PTGER1

Functionⁱ

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.

GO - Molecular functionⁱ

D1 dopamine receptor binding Source: Ensembl
prostaglandin E receptor activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-activating dopamine receptor signaling pathway Source: Ensembl
G-protein coupled receptor signaling pathway Source: Reactome
response to lipopolysaccharide Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-391908 Prostanoid ligand receptors R-HSA-416476 G alpha (q) signalling events
SIGNORⁱ	P34995

Protein family/group databases

TCDBⁱ

9.A.14.9.1 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Prostaglandin E2 receptor EP1 subtype Short name: PGE receptor EP1 subtype Short name: PGE2 receptor EP1 subtype Alternative name(s): Prostanoid EP1 receptor
Gene namesⁱ	Name:PTGER1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000160951.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9593 PTGER1
MIMⁱ	176802 gene
neXtProtⁱ	NX_P34995

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 35	ExtracellularSequence analysisAdd BLAST	35
Transmembraneⁱ	36 – 62	Helical; Name=1Sequence analysisAdd BLAST	27
Topological domainⁱ	63 – 72	CytoplasmicSequence analysis	10
Transmembraneⁱ	73 – 96	Helical; Name=2Sequence analysisAdd BLAST	24
Topological domainⁱ	97 – 111	ExtracellularSequence analysisAdd BLAST	15
Transmembraneⁱ	112 – 133	Helical; Name=3Sequence analysisAdd BLAST	22
Topological domainⁱ	134 – 155	CytoplasmicSequence analysisAdd BLAST	22
Transmembraneⁱ	156 – 177	Helical; Name=4Sequence analysisAdd BLAST	22
Topological domainⁱ	178 – 201	ExtracellularSequence analysisAdd BLAST	24
Transmembraneⁱ	202 – 227	Helical; Name=5Sequence analysisAdd BLAST	26
Topological domainⁱ	228 – 294	CytoplasmicSequence analysisAdd BLAST	67
Transmembraneⁱ	295 – 321	Helical; Name=6Sequence analysisAdd BLAST	27
Topological domainⁱ	322 – 332	ExtracellularSequence analysisAdd BLAST	11
Transmembraneⁱ	333 – 354	Helical; Name=7Sequence analysisAdd BLAST	22
Topological domainⁱ	355 – 402	CytoplasmicSequence analysisAdd BLAST	48

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5731
Open Targets More...OpenTargetsⁱ	ENSG00000160951
PharmGKBⁱ	PA286

Chemistry databases

ChEMBLⁱ	CHEMBL1811
Drug and drug target database More...DrugBankⁱ	DB00770 Alprostadil DB00905 Bimatoprost DB00297 Bupivacaine DB00429 Carboprost Tromethamine DB00917 Dinoprostone DB01088 Iloprost
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	340

Polymorphism and mutation databases

BioMutaⁱ	PTGER1
DMDMⁱ	83287886

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000070050	1 – 402	Prostaglandin E2 receptor EP1 subtypeAdd BLAST		402

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	8	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	25	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	110 ↔ 188	PROSITE-ProRule annotation

Post-translational modificationⁱ

Phosphorylated.Curated

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	P34995
PeptideAtlas More...PeptideAtlasⁱ	P34995
PRIDEⁱ	P34995
ProteomicsDBⁱ	54967

PTM databases

PhosphoSitePlusⁱ	P34995

PhosphoSitePlusⁱ

P34995

Expressionⁱ

Tissue specificityⁱ

Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart.

Gene expression databases

Bgeeⁱ	ENSG00000160951 Expressed in 89 organ(s), highest expression level in cortex of kidney
CleanExⁱ	HS_PTGER1
Genevisibleⁱ	P34995 HS

Interactionⁱ

GO - Molecular functionⁱ

D1 dopamine receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111703, 2 interactors
STRINGⁱ	9606.ENSP00000292513

Chemistry databases

BindingDBⁱ

P34995

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P34995
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119188
HOGENOMⁱ	HOG000015238
HOVERGENⁱ	HBG003621
InParanoidⁱ	P34995
KEGG Orthology (KO) More...KOⁱ	K04258
OMAⁱ	CICWSPM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0NMF
PhylomeDBⁱ	P34995
TreeFamⁱ	TF324982

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR008365 Prostanoid_rcpt IPR001244 Prostglndn_DP_rcpt IPR000708 Prostglndn_EP1_rcpt
PANTHERⁱ	PTHR11866 PTHR11866, 1 hit PTHR11866:SF3 PTHR11866:SF3, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00428 PROSTAGLNDNR PR01788 PROSTANOIDR PR00580 PRSTNOIDEP1R
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P34995-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSPCGPLNLS LAGEATTCAA PWVPNTSAVP PSGASPALPI FSMTLGAVSN 
        60         70         80         90        100
LLALALLAQA AGRLRRRRSA ATFLLFVASL LATDLAGHVI PGALVLRLYT 
       110        120        130        140        150
AGRAPAGGAC HFLGGCMVFF GLCPLLLGCG MAVERCVGVT RPLLHAARVS 
       160        170        180        190        200
VARARLALAA VAAVALAVAL LPLARVGRYE LQYPGTWCFI GLGPPGGWRQ 
       210        220        230        240        250
ALLAGLFASL GLVALLAALV CNTLSGLALL RARWRRRSRR PPPASGPDSR 
       260        270        280        290        300
RRWGAHGPRS ASASSASSIA SASTFFGGSR SSGSARRARA HDVEMVGQLV 
       310        320        330        340        350
GIMVVSCICW SPMLVLVALA VGGWSSTSLQ RPLFLAVRLA SWNQILDPWV 
       360        370        380        390        400
YILLRQAVLR QLLRLLPPRA GAKGGPAGLG LTPSAWEASS LRSSRHSGLS 

HF

Length:402

Mass (Da):41,801

Last modified:May 10, 2005 - v3

Checksum:ⁱB925359ABD86880C

GO

Sequence cautionⁱ

The sequence BAC05723 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	230	L → H in AAC37539 (PubMed:8253813).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_017190	71	A → T2 PublicationsCorresponds to variant dbSNP:rs1057362Ensembl.	1
Natural variantⁱVAR_029216	223	T → M. Corresponds to variant dbSNP:rs28364042Ensembl.	1
Natural variantⁱVAR_029217	256	H → R. Corresponds to variant dbSNP:rs7249305Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L22647 mRNA Translation: AAC37539.1 AB065464 Genomic DNA Translation: BAC05723.1 Sequence problems. AY275470 mRNA Translation: AAP32302.1 BC039034 mRNA Translation: AAH39034.1 BC051286 mRNA Translation: AAH51286.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12309.1
PIRⁱ	A49690
NCBI Reference Sequences More...RefSeqⁱ	NP_000946.2, NM_000955.2
UniGeneⁱ	Hs.159360

Genome annotation databases

Ensemblⁱ	ENST00000292513; ENSP00000292513; ENSG00000160951
GeneIDⁱ	5731
KEGGⁱ	hsa:5731
UCSC genome browser More...UCSCⁱ	uc002mys.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P34995	Prostaglandin E receptor 1		CALJA		493	UniRef90_P34995
Uncharacterized protein		PROCO		405
Uncharacterized protein		Cebus capucinus imitator		405
Prostaglandin EP1 receptor		MACMU		402
Uncharacterized protein		MACFA		402
+13

Protein	Similar proteins		Species	Score	Length	Source
P34995	Prostaglandin E2 receptor EP1 subtype		CANLF		403	UniRef50_P34995
Prostaglandin E2 receptor EP1 subtype		MOUSE		405
Prostaglandin E2 receptor EP1 subtype		RAT		405
Prostaglandin E receptor 1		CALJA		493
Uncharacterized protein		PROCO		405
+63

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L22647 mRNA Translation: AAC37539.1 AB065464 Genomic DNA Translation: BAC05723.1 Sequence problems. AY275470 mRNA Translation: AAP32302.1 BC039034 mRNA Translation: AAH39034.1 BC051286 mRNA Translation: AAH51286.1
CCDSⁱ	CCDS12309.1
PIRⁱ	A49690
RefSeqⁱ	NP_000946.2, NM_000955.2
UniGeneⁱ	Hs.159360

3D structure databases

ProteinModelPortalⁱ	P34995
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111703, 2 interactors
STRINGⁱ	9606.ENSP00000292513

Chemistry databases

BindingDBⁱ	P34995
ChEMBLⁱ	CHEMBL1811
DrugBankⁱ	DB00770 Alprostadil DB00905 Bimatoprost DB00297 Bupivacaine DB00429 Carboprost Tromethamine DB00917 Dinoprostone DB01088 Iloprost
GuidetoPHARMACOLOGYⁱ	340

Protein family/group databases

TCDBⁱ	9.A.14.9.1 the g-protein-coupled receptor (gpcr) family
GPCRDBⁱ	Search...

PTM databases

PhosphoSitePlusⁱ	P34995

PhosphoSitePlusⁱ

P34995

Polymorphism and mutation databases

BioMutaⁱ	PTGER1
DMDMⁱ	83287886

Proteomic databases

PaxDbⁱ	P34995
PeptideAtlasⁱ	P34995
PRIDEⁱ	P34995
ProteomicsDBⁱ	54967

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5731
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000292513; ENSP00000292513; ENSG00000160951
GeneIDⁱ	5731
KEGGⁱ	hsa:5731
UCSCⁱ	uc002mys.3 human

Organism-specific databases

CTDⁱ	5731
DisGeNETⁱ	5731
EuPathDBⁱ	HostDB:ENSG00000160951.3
GeneCardsⁱ	PTGER1
HGNCⁱ	HGNC:9593 PTGER1
MIMⁱ	176802 gene
neXtProtⁱ	NX_P34995
OpenTargetsⁱ	ENSG00000160951
PharmGKBⁱ	PA286
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00760000119188
HOGENOMⁱ	HOG000015238
HOVERGENⁱ	HBG003621
InParanoidⁱ	P34995
KOⁱ	K04258
OMAⁱ	CICWSPM
OrthoDBⁱ	EOG091G0NMF
PhylomeDBⁱ	P34995
TreeFamⁱ	TF324982

Enzyme and pathway databases

Reactomeⁱ	R-HSA-391908 Prostanoid ligand receptors R-HSA-416476 G alpha (q) signalling events
SIGNORⁱ	P34995

Miscellaneous databases

GeneWikiⁱ	EP1_receptor
GenomeRNAiⁱ	5731
Protein Ontology More...PROⁱ	PR:P34995
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000160951 Expressed in 89 organ(s), highest expression level in cortex of kidney
CleanExⁱ	HS_PTGER1
Genevisibleⁱ	P34995 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR008365 Prostanoid_rcpt IPR001244 Prostglndn_DP_rcpt IPR000708 Prostglndn_EP1_rcpt
PANTHERⁱ	PTHR11866 PTHR11866, 1 hit PTHR11866:SF3 PTHR11866:SF3, 1 hit
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00428 PROSTAGLNDNR PR01788 PROSTANOIDR PR00580 PRSTNOIDEP1R
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PE2R1_HUMAN
Accessionⁱ	P34995Primary (citable) accession number: P34995 Secondary accession number(s): Q5U5U4 , Q86UH3, Q86VB5, Q8NHB2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
	Last sequence update:	May 10, 2005
	Last modified:	September 12, 2018
	This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P34995 (PE2R1_HUMAN)

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Prostaglandin E2 receptor EP1 subtype

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ