Prostaglandin E2 receptor EP3 subtype

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• prostaglandin E receptor activity Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Localization of functional prostaglandin E2 receptors EP3 and EP4 in the nuclear envelope."
    Bhattacharya M., Peri K., Ribeiro-da-Silva A., Almazan G., Shichi H., Hou X., Varma D.R., Chemtob S.
    J Biol Chem 274:15719-15724(1999) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: RGD
• bicarbonate transport Source: RGD
• cellular response to forskolin Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "A Ser/Thr cluster within the C-terminal domain of the rat prostaglandin receptor EP3alpha is essential for agonist-induced phosphorylation, desensitization and internalization."
    Neuschafer-Rube F., Hermosilla R., Kuna M., Pathe-Neuschafer-Rube A., Schulein R., Puschel G.P.
    Br J Pharmacol 145:1132-1142(2005) [PubMed] [Europe PMC] [Abstract]
• cellular response to interleukin-1 Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB."
    Waschbisch A., Fiebich B.L., Akundi R.S., Schmitz M.L., Hoozemans J.J., Candelario-Jalil E., Virtainen N., Veerhuis R., Slawik H., Yrjanheikki J., Hull M.
    J Neurochem 96:680-693(2006) [PubMed] [Europe PMC] [Abstract]
• cellular response to lipopolysaccharide Source: RGDInferred from expression patternⁱ
  • "COX-2 inhibition and prostaglandin receptors in experimental nephritis."
    Waldner C., Heise G., Schror K., Heering P.
    Eur J Clin Invest 33:969-975(2003) [PubMed] [Europe PMC] [Abstract]
• desensitization of G protein-coupled receptor signaling pathway Source: RGDInferred from mutant phenotypeⁱ
  • "The C-terminal domain of the human EP4 receptor confers agonist-induced receptor desensitization in a receptor hybrid with the rat EP3beta receptor."
    Neuschafer-Rube F., Hanecke K., Puschel G.P.
    FEBS Lett 415:119-124(1997) [PubMed] [Europe PMC] [Abstract]
• female pregnancy Source: RGDInferred from expression patternⁱ
  • "Characterization of temporal and cell-specific changes in transcripts for prostaglandin E(2) receptors in pseudopregnant rat endometrium."
    Papay K.D., Kennedy T.G.
    Biol Reprod 62:1515-1525(2000) [PubMed] [Europe PMC] [Abstract]
• fever generation Source: RGD
• inflammatory response Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• intestine smooth muscle contraction Source: RGDInferred from mutant phenotypeⁱ
  • "Role of PGE2 in the colonic motility: PGE2 generates and enhances spontaneous contractions of longitudinal smooth muscle in the rat colon."
    Iizuka Y., Kuwahara A., Karaki S.
    J Physiol Sci 64:85-96(2014) [PubMed] [Europe PMC] [Abstract]
• maternal process involved in parturition Source: RGDInferred from expression patternⁱ
  • "Hormonal regulation of prostaglandin E2 receptors: localization and expression in rat cervical tissue."
    Hinton A.C., Grigsby P.L., Pitzer B.A., Brockman D.E., Ittenbach R.F., Hinton R.B., Myatt L.
    Reprod Sci 17:136-146(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: RGDInferred from mutant phenotypeⁱ
  • "The C-terminal domain of the Gs-coupled EP4 receptor confers agonist-dependent coupling control to Gi but no coupling to Gs in a receptor hybrid with the Gi-coupled EP3 receptor."
    Neuschafer-Rube F., Hanecke K., Blaschke V., Jungermann K., Puschel G.P.
    FEBS Lett 401:185-190(1997) [PubMed] [Europe PMC] [Abstract]
• negative regulation of calcium ion transmembrane transport Source: RGDInferred from mutant phenotypeⁱ
  • "The prostaglandin E series modulates high-voltage-activated calcium channels probably through the EP3 receptor in rat paratracheal ganglia."
    Ito Y., Murai Y., Ishibashi H., Onoue H., Akaike N.
    Neuropharmacology 39:181-190(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of circadian sleep/wake cycle, wakefulness Source: RGDInferred from mutant phenotypeⁱ
  • "Prostaglandin E (EP) receptor subtypes and sleep: promotion by EP4 and inhibition by EP1/EP2."
    Yoshida Y., Matsumura H., Nakajima T., Mandai M., Urakami T., Kuroda K., Yoneda H.
    Neuroreport 11:2127-2131(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of forebrain neuron differentiation Source: RGDInferred from mutant phenotypeⁱ
  • "Prostaglandins compromise basal forebrain cholinergic neuron differentiation and survival: action at EP1/3 receptors results in AIF-induced death."
    Jonakait G.M., Ni L.
    Brain Res 1285:30-41(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gastric acid secretion Source: RGDInferred from mutant phenotypeⁱ
  • "Dual action of prostaglandin E2 on gastric acid secretion through different EP-receptor subtypes in the rat."
    Kato S., Aihara E., Yoshii K., Takeuchi K.
    Am J Physiol Gastrointest Liver Physiol 289:G64-9(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gastrin-induced gastric acid secretion Source: RGDInferred from mutant phenotypeⁱ
  • "Dual action of prostaglandin E2 on gastric acid secretion through different EP-receptor subtypes in the rat."
    Kato S., Aihara E., Yoshii K., Takeuchi K.
    Am J Physiol Gastrointest Liver Physiol 289:G64-9(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of insulin secretion Source: RGDInferred from direct assayⁱ
  • "Prostaglandin E(2) mediates inhibition of insulin secretion by interleukin-1beta."
    Tran P.O., Gleason C.E., Poitout V., Robertson R.P.
    J Biol Chem 274:31245-31248(1999) [PubMed] [Europe PMC] [Abstract]
• negative regulation of norepinephrine secretion Source: RGDInferred from mutant phenotypeⁱ
  • "Prostanoid EP3 and TP receptors-mediated inhibition of noradrenaline release from the isolated rat stomach."
    Yokotani K., Nakamura K., Okada S.
    Eur J Pharmacol 459:187-193(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of platelet aggregation Source: RGDInferred from mutant phenotypeⁱ
  • "1,7-Disubstituted oxyindoles are potent and selective EP(3) receptor antagonists."
    Zhou N., Polozov A.M., O'Connell M., Burgeson J., Yu P., Zeller W., Zhang J., Onua E., Ramirez J., Palsdottir G.A., Halldorsdottir G.V., Andresson T., Kiselyov A.S., Gurney M., Singh J.
    Bioorg Med Chem Lett 20:2658-2664(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of potassium ion transmembrane transport Source: RGDInferred from mutant phenotypeⁱ
  • "PGE2 inhibits basolateral 50 pS potassium channels in the thick ascending limb of the rat kidney."
    Gu R., Jin Y., Zhai Y., Yang L., Zhang C., Li W., Wang L., Kong S., Zhang Y., Yang B., Wang W.H.
    Kidney Int 74:478-485(2008) [PubMed] [Europe PMC] [Abstract]
• phospholipase C-activating G protein-coupled receptor signaling pathway Source: RGD
• positive regulation of cAMP-mediated signaling Source: RGDInferred from mutant phenotypeⁱ
  • "Prostaglandin receptor subtypes, EP3C and EP4, mediate the prostaglandin E2-induced cAMP production and sensitization of sensory neurons."
    Southall M.D., Vasko M.R.
    J Biol Chem 276:16083-16091(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of circadian sleep/wake cycle, non-REM sleep Source: RGDInferred from mutant phenotypeⁱ
  • "Prostaglandin E (EP) receptor subtypes and sleep: promotion by EP4 and inhibition by EP1/EP2."
    Yoshida Y., Matsumura H., Nakajima T., Mandai M., Urakami T., Kuroda K., Yoneda H.
    Neuroreport 11:2127-2131(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of colon smooth muscle contraction Source: RGDInferred from mutant phenotypeⁱ
  • "Role of PGE2 in the colonic motility: PGE2 generates and enhances spontaneous contractions of longitudinal smooth muscle in the rat colon."
    Iizuka Y., Kuwahara A., Karaki S.
    J Physiol Sci 64:85-96(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cytosolic calcium ion concentration Source: RGDInferred from mutant phenotypeⁱ
  • "Functional analysis and chromosomal gene assignment of rat kidney prostaglandin EP3 receptor."
    Takeuchi K., Takahashi N., Kato T., Abe T., Taniyama Y., Tsutsumi E., Ito O., Nakagawara K., Abe K.
    Kidney Int Suppl 55:S183-6(1996) [PubMed] [Europe PMC] [Abstract]
• positive regulation of fever generation Source: RGD
• positive regulation of gastric mucosal blood circulation Source: RGDInferred from mutant phenotypeⁱ
  • "The roles of prostaglandin E receptor subtypes in the cytoprotective action of prostaglandin E2 in rat stomach."
    Araki H., Ukawa H., Sugawa Y., Yagi K., Suzuki K., Takeuchi K.
    Aliment Pharmacol Ther 14 Suppl 1:116-124(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: RGDInferred from mutant phenotypeⁱ
  • "Exploration of prostanoid receptor subtype regulating estradiol and prostaglandin E2 induction of spinophilin in developing preoptic area neurons."
    Burks S.R., Wright C.L., McCarthy M.M.
    Neuroscience 146:1117-1127(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of inhibitory G protein-coupled receptor phosphorylation Source: RGDInferred from mutant phenotypeⁱ
  • "A Ser/Thr cluster within the C-terminal domain of the rat prostaglandin receptor EP3alpha is essential for agonist-induced phosphorylation, desensitization and internalization."
    Neuschafer-Rube F., Hermosilla R., Kuna M., Pathe-Neuschafer-Rube A., Schulein R., Puschel G.P.
    Br J Pharmacol 145:1132-1142(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of myofibroblast contraction Source: RGDInferred from mutant phenotypeⁱ
  • "Prostaglandin E2 induces contraction of liver myofibroblasts by activating EP3 and FP prostanoid receptors."
    Ayabe S., Murata T., Maruyama T., Hori M., Ozaki H.
    Br J Pharmacol 156:835-845(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neutrophil extravasation Source: RGDInferred from mutant phenotypeⁱ
  • "Role of prostaglandin E2 receptor subtypes in ovarian follicle growth in the rat in vivo. Correlation with interleukin-8 and neutrophils."
    El-Nefiawy N., Abdel-Hakim K., Kanayama N., Terao T.
    Histol Histopathol 20:825-831(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein phosphorylation Source: RGDInferred from mutant phenotypeⁱ
  • "A Ser/Thr cluster within the C-terminal domain of the rat prostaglandin receptor EP3alpha is essential for agonist-induced phosphorylation, desensitization and internalization."
    Neuschafer-Rube F., Hermosilla R., Kuna M., Pathe-Neuschafer-Rube A., Schulein R., Puschel G.P.
    Br J Pharmacol 145:1132-1142(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of smooth muscle contraction involved in micturition Source: RGDInferred from mutant phenotypeⁱ
  • "An excitatory role for peripheral EP3 receptors in bladder afferent function."
    Su X., Lashinger E.S., Leon L.A., Hoffman B.E., Hieble J.P., Gardner S.D., Fries H.E., Edwards R.M., Li J., Laping N.J.
    Am J Physiol Renal Physiol 295:F585-94(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of urine volume Source: RGD
• positive regulation of vasoconstriction Source: RGDInferred from mutant phenotypeⁱ
  • "Biphasic actions of prostaglandin E(2) on the renal afferent arteriole : role of EP(3) and EP(4) receptors."
    Tang L., Loutzenhiser K., Loutzenhiser R.
    Circ Res 86:663-670(2000) [PubMed] [Europe PMC] [Abstract]
• prostaglandin receptor internalization Source: RGDInferred from mutant phenotypeⁱ
  • "A Ser/Thr cluster within the C-terminal domain of the rat prostaglandin receptor EP3alpha is essential for agonist-induced phosphorylation, desensitization and internalization."
    Neuschafer-Rube F., Hermosilla R., Kuna M., Pathe-Neuschafer-Rube A., Schulein R., Puschel G.P.
    Br J Pharmacol 145:1132-1142(2005) [PubMed] [Europe PMC] [Abstract]
• receptor internalization Source: RGDInferred from mutant phenotypeⁱ
  • "A Ser/Thr cluster within the C-terminal domain of the rat prostaglandin receptor EP3alpha is essential for agonist-induced phosphorylation, desensitization and internalization."
    Neuschafer-Rube F., Hermosilla R., Kuna M., Pathe-Neuschafer-Rube A., Schulein R., Puschel G.P.
    Br J Pharmacol 145:1132-1142(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of circadian sleep/wake cycle, wakefulness Source: RGDInferred from mutant phenotypeⁱ
  • "Prostaglandin E (EP) receptor subtypes and sleep: promotion by EP4 and inhibition by EP1/EP2."
    Yoshida Y., Matsumura H., Nakajima T., Mandai M., Urakami T., Kuroda K., Yoneda H.
    Neuroreport 11:2127-2131(2000) [PubMed] [Europe PMC] [Abstract]
• regulation of norepinephrine secretion Source: RGDInferred from mutant phenotypeⁱ
  • "Prostanoid EP3 and TP receptors-mediated inhibition of noradrenaline release from the isolated rat stomach."
    Yokotani K., Nakamura K., Okada S.
    Eur J Pharmacol 459:187-193(2003) [PubMed] [Europe PMC] [Abstract]
• response to estradiol Source: RGDInferred from expression patternⁱ
  • "Characterization of temporal and cell-specific changes in transcripts for prostaglandin E(2) receptors in pseudopregnant rat endometrium."
    Papay K.D., Kennedy T.G.
    Biol Reprod 62:1515-1525(2000) [PubMed] [Europe PMC] [Abstract]
• response to lipopolysaccharide Source: RGD
• response to progesterone Source: RGDInferred from expression patternⁱ
  • "Hormonal regulation of prostaglandin E2 receptors: localization and expression in rat cervical tissue."
    Hinton A.C., Grigsby P.L., Pitzer B.A., Brockman D.E., Ittenbach R.F., Hinton R.B., Myatt L.
    Reprod Sci 17:136-146(2010) [PubMed] [Europe PMC] [Abstract]
• response to salt Source: RGDInferred from expression patternⁱ
  • "Differential regulation of renal prostaglandin receptor mRNAs by dietary salt intake in the rat."
    Jensen B.L., Mann B., Skott O., Kurtz A.
    Kidney Int 56:528-537(1999) [PubMed] [Europe PMC] [Abstract]
• response to xenobiotic stimulus Source: RGDInferred from expression patternⁱ
  • "Hormonal regulation of prostaglandin E2 receptors: localization and expression in rat cervical tissue."
    Hinton A.C., Grigsby P.L., Pitzer B.A., Brockman D.E., Ittenbach R.F., Hinton R.B., Myatt L.
    Reprod Sci 17:136-146(2010) [PubMed] [Europe PMC] [Abstract]
• urinary bladder smooth muscle contraction Source: RGDInferred from mutant phenotypeⁱ
  • "An excitatory role for peripheral EP3 receptors in bladder afferent function."
    Su X., Lashinger E.S., Leon L.A., Hoffman B.E., Hieble J.P., Gardner S.D., Fries H.E., Edwards R.M., Li J., Laping N.J.
    Am J Physiol Renal Physiol 295:F585-94(2008) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MAGVWAPEHS VEAHSNQSSA ADGCGSVSVA FPITMMVTGF VGNALAMLLV 
        60         70         80         90        100
VRSYRRRESK RKKSFLLCIG WLALTDLVGQ LLTSPVVILV YLSQRRWEQL 
       110        120        130        140        150
DPSGRLCTFF GLTMTVFGLS SLLVASAMAV ERALAIRAPH WYASHMKTRA 
       160        170        180        190        200
TPVLLGVWLS VLAFALLPVL GVGRYSVQWP GTWCFISTGP AGNETDSARE 
       210        220        230        240        250
PGSVAFASAF ACLGLLALVV TFACNLATIK ALVSRCRAKA AASQSSAQWG 
       260        270        280        290        300
RITTETAIQL MGIMCVLSVC WSPLLIMMLK MIFNQMSVEQ CKTQMGKEKE 
       310        320        330        340        350
CNSFLIAVRL ASLNQILDPW VYLLLRKILL RKFCQIRDHT NYASSSTSLP 
       360 
CPGSSVLMWS DQLER                                       

        10         20         30         40         50
MAGVWAPEHS VEAHSNQSSA ADGCGSVSVA FPITMMVTGF VGNALAMLLV 
        60         70         80         90        100
VRSYRRRESK RKKSFLLCIG WLALTDLVGQ LLTSPVVILV YLSQRRWEQL 
       110        120        130        140        150
DPSGRLCTFF GLTMTVFGLS SLLVASAMAV ERALAIRAPH WYASHMKTRA 
       160        170        180        190        200
TPVLLGVWLS VLAFALLPVL GVGRYSVQWP GTWCFISTGP AGNETDSARE 
       210        220        230        240        250
PGSVAFASAF ACLGLLALVV TFACNLATIK ALVSRCRAKA AASQSSAQWG 
       260        270        280        290        300
RITTETAIQL MGIMCVLSVC WSPLLIMMLK MIFNQMSVEQ CKTQMGKEKE 
       310        320        330        340        350
CNSFLIAVRL ASLNQILDPW VYLLLRKILL RKFCQMMNNL KRSFIAIPAS 
       360 
LSMRISSPRE G                                           

        10         20         30         40         50
MAGVWAPEHS VEAHSNQSSA ADGCGSVSVA FPITMMVTGF VGNALAMLLV 
        60         70         80         90        100
VRSYRRRESK RKKSFLLCIG WLALTDLVGQ LLTSPVVILV YLSQRRWEQL 
       110        120        130        140        150
DPSGRLCTFF GLTMTVFGLS SLLVASAMAV ERALAIRAPH WYASHMKTRA 
       160        170        180        190        200
TPVLLGVWLS VLAFALLPVL GVGRYSVQWP GTWCFISTGP AGNETDSARE 
       210        220        230        240        250
PGSVAFASAF ACLGLLALVV TFACNLATIK ALVSRCRAKA AASQSSAQWG 
       260        270        280        290        300
RITTETAIQL MGIMCVLSVC WSPLLIMMLK MIFNQMSVEQ CKTQMGKEKE 
       310        320        330        340        350
CNSFLIAVRL ASLNQILDPW VYLLLRKILL RKFCQVANAV SSCSSDQQKG 
       360 
QAISLSNEVV HPGP                                        

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries
2. SIMILARITY comments
   Index of protein domains and families