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Entry version 178 (07 Oct 2020)
Sequence version 1 (01 Feb 1994)
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Protein

Probetacellulin

Gene

BTC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor, Mitogen

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P35070

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1227986, Signaling by ERBB2
R-HSA-1236394, Signaling by ERBB4
R-HSA-1250196, SHC1 events in ERBB2 signaling
R-HSA-1250342, PI3K events in ERBB4 signaling
R-HSA-1250347, SHC1 events in ERBB4 signaling
R-HSA-1251985, Nuclear signaling by ERBB4
R-HSA-1257604, PIP3 activates AKT signaling
R-HSA-177929, Signaling by EGFR
R-HSA-179812, GRB2 events in EGFR signaling
R-HSA-180292, GAB1 signalosome
R-HSA-180336, SHC1 events in EGFR signaling
R-HSA-182971, EGFR downregulation
R-HSA-1963640, GRB2 events in ERBB2 signaling
R-HSA-1963642, PI3K events in ERBB2 signaling
R-HSA-212718, EGFR interacts with phospholipase C-gamma
R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5638303, Inhibition of Signaling by Overexpressed EGFR
R-HSA-5673001, RAF/MAP kinase cascade
R-HSA-6785631, ERBB2 Regulates Cell Motility
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8847993, ERBB2 Activates PTK6 Signaling
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis
R-HSA-8863795, Downregulation of ERBB2 signaling
R-HSA-9009391, Extra-nuclear estrogen signaling
R-HSA-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling
R-HSA-9664565, Signaling by ERBB2 KD Mutants
R-HSA-9665686, Signaling by ERBB2 TMD/JMD mutants

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P35070

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P35070

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probetacellulin
Cleaved into the following chain:
Betacellulin
Short name:
BTC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BTC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000174808.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1121, BTC

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600345, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P35070

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini32 – 118ExtracellularSequence analysisAdd BLAST87
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 178CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
685

Open Targets

More...
OpenTargetsi
ENSG00000174808

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25442

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P35070, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BTC

Domain mapping of disease mutations (DMDM)

More...
DMDMi
461653

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31By similarityAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000030068532 – 178ProbetacellulinAdd BLAST147
ChainiPRO_000000749032 – 111BetacellulinAdd BLAST80
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000007491112 – 178Removed in mature formBy similarityAdd BLAST67

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi69 ↔ 82
Disulfide bondi77 ↔ 93
Disulfide bondi95 ↔ 104

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P35070

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P35070

PeptideAtlas

More...
PeptideAtlasi
P35070

PRoteomics IDEntifications database

More...
PRIDEi
P35070

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
54977

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P35070, 1 site

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P35070

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P35070

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000174808, Expressed in lower esophagus and 159 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P35070, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P35070, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000174808, Tissue enhanced (intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

Interacts with EGFR and ERBB4.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
107150, 25 interactors

Database of interacting proteins

More...
DIPi
DIP-5768N

Protein interaction database and analysis system

More...
IntActi
P35070, 9 interactors

Molecular INTeraction database

More...
MINTi
P35070

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000379092

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P35070, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P35070

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P35070

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini65 – 105EGF-likePROSITE-ProRule annotationAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi146 – 154Arg/Lys-rich (basic)9

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RZHQ, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160508

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_112513_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P35070

KEGG Orthology (KO)

More...
KOi
K09783

Identification of Orthologs from Complete Genome Data

More...
OMAi
PKRKGHF

Database of Orthologous Groups

More...
OrthoDBi
1401257at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P35070

TreeFam database of animal gene trees

More...
TreeFami
TF332938

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000742, EGF-like_dom

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P35070-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRAARCSGA SSLPLLLALA LGLVILHCVV ADGNSTRSPE TNGLLCGDPE
60 70 80 90 100
ENCAATTTQS KRKGHFSRCP KQYKHYCIKG RCRFVVAEQT PSCVCDEGYI
110 120 130 140 150
GARCERVDLF YLRGDRGQIL VICLIAVMVV FIILVIGVCT CCHPLRKRRK
160 170
RKKKEEEMET LGKDITPINE DIEETNIA
Length:178
Mass (Da):19,746
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i27AC77BD92001F0F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y8Q5H0Y8Q5_HUMAN
Probetacellulin
BTC
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0293077C → G. Corresponds to variant dbSNP:rs28549760Ensembl.1
Natural variantiVAR_06115144L → F. Corresponds to variant dbSNP:rs56320257EnsemblClinVar.1
Natural variantiVAR_029308124L → M1 PublicationCorresponds to variant dbSNP:rs11938093Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S55606 mRNA Translation: AAB25452.1
BC011618 mRNA Translation: AAH11618.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3566.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC1467

NCBI Reference Sequences

More...
RefSeqi
NP_001303892.1, NM_001316963.1
NP_001720.1, NM_001729.3
XP_011530513.1, XM_011532211.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000395743; ENSP00000379092; ENSG00000174808

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
685

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:685

UCSC genome browser

More...
UCSCi
uc003hig.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S55606 mRNA Translation: AAB25452.1
BC011618 mRNA Translation: AAH11618.1
CCDSiCCDS3566.1
PIRiJC1467
RefSeqiNP_001303892.1, NM_001316963.1
NP_001720.1, NM_001729.3
XP_011530513.1, XM_011532211.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IOXNMR-A62-111[»]
1IP0NMR-A62-111[»]
SMRiP35070
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107150, 25 interactors
DIPiDIP-5768N
IntActiP35070, 9 interactors
MINTiP35070
STRINGi9606.ENSP00000379092

PTM databases

GlyGeniP35070, 1 site
PhosphoSitePlusiP35070
SwissPalmiP35070

Polymorphism and mutation databases

BioMutaiBTC
DMDMi461653

Proteomic databases

MassIVEiP35070
PaxDbiP35070
PeptideAtlasiP35070
PRIDEiP35070
ProteomicsDBi54977

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
13367, 411 antibodies

The DNASU plasmid repository

More...
DNASUi
685

Genome annotation databases

EnsembliENST00000395743; ENSP00000379092; ENSG00000174808
GeneIDi685
KEGGihsa:685
UCSCiuc003hig.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
685
DisGeNETi685
EuPathDBiHostDB:ENSG00000174808.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BTC
HGNCiHGNC:1121, BTC
HPAiENSG00000174808, Tissue enhanced (intestine)
MIMi600345, gene
neXtProtiNX_P35070
OpenTargetsiENSG00000174808
PharmGKBiPA25442

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502RZHQ, Eukaryota
GeneTreeiENSGT00940000160508
HOGENOMiCLU_112513_1_0_1
InParanoidiP35070
KOiK09783
OMAiPKRKGHF
OrthoDBi1401257at2759
PhylomeDBiP35070
TreeFamiTF332938

Enzyme and pathway databases

PathwayCommonsiP35070
ReactomeiR-HSA-1227986, Signaling by ERBB2
R-HSA-1236394, Signaling by ERBB4
R-HSA-1250196, SHC1 events in ERBB2 signaling
R-HSA-1250342, PI3K events in ERBB4 signaling
R-HSA-1250347, SHC1 events in ERBB4 signaling
R-HSA-1251985, Nuclear signaling by ERBB4
R-HSA-1257604, PIP3 activates AKT signaling
R-HSA-177929, Signaling by EGFR
R-HSA-179812, GRB2 events in EGFR signaling
R-HSA-180292, GAB1 signalosome
R-HSA-180336, SHC1 events in EGFR signaling
R-HSA-182971, EGFR downregulation
R-HSA-1963640, GRB2 events in ERBB2 signaling
R-HSA-1963642, PI3K events in ERBB2 signaling
R-HSA-212718, EGFR interacts with phospholipase C-gamma
R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5638303, Inhibition of Signaling by Overexpressed EGFR
R-HSA-5673001, RAF/MAP kinase cascade
R-HSA-6785631, ERBB2 Regulates Cell Motility
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8847993, ERBB2 Activates PTK6 Signaling
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis
R-HSA-8863795, Downregulation of ERBB2 signaling
R-HSA-9009391, Extra-nuclear estrogen signaling
R-HSA-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling
R-HSA-9664565, Signaling by ERBB2 KD Mutants
R-HSA-9665686, Signaling by ERBB2 TMD/JMD mutants
SignaLinkiP35070
SIGNORiP35070

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
685, 4 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
BTC, human
EvolutionaryTraceiP35070

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
685
PharosiP35070, Tbio

Protein Ontology

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PROi
PR:P35070
RNActiP35070, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000174808, Expressed in lower esophagus and 159 other tissues
ExpressionAtlasiP35070, baseline and differential
GenevisibleiP35070, HS

Family and domain databases

InterProiView protein in InterPro
IPR000742, EGF-like_dom
PROSITEiView protein in PROSITE
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBTC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35070
Secondary accession number(s): Q96F48
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 7, 2020
This is version 178 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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