UniProtKB - P35005 (TRYE_DROME)
Protein
Trypsin epsilon
Gene
epsilonTry
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Catalytic activityi
- Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa. EC:3.4.21.4
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 71 | Charge relay systemBy similarity | 1 | |
Active sitei | 116 | Charge relay systemBy similarity | 1 | |
Sitei | 204 | Required for specificityBy similarity | 1 | |
Active sitei | 210 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- serine-type endopeptidase activity Source: FlyBase
GO - Biological processi
- proteolysis Source: FlyBase
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Protein family/group databases
MEROPSi | S01.A82 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:epsilonTry Synonyms:TRY-EPSILON ORF Names:CG18681 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0010425, epsilonTry |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | CuratedAdd BLAST | 22 | |
PropeptideiPRO_0000028273 | 23 – 30 | Activation peptide | 8 | |
ChainiPRO_0000028274 | 31 – 256 | Trypsin epsilonAdd BLAST | 226 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 56 ↔ 72 | PROSITE-ProRule annotation | ||
Disulfide bondi | 180 ↔ 197 | PROSITE-ProRule annotation | ||
Disulfide bondi | 206 ↔ 230 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, ZymogenProteomic databases
PaxDbi | P35005 |
Expressioni
Gene expression databases
Bgeei | FBgn0010425, Expressed in digestive system element and 31 other tissues |
Genevisiblei | P35005, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 71965, 2 interactors |
DIPi | DIP-21329N |
IntActi | P35005, 1 interactor |
STRINGi | 7227.FBpp0087256 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 254 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 224 |
Sequence similaritiesi
Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3627, Eukaryota |
GeneTreei | ENSGT00940000169778 |
HOGENOMi | CLU_006842_7_1_1 |
InParanoidi | P35005 |
OMAi | WIERTAE |
OrthoDBi | 1314811at2759 |
PhylomeDBi | P35005 |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P35005-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLKFAVLLSV LACALAGTIP DGLLPQLDGR IVGGYETSID AHPYQVSLQR
60 70 80 90 100
YGSHFCGGSI YSHDIVITAA HCLQSIEAKD LKIRVGSTYW RSGGSVHSVR
110 120 130 140 150
SFRNHEGYNS RTMVNDIAII RIESDLSFRS SIREIRIADS NPREGATAVV
160 170 180 190 200
SGWGTTESGG STIPDHLLAV DLEIIDVSRC RSDEFGYGKK IKDTMLCAYA
210 220 230 240 250
PHKDACQGDS GGPLVSGDRL VGVVSWGYGC GDVRYPGVYA DVAHFHEWIE
RTAEEV
Sequence cautioni
The sequence AAT27275 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M96372 Genomic DNA Translation: AAA28981.1 U04853 Genomic DNA Translation: AAA17452.1 AE013599 Genomic DNA Translation: AAF58660.1 BT014651 mRNA Translation: AAT27275.1 Different initiation. |
RefSeqi | NP_525112.1, NM_080373.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0088160; FBpp0087256; FBgn0010425 |
GeneIDi | 49080 |
KEGGi | dme:Dmel_CG18681 |
UCSCi | CG18681-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M96372 Genomic DNA Translation: AAA28981.1 U04853 Genomic DNA Translation: AAA17452.1 AE013599 Genomic DNA Translation: AAF58660.1 BT014651 mRNA Translation: AAT27275.1 Different initiation. |
RefSeqi | NP_525112.1, NM_080373.3 |
3D structure databases
SMRi | P35005 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 71965, 2 interactors |
DIPi | DIP-21329N |
IntActi | P35005, 1 interactor |
STRINGi | 7227.FBpp0087256 |
Protein family/group databases
MEROPSi | S01.A82 |
Proteomic databases
PaxDbi | P35005 |
Genome annotation databases
EnsemblMetazoai | FBtr0088160; FBpp0087256; FBgn0010425 |
GeneIDi | 49080 |
KEGGi | dme:Dmel_CG18681 |
UCSCi | CG18681-RA, d. melanogaster |
Organism-specific databases
CTDi | 49080 |
FlyBasei | FBgn0010425, epsilonTry |
Phylogenomic databases
eggNOGi | KOG3627, Eukaryota |
GeneTreei | ENSGT00940000169778 |
HOGENOMi | CLU_006842_7_1_1 |
InParanoidi | P35005 |
OMAi | WIERTAE |
OrthoDBi | 1314811at2759 |
PhylomeDBi | P35005 |
Miscellaneous databases
BioGRID-ORCSi | 49080, 0 hits in 1 CRISPR screen |
GenomeRNAii | 49080 |
PROi | PR:P35005 |
Gene expression databases
Bgeei | FBgn0010425, Expressed in digestive system element and 31 other tissues |
Genevisiblei | P35005, DM |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRYE_DROME | |
Accessioni | P35005Primary (citable) accession number: P35005 Secondary accession number(s): Q6IDF4, Q9V5Y1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | February 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families - Peptidase families
Classification of peptidase families and list of entries