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Entry version 175 (07 Oct 2020)
Sequence version 1 (01 Feb 1994)
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Protein

Thyrotropin-releasing hormone receptor

Gene

TRHR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P34981

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-375276, Peptide ligand-binding receptors
R-HSA-416476, G alpha (q) signalling events

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.14.1.4, the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thyrotropin-releasing hormone receptor
Short name:
TRH-R
Alternative name(s):
Thyroliberin receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRHR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000174417.2

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12299, TRHR

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
188545, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P34981

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei29 – 51Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini52 – 61CytoplasmicSequence analysis10
Transmembranei62 – 83Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini84 – 99ExtracellularSequence analysisAdd BLAST16
Transmembranei100 – 121Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini122 – 144CytoplasmicSequence analysisAdd BLAST23
Transmembranei145 – 168Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini169 – 193ExtracellularSequence analysisAdd BLAST25
Transmembranei194 – 215Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini216 – 266CytoplasmicSequence analysisAdd BLAST51
Transmembranei267 – 288Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini289 – 296ExtracellularSequence analysis8
Transmembranei297 – 319Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini320 – 398CytoplasmicSequence analysisAdd BLAST79

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hypothyroidism, congenital, non-goitrous, 7 (CHNG7)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of central hypothyroidism, a disorder characterized by sub-optimal thyroid hormone secretion, due to insufficient stimulation by thyrotropin of an otherwise normal thyroid gland. It may be caused by congenital or acquired disorders of the pituitary gland or hypothalamus. CHNG7 is a congenital, autosomal recessive form characterized by normal-to-low T4 and normal-to-high thyrotropin levels, and reduced or absent pituitary responsiveness to thyrotropin-releasing hormone. Patients may exhibit short stature, growth retardation, and delayed bone age, as well as lethargy or fatigue.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08328117 – 398Missing in CHNG7; loss of thyrotropin-releasing hormone receptor activity. 2 PublicationsAdd BLAST382
Natural variantiVAR_08328281P → R in CHNG7; loss of thyrotropin-releasing hormone receptor activity; no effect on localization to plasma membrane. 1 Publication1
Natural variantiVAR_083283115 – 118SITA → T in CHNG7; loss of thyrotropin-releasing hormone receptor activity. 1 Publication4
Natural variantiVAR_083284131I → T in CHNG7; decreased affinity for TRH. 1 Publication1

Keywords - Diseasei

Congenital hypothyroidism, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
7201

MalaCards human disease database

More...
MalaCardsi
TRHR
MIMi618573, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000174417

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
99832, Resistance to thyrotropin-releasing hormone syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36979

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P34981, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1810

Drug and drug target database

More...
DrugBanki
DB09421, Protirelin

DrugCentral

More...
DrugCentrali
P34981

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
363

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRHR

Domain mapping of disease mutations (DMDM)

More...
DMDMi
464921

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000701871 – 398Thyrotropin-releasing hormone receptorAdd BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi98 ↔ 179PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P34981

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P34981

PeptideAtlas

More...
PeptideAtlasi
P34981

PRoteomics IDEntifications database

More...
PRIDEi
P34981

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
54965

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P34981, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P34981

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P34981

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000174417, Expressed in calcaneal tendon and 16 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P34981, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000174417, Group enriched (brain, pituitary gland, thyroid gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P34981

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3656, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01000000214570

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009579_6_5_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P34981

KEGG Orthology (KO)

More...
KOi
K04282

Identification of Orthologs from Complete Genome Data

More...
OMAi
YLPIYFT

Database of Orthologous Groups

More...
OrthoDBi
1255241at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P34981

TreeFam database of animal gene trees

More...
TreeFami
TF326170

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR002120, TRH_rcpt_1

The PANTHER Classification System

More...
PANTHERi
PTHR46061, PTHR46061, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00237, GPCRRHODOPSN
PR00751, THYROLIBRINR
PR01846, TRHRFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P34981-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENETVSELN QTQLQPRAVV ALEYQVVTIL LVLIICGLGI VGNIMVVLVV
60 70 80 90 100
MRTKHMRTPT NCYLVSLAVA DLMVLVAAGL PNITDSIYGS WVYGYVGCLC
110 120 130 140 150
ITYLQYLGIN ASSCSITAFT IERYIAICHP IKAQFLCTFS RAKKIIIFVW
160 170 180 190 200
AFTSLYCMLW FFLLDLNIST YKDAIVISCG YKISRNYYSP IYLMDFGVFY
210 220 230 240 250
VVPMILATVL YGFIARILFL NPIPSDPKEN SKTWKNDSTH QNTNLNVNTS
260 270 280 290 300
NRCFNSTVSS RKQVTKMLAV VVILFALLWM PYRTLVVVNS FLSSPFQENW
310 320 330 340 350
FLLFCRICIY LNSAINPVIY NLMSQKFRAA FRKLCNCKQK PTEKPANYSV
360 370 380 390
ALNYSVIKES DHFSTELDDI TVTDTYLSAT KVSFDDTCLA SEVSFSQS
Length:398
Mass (Da):45,085
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE920B5F2E933D3E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01185710N → K. Corresponds to variant dbSNP:rs5774Ensembl.1
Natural variantiVAR_08328117 – 398Missing in CHNG7; loss of thyrotropin-releasing hormone receptor activity. 2 PublicationsAdd BLAST382
Natural variantiVAR_08328281P → R in CHNG7; loss of thyrotropin-releasing hormone receptor activity; no effect on localization to plasma membrane. 1 Publication1
Natural variantiVAR_083283115 – 118SITA → T in CHNG7; loss of thyrotropin-releasing hormone receptor activity. 1 Publication4
Natural variantiVAR_083284131I → T in CHNG7; decreased affinity for TRH. 1 Publication1
Natural variantiVAR_049450168I → M. Corresponds to variant dbSNP:rs13306060Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D16845 mRNA Translation: BAA04120.1
X75071 mRNA Translation: CAA52965.1
X72089 mRNA Translation: CAA50979.1
S75283, S75281 Genomic DNA Translation: AAB32222.1
D85376 Genomic DNA Translation: BAA12796.1
AY493373 mRNA Translation: AAR84356.1
BC105045 mRNA Translation: AAI05046.1
BC113360 mRNA Translation: AAI13361.1
AJ011701 Genomic DNA Translation: CAA09746.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6311.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S40682, JN0708

NCBI Reference Sequences

More...
RefSeqi
NP_003292.1, NM_003301.5
XP_011515565.1, XM_011517263.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000311762; ENSP00000309818; ENSG00000174417
ENST00000518632; ENSP00000430711; ENSG00000174417

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7201

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7201

UCSC genome browser

More...
UCSCi
uc003ymz.5, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16845 mRNA Translation: BAA04120.1
X75071 mRNA Translation: CAA52965.1
X72089 mRNA Translation: CAA50979.1
S75283, S75281 Genomic DNA Translation: AAB32222.1
D85376 Genomic DNA Translation: BAA12796.1
AY493373 mRNA Translation: AAR84356.1
BC105045 mRNA Translation: AAI05046.1
BC113360 mRNA Translation: AAI13361.1
AJ011701 Genomic DNA Translation: CAA09746.1
CCDSiCCDS6311.1
PIRiS40682, JN0708
RefSeqiNP_003292.1, NM_003301.5
XP_011515565.1, XM_011517263.2

3D structure databases

SMRiP34981
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113052, 19 interactors
IntActiP34981, 17 interactors
STRINGi9606.ENSP00000430711

Chemistry databases

BindingDBiP34981
ChEMBLiCHEMBL1810
DrugBankiDB09421, Protirelin
DrugCentraliP34981
GuidetoPHARMACOLOGYi363

Protein family/group databases

TCDBi9.A.14.1.4, the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

GlyGeniP34981, 2 sites
iPTMnetiP34981
PhosphoSitePlusiP34981

Polymorphism and mutation databases

BioMutaiTRHR
DMDMi464921

Proteomic databases

MassIVEiP34981
PaxDbiP34981
PeptideAtlasiP34981
PRIDEiP34981
ProteomicsDBi54965

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
13449, 296 antibodies

The DNASU plasmid repository

More...
DNASUi
7201

Genome annotation databases

EnsembliENST00000311762; ENSP00000309818; ENSG00000174417
ENST00000518632; ENSP00000430711; ENSG00000174417
GeneIDi7201
KEGGihsa:7201
UCSCiuc003ymz.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7201
DisGeNETi7201
EuPathDBiHostDB:ENSG00000174417.2

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TRHR
HGNCiHGNC:12299, TRHR
HPAiENSG00000174417, Group enriched (brain, pituitary gland, thyroid gland)
MalaCardsiTRHR
MIMi188545, gene
618573, phenotype
neXtProtiNX_P34981
OpenTargetsiENSG00000174417
Orphaneti99832, Resistance to thyrotropin-releasing hormone syndrome
PharmGKBiPA36979

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3656, Eukaryota
GeneTreeiENSGT01000000214570
HOGENOMiCLU_009579_6_5_1
InParanoidiP34981
KOiK04282
OMAiYLPIYFT
OrthoDBi1255241at2759
PhylomeDBiP34981
TreeFamiTF326170

Enzyme and pathway databases

PathwayCommonsiP34981
ReactomeiR-HSA-375276, Peptide ligand-binding receptors
R-HSA-416476, G alpha (q) signalling events

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
7201, 3 hits in 862 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TRHR, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Thyrotropin-releasing_hormone_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7201
PharosiP34981, Tclin

Protein Ontology

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PROi
PR:P34981
RNActiP34981, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000174417, Expressed in calcaneal tendon and 16 other tissues
GenevisibleiP34981, HS

Family and domain databases

InterProiView protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR002120, TRH_rcpt_1
PANTHERiPTHR46061, PTHR46061, 1 hit
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00237, GPCRRHODOPSN
PR00751, THYROLIBRINR
PR01846, TRHRFAMILY
SMARTiView protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRFR_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34981
Secondary accession number(s): Q2M339
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 7, 2020
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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