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UniProtKB - P35154 (SCPA_BACSU)
Protein
Segregation and condensation protein A
Gene
scpA
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
GO - Molecular functioni
- identical protein binding Source: IntAct
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- chromosome segregation Source: UniProtKB-UniRule
- DNA replication Source: UniProtKB-UniRule
Keywordsi
Biological process | Cell cycle, Cell division, Chromosome partition |
Enzyme and pathway databases
BioCyci | BSUB:BSU23220-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Segregation and condensation protein A |
Gene namesi | Name:scpA Synonyms:ypuG Ordered Locus Names:BSU23220 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Note: Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000211080 | 1 – 251 | Segregation and condensation protein AAdd BLAST | 251 |
Proteomic databases
PaxDbi | P35154 |
Interactioni
Subunit structurei
Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.
Binary interactionsi
P35154
With | #Exp. | IntAct |
---|---|---|
itself | 4 | EBI-2121359,EBI-2121359 |
scpB [P35155] | 5 | EBI-2121359,EBI-2121445 |
smc [P51834] | 20 | EBI-2121359,EBI-2121372 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
DIPi | DIP-52200N |
IntActi | P35154, 15 interactors |
STRINGi | 224308.BSU23220 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P35154 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the ScpA family.Curated
Phylogenomic databases
eggNOGi | COG1354, Bacteria |
InParanoidi | P35154 |
OMAi | YLVMAAM |
PhylomeDBi | P35154 |
Family and domain databases
Gene3Di | 1.10.10.580, 1 hit |
HAMAPi | MF_01805, ScpA, 1 hit |
InterProi | View protein in InterPro IPR003768, ScpA IPR023093, ScpA-like_C |
PANTHERi | PTHR33969, PTHR33969, 1 hit |
Pfami | View protein in Pfam PF02616, SMC_ScpA, 1 hit |
i Sequence
Sequence statusi: Complete.
P35154-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEEYQVKIDT FEGPLDLLLH LINRLEIDIY DIPVAKITEQ YLLYVHTMRV
60 70 80 90 100
LELDIASEYL VMAATLLSIK SRMLLPKQEE ELFEDELLEE EDPREELIEK
110 120 130 140 150
LIEYRKYKDA AKDLKEREEE RQKSFTKPPS DLSEYAKEVK QSEQKLSVTV
160 170 180 190 200
YDMIGAFQKV LKRKKINRPM ETTITRQDIP IEARMNEIVH SLKSRGTRIN
210 220 230 240 250
FMDLFPYEQK EHLVVTFLAV LELMKNQLVL IEQEHNFSDI YITGSESIHG
A
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L09228 Genomic DNA Translation: AAA67487.1 AL009126 Genomic DNA Translation: CAB14254.1 |
PIRi | S45549 |
RefSeqi | NP_390203.1, NC_000964.3 WP_003246108.1, NZ_JNCM01000036.1 |
Genome annotation databases
EnsemblBacteriai | CAB14254; CAB14254; BSU_23220 |
GeneIDi | 938950 |
KEGGi | bsu:BSU23220 |
PATRICi | fig|224308.179.peg.2529 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L09228 Genomic DNA Translation: AAA67487.1 AL009126 Genomic DNA Translation: CAB14254.1 |
PIRi | S45549 |
RefSeqi | NP_390203.1, NC_000964.3 WP_003246108.1, NZ_JNCM01000036.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3ZGX | X-ray | 3.40 | C/Z | 1-86 | [»] | |
5H66 | X-ray | 1.82 | C | 176-251 | [»] | |
5H67 | X-ray | 2.07 | C | 176-251 | [»] | |
5XG3 | X-ray | 3.50 | C/D | 167-251 | [»] | |
SMRi | P35154 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-52200N |
IntActi | P35154, 15 interactors |
STRINGi | 224308.BSU23220 |
Proteomic databases
PaxDbi | P35154 |
Genome annotation databases
EnsemblBacteriai | CAB14254; CAB14254; BSU_23220 |
GeneIDi | 938950 |
KEGGi | bsu:BSU23220 |
PATRICi | fig|224308.179.peg.2529 |
Phylogenomic databases
eggNOGi | COG1354, Bacteria |
InParanoidi | P35154 |
OMAi | YLVMAAM |
PhylomeDBi | P35154 |
Enzyme and pathway databases
BioCyci | BSUB:BSU23220-MONOMER |
Family and domain databases
Gene3Di | 1.10.10.580, 1 hit |
HAMAPi | MF_01805, ScpA, 1 hit |
InterProi | View protein in InterPro IPR003768, ScpA IPR023093, ScpA-like_C |
PANTHERi | PTHR33969, PTHR33969, 1 hit |
Pfami | View protein in Pfam PF02616, SMC_ScpA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SCPA_BACSU | |
Accessioni | P35154Primary (citable) accession number: P35154 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | February 1, 1994 | |
Last modified: | February 23, 2022 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families