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UniProtKB - P35049 (TRYP_FUSOX)
Protein
Trypsin
Gene
N/A
Organism
Fusarium oxysporum (Fusarium vascular wilt)
Status
Functioni
Catalytic activityi
- Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa. EC:3.4.21.4
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 65 | Charge relay system | 1 | |
Active sitei | 108 | Charge relay system | 1 | |
Sitei | 198 | Required for specificity | 1 | |
Active sitei | 204 | Charge relay system | 1 |
GO - Molecular functioni
- serine-type endopeptidase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Enzyme and pathway databases
BRENDAi | 3.4.21.4, 2351 |
Protein family/group databases
MEROPSi | S01.103 |
Names & Taxonomyi
Protein namesi | |
Organismi | Fusarium oxysporum (Fusarium vascular wilt) |
Taxonomic identifieri | 5507 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Hypocreales › Nectriaceae › Fusarium › Fusarium oxysporum species complex |
Organism-specific databases
VEuPathDBi | FungiDB:FOC1_g10004256 FungiDB:FOC4_g10005692 FungiDB:FOIG_10361 FungiDB:FOMG_09652 FungiDB:FOXG_13248 FungiDB:FOZG_15528 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
PropeptideiPRO_0000028301 | 18 – 24 | Activation peptide | 7 | |
ChainiPRO_0000028302 | 25 – 248 | TrypsinAdd BLAST | 224 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 50 ↔ 66 | |||
Disulfide bondi | 174 ↔ 189 | |||
Disulfide bondi | 200 ↔ 225 |
Keywords - PTMi
Disulfide bond, ZymogenStructurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P35049 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P35049 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 248 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 224 |
Sequence similaritiesi
Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Keywords - Domaini
SignalFamily and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P35049-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVKFASVVAL VAPLAAAAPQ EIPNIVGGTS ASAGDFPFIV SISRNGGPWC
60 70 80 90 100
GGSLLNANTV LTAAHCVSGY AQSGFQIRAG SLSRTSGGIT SSLSSVRVHP
110 120 130 140 150
SYSGNNNDLA ILKLSTSIPS GGNIGYARLA ASGSDPVAGS SATVAGWGAT
160 170 180 190 200
SEGGSSTPVN LLKVTVPIVS RATCRAQYGT SAITNQMFCA GVSSGGKDSC
210 220 230 240
QGDSGGPIVD SSNTLIGAVS WGNGCARPNY SGVYASVGAL RSFIDTYA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S63827 mRNA Translation: AAB27568.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S63827 mRNA Translation: AAB27568.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1FN8 | X-ray | 0.81 | A | 25-248 | [»] | |
1FY4 | X-ray | 0.81 | A | 25-248 | [»] | |
1FY5 | X-ray | 0.81 | A | 25-248 | [»] | |
1GDN | X-ray | 0.81 | A | 25-248 | [»] | |
1GDQ | X-ray | 0.93 | A | 25-248 | [»] | |
1GDU | X-ray | 1.07 | A | 25-248 | [»] | |
1PPZ | X-ray | 1.23 | A | 25-248 | [»] | |
1PQ5 | X-ray | 0.85 | A | 25-248 | [»] | |
1PQ7 | X-ray | 0.80 | A | 25-248 | [»] | |
1PQ8 | X-ray | 1.00 | A | 25-248 | [»] | |
1PQA | X-ray | 1.23 | A | 25-248 | [»] | |
1TRY | X-ray | 1.55 | A | 25-248 | [»] | |
1XVM | X-ray | 1.10 | A | 25-248 | [»] | |
1XVO | X-ray | 0.84 | A | 25-248 | [»] | |
2G51 | X-ray | 1.84 | A | 25-248 | [»] | |
2G52 | X-ray | 1.84 | A | 25-248 | [»] | |
2VU8 | X-ray | 1.80 | E | 25-248 | [»] | |
SMRi | P35049 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein family/group databases
MEROPSi | S01.103 |
Organism-specific databases
VEuPathDBi | FungiDB:FOC1_g10004256 FungiDB:FOC4_g10005692 FungiDB:FOIG_10361 FungiDB:FOMG_09652 FungiDB:FOXG_13248 FungiDB:FOZG_15528 |
Enzyme and pathway databases
BRENDAi | 3.4.21.4, 2351 |
Miscellaneous databases
EvolutionaryTracei | P35049 |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TRYP_FUSOX | |
Accessioni | P35049Primary (citable) accession number: P35049 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | February 1, 1994 | |
Last modified: | February 23, 2022 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- Peptidase families
Classification of peptidase families and list of entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families