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UniProtKB - P35211 (ORYZ_ASPFL)
Protein
Alkaline protease 1
Gene
alp1
Organism
Aspergillus flavus
Status
Functioni
Secreted alkaline protease that allows assimilation of proteinaceous substrates.
By similarityCatalytic activityi
- Hydrolysis of proteins with broad specificity, and of Bz-Arg-OEt > Ac-Tyr-OEt. Does not hydrolyze peptide amides. EC:3.4.21.63
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 162 | Charge relay systemPROSITE-ProRule annotation | 1 | |
Active sitei | 193 | Charge relay systemPROSITE-ProRule annotation | 1 | |
Active sitei | 349 | Charge relay systemPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- serine-type endopeptidase activity Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Enzyme and pathway databases
BRENDAi | 3.4.21.63, 506 |
Protein family/group databases
MEROPSi | S08.053 |
Names & Taxonomyi
Protein namesi | Recommended name: Alkaline protease 1 (EC:3.4.21.63)Short name: ALP Alternative name(s): Aspergillopeptidase B Aspergillus proteinase B Elastase Elastinolytic serine proteinase Oryzin |
Gene namesi | Name:alp1 Synonyms:alk1, alp |
Organismi | Aspergillus flavus |
Taxonomic identifieri | 5059 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Circumdati |
Organism-specific databases
VEuPathDBi | FungiDB:AFLA_027810 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
PropeptideiPRO_0000027080 | 22 – 121 | Add BLAST | 100 | |
ChainiPRO_0000027081 | 122 – 403 | Alkaline protease 1Add BLAST | 282 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 253 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 309 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, ZymogenFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 120 | Inhibitor I9Sequence analysisAdd BLAST | 85 | |
Domaini | 130 – 403 | Peptidase S8PROSITE-ProRule annotationAdd BLAST | 274 |
Sequence similaritiesi
Belongs to the peptidase S8 family.Curated
Keywords - Domaini
SignalFamily and domain databases
CDDi | cd04077, Peptidases_S8_PCSK9_ProteinaseK_like, 1 hit |
Gene3Di | 3.30.70.80, 1 hit 3.40.50.200, 1 hit |
InterProi | View protein in InterPro IPR034193, PCSK9_ProteinaseK-like IPR000209, Peptidase_S8/S53_dom IPR036852, Peptidase_S8/S53_dom_sf IPR022398, Peptidase_S8_His-AS IPR023828, Peptidase_S8_Ser-AS IPR015500, Peptidase_S8_subtilisin-rel IPR010259, S8pro/Inhibitor_I9 IPR037045, S8pro/Inhibitor_I9_sf |
Pfami | View protein in Pfam PF05922, Inhibitor_I9, 1 hit PF00082, Peptidase_S8, 1 hit |
PRINTSi | PR00723, SUBTILISIN |
SUPFAMi | SSF52743, SSF52743, 1 hit |
PROSITEi | View protein in PROSITE PS51892, SUBTILASE, 1 hit PS00137, SUBTILASE_HIS, 1 hit PS00138, SUBTILASE_SER, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P35211-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQSIKRTLLL LGAVLPAVLA GPIFPHRRAP TTIPGKYIVT FKSDVDQAAI
60 70 80 90 100
DKHTAWATDI HKRNLQRRDS SEEDLPIGIE RNFKINKFAA YSGSFDEDTI
110 120 130 140 150
AQIRQSDEVA AVEEDQVWHL FDLTTQSDAP WGLGSISHKG QPSTDYIYDT
160 170 180 190 200
NGGEGTYAYV VDIGINVDHE EFEGRASLAY HAAGGQHVDG VGHGTHVSGT
210 220 230 240 250
IGGKTYGVAK KANLLSVKVF VGESSSTSII LDGFNWAAND IVSKKRTGKA
260 270 280 290 300
AINMSLGGGY SKAFNDAVEN AFNEGVLSIV AAGNENTDAS RTSPASAPDA
310 320 330 340 350
FTVAAINVNN TRAYFSNYGS VVDIFAPGQN ILSAWIGSNT ATNTISGTSM
360 370 380 390 400
ATPHIVGLSI YLMSLEVLSS PKAVSDRIKE LATRGVVSNV AGSPNLLAYN
GNA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L08473 Genomic DNA Translation: AAA32691.1 S67840 Genomic DNA Translation: AAB29384.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L08473 Genomic DNA Translation: AAA32691.1 S67840 Genomic DNA Translation: AAB29384.1 |
3D structure databases
SMRi | P35211 |
ModBasei | Search... |
Protein family/group databases
MEROPSi | S08.053 |
Organism-specific databases
VEuPathDBi | FungiDB:AFLA_027810 |
Enzyme and pathway databases
BRENDAi | 3.4.21.63, 506 |
Family and domain databases
CDDi | cd04077, Peptidases_S8_PCSK9_ProteinaseK_like, 1 hit |
Gene3Di | 3.30.70.80, 1 hit 3.40.50.200, 1 hit |
InterProi | View protein in InterPro IPR034193, PCSK9_ProteinaseK-like IPR000209, Peptidase_S8/S53_dom IPR036852, Peptidase_S8/S53_dom_sf IPR022398, Peptidase_S8_His-AS IPR023828, Peptidase_S8_Ser-AS IPR015500, Peptidase_S8_subtilisin-rel IPR010259, S8pro/Inhibitor_I9 IPR037045, S8pro/Inhibitor_I9_sf |
Pfami | View protein in Pfam PF05922, Inhibitor_I9, 1 hit PF00082, Peptidase_S8, 1 hit |
PRINTSi | PR00723, SUBTILISIN |
SUPFAMi | SSF52743, SSF52743, 1 hit |
PROSITEi | View protein in PROSITE PS51892, SUBTILASE, 1 hit PS00137, SUBTILASE_HIS, 1 hit PS00138, SUBTILASE_SER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ORYZ_ASPFL | |
Accessioni | P35211Primary (citable) accession number: P35211 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | February 1, 1994 | |
Last modified: | February 23, 2022 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families