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UniProtKB - P34995 (PE2R1_HUMAN)
Protein
Prostaglandin E2 receptor EP1 subtype
Gene
PTGER1
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.
GO - Molecular functioni
- D1 dopamine receptor binding Source: Ensembl
- prostaglandin E receptor activity Source: GO_Central
GO - Biological processi
- adenylate cyclase-activating dopamine receptor signaling pathway Source: Ensembl
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
- G protein-coupled receptor signaling pathway Source: ProtInc
- inflammatory response Source: GO_Central
- positive regulation of cytosolic calcium ion concentration Source: GO_Central
- response to lipopolysaccharide Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P34995 |
Reactomei | R-HSA-391908, Prostanoid ligand receptors R-HSA-416476, G alpha (q) signalling events |
SignaLinki | P34995 |
SIGNORi | P34995 |
Protein family/group databases
TCDBi | 9.A.14.9.1, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Prostaglandin E2 receptor EP1 subtypeShort name: PGE receptor EP1 subtype Short name: PGE2 receptor EP1 subtype Alternative name(s): Prostanoid EP1 receptor |
Gene namesi | Name:PTGER1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9593, PTGER1 |
MIMi | 176802, gene |
neXtProti | NX_P34995 |
VEuPathDBi | HostDB:ENSG00000160951 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 35 | ExtracellularSequence analysisAdd BLAST | 35 | |
Transmembranei | 36 – 62 | Helical; Name=1Sequence analysisAdd BLAST | 27 | |
Topological domaini | 63 – 72 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 73 – 96 | Helical; Name=2Sequence analysisAdd BLAST | 24 | |
Topological domaini | 97 – 111 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 112 – 133 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 134 – 155 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 156 – 177 | Helical; Name=4Sequence analysisAdd BLAST | 22 | |
Topological domaini | 178 – 201 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 202 – 227 | Helical; Name=5Sequence analysisAdd BLAST | 26 | |
Topological domaini | 228 – 294 | CytoplasmicSequence analysisAdd BLAST | 67 | |
Transmembranei | 295 – 321 | Helical; Name=6Sequence analysisAdd BLAST | 27 | |
Topological domaini | 322 – 332 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 333 – 354 | Helical; Name=7Sequence analysisAdd BLAST | 22 | |
Topological domaini | 355 – 402 | CytoplasmicSequence analysisAdd BLAST | 48 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 5731 |
OpenTargetsi | ENSG00000160951 |
PharmGKBi | PA286 |
Miscellaneous databases
Pharosi | P34995, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1811 |
DrugBanki | DB00770, Alprostadil DB00905, Bimatoprost DB00297, Bupivacaine DB00429, Carboprost tromethamine DB00917, Dinoprostone DB01088, Iloprost DB09211, Limaprost DB00929, Misoprostol |
DrugCentrali | P34995 |
GuidetoPHARMACOLOGYi | 340 |
Genetic variation databases
BioMutai | PTGER1 |
DMDMi | 83287886 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070050 | 1 – 402 | Prostaglandin E2 receptor EP1 subtypeAdd BLAST | 402 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 8 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 25 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 110 ↔ 188 | PROSITE-ProRule annotation |
Post-translational modificationi
Phosphorylated.Curated
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P34995 |
PeptideAtlasi | P34995 |
PRIDEi | P34995 |
PTM databases
GlyGeni | P34995, 2 sites |
PhosphoSitePlusi | P34995 |
Expressioni
Tissue specificityi
Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart.
Gene expression databases
Bgeei | ENSG00000160951, Expressed in stomach and 104 other tissues |
Genevisiblei | P34995, HS |
Organism-specific databases
HPAi | ENSG00000160951, Tissue enhanced (kidney, lymphoid tissue) |
Interactioni
GO - Molecular functioni
- D1 dopamine receptor binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 111703, 3 interactors |
STRINGi | 9606.ENSP00000292513 |
Chemistry databases
BindingDBi | P34995 |
Miscellaneous databases
RNActi | P34995, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 238 – 266 | DisorderedSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01030000234559 |
HOGENOMi | CLU_045991_3_0_1 |
InParanoidi | P34995 |
OMAi | IYLIAKC |
OrthoDBi | 972015at2759 |
PhylomeDBi | P34995 |
TreeFami | TF324982 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR008365, Prostanoid_rcpt IPR001244, Prostglndn_DP_rcpt IPR000708, Prostglndn_EP1_rcpt |
PANTHERi | PTHR11866, PTHR11866, 1 hit PTHR11866:SF3, PTHR11866:SF3, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00428, PROSTAGLNDNR PR01788, PROSTANOIDR PR00580, PRSTNOIDEP1R |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P34995-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSPCGPLNLS LAGEATTCAA PWVPNTSAVP PSGASPALPI FSMTLGAVSN
60 70 80 90 100
LLALALLAQA AGRLRRRRSA ATFLLFVASL LATDLAGHVI PGALVLRLYT
110 120 130 140 150
AGRAPAGGAC HFLGGCMVFF GLCPLLLGCG MAVERCVGVT RPLLHAARVS
160 170 180 190 200
VARARLALAA VAAVALAVAL LPLARVGRYE LQYPGTWCFI GLGPPGGWRQ
210 220 230 240 250
ALLAGLFASL GLVALLAALV CNTLSGLALL RARWRRRSRR PPPASGPDSR
260 270 280 290 300
RRWGAHGPRS ASASSASSIA SASTFFGGSR SSGSARRARA HDVEMVGQLV
310 320 330 340 350
GIMVVSCICW SPMLVLVALA VGGWSSTSLQ RPLFLAVRLA SWNQILDPWV
360 370 380 390 400
YILLRQAVLR QLLRLLPPRA GAKGGPAGLG LTPSAWEASS LRSSRHSGLS
HF
Sequence cautioni
The sequence BAC05723 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 230 | L → H in AAC37539 (PubMed:8253813).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_017190 | 71 | A → T2 PublicationsCorresponds to variant dbSNP:rs1057362Ensembl. | 1 | |
Natural variantiVAR_029216 | 223 | T → M. Corresponds to variant dbSNP:rs28364042Ensembl. | 1 | |
Natural variantiVAR_029217 | 256 | H → R. Corresponds to variant dbSNP:rs7249305Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L22647 mRNA Translation: AAC37539.1 AB065464 Genomic DNA Translation: BAC05723.1 Sequence problems. AY275470 mRNA Translation: AAP32302.1 BC039034 mRNA Translation: AAH39034.1 BC051286 mRNA Translation: AAH51286.1 |
CCDSi | CCDS12309.1 |
PIRi | A49690 |
RefSeqi | NP_000946.2, NM_000955.2 |
Genome annotation databases
Ensembli | ENST00000292513; ENSP00000292513; ENSG00000160951 |
GeneIDi | 5731 |
KEGGi | hsa:5731 |
MANE-Selecti | ENST00000292513.4; ENSP00000292513.3; NM_000955.3; NP_000946.2 |
UCSCi | uc002mys.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L22647 mRNA Translation: AAC37539.1 AB065464 Genomic DNA Translation: BAC05723.1 Sequence problems. AY275470 mRNA Translation: AAP32302.1 BC039034 mRNA Translation: AAH39034.1 BC051286 mRNA Translation: AAH51286.1 |
CCDSi | CCDS12309.1 |
PIRi | A49690 |
RefSeqi | NP_000946.2, NM_000955.2 |
3D structure databases
SMRi | P34995 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111703, 3 interactors |
STRINGi | 9606.ENSP00000292513 |
Chemistry databases
BindingDBi | P34995 |
ChEMBLi | CHEMBL1811 |
DrugBanki | DB00770, Alprostadil DB00905, Bimatoprost DB00297, Bupivacaine DB00429, Carboprost tromethamine DB00917, Dinoprostone DB01088, Iloprost DB09211, Limaprost DB00929, Misoprostol |
DrugCentrali | P34995 |
GuidetoPHARMACOLOGYi | 340 |
Protein family/group databases
TCDBi | 9.A.14.9.1, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | P34995, 2 sites |
PhosphoSitePlusi | P34995 |
Genetic variation databases
BioMutai | PTGER1 |
DMDMi | 83287886 |
Proteomic databases
PaxDbi | P34995 |
PeptideAtlasi | P34995 |
PRIDEi | P34995 |
Protocols and materials databases
Antibodypediai | 13701, 260 antibodies from 32 providers |
DNASUi | 5731 |
Genome annotation databases
Ensembli | ENST00000292513; ENSP00000292513; ENSG00000160951 |
GeneIDi | 5731 |
KEGGi | hsa:5731 |
MANE-Selecti | ENST00000292513.4; ENSP00000292513.3; NM_000955.3; NP_000946.2 |
UCSCi | uc002mys.3, human |
Organism-specific databases
CTDi | 5731 |
DisGeNETi | 5731 |
GeneCardsi | PTGER1 |
HGNCi | HGNC:9593, PTGER1 |
HPAi | ENSG00000160951, Tissue enhanced (kidney, lymphoid tissue) |
MIMi | 176802, gene |
neXtProti | NX_P34995 |
OpenTargetsi | ENSG00000160951 |
PharmGKBi | PA286 |
VEuPathDBi | HostDB:ENSG00000160951 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01030000234559 |
HOGENOMi | CLU_045991_3_0_1 |
InParanoidi | P34995 |
OMAi | IYLIAKC |
OrthoDBi | 972015at2759 |
PhylomeDBi | P34995 |
TreeFami | TF324982 |
Enzyme and pathway databases
PathwayCommonsi | P34995 |
Reactomei | R-HSA-391908, Prostanoid ligand receptors R-HSA-416476, G alpha (q) signalling events |
SignaLinki | P34995 |
SIGNORi | P34995 |
Miscellaneous databases
BioGRID-ORCSi | 5731, 6 hits in 1038 CRISPR screens |
GeneWikii | EP1_receptor |
GenomeRNAii | 5731 |
Pharosi | P34995, Tclin |
PROi | PR:P34995 |
RNActi | P34995, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000160951, Expressed in stomach and 104 other tissues |
Genevisiblei | P34995, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR008365, Prostanoid_rcpt IPR001244, Prostglndn_DP_rcpt IPR000708, Prostglndn_EP1_rcpt |
PANTHERi | PTHR11866, PTHR11866, 1 hit PTHR11866:SF3, PTHR11866:SF3, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00428, PROSTAGLNDNR PR01788, PROSTANOIDR PR00580, PRSTNOIDEP1R |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PE2R1_HUMAN | |
Accessioni | P34995Primary (citable) accession number: P34995 Secondary accession number(s): Q5U5U4 Q8NHB2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | May 10, 2005 | |
Last modified: | February 23, 2022 | |
This is version 171 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families