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Protein

Elongation factor 1-alpha

Gene

tuf

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 20GTPUniRule annotation8
Nucleotide bindingi90 – 94GTPUniRule annotation5
Nucleotide bindingi152 – 155GTPUniRule annotation4

GO - Molecular functioni

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.5.3 6163

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor 1-alphaUniRule annotation
Short name:
EF-1-alphaUniRule annotation
Alternative name(s):
Elongation factor TuUniRule annotation
Short name:
EF-TuUniRule annotation
Gene namesi
Name:tufUniRule annotation
Synonyms:tef1
Ordered Locus Names:SSO0216
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000909941 – 435Elongation factor 1-alphaAdd BLAST435

Proteomic databases

PRIDEiP35021

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO0216

Structurei

Secondary structure

1435
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP35021
SMRiP35021
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35021

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 227tr-type GAdd BLAST224

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni13 – 20G1By similarity8
Regioni69 – 73G2By similarity5
Regioni90 – 93G3By similarity4
Regioni152 – 155G4By similarity4
Regioni193 – 195G5By similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01561 Archaea
COG5256 LUCA
HOGENOMiHOG000229291
InParanoidiP35021
KOiK03231
OMAiAIRDMGM
OrthoDBiPOG093Z025H

Family and domain databases

HAMAPiMF_00118_A EF_Tu_A, 1 hit
InterProiView protein in InterPro
IPR004161 EFTu-like_2
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
IPR004539 Transl_elong_EF1A_euk/arc
IPR004160 Transl_elong_EFTu/EF1A_C
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PF03144 GTP_EFTU_D2, 1 hit
PF03143 GTP_EFTU_D3, 1 hit
PRINTSiPR00315 ELONGATNFCT
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00483 EF-1_alpha, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS00301 G_TR_1, 1 hit
PS51722 G_TR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P35021-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQKPHLNLI VIGHIDHGKS TLVGRLLMDR GFIDEKTVKE AEEAAKKLGK
60 70 80 90 100
ESEKFAFLLD RLKEERERGV TINLTFMRFE TKKYFFTIID APGHRDFVKN
110 120 130 140 150
MITGASQADA AILVVSAKKG EYEAGMSVEG QTREHIILAK TMGLDQLIVA
160 170 180 190 200
VNKMDLTEPP YDEKRYKEIV DQVSKFMRSY GFNTNKVRFV PVVAPAGDNI
210 220 230 240 250
THRSENMKWY NGPTLEEYLD QLELPPKPVD KPLRIPIQDV YSISGVGTVP
260 270 280 290 300
VGRVESGVLK VGDKIVFMPA GKVGEVRSIE THHTKMDKAE PGDNIGFNVR
310 320 330 340 350
GVEKKDIKRG DVVGHPNNPP TVADEFTARI IVVWHPTALA NGYTPVIHVH
360 370 380 390 400
TASVACRVSE LVSKLDPRTG QEAEKNPQFL KQGDVAIVKF KPIKPLCVEK
410 420 430
YNEFPPLGRF AMRDMGKTVG VGIIVDVKPA KVEIK
Length:435
Mass (Da):48,489
Last modified:June 1, 2001 - v3
Checksum:i222B540A31768A59
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14H → Q (PubMed:8369039).Curated1
Sequence conflicti240V → R (PubMed:8369039).Curated1
Sequence conflicti240V → R (PubMed:8148382).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti196A → S in strain: MT-3 and MT-4. 1
Natural varianti203R → K in strain: MT-3 and MT-4. 1
Natural varianti347I → L in strain: MT-3 and MT-4. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70701 Genomic DNA Translation: CAA50033.1
X76767 Genomic DNA Translation: CAA54162.1
AJ312397 Genomic DNA Translation: CAC42886.1
AE006641 Genomic DNA Translation: AAK40559.1
PIRiH90162
S43507
RefSeqiWP_010922916.1, NC_002754.1

Genome annotation databases

EnsemblBacteriaiAAK40559; AAK40559; SSO0216
GeneIDi27426513
KEGGisso:SSO0216
PATRICifig|273057.12.peg.214

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70701 Genomic DNA Translation: CAA50033.1
X76767 Genomic DNA Translation: CAA54162.1
AJ312397 Genomic DNA Translation: CAC42886.1
AE006641 Genomic DNA Translation: AAK40559.1
PIRiH90162
S43507
RefSeqiWP_010922916.1, NC_002754.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JNYX-ray1.80A/B1-435[»]
1SKQX-ray1.80A/B1-435[»]
ProteinModelPortaliP35021
SMRiP35021
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO0216

Proteomic databases

PRIDEiP35021

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK40559; AAK40559; SSO0216
GeneIDi27426513
KEGGisso:SSO0216
PATRICifig|273057.12.peg.214

Phylogenomic databases

eggNOGiarCOG01561 Archaea
COG5256 LUCA
HOGENOMiHOG000229291
InParanoidiP35021
KOiK03231
OMAiAIRDMGM
OrthoDBiPOG093Z025H

Enzyme and pathway databases

BRENDAi3.6.5.3 6163

Miscellaneous databases

EvolutionaryTraceiP35021

Family and domain databases

HAMAPiMF_00118_A EF_Tu_A, 1 hit
InterProiView protein in InterPro
IPR004161 EFTu-like_2
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
IPR004539 Transl_elong_EF1A_euk/arc
IPR004160 Transl_elong_EFTu/EF1A_C
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PF03144 GTP_EFTU_D2, 1 hit
PF03143 GTP_EFTU_D3, 1 hit
PRINTSiPR00315 ELONGATNFCT
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00483 EF-1_alpha, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS00301 G_TR_1, 1 hit
PS51722 G_TR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEF1A_SULSO
AccessioniPrimary (citable) accession number: P35021
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 1, 2001
Last modified: October 10, 2018
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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