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Protein

Prostaglandin E2 receptor EP1 subtype

Gene

PTGER1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-391908 Prostanoid ligand receptors
R-HSA-416476 G alpha (q) signalling events
SIGNORiP34995

Protein family/group databases

TCDBi9.A.14.9.1 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E2 receptor EP1 subtype
Short name:
PGE receptor EP1 subtype
Short name:
PGE2 receptor EP1 subtype
Alternative name(s):
Prostanoid EP1 receptor
Gene namesi
Name:PTGER1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000160951.3
HGNCiHGNC:9593 PTGER1
MIMi176802 gene
neXtProtiNX_P34995

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35ExtracellularSequence analysisAdd BLAST35
Transmembranei36 – 62Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini63 – 72CytoplasmicSequence analysis10
Transmembranei73 – 96Helical; Name=2Sequence analysisAdd BLAST24
Topological domaini97 – 111ExtracellularSequence analysisAdd BLAST15
Transmembranei112 – 133Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini134 – 155CytoplasmicSequence analysisAdd BLAST22
Transmembranei156 – 177Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini178 – 201ExtracellularSequence analysisAdd BLAST24
Transmembranei202 – 227Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini228 – 294CytoplasmicSequence analysisAdd BLAST67
Transmembranei295 – 321Helical; Name=6Sequence analysisAdd BLAST27
Topological domaini322 – 332ExtracellularSequence analysisAdd BLAST11
Transmembranei333 – 354Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini355 – 402CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5731
OpenTargetsiENSG00000160951
PharmGKBiPA286

Chemistry databases

ChEMBLiCHEMBL1811
DrugBankiDB00770 Alprostadil
DB00905 Bimatoprost
DB00297 Bupivacaine
DB00429 Carboprost Tromethamine
DB00917 Dinoprostone
DB01088 Iloprost
GuidetoPHARMACOLOGYi340

Polymorphism and mutation databases

BioMutaiPTGER1
DMDMi83287886

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700501 – 402Prostaglandin E2 receptor EP1 subtypeAdd BLAST402

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi110 ↔ 188PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated.Curated

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP34995
PeptideAtlasiP34995
PRIDEiP34995
ProteomicsDBi54967

PTM databases

PhosphoSitePlusiP34995

Expressioni

Tissue specificityi

Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart.

Gene expression databases

BgeeiENSG00000160951 Expressed in 89 organ(s), highest expression level in cortex of kidney
CleanExiHS_PTGER1
GenevisibleiP34995 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111703, 2 interactors
STRINGi9606.ENSP00000292513

Chemistry databases

BindingDBiP34995

Structurei

3D structure databases

ProteinModelPortaliP34995
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119188
HOGENOMiHOG000015238
HOVERGENiHBG003621
InParanoidiP34995
KOiK04258
OMAiCICWSPM
OrthoDBiEOG091G0NMF
PhylomeDBiP34995
TreeFamiTF324982

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR008365 Prostanoid_rcpt
IPR001244 Prostglndn_DP_rcpt
IPR000708 Prostglndn_EP1_rcpt
PANTHERiPTHR11866 PTHR11866, 1 hit
PTHR11866:SF3 PTHR11866:SF3, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00428 PROSTAGLNDNR
PR01788 PROSTANOIDR
PR00580 PRSTNOIDEP1R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P34995-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPCGPLNLS LAGEATTCAA PWVPNTSAVP PSGASPALPI FSMTLGAVSN
60 70 80 90 100
LLALALLAQA AGRLRRRRSA ATFLLFVASL LATDLAGHVI PGALVLRLYT
110 120 130 140 150
AGRAPAGGAC HFLGGCMVFF GLCPLLLGCG MAVERCVGVT RPLLHAARVS
160 170 180 190 200
VARARLALAA VAAVALAVAL LPLARVGRYE LQYPGTWCFI GLGPPGGWRQ
210 220 230 240 250
ALLAGLFASL GLVALLAALV CNTLSGLALL RARWRRRSRR PPPASGPDSR
260 270 280 290 300
RRWGAHGPRS ASASSASSIA SASTFFGGSR SSGSARRARA HDVEMVGQLV
310 320 330 340 350
GIMVVSCICW SPMLVLVALA VGGWSSTSLQ RPLFLAVRLA SWNQILDPWV
360 370 380 390 400
YILLRQAVLR QLLRLLPPRA GAKGGPAGLG LTPSAWEASS LRSSRHSGLS

HF
Length:402
Mass (Da):41,801
Last modified:May 10, 2005 - v3
Checksum:iB925359ABD86880C
GO

Sequence cautioni

The sequence BAC05723 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti230L → H in AAC37539 (PubMed:8253813).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01719071A → T2 PublicationsCorresponds to variant dbSNP:rs1057362Ensembl.1
Natural variantiVAR_029216223T → M. Corresponds to variant dbSNP:rs28364042Ensembl.1
Natural variantiVAR_029217256H → R. Corresponds to variant dbSNP:rs7249305Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22647 mRNA Translation: AAC37539.1
AB065464 Genomic DNA Translation: BAC05723.1 Sequence problems.
AY275470 mRNA Translation: AAP32302.1
BC039034 mRNA Translation: AAH39034.1
BC051286 mRNA Translation: AAH51286.1
CCDSiCCDS12309.1
PIRiA49690
RefSeqiNP_000946.2, NM_000955.2
UniGeneiHs.159360

Genome annotation databases

EnsembliENST00000292513; ENSP00000292513; ENSG00000160951
GeneIDi5731
KEGGihsa:5731
UCSCiuc002mys.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22647 mRNA Translation: AAC37539.1
AB065464 Genomic DNA Translation: BAC05723.1 Sequence problems.
AY275470 mRNA Translation: AAP32302.1
BC039034 mRNA Translation: AAH39034.1
BC051286 mRNA Translation: AAH51286.1
CCDSiCCDS12309.1
PIRiA49690
RefSeqiNP_000946.2, NM_000955.2
UniGeneiHs.159360

3D structure databases

ProteinModelPortaliP34995
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111703, 2 interactors
STRINGi9606.ENSP00000292513

Chemistry databases

BindingDBiP34995
ChEMBLiCHEMBL1811
DrugBankiDB00770 Alprostadil
DB00905 Bimatoprost
DB00297 Bupivacaine
DB00429 Carboprost Tromethamine
DB00917 Dinoprostone
DB01088 Iloprost
GuidetoPHARMACOLOGYi340

Protein family/group databases

TCDBi9.A.14.9.1 the g-protein-coupled receptor (gpcr) family
GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP34995

Polymorphism and mutation databases

BioMutaiPTGER1
DMDMi83287886

Proteomic databases

PaxDbiP34995
PeptideAtlasiP34995
PRIDEiP34995
ProteomicsDBi54967

Protocols and materials databases

DNASUi5731
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292513; ENSP00000292513; ENSG00000160951
GeneIDi5731
KEGGihsa:5731
UCSCiuc002mys.3 human

Organism-specific databases

CTDi5731
DisGeNETi5731
EuPathDBiHostDB:ENSG00000160951.3
GeneCardsiPTGER1
HGNCiHGNC:9593 PTGER1
MIMi176802 gene
neXtProtiNX_P34995
OpenTargetsiENSG00000160951
PharmGKBiPA286
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119188
HOGENOMiHOG000015238
HOVERGENiHBG003621
InParanoidiP34995
KOiK04258
OMAiCICWSPM
OrthoDBiEOG091G0NMF
PhylomeDBiP34995
TreeFamiTF324982

Enzyme and pathway databases

ReactomeiR-HSA-391908 Prostanoid ligand receptors
R-HSA-416476 G alpha (q) signalling events
SIGNORiP34995

Miscellaneous databases

GeneWikiiEP1_receptor
GenomeRNAii5731
PROiPR:P34995
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160951 Expressed in 89 organ(s), highest expression level in cortex of kidney
CleanExiHS_PTGER1
GenevisibleiP34995 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR008365 Prostanoid_rcpt
IPR001244 Prostglndn_DP_rcpt
IPR000708 Prostglndn_EP1_rcpt
PANTHERiPTHR11866 PTHR11866, 1 hit
PTHR11866:SF3 PTHR11866:SF3, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00428 PROSTAGLNDNR
PR01788 PROSTANOIDR
PR00580 PRSTNOIDEP1R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPE2R1_HUMAN
AccessioniPrimary (citable) accession number: P34995
Secondary accession number(s): Q5U5U4
, Q86UH3, Q86VB5, Q8NHB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 10, 2005
Last modified: September 12, 2018
This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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