Prostaglandin E2 receptor EP3 subtype

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• prostaglandin E receptor activity Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Localization of functional prostaglandin E2 receptors EP3 and EP4 in the nuclear envelope."
    Bhattacharya M., Peri K., Ribeiro-da-Silva A., Almazan G., Shichi H., Hou X., Varma D.R., Chemtob S.
    J. Biol. Chem. 274:15719-15724(1999) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Third isoform of the prostaglandin-E-receptor EP3 subtype with different C-terminal tail coupling to both stimulation and inhibition of adenylate cyclase."
    Irie A., Sugimoto Y., Namba T., Harazono A., Honda A., Watabe A., Negishi M., Narumiya S., Ichikawa A.
    Eur. J. Biochem. 217:313-318(1993) [PubMed] [Europe PMC] [Abstract]
  • "Two isoforms of the EP3 receptor with different carboxyl-terminal domains. Identical ligand binding properties and different coupling properties with Gi proteins."
    Sugimoto Y., Negishi M., Hayashi Y., Namba T., Honda A., Watabe A., Hirata M., Narumiya S., Ichikawa A.
    J. Biol. Chem. 268:2712-2718(1993) [PubMed] [Europe PMC] [Abstract]
• bicarbonate transport Source: RGDInferred from sequence orthologyⁱ
  • "Impaired duodenal bicarbonate secretion and mucosal integrity in mice lacking prostaglandin E-receptor subtype EP(3)."
    Takeuchi K., Ukawa H., Kato S., Furukawa O., Araki H., Sugimoto Y., Ichikawa A., Ushikubi F., Narumiya S.
    Gastroenterology 117:1128-1135(1999) [PubMed] [Europe PMC] [Abstract]
• cellular response to forskolin Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "A Ser/Thr cluster within the C-terminal domain of the rat prostaglandin receptor EP3alpha is essential for agonist-induced phosphorylation, desensitization and internalization."
    Neuschafer-Rube F., Hermosilla R., Kuna M., Pathe-Neuschafer-Rube A., Schulein R., Puschel G.P.
    Br. J. Pharmacol. 145:1132-1142(2005) [PubMed] [Europe PMC] [Abstract]
• cellular response to interleukin-1 Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB."
    Waschbisch A., Fiebich B.L., Akundi R.S., Schmitz M.L., Hoozemans J.J., Candelario-Jalil E., Virtainen N., Veerhuis R., Slawik H., Yrjanheikki J., Hull M.
    J. Neurochem. 96:680-693(2006) [PubMed] [Europe PMC] [Abstract]
• cellular response to lipopolysaccharide Source: RGDInferred from expression patternⁱ
  • "COX-2 inhibition and prostaglandin receptors in experimental nephritis."
    Waldner C., Heise G., Schror K., Heering P.
    Eur. J. Clin. Invest. 33:969-975(2003) [PubMed] [Europe PMC] [Abstract]
• desensitization of G protein-coupled receptor signaling pathway Source: RGDInferred from mutant phenotypeⁱ
  • "The C-terminal domain of the human EP4 receptor confers agonist-induced receptor desensitization in a receptor hybrid with the rat EP3beta receptor."
    Neuschafer-Rube F., Hanecke K., Puschel G.P.
    FEBS Lett. 415:119-124(1997) [PubMed] [Europe PMC] [Abstract]
• female pregnancy Source: RGDInferred from expression patternⁱ
  • "Characterization of temporal and cell-specific changes in transcripts for prostaglandin E(2) receptors in pseudopregnant rat endometrium."
    Papay K.D., Kennedy T.G.
    Biol. Reprod. 62:1515-1525(2000) [PubMed] [Europe PMC] [Abstract]
• fever generation Source: RGDInferred from sequence orthologyⁱ
  • "Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3."
    Ushikubi F., Segi E., Sugimoto Y., Murata T., Matsuoka T., Kobayashi T., Hizaki H., Tuboi K., Katsuyama M., Ichikawa A., Tanaka T., Yoshida N., Narumiya S.
    Nature 395:281-284(1998) [PubMed] [Europe PMC] [Abstract]
• inflammatory response Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• intestine smooth muscle contraction Source: RGDInferred from mutant phenotypeⁱ
  • "Role of PGE2 in the colonic motility: PGE2 generates and enhances spontaneous contractions of longitudinal smooth muscle in the rat colon."
    Iizuka Y., Kuwahara A., Karaki S.
    J Physiol Sci 64:85-96(2014) [PubMed] [Europe PMC] [Abstract]
• maternal process involved in parturition Source: RGDInferred from expression patternⁱ
  • "Hormonal regulation of prostaglandin E2 receptors: localization and expression in rat cervical tissue."
    Hinton A.C., Grigsby P.L., Pitzer B.A., Brockman D.E., Ittenbach R.F., Hinton R.B., Myatt L.
    Reprod Sci 17:136-146(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: RGDInferred from mutant phenotypeⁱ
  • "The C-terminal domain of the Gs-coupled EP4 receptor confers agonist-dependent coupling control to Gi but no coupling to Gs in a receptor hybrid with the Gi-coupled EP3 receptor."
    Neuschafer-Rube F., Hanecke K., Blaschke V., Jungermann K., Puschel G.P.
    FEBS Lett. 401:185-190(1997) [PubMed] [Europe PMC] [Abstract]
• negative regulation of calcium ion transmembrane transport Source: RGDInferred from mutant phenotypeⁱ
  • "The prostaglandin E series modulates high-voltage-activated calcium channels probably through the EP3 receptor in rat paratracheal ganglia."
    Ito Y., Murai Y., Ishibashi H., Onoue H., Akaike N.
    Neuropharmacology 39:181-190(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of circadian sleep/wake cycle, wakefulness Source: RGDInferred from mutant phenotypeⁱ
  • "Prostaglandin E (EP) receptor subtypes and sleep: promotion by EP4 and inhibition by EP1/EP2."
    Yoshida Y., Matsumura H., Nakajima T., Mandai M., Urakami T., Kuroda K., Yoneda H.
    Neuroreport 11:2127-2131(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of forebrain neuron differentiation Source: RGDInferred from mutant phenotypeⁱ
  • "Prostaglandins compromise basal forebrain cholinergic neuron differentiation and survival: action at EP1/3 receptors results in AIF-induced death."
    Jonakait G.M., Ni L.
    Brain Res. 1285:30-41(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gastric acid secretion Source: RGDInferred from mutant phenotypeⁱ
  • "Dual action of prostaglandin E2 on gastric acid secretion through different EP-receptor subtypes in the rat."
    Kato S., Aihara E., Yoshii K., Takeuchi K.
    Am. J. Physiol. Gastrointest. Liver Physiol. 289:G64-9(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gastrin-induced gastric acid secretion Source: RGDInferred from mutant phenotypeⁱ
  • "Dual action of prostaglandin E2 on gastric acid secretion through different EP-receptor subtypes in the rat."
    Kato S., Aihara E., Yoshii K., Takeuchi K.
    Am. J. Physiol. Gastrointest. Liver Physiol. 289:G64-9(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of insulin secretion Source: RGDInferred from direct assayⁱ
  • "Prostaglandin E(2) mediates inhibition of insulin secretion by interleukin-1beta."
    Tran P.O., Gleason C.E., Poitout V., Robertson R.P.
    J. Biol. Chem. 274:31245-31248(1999) [PubMed] [Europe PMC] [Abstract]
• negative regulation of norepinephrine secretion Source: RGDInferred from mutant phenotypeⁱ
  • "Prostanoid EP3 and TP receptors-mediated inhibition of noradrenaline release from the isolated rat stomach."
    Yokotani K., Nakamura K., Okada S.
    Eur. J. Pharmacol. 459:187-193(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of platelet aggregation Source: RGDInferred from mutant phenotypeⁱ
  • "1,7-Disubstituted oxyindoles are potent and selective EP(3) receptor antagonists."
    Zhou N., Polozov A.M., O'Connell M., Burgeson J., Yu P., Zeller W., Zhang J., Onua E., Ramirez J., Palsdottir G.A., Halldorsdottir G.V., Andresson T., Kiselyov A.S., Gurney M., Singh J.
    Bioorg. Med. Chem. Lett. 20:2658-2664(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of potassium ion transmembrane transport Source: RGDInferred from mutant phenotypeⁱ
  • "PGE2 inhibits basolateral 50 pS potassium channels in the thick ascending limb of the rat kidney."
    Gu R., Jin Y., Zhai Y., Yang L., Zhang C., Li W., Wang L., Kong S., Zhang Y., Yang B., Wang W.H.
    Kidney Int. 74:478-485(2008) [PubMed] [Europe PMC] [Abstract]
• phospholipase C-activating G protein-coupled receptor signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Mouse prostaglandin E receptor EP3 subtype mediates calcium signals via Gi in cDNA-transfected Chinese hamster ovary cells."
    Irie A., Segi E., Sugimoto Y., Ichikawa A., Negishi M.
    Biochem. Biophys. Res. Commun. 204:303-309(1994) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cAMP-mediated signaling Source: RGDInferred from mutant phenotypeⁱ
  • "Prostaglandin receptor subtypes, EP3C and EP4, mediate the prostaglandin E2-induced cAMP production and sensitization of sensory neurons."
    Southall M.D., Vasko M.R.
    J. Biol. Chem. 276:16083-16091(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of circadian sleep/wake cycle, non-REM sleep Source: RGDInferred from mutant phenotypeⁱ
  • "Prostaglandin E (EP) receptor subtypes and sleep: promotion by EP4 and inhibition by EP1/EP2."
    Yoshida Y., Matsumura H., Nakajima T., Mandai M., Urakami T., Kuroda K., Yoneda H.
    Neuroreport 11:2127-2131(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of colon smooth muscle contraction Source: RGDInferred from mutant phenotypeⁱ
  • "Role of PGE2 in the colonic motility: PGE2 generates and enhances spontaneous contractions of longitudinal smooth muscle in the rat colon."
    Iizuka Y., Kuwahara A., Karaki S.
    J Physiol Sci 64:85-96(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cytosolic calcium ion concentration Source: RGDInferred from mutant phenotypeⁱ
  • "Functional analysis and chromosomal gene assignment of rat kidney prostaglandin EP3 receptor."
    Takeuchi K., Takahashi N., Kato T., Abe T., Taniyama Y., Tsutsumi E., Ito O., Nakagawara K., Abe K.
    Kidney Int. Suppl. 55:S183-6(1996) [PubMed] [Europe PMC] [Abstract]
• positive regulation of fever generation Source: RGDInferred from sequence orthologyⁱ
  • "Central control of fever and female body temperature by RANKL/RANK."
    Hanada R., Leibbrandt A., Hanada T., Kitaoka S., Furuyashiki T., Fujihara H., Trichereau J., Paolino M., Qadri F., Plehm R., Klaere S., Komnenovic V., Mimata H., Yoshimatsu H., Takahashi N., von Haeseler A., Bader M., Kilic S.S.

    , Ueta Y., Pifl C., Narumiya S., Penninger J.M.
    Nature 462:505-509(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gastric mucosal blood circulation Source: RGDInferred from mutant phenotypeⁱ
  • "The roles of prostaglandin E receptor subtypes in the cytoprotective action of prostaglandin E2 in rat stomach."
    Araki H., Ukawa H., Sugawa Y., Yagi K., Suzuki K., Takeuchi K.
    Aliment. Pharmacol. Ther. 14 Suppl 1:116-124(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: RGDInferred from mutant phenotypeⁱ
  • "Exploration of prostanoid receptor subtype regulating estradiol and prostaglandin E2 induction of spinophilin in developing preoptic area neurons."
    Burks S.R., Wright C.L., McCarthy M.M.
    Neuroscience 146:1117-1127(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of inhibitory G protein-coupled receptor phosphorylation Source: RGDInferred from mutant phenotypeⁱ
  • "A Ser/Thr cluster within the C-terminal domain of the rat prostaglandin receptor EP3alpha is essential for agonist-induced phosphorylation, desensitization and internalization."
    Neuschafer-Rube F., Hermosilla R., Kuna M., Pathe-Neuschafer-Rube A., Schulein R., Puschel G.P.
    Br. J. Pharmacol. 145:1132-1142(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of myofibroblast contraction Source: RGDInferred from mutant phenotypeⁱ
  • "Prostaglandin E2 induces contraction of liver myofibroblasts by activating EP3 and FP prostanoid receptors."
    Ayabe S., Murata T., Maruyama T., Hori M., Ozaki H.
    Br. J. Pharmacol. 156:835-845(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neutrophil extravasation Source: RGDInferred from mutant phenotypeⁱ
  • "Role of prostaglandin E2 receptor subtypes in ovarian follicle growth in the rat in vivo. Correlation with interleukin-8 and neutrophils."
    El-Nefiawy N., Abdel-Hakim K., Kanayama N., Terao T.
    Histol. Histopathol. 20:825-831(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein phosphorylation Source: RGDInferred from mutant phenotypeⁱ
  • "A Ser/Thr cluster within the C-terminal domain of the rat prostaglandin receptor EP3alpha is essential for agonist-induced phosphorylation, desensitization and internalization."
    Neuschafer-Rube F., Hermosilla R., Kuna M., Pathe-Neuschafer-Rube A., Schulein R., Puschel G.P.
    Br. J. Pharmacol. 145:1132-1142(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of smooth muscle contraction involved in micturition Source: RGDInferred from mutant phenotypeⁱ
  • "An excitatory role for peripheral EP3 receptors in bladder afferent function."
    Su X., Lashinger E.S., Leon L.A., Hoffman B.E., Hieble J.P., Gardner S.D., Fries H.E., Edwards R.M., Li J., Laping N.J.
    Am. J. Physiol. Renal Physiol. 295:F585-94(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of urine volume Source: RGDInferred from sequence orthologyⁱ
  • "Urinary concentrating function in mice lacking EP3 receptors for prostaglandin E2."
    Fleming E.F., Athirakul K., Oliverio M.I., Key M., Goulet J., Koller B.H., Coffman T.M.
    Am. J. Physiol. 275:F955-F961(1998) [PubMed] [Europe PMC] [Abstract]
• positive regulation of vasoconstriction Source: RGDInferred from mutant phenotypeⁱ
  • "Biphasic actions of prostaglandin E(2) on the renal afferent arteriole : role of EP(3) and EP(4) receptors."
    Tang L., Loutzenhiser K., Loutzenhiser R.
    Circ. Res. 86:663-670(2000) [PubMed] [Europe PMC] [Abstract]
• prostaglandin receptor internalization Source: RGDInferred from mutant phenotypeⁱ
  • "A Ser/Thr cluster within the C-terminal domain of the rat prostaglandin receptor EP3alpha is essential for agonist-induced phosphorylation, desensitization and internalization."
    Neuschafer-Rube F., Hermosilla R., Kuna M., Pathe-Neuschafer-Rube A., Schulein R., Puschel G.P.
    Br. J. Pharmacol. 145:1132-1142(2005) [PubMed] [Europe PMC] [Abstract]
• receptor internalization Source: RGDInferred from mutant phenotypeⁱ
  • "A Ser/Thr cluster within the C-terminal domain of the rat prostaglandin receptor EP3alpha is essential for agonist-induced phosphorylation, desensitization and internalization."
    Neuschafer-Rube F., Hermosilla R., Kuna M., Pathe-Neuschafer-Rube A., Schulein R., Puschel G.P.
    Br. J. Pharmacol. 145:1132-1142(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of circadian sleep/wake cycle, wakefulness Source: RGDInferred from mutant phenotypeⁱ
  • "Prostaglandin E (EP) receptor subtypes and sleep: promotion by EP4 and inhibition by EP1/EP2."
    Yoshida Y., Matsumura H., Nakajima T., Mandai M., Urakami T., Kuroda K., Yoneda H.
    Neuroreport 11:2127-2131(2000) [PubMed] [Europe PMC] [Abstract]
• regulation of norepinephrine secretion Source: RGDInferred from mutant phenotypeⁱ
  • "Prostanoid EP3 and TP receptors-mediated inhibition of noradrenaline release from the isolated rat stomach."
    Yokotani K., Nakamura K., Okada S.
    Eur. J. Pharmacol. 459:187-193(2003) [PubMed] [Europe PMC] [Abstract]
• response to drug Source: RGDInferred from expression patternⁱ
  • "Hormonal regulation of prostaglandin E2 receptors: localization and expression in rat cervical tissue."
    Hinton A.C., Grigsby P.L., Pitzer B.A., Brockman D.E., Ittenbach R.F., Hinton R.B., Myatt L.
    Reprod Sci 17:136-146(2010) [PubMed] [Europe PMC] [Abstract]
• response to estradiol Source: RGDInferred from expression patternⁱ
  • "Characterization of temporal and cell-specific changes in transcripts for prostaglandin E(2) receptors in pseudopregnant rat endometrium."
    Papay K.D., Kennedy T.G.
    Biol. Reprod. 62:1515-1525(2000) [PubMed] [Europe PMC] [Abstract]
• response to lipopolysaccharide Source: RGDInferred from sequence orthologyⁱ
  • "Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia."
    Takayama K., Yuhki K., Ono K., Fujino T., Hara A., Yamada T., Kuriyama S., Karibe H., Okada Y., Takahata O., Taniguchi T., Iijima T., Iwasaki H., Narumiya S., Ushikubi F.
    Nat. Med. 11:562-566(2005) [PubMed] [Europe PMC] [Abstract]
• response to progesterone Source: RGDInferred from expression patternⁱ
  • "Hormonal regulation of prostaglandin E2 receptors: localization and expression in rat cervical tissue."
    Hinton A.C., Grigsby P.L., Pitzer B.A., Brockman D.E., Ittenbach R.F., Hinton R.B., Myatt L.
    Reprod Sci 17:136-146(2010) [PubMed] [Europe PMC] [Abstract]
• response to salt Source: RGDInferred from expression patternⁱ
  • "Differential regulation of renal prostaglandin receptor mRNAs by dietary salt intake in the rat."
    Jensen B.L., Mann B., Skott O., Kurtz A.
    Kidney Int. 56:528-537(1999) [PubMed] [Europe PMC] [Abstract]
• urinary bladder smooth muscle contraction Source: RGDInferred from mutant phenotypeⁱ
  • "An excitatory role for peripheral EP3 receptors in bladder afferent function."
    Su X., Lashinger E.S., Leon L.A., Hoffman B.E., Hieble J.P., Gardner S.D., Fries H.E., Edwards R.M., Li J., Laping N.J.
    Am. J. Physiol. Renal Physiol. 295:F585-94(2008) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MAGVWAPEHS VEAHSNQSSA ADGCGSVSVA FPITMMVTGF VGNALAMLLV 
        60         70         80         90        100
VRSYRRRESK RKKSFLLCIG WLALTDLVGQ LLTSPVVILV YLSQRRWEQL 
       110        120        130        140        150
DPSGRLCTFF GLTMTVFGLS SLLVASAMAV ERALAIRAPH WYASHMKTRA 
       160        170        180        190        200
TPVLLGVWLS VLAFALLPVL GVGRYSVQWP GTWCFISTGP AGNETDSARE 
       210        220        230        240        250
PGSVAFASAF ACLGLLALVV TFACNLATIK ALVSRCRAKA AASQSSAQWG 
       260        270        280        290        300
RITTETAIQL MGIMCVLSVC WSPLLIMMLK MIFNQMSVEQ CKTQMGKEKE 
       310        320        330        340        350
CNSFLIAVRL ASLNQILDPW VYLLLRKILL RKFCQIRDHT NYASSSTSLP 
       360 
CPGSSVLMWS DQLER                                       

        10         20         30         40         50
MAGVWAPEHS VEAHSNQSSA ADGCGSVSVA FPITMMVTGF VGNALAMLLV 
        60         70         80         90        100
VRSYRRRESK RKKSFLLCIG WLALTDLVGQ LLTSPVVILV YLSQRRWEQL 
       110        120        130        140        150
DPSGRLCTFF GLTMTVFGLS SLLVASAMAV ERALAIRAPH WYASHMKTRA 
       160        170        180        190        200
TPVLLGVWLS VLAFALLPVL GVGRYSVQWP GTWCFISTGP AGNETDSARE 
       210        220        230        240        250
PGSVAFASAF ACLGLLALVV TFACNLATIK ALVSRCRAKA AASQSSAQWG 
       260        270        280        290        300
RITTETAIQL MGIMCVLSVC WSPLLIMMLK MIFNQMSVEQ CKTQMGKEKE 
       310        320        330        340        350
CNSFLIAVRL ASLNQILDPW VYLLLRKILL RKFCQMMNNL KRSFIAIPAS 
       360 
LSMRISSPRE G                                           

        10         20         30         40         50
MAGVWAPEHS VEAHSNQSSA ADGCGSVSVA FPITMMVTGF VGNALAMLLV 
        60         70         80         90        100
VRSYRRRESK RKKSFLLCIG WLALTDLVGQ LLTSPVVILV YLSQRRWEQL 
       110        120        130        140        150
DPSGRLCTFF GLTMTVFGLS SLLVASAMAV ERALAIRAPH WYASHMKTRA 
       160        170        180        190        200
TPVLLGVWLS VLAFALLPVL GVGRYSVQWP GTWCFISTGP AGNETDSARE 
       210        220        230        240        250
PGSVAFASAF ACLGLLALVV TFACNLATIK ALVSRCRAKA AASQSSAQWG 
       260        270        280        290        300
RITTETAIQL MGIMCVLSVC WSPLLIMMLK MIFNQMSVEQ CKTQMGKEKE 
       310        320        330        340        350
CNSFLIAVRL ASLNQILDPW VYLLLRKILL RKFCQVANAV SSCSSDQQKG 
       360 
QAISLSNEVV HPGP                                        

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries