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UniProtKB - P34995 (PE2R1_HUMAN)

Entry version 171 (23 Feb 2022)
Sequence version 3 (10 May 2005)
Previous versions | rss
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Protein

Prostaglandin E2 receptor EP1 subtype

Gene

PTGER1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P34995

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-391908, Prostanoid ligand receptors
R-HSA-416476, G alpha (q) signalling events

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P34995

SIGNOR Signaling Network Open Resource

More...SIGNORi		P34995

Protein family/group databases

Transport Classification Database

More...TCDBi		9.A.14.9.1, the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prostaglandin E2 receptor EP1 subtype
Short name:
PGE receptor EP1 subtype
Short name:
PGE2 receptor EP1 subtype
Alternative name(s):
Prostanoid EP1 receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTGER1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9593, PTGER1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		176802, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P34995

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000160951

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 35ExtracellularSequence analysisAdd BLAST35
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei36 – 62Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini63 – 72CytoplasmicSequence analysis10
Transmembranei73 – 96Helical; Name=2Sequence analysisAdd BLAST24
Topological domaini97 – 111ExtracellularSequence analysisAdd BLAST15
Transmembranei112 – 133Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini134 – 155CytoplasmicSequence analysisAdd BLAST22
Transmembranei156 – 177Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini178 – 201ExtracellularSequence analysisAdd BLAST24
Transmembranei202 – 227Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini228 – 294CytoplasmicSequence analysisAdd BLAST67
Transmembranei295 – 321Helical; Name=6Sequence analysisAdd BLAST27
Topological domaini322 – 332ExtracellularSequence analysisAdd BLAST11
Transmembranei333 – 354Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini355 – 402CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5731

Open Targets

More...OpenTargetsi		ENSG00000160951

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA286

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P34995, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1811

Drug and drug target database

More...DrugBanki		DB00770, Alprostadil
DB00905, Bimatoprost
DB00297, Bupivacaine
DB00429, Carboprost tromethamine
DB00917, Dinoprostone
DB01088, Iloprost
DB09211, Limaprost
DB00929, Misoprostol

DrugCentral

More...DrugCentrali		P34995

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		340

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PTGER1

Domain mapping of disease mutations (DMDM)

More...DMDMi		83287886

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000700501 – 402Prostaglandin E2 receptor EP1 subtypeAdd BLAST402

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi8N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi110 ↔ 188PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.Curated

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P34995

PeptideAtlas

More...PeptideAtlasi		P34995

PRoteomics IDEntifications database

More...PRIDEi		P34995

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P34995, 2 sites

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P34995

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000160951, Expressed in stomach and 104 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P34995, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000160951, Tissue enhanced (kidney, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111703, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000292513

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P34995

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P34995, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P34995

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni238 – 266DisorderedSequence analysisAdd BLAST29

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3656, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01030000234559

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_045991_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P34995

Identification of Orthologs from Complete Genome Data

More...OMAi		IYLIAKC

Database of Orthologous Groups

More...OrthoDBi		972015at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P34995

TreeFam database of animal gene trees

More...TreeFami		TF324982

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR008365, Prostanoid_rcpt
IPR001244, Prostglndn_DP_rcpt
IPR000708, Prostglndn_EP1_rcpt

The PANTHER Classification System

More...PANTHERi		PTHR11866, PTHR11866, 1 hit
PTHR11866:SF3, PTHR11866:SF3, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00428, PROSTAGLNDNR
PR01788, PROSTANOIDR
PR00580, PRSTNOIDEP1R

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P34995-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPCGPLNLS LAGEATTCAA PWVPNTSAVP PSGASPALPI FSMTLGAVSN 
        60         70         80         90        100
LLALALLAQA AGRLRRRRSA ATFLLFVASL LATDLAGHVI PGALVLRLYT 
       110        120        130        140        150
AGRAPAGGAC HFLGGCMVFF GLCPLLLGCG MAVERCVGVT RPLLHAARVS 
       160        170        180        190        200
VARARLALAA VAAVALAVAL LPLARVGRYE LQYPGTWCFI GLGPPGGWRQ 
       210        220        230        240        250
ALLAGLFASL GLVALLAALV CNTLSGLALL RARWRRRSRR PPPASGPDSR 
       260        270        280        290        300
RRWGAHGPRS ASASSASSIA SASTFFGGSR SSGSARRARA HDVEMVGQLV 
       310        320        330        340        350
GIMVVSCICW SPMLVLVALA VGGWSSTSLQ RPLFLAVRLA SWNQILDPWV 
       360        370        380        390        400
YILLRQAVLR QLLRLLPPRA GAKGGPAGLG LTPSAWEASS LRSSRHSGLS 

HF
Length:402
Mass (Da):41,801
Last modified:May 10, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB925359ABD86880C
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC05723 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti230L → H in AAC37539 (PubMed:8253813).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01719071A → T2 PublicationsCorresponds to variant dbSNP:rs1057362Ensembl.1
Natural variantiVAR_029216223T → M. Corresponds to variant dbSNP:rs28364042Ensembl.1
Natural variantiVAR_029217256H → R. Corresponds to variant dbSNP:rs7249305Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L22647 mRNA Translation: AAC37539.1
AB065464 Genomic DNA Translation: BAC05723.1 Sequence problems.
AY275470 mRNA Translation: AAP32302.1
BC039034 mRNA Translation: AAH39034.1
BC051286 mRNA Translation: AAH51286.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12309.1

Protein sequence database of the Protein Information Resource

More...PIRi		A49690

NCBI Reference Sequences

More...RefSeqi		NP_000946.2, NM_000955.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000292513; ENSP00000292513; ENSG00000160951

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5731

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5731

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000292513.4; ENSP00000292513.3; NM_000955.3; NP_000946.2

UCSC genome browser

More...UCSCi		uc002mys.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22647 mRNA Translation: AAC37539.1
AB065464 Genomic DNA Translation: BAC05723.1 Sequence problems.
AY275470 mRNA Translation: AAP32302.1
BC039034 mRNA Translation: AAH39034.1
BC051286 mRNA Translation: AAH51286.1
CCDSiCCDS12309.1
PIRiA49690
RefSeqiNP_000946.2, NM_000955.2

3D structure databases

SMRiP34995
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi111703, 3 interactors
STRINGi9606.ENSP00000292513

Chemistry databases

BindingDBiP34995
ChEMBLiCHEMBL1811
DrugBankiDB00770, Alprostadil
DB00905, Bimatoprost
DB00297, Bupivacaine
DB00429, Carboprost tromethamine
DB00917, Dinoprostone
DB01088, Iloprost
DB09211, Limaprost
DB00929, Misoprostol
DrugCentraliP34995
GuidetoPHARMACOLOGYi340

Protein family/group databases

TCDBi9.A.14.9.1, the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniP34995, 2 sites
PhosphoSitePlusiP34995

Genetic variation databases

BioMutaiPTGER1
DMDMi83287886

Proteomic databases

PaxDbiP34995
PeptideAtlasiP34995
PRIDEiP34995

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		13701, 260 antibodies from 32 providers

The DNASU plasmid repository

More...DNASUi		5731

Genome annotation databases

EnsembliENST00000292513; ENSP00000292513; ENSG00000160951
GeneIDi5731
KEGGihsa:5731
MANE-SelectiENST00000292513.4; ENSP00000292513.3; NM_000955.3; NP_000946.2
UCSCiuc002mys.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5731
DisGeNETi5731

GeneCards: human genes, protein and diseases

More...GeneCardsi		PTGER1
HGNCiHGNC:9593, PTGER1
HPAiENSG00000160951, Tissue enhanced (kidney, lymphoid tissue)
MIMi176802, gene
neXtProtiNX_P34995
OpenTargetsiENSG00000160951
PharmGKBiPA286
VEuPathDBiHostDB:ENSG00000160951

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3656, Eukaryota
GeneTreeiENSGT01030000234559
HOGENOMiCLU_045991_3_0_1
InParanoidiP34995
OMAiIYLIAKC
OrthoDBi972015at2759
PhylomeDBiP34995
TreeFamiTF324982

Enzyme and pathway databases

PathwayCommonsiP34995
ReactomeiR-HSA-391908, Prostanoid ligand receptors
R-HSA-416476, G alpha (q) signalling events
SignaLinkiP34995
SIGNORiP34995

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5731, 6 hits in 1038 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		EP1_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5731
PharosiP34995, Tclin

Protein Ontology

More...PROi		PR:P34995
RNActiP34995, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000160951, Expressed in stomach and 104 other tissues
GenevisibleiP34995, HS

Family and domain databases

InterProiView protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR008365, Prostanoid_rcpt
IPR001244, Prostglndn_DP_rcpt
IPR000708, Prostglndn_EP1_rcpt
PANTHERiPTHR11866, PTHR11866, 1 hit
PTHR11866:SF3, PTHR11866:SF3, 1 hit
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00428, PROSTAGLNDNR
PR01788, PROSTANOIDR
PR00580, PRSTNOIDEP1R
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPE2R1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34995
Secondary accession number(s): Q5U5U4
, Q86UH3, Q86VB5, Q8NHB2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 10, 2005
Last modified: February 23, 2022
This is version 171 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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