681 Eukaryota
ENOG410XSRU LUCA
GeneTreeiENSGT00940000153356
HOGENOMiHOG000280724
HOVERGENiHBG000069
InParanoidiP35221
KOiK05691
OMAiADMSDVY
OrthoDBiEOG091G01KR
PhylomeDBiP35221
TreeFamiTF313686

Enzyme and pathway databases

ReactomeiR-HSA-375170 CDO in myogenesis
R-HSA-418990 Adherens junctions interactions
R-HSA-5218920 VEGFR2 mediated vascular permeability
R-HSA-5626467 RHO GTPases activate IQGAPs
SIGNORiP35221

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CTNNA1 human
EvolutionaryTraceiP35221

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Catenin_(cadherin-associated_protein),_alpha_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1495

Protein Ontology

More...
PROi
PR:P35221

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000044115 Expressed in 237 organ(s), highest expression level in corpus callosum
CleanExiHS_CTNNA1
ExpressionAtlasiP35221 baseline and differential
GenevisibleiP35221 HS

Family and domain databases

InterProiView protein in InterPro
IPR036723 Alpha-catenin/vinculin-like_sf
IPR001033 Alpha_catenin
IPR030047 CTNNA1
IPR006077 Vinculin/catenin
IPR000633 Vinculin_CS
PANTHERiPTHR18914 PTHR18914, 1 hit
PTHR18914:SF24 PTHR18914:SF24, 1 hit
PfamiView protein in Pfam
PF01044 Vinculin, 2 hits
PRINTSiPR00805 ALPHACATENIN
SUPFAMiSSF47220 SSF47220, 4 hits
PROSITEiView protein in PROSITE
PS00663 VINCULIN_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTNA1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35221
Secondary accession number(s): Q12795, Q8N1C0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: December 5, 2018
This is version 196 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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