UniProtKB - P35169 (TOR1_YEAST)

BLAST

>sp|P35169|TOR1_YEAST Serine/threonine-protein kinase TOR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=TOR1 PE=1 SV=3
MEPHEEQIWKSKLLKAANNDMDMDRNVPLAPNLNVNMNMKMNASRNGDEFGLTSSRFDGV
VIGSNGDVNFKPILEKIFRELTSDYKEERKLASISLFDLLVSLEHELSIEEFQAVSNDIN
NKILELVHTKKTSTRVGAVLSIDTLISFYAYTERLPNETSRLAGYLRGLIPSNDVEVMRL
AAKTLGKLAVPGGTYTSDFVEFEIKSCLEWLTASTEKNSFSSSKPDHAKHAALLIITALA
ENCPYLLYQYLNSILDNIWRALRDPHLVIRIDASITLAKCLSTLRNRDPQLTSQWVQRLA
TSCEYGFQVNTLECIHASLLVYKEILFLKDPFLNQVFDQMCLNCIAYENHKAKMIREKIY
QIVPLLASFNPQLFAGKYLHQIMDNYLEILTNAPANKIPHLKDDKPQILISIGDIAYEVG
PDIAPYVKQILDYIEHDLQTKFKFRKKFENEIFYCIGRLAVPLGPVLGKLLNRNILDLMF
KCPLSDYMQETFQILTERIPSLGPKINDELLNLVCSTLSGTPFIQPGSPMEIPSFSRERA
REWRNKNILQKTGESNDDNNDIKIIIQAFRMLKNIKSRFSLVEFVRIVALSYIEHTDPRV
RKLAALTSCEIYVKDNICKQTSLHSLNTVSEVLSKLLAITIADPLQDIRLEVLKNLNPCF
DPQLAQPDNLRLLFTALHDESFNIQSVAMELVGRLSSVNPAYVIPSIRKILLELLTKLKF
STSSREKEETASLLCTLIRSSKDVAKPYIEPLLNVLLPKFQDTSSTVASTALRTIGELSV
VGGEDMKIYLKDLFPLIIKTFQDQSNSFKREAALKALGQLAASSGYVIDPLLDYPELLGI
LVNILKTENSQNIRRQTVTLIGILGAIDPYRQKEREVTSTTDISTEQNAPPIDIALLMQG
MSPSNDEYYTTVVIHCLLKILKDPSLSSYHTAVIQAIMHIFQTLGLKCVSFLDQIIPTIL
DVMRTCSQSLLEFYFQQLCSLIIIVRQHIRPHVDSIFQAIKDFSSVAKLQITLVSVIEAI
SKALEGEFKRLVPLTLTLFLVILENDKSSDKVLSRRVLRLLESFGPNLEGYSHLITPKIV
QMAEFTSGNLQRSAIITIGKLAKDVDLFEMSSRIVHSLLRVLSSTTSDELSKVIMNTLSL
LLIQMGTSFAIFIPVINEVLMKKHIQHTIYDDLTNRILNNDVLPTKILEANTTDYKPAEQ
MEAADAGVAKLPINQSVLKSAWNSSQQRTKEDWQEWSKRLSIQLLKESPSHALRACSNLA
SMYYPLAKELFNTAFACVWTELYSQYQEDLIGSLCIALSSPLNPPEIHQTLLNLVEFMEH
DDKALPIPTQSLGEYAERCHAYAKALHYKEIKFIKEPENSTIESLISINNQLNQTDAAIG
ILKHAQQHHSLQLKETWFEKLERWEDALHAYNEREKAGDTSVSVTLGKMRSLHALGEWEQ
LSQLAARKWKVSKLQTKKLIAPLAAGAAWGLGEWDMLEQYISVMKPKSPDKEFFDAILYL
HKNDYDNASKHILNARDLLVTEISALINESYNRAYSVIVRTQIITEFEEIIKYKQLPPNS
EKKLHYQNLWTKRLLGCQKNVDLWQRVLRVRSLVIKPKQDLQIWIKFANLCRKSGRMRLA
NKALNMLLEGGNDPSLPNTFKAPPPVVYAQLKYIWATGAYKEALNHLIGFTSRLAHDLGL
DPNNMIAQSVKLSSASTAPYVEEYTKLLARCFLKQGEWRIATQPNWRNTNPDAILGSYLL
ATHFDKNWYKAWHNWALANFEVISMVQEETKLNGGKNDDDDDTAVNNDNVRIDGSILGSG
SLTINGNRYPLELIQRHVVPAIKGFFHSISLLETSCLQDTLRLLTLLFNFGGIKEVSQAM
YEGFNLMKIENWLEVLPQLISRIHQPDPTVSNSLLSLLSDLGKAHPQALVYPLTVAIKSE
SVSRQKAALSIIEKIRIHSPVLVNQAELVSHELIRVAVLWHELWYEGLEDASRQFFVEHN
IEKMFSTLEPLHKHLGNEPQTLSEVSFQKSFGRDLNDAYEWLNNYKKSKDINNLNQAWDI
YYNVFRKITRQIPQLQTLDLQHVSPQLLATHDLELAVPGTYFPGKPTIRIAKFEPLFSVI
SSKQRPRKFSIKGSDGKDYKYVLKGHEDIRQDSLVMQLFGLVNTLLKNDSECFKRHLDIQ
QYPAIPLSPKSGLLGWVPNSDTFHVLIREHRDAKKIPLNIEHWVMLQMAPDYENLTLLQK
IEVFTYALDNTKGQDLYKILWLKSRSSETWLERRTTYTRSLAVMSMTGYILGLGDRHPSN
LMLDRITGKVIHIDFGDCFEAAILREKYPEKVPFRLTRMLTYAMEVSGIEGSFRITCENV
MRVLRDNKESLMAILEAFALDPLIHWGFDLPPQKLTEQTGIPLPLINPSELLRKGAITVE
EAANMEAEQQNETKNARAMLVLRRITDKLTGNDIKRFNELDVPEQVDKLIQQATSIERLC
QHYIGWCPFW

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History
Entry version 189 (05 Dec 2018)
Sequence version 3 (01 Nov 1995)
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Protein

Serine/threonine-protein kinase TOR1

Gene

TOR1

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Phosphatidylinositol 3-kinase homolog, component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. TORC1 controls many of these processes via TIP41-TAP42-mediated inhibition of the type 2A-related phosphatases PP2A and SIT4 (PubMed:10198052, PubMed:10329624, PubMed:10604478, PubMed:10995454, PubMed:11741537, PubMed:15620355, PubMed:7606777, PubMed:8741837, PubMed:9539725, PubMed:9843498). In nutrient rich conditions, responsible for the phosphorylation of AGC S6 kinase (S6K) YPK3, activating YPK3 kinase activity and promoting phosphorylation of ribosomal protein S6 (PubMed:25767889). Phosphorylates kinase SCH9 at 6 amino acids in the C-terminus, activating SCH9 kinase activity to properly regulate ribosome biogenesis, translation initiation, and entry into stationary phase (PubMed:17560372).12 Publications

Miscellaneous

It may act on another substrate or phosphorylate a different position in the phosphatidylinositol ring.

Present with 589 molecules/cell in log phase SD medium.1 Publication

Caution

It is uncertain whether Met-1 is the initiator.Curated

Catalytic activityⁱ

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
protein-containing complex binding Source: InterPro
protein kinase activity
Source: SGD
Inferred from mutant phenotypeⁱ
- 10329624
protein serine/threonine kinase activity
Source: SGD
Inferred from direct assayⁱ
- 26582391

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to DNA damage stimulus
Source: SGD
Inferred from mutant phenotypeⁱ
- 17698581
cellular response to heat
Source: SGD
Inferred from genetic interactionⁱ
- 27922823
cellular response to oxidative stress
Source: SGD
Inferred from genetic interactionⁱ
- 27922823
chronological cell aging
Source: SGD
Inferred from genetic interactionⁱ
- 27922823
fungal-type cell wall organization
Source: SGD
Inferred from mutant phenotypeⁱ
- 14736892
meiotic cell cycle
Source: SGD
Inferred from mutant phenotypeⁱ
- 9096347
mitochondria-nucleus signaling pathway
Source: SGD
Inferred from mutant phenotypeⁱ
- 11997479
negative regulation of autophagy
Source: SGD
Inferred from genetic interactionⁱ
- 9461583
negative regulation of macroautophagy
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of protein kinase activity by regulation of protein phosphorylation
Source: SGD
Inferred from mutant phenotypeⁱ
- 16980405
nucleolar large rRNA transcription by RNA polymerase I
Source: SGD
Inferred from mutant phenotypeⁱ
- 16900101
peptidyl-serine phosphorylation
Source: SGD
Inferred from direct assayⁱ
- 26582391
regulation of cell cycle
Source: SGD
Inferred from mutant phenotypeⁱ
- 8741837
regulation of cell growth
Source: SGD
Inferred from mutant phenotypeⁱ
- 12171921
regulation of snRNA pseudouridine synthesis
Source: SGD
Inferred from genetic interactionⁱ
- 27268497
regulation of sphingolipid biosynthetic process
Source: SGD
Inferred from mutant phenotypeⁱ
- 23363605
ribosome biogenesis
Source: SGD
Inferred from mutant phenotypeⁱ
- 10198052
TORC1 signaling
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
TOR signaling
Source: SGD
Inferred from mutant phenotypeⁱ
- 12719473
- 8186460
translational initiation
Source: SGD
Inferred from mutant phenotypeⁱ
- 8741837

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Biological process	Cell cycle
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-31699-MONOMER
BRENDAⁱ	2.7.1.137 984

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine-protein kinase TOR1 (EC:2.7.11.1) Alternative name(s): Dominant rapamycin resistance protein 1 Phosphatidylinositol kinase homolog TOR1 Target of rapamycin kinase 1
Gene namesⁱ	Name:TOR1 Synonyms:DRR1 Ordered Locus Names:YJR066W ORF Names:J1803
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome X

Organism-specific databases

Saccharomyces Genome Database More...SGDⁱ	S000003827 TOR1

SGDⁱ

S000003827 TOR1

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Vacuole

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	1972	S → A: No effect. 2 Publications	1
Mutagenesisⁱ	1972	S → E or I: Confers resistance to rapamycin. Abolishes interaction with FKBP-rapamycin. 2 Publications	1
Mutagenesisⁱ	1972	S → N in DRR1-27; confers resistance to rapamycin. 2 Publications	1
Mutagenesisⁱ	1972	S → R in DRR1-1; confers resistance to rapamycin. Abolishes interaction with FKBP-rapamycin. 2 Publications	1
Mutagenesisⁱ	2275	D → A: Abolishes protein kinase activity. 1 Publication	1
Mutagenesisⁱ	2276	R → P: Abolishes rapamycin-resistance of mutants E-1972; I-1972 and R-1972. 1 Publication	1
Mutagenesisⁱ	2294	D → E: Abolishes rapamycin-resistance of mutants E-1972; I-1972 and R-1972. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000088813	1 – 2470	Serine/threonine-protein kinase TOR1Add BLAST		2470

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P35169
PaxDbⁱ	P35169
PRIDEⁱ	P35169

PTM databases

iPTMnetⁱ	P35169

iPTMnetⁱ

P35169

Interactionⁱ

Subunit structureⁱ

The target of rapamycin complex 1 (TORC1) is composed of at least KOG1, LST8, TCO89 and either TOR1 (TORC1-A) or TOR2 (TORC1-B). TORC1 binds to and is inhibited by FKBP-rapamycin.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
FMP48	P53233	3	EBI-19374,EBI-9664
FPR1	P20081	4	EBI-19374,EBI-6961
KOG1	P38873	7	EBI-19374,EBI-24864
KSP1	P38691	2	EBI-19374,EBI-9937
LST8	P41318	5	EBI-19374,EBI-28598
MKS1	P34072	3	EBI-19374,EBI-10978
NNK1	P36003	3	EBI-19374,EBI-9796
NPR1	P22211	2	EBI-19374,EBI-12207
SKY1	Q03656	2	EBI-19374,EBI-9800
TCO89	Q08921	4	EBI-19374,EBI-37395

Protein-protein interaction databases

BioGridⁱ	33823, 449 interactors
ComplexPortalⁱ	CPX-1715 TORC1 complex variant 1
Database of interacting proteins More...DIPⁱ	DIP-917N
IntActⁱ	P35169, 37 interactors
Molecular INTeraction database More...MINTⁱ	P35169
STRINGⁱ	4932.YJR066W

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	2444 – 2460	Combined sources		17

Show more details

3D structure databases

ProteinModelPortalⁱ	P35169
SMRⁱ	P35169
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P35169

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	114 – 151	HEAT 1Add BLAST	38
Repeatⁱ	249 – 286	HEAT 2Add BLAST	38
Repeatⁱ	627 – 663	HEAT 3Add BLAST	37
Repeatⁱ	664 – 701	HEAT 4Add BLAST	38
Repeatⁱ	747 – 784	HEAT 5Add BLAST	38
Repeatⁱ	788 – 826	HEAT 6Add BLAST	39
Repeatⁱ	832 – 870	HEAT 7Add BLAST	39
Repeatⁱ	908 – 946	HEAT 8Add BLAST	39
Repeatⁱ	950 – 987	HEAT 9Add BLAST	38
Repeatⁱ	1069 – 1107	HEAT 10Add BLAST	39
Repeatⁱ	1109 – 1147	HEAT 11Add BLAST	39
Domainⁱ	1331 – 1919	FATPROSITE-ProRule annotationAdd BLAST	589
Domainⁱ	2125 – 2437	PI3K/PI4KPROSITE-ProRule annotationAdd BLAST	313
Domainⁱ	2438 – 2470	FATCPROSITE-ProRule annotationAdd BLAST	33

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1775 – 2157	Interaction with FKBP-rapamycinAdd BLAST		383

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	441 – 447	Arg/Lys-rich (basic)		7

Sequence similaritiesⁱ

Belongs to the PI3/PI4-kinase family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000174195
HOGENOMⁱ	HOG000163215
InParanoidⁱ	P35169
KEGG Orthology (KO) More...KOⁱ	K07203
OMAⁱ	VCSLCIC
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C00HJ

Family and domain databases

Gene3Dⁱ	1.10.1070.11, 1 hit 1.20.120.150, 1 hit 1.25.10.10, 3 hits
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR024585 DUF3385_TOR IPR003152 FATC_dom IPR009076 FRB_dom IPR036738 FRB_sf IPR011009 Kinase-like_dom_sf IPR000403 PI3/4_kinase_cat_dom IPR036940 PI3/4_kinase_cat_sf IPR018936 PI3/4_kinase_CS IPR003151 PIK-rel_kinase_FAT IPR014009 PIK_FAT IPR026683 TOR
PANTHERⁱ	PTHR11139:SF9 PTHR11139:SF9, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11865 DUF3385, 1 hit PF02259 FAT, 1 hit PF02260 FATC, 1 hit PF08771 FRB_dom, 1 hit PF00454 PI3_PI4_kinase, 1 hit
SMARTⁱ	View protein in SMART SM01346 DUF3385, 1 hit SM01343 FATC, 1 hit SM00146 PI3Kc, 1 hit
SUPFAMⁱ	SSF47212 SSF47212, 1 hit SSF48371 SSF48371, 2 hits SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51189 FAT, 1 hit PS51190 FATC, 1 hit PS00915 PI3_4_KINASE_1, 1 hit PS00916 PI3_4_KINASE_2, 1 hit PS50290 PI3_4_KINASE_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P35169-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MEPHEEQIWK SKLLKAANND MDMDRNVPLA PNLNVNMNMK MNASRNGDEF 
        60         70         80         90        100
GLTSSRFDGV VIGSNGDVNF KPILEKIFRE LTSDYKEERK LASISLFDLL 
       110        120        130        140        150
VSLEHELSIE EFQAVSNDIN NKILELVHTK KTSTRVGAVL SIDTLISFYA 
       160        170        180        190        200
YTERLPNETS RLAGYLRGLI PSNDVEVMRL AAKTLGKLAV PGGTYTSDFV 
       210        220        230        240        250
EFEIKSCLEW LTASTEKNSF SSSKPDHAKH AALLIITALA ENCPYLLYQY 
       260        270        280        290        300
LNSILDNIWR ALRDPHLVIR IDASITLAKC LSTLRNRDPQ LTSQWVQRLA 
       310        320        330        340        350
TSCEYGFQVN TLECIHASLL VYKEILFLKD PFLNQVFDQM CLNCIAYENH 
       360        370        380        390        400
KAKMIREKIY QIVPLLASFN PQLFAGKYLH QIMDNYLEIL TNAPANKIPH 
       410        420        430        440        450
LKDDKPQILI SIGDIAYEVG PDIAPYVKQI LDYIEHDLQT KFKFRKKFEN 
       460        470        480        490        500
EIFYCIGRLA VPLGPVLGKL LNRNILDLMF KCPLSDYMQE TFQILTERIP 
       510        520        530        540        550
SLGPKINDEL LNLVCSTLSG TPFIQPGSPM EIPSFSRERA REWRNKNILQ 
       560        570        580        590        600
KTGESNDDNN DIKIIIQAFR MLKNIKSRFS LVEFVRIVAL SYIEHTDPRV 
       610        620        630        640        650
RKLAALTSCE IYVKDNICKQ TSLHSLNTVS EVLSKLLAIT IADPLQDIRL 
       660        670        680        690        700
EVLKNLNPCF DPQLAQPDNL RLLFTALHDE SFNIQSVAME LVGRLSSVNP 
       710        720        730        740        750
AYVIPSIRKI LLELLTKLKF STSSREKEET ASLLCTLIRS SKDVAKPYIE 
       760        770        780        790        800
PLLNVLLPKF QDTSSTVAST ALRTIGELSV VGGEDMKIYL KDLFPLIIKT 
       810        820        830        840        850
FQDQSNSFKR EAALKALGQL AASSGYVIDP LLDYPELLGI LVNILKTENS 
       860        870        880        890        900
QNIRRQTVTL IGILGAIDPY RQKEREVTST TDISTEQNAP PIDIALLMQG 
       910        920        930        940        950
MSPSNDEYYT TVVIHCLLKI LKDPSLSSYH TAVIQAIMHI FQTLGLKCVS 
       960        970        980        990       1000
FLDQIIPTIL DVMRTCSQSL LEFYFQQLCS LIIIVRQHIR PHVDSIFQAI 
      1010       1020       1030       1040       1050
KDFSSVAKLQ ITLVSVIEAI SKALEGEFKR LVPLTLTLFL VILENDKSSD 
      1060       1070       1080       1090       1100
KVLSRRVLRL LESFGPNLEG YSHLITPKIV QMAEFTSGNL QRSAIITIGK 
      1110       1120       1130       1140       1150
LAKDVDLFEM SSRIVHSLLR VLSSTTSDEL SKVIMNTLSL LLIQMGTSFA 
      1160       1170       1180       1190       1200
IFIPVINEVL MKKHIQHTIY DDLTNRILNN DVLPTKILEA NTTDYKPAEQ 
      1210       1220       1230       1240       1250
MEAADAGVAK LPINQSVLKS AWNSSQQRTK EDWQEWSKRL SIQLLKESPS 
      1260       1270       1280       1290       1300
HALRACSNLA SMYYPLAKEL FNTAFACVWT ELYSQYQEDL IGSLCIALSS 
      1310       1320       1330       1340       1350
PLNPPEIHQT LLNLVEFMEH DDKALPIPTQ SLGEYAERCH AYAKALHYKE 
      1360       1370       1380       1390       1400
IKFIKEPENS TIESLISINN QLNQTDAAIG ILKHAQQHHS LQLKETWFEK 
      1410       1420       1430       1440       1450
LERWEDALHA YNEREKAGDT SVSVTLGKMR SLHALGEWEQ LSQLAARKWK 
      1460       1470       1480       1490       1500
VSKLQTKKLI APLAAGAAWG LGEWDMLEQY ISVMKPKSPD KEFFDAILYL 
      1510       1520       1530       1540       1550
HKNDYDNASK HILNARDLLV TEISALINES YNRAYSVIVR TQIITEFEEI 
      1560       1570       1580       1590       1600
IKYKQLPPNS EKKLHYQNLW TKRLLGCQKN VDLWQRVLRV RSLVIKPKQD 
      1610       1620       1630       1640       1650
LQIWIKFANL CRKSGRMRLA NKALNMLLEG GNDPSLPNTF KAPPPVVYAQ 
      1660       1670       1680       1690       1700
LKYIWATGAY KEALNHLIGF TSRLAHDLGL DPNNMIAQSV KLSSASTAPY 
      1710       1720       1730       1740       1750
VEEYTKLLAR CFLKQGEWRI ATQPNWRNTN PDAILGSYLL ATHFDKNWYK 
      1760       1770       1780       1790       1800
AWHNWALANF EVISMVQEET KLNGGKNDDD DDTAVNNDNV RIDGSILGSG 
      1810       1820       1830       1840       1850
SLTINGNRYP LELIQRHVVP AIKGFFHSIS LLETSCLQDT LRLLTLLFNF 
      1860       1870       1880       1890       1900
GGIKEVSQAM YEGFNLMKIE NWLEVLPQLI SRIHQPDPTV SNSLLSLLSD 
      1910       1920       1930       1940       1950
LGKAHPQALV YPLTVAIKSE SVSRQKAALS IIEKIRIHSP VLVNQAELVS 
      1960       1970       1980       1990       2000
HELIRVAVLW HELWYEGLED ASRQFFVEHN IEKMFSTLEP LHKHLGNEPQ 
      2010       2020       2030       2040       2050
TLSEVSFQKS FGRDLNDAYE WLNNYKKSKD INNLNQAWDI YYNVFRKITR 
      2060       2070       2080       2090       2100
QIPQLQTLDL QHVSPQLLAT HDLELAVPGT YFPGKPTIRI AKFEPLFSVI 
      2110       2120       2130       2140       2150
SSKQRPRKFS IKGSDGKDYK YVLKGHEDIR QDSLVMQLFG LVNTLLKNDS 
      2160       2170       2180       2190       2200
ECFKRHLDIQ QYPAIPLSPK SGLLGWVPNS DTFHVLIREH RDAKKIPLNI 
      2210       2220       2230       2240       2250
EHWVMLQMAP DYENLTLLQK IEVFTYALDN TKGQDLYKIL WLKSRSSETW 
      2260       2270       2280       2290       2300
LERRTTYTRS LAVMSMTGYI LGLGDRHPSN LMLDRITGKV IHIDFGDCFE 
      2310       2320       2330       2340       2350
AAILREKYPE KVPFRLTRML TYAMEVSGIE GSFRITCENV MRVLRDNKES 
      2360       2370       2380       2390       2400
LMAILEAFAL DPLIHWGFDL PPQKLTEQTG IPLPLINPSE LLRKGAITVE 
      2410       2420       2430       2440       2450
EAANMEAEQQ NETKNARAML VLRRITDKLT GNDIKRFNEL DVPEQVDKLI 
      2460       2470
QQATSIERLC QHYIGWCPFW

Length:2,470

Mass (Da):281,140

Last modified:November 1, 1995 - v3

Checksum:ⁱACB1781B9963BB1E

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	58	D → G in AAB66881 (PubMed:8413204).Curated	1
Sequence conflictⁱ	115	V → I in AAB66881 (PubMed:8413204).Curated	1
Sequence conflictⁱ	133	S → N in AAB66881 (PubMed:8413204).Curated	1
Sequence conflictⁱ	231	A → R in CAA52849 (PubMed:8186460).Curated	1
Sequence conflictⁱ	396	N → K in AAB66881 (PubMed:8413204).Curated	1
Sequence conflictⁱ	396	N → K in CAA52849 (PubMed:8186460).Curated	1
Sequence conflictⁱ	547	N → S in AAB66881 (PubMed:8413204).Curated	1
Sequence conflictⁱ	547	N → S in CAA52849 (PubMed:8186460).Curated	1
Sequence conflictⁱ	675	T → I in CAA52849 (PubMed:8186460).Curated	1
Sequence conflictⁱ	1292	G → E in CAA52849 (PubMed:8186460).Curated	1
Sequence conflictⁱ	1436	G → A in CAA52849 (PubMed:8186460).Curated	1
Sequence conflictⁱ	1468	A → R in AAB66881 (PubMed:8413204).Curated	1
Sequence conflictⁱ	1468	A → R in CAA52849 (PubMed:8186460).Curated	1
Sequence conflictⁱ	1469 – 1471	WGL → GGS in CAA52849 (PubMed:8186460).Curated	3
Sequence conflictⁱ	1478 – 1479	EQ → DE in CAA52849 (PubMed:8186460).Curated	2
Sequence conflictⁱ	1590	V → I in CAA52849 (PubMed:8186460).Curated	1
Sequence conflictⁱ	1632 – 1642	NDPSLPNTFKA → TILVYQIRSKP in CAA52849 (PubMed:8186460).CuratedAdd BLAST	11
Sequence conflictⁱ	1640	F → V in AAB66881 (PubMed:8413204).Curated	1
Sequence conflictⁱ	1844	L → S in CAA52849 (PubMed:8186460).Curated	1
Sequence conflictⁱ	2202	H → Q in AAB66881 (PubMed:8413204).Curated	1
Sequence conflictⁱ	2414	K → R in AAB66881 (PubMed:8413204).Curated	1
Sequence conflictⁱ	2414	K → R in CAA52849 (PubMed:8186460).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L19540 Genomic DNA Translation: AAB66881.1 X74857 Genomic DNA Translation: CAA52849.1 Z49566 Genomic DNA Translation: CAA89594.1 L47993 Genomic DNA Translation: AAB39292.1 BK006943 Genomic DNA Translation: DAA08853.1
PIRⁱ	S57085
NCBI Reference Sequences More...RefSeqⁱ	NP_012600.1, NM_001181724.1

Genome annotation databases

EnsemblFungiⁱ	YJR066W_mRNA; YJR066W_mRNA; YJR066W
GeneIDⁱ	853529
KEGGⁱ	sce:YJR066W

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P35169	Serine/threonine-protein kinase TOR		SACAR		2472	UniRef90_P35169
Serine/threonine-protein kinase TOR		YEAS7		2471
Serine/threonine-protein kinase TOR		SACEU		2470
Serine/threonine-protein kinase TOR		YEASK		2470
Serine/threonine-protein kinase TOR		YEAS8		2470
+4

Protein	Similar proteins		Species	Score	Length	Source
P35169	Serine/threonine-protein kinase TOR2	)	YEAST		2474	UniRef50_P35169
Serine/threonine-protein kinase TOR		SACAR		2472
Serine/threonine-protein kinase TOR		YEAS7		2471
Serine/threonine-protein kinase TOR		SACCK		2470
Serine/threonine-protein kinase TOR		Saccharomyces sp. 'boulardii'		2470
+39

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L19540 Genomic DNA Translation: AAB66881.1 X74857 Genomic DNA Translation: CAA52849.1 Z49566 Genomic DNA Translation: CAA89594.1 L47993 Genomic DNA Translation: AAB39292.1 BK006943 Genomic DNA Translation: DAA08853.1
PIRⁱ	S57085
RefSeqⁱ	NP_012600.1, NM_001181724.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1W1N	NMR	-	A	2438-2470	[»]
	2KIO	NMR	-	A	2438-2470	[»]
	2KIT	NMR	-	A	2438-2470	[»]
ProteinModelPortalⁱ	P35169
SMRⁱ	P35169
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	33823, 449 interactors
ComplexPortalⁱ	CPX-1715 TORC1 complex variant 1
DIPⁱ	DIP-917N
IntActⁱ	P35169, 37 interactors
MINTⁱ	P35169
STRINGⁱ	4932.YJR066W

PTM databases

iPTMnetⁱ	P35169

iPTMnetⁱ

P35169

Proteomic databases

MaxQBⁱ	P35169
PaxDbⁱ	P35169
PRIDEⁱ	P35169

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YJR066W_mRNA; YJR066W_mRNA; YJR066W
GeneIDⁱ	853529
KEGGⁱ	sce:YJR066W

Organism-specific databases

SGDⁱ	S000003827 TOR1

Phylogenomic databases

GeneTreeⁱ	ENSGT00940000174195
HOGENOMⁱ	HOG000163215
InParanoidⁱ	P35169
KOⁱ	K07203
OMAⁱ	VCSLCIC
OrthoDBⁱ	EOG092C00HJ

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-31699-MONOMER
BRENDAⁱ	2.7.1.137 984

Miscellaneous databases

EvolutionaryTraceⁱ	P35169
Protein Ontology More...PROⁱ	PR:P35169

Family and domain databases

Gene3Dⁱ	1.10.1070.11, 1 hit 1.20.120.150, 1 hit 1.25.10.10, 3 hits
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR024585 DUF3385_TOR IPR003152 FATC_dom IPR009076 FRB_dom IPR036738 FRB_sf IPR011009 Kinase-like_dom_sf IPR000403 PI3/4_kinase_cat_dom IPR036940 PI3/4_kinase_cat_sf IPR018936 PI3/4_kinase_CS IPR003151 PIK-rel_kinase_FAT IPR014009 PIK_FAT IPR026683 TOR
PANTHERⁱ	PTHR11139:SF9 PTHR11139:SF9, 1 hit
Pfamⁱ	View protein in Pfam PF11865 DUF3385, 1 hit PF02259 FAT, 1 hit PF02260 FATC, 1 hit PF08771 FRB_dom, 1 hit PF00454 PI3_PI4_kinase, 1 hit
SMARTⁱ	View protein in SMART SM01346 DUF3385, 1 hit SM01343 FATC, 1 hit SM00146 PI3Kc, 1 hit
SUPFAMⁱ	SSF47212 SSF47212, 1 hit SSF48371 SSF48371, 2 hits SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51189 FAT, 1 hit PS51190 FATC, 1 hit PS00915 PI3_4_KINASE_1, 1 hit PS00916 PI3_4_KINASE_2, 1 hit PS50290 PI3_4_KINASE_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TOR1_YEAST
Accessionⁱ	P35169Primary (citable) accession number: P35169 Secondary accession number(s): D6VWN7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
	Last sequence update:	November 1, 1995
	Last modified:	December 5, 2018
	This is version 189 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Yeast chromosome X
Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

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UniProtKB - P35169 (TOR1_YEAST)

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Serine/threonine-protein kinase TOR1

TOR1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

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Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ