Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 173 (31 Jul 2019)
Sequence version 1 (01 Feb 1994)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Cannabinoid receptor 2

Gene

CNR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processInflammatory response

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-418594 G alpha (i) signalling events

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P34972

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.14.2.6 the g-protein-coupled receptor (gpcr) family

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001608

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cannabinoid receptor 2
Short name:
CB-2
Short name:
CB2
Short name:
hCB2
Alternative name(s):
CX5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CNR2
Synonyms:CB2A, CB2B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2160 CNR2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605051 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P34972

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei34 – 59Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini60 – 71CytoplasmicSequence analysisAdd BLAST12
Transmembranei72 – 92Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini93 – 104ExtracellularSequence analysisAdd BLAST12
Transmembranei105 – 129Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini130 – 149CytoplasmicSequence analysisAdd BLAST20
Transmembranei150 – 172Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini173 – 188ExtracellularSequence analysisAdd BLAST16
Transmembranei189 – 214Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini215 – 246CytoplasmicSequence analysisAdd BLAST32
Transmembranei247 – 267Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini268 – 279ExtracellularSequence analysisAdd BLAST12
Transmembranei280 – 301Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini302 – 360CytoplasmicSequence analysisAdd BLAST59

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi109K → A: No effect on agonist binding. Affects cannabinoid agonist binding; when associated with G-112. 1 Publication1
Mutagenesisi109K → R: No effect on agonist binding. 1 Publication1
Mutagenesisi112S → G: Affects cannabinoid agonist binding; when associated with A-109. 1 Publication1
Mutagenesisi130D → A: Loss of ligand binding. Alters agonist-induced inhibitory effect on adenylate cyclase. 1 Publication1
Mutagenesisi131R → A: No effect on ligand binding. Alters agonist-induced inhibitory effect on adenylate cyclase. 1 Publication1
Mutagenesisi201L → P: Abolishes ligand binding and agonist-induced inhibitory effect on adenylate cyclase. 1 Publication1
Mutagenesisi207Y → A: Abolishes agonist-induced inhibitory effect on adenylate cyclase. No effect on ligand binding. 1 Publication1
Mutagenesisi244A → E: Loss of ligand binding. Alters agonist-induced inhibitory effect on adenylate cyclase. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
1269

Open Targets

More...
OpenTargetsi
ENSG00000188822

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26682

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL253

Drug and drug target database

More...
DrugBanki
DB00470 Dronabinol
DB00486 Nabilone

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
57

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CNR2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
461697

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000693231 – 360Cannabinoid receptor 2Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi11N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei335PhosphoserineBy similarity1
Modified residuei336PhosphoserineBy similarity1
Modified residuei338PhosphothreonineBy similarity1
Modified residuei352Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P34972

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P34972

PeptideAtlas

More...
PeptideAtlasi
P34972

PRoteomics IDEntifications database

More...
PRIDEi
P34972

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54964

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P34972

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P34972

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes.7 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

In macrophages, down-regulated by endocannabinoid anandamide/AEA.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000188822 Expressed in 36 organ(s), highest expression level in spleen

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P34972 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P34972 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB009719

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P34972, 23 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000363596

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P34972

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1360
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P34972

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P34972

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00960000186614

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049272

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P34972

KEGG Orthology (KO)

More...
KOi
K04278

Identification of Orthologs from Complete Genome Data

More...
OMAi
VNFHVFH

Database of Orthologous Groups

More...
OrthoDBi
822074at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P34972

TreeFam database of animal gene trees

More...
TreeFami
TF330052

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15341 7tmA_CB2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001551 Canbinoid_rcpt_2
IPR002230 Cnbnoid_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

The PANTHER Classification System

More...
PANTHERi
PTHR22750:SF10 PTHR22750:SF10, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00523 CANABINOID2R
PR00362 CANNABINOIDR
PR00237 GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P34972-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEECWVTEIA NGSKDGLDSN PMKDYMILSG PQKTAVAVLC TLLGLLSALE
60 70 80 90 100
NVAVLYLILS SHQLRRKPSY LFIGSLAGAD FLASVVFACS FVNFHVFHGV
110 120 130 140 150
DSKAVFLLKI GSVTMTFTAS VGSLLLTAID RYLCLRYPPS YKALLTRGRA
160 170 180 190 200
LVTLGIMWVL SALVSYLPLM GWTCCPRPCS ELFPLIPNDY LLSWLLFIAF
210 220 230 240 250
LFSGIIYTYG HVLWKAHQHV ASLSGHQDRQ VPGMARMRLD VRLAKTLGLV
260 270 280 290 300
LAVLLICWFP VLALMAHSLA TTLSDQVKKA FAFCSMLCLI NSMVNPVIYA
310 320 330 340 350
LRSGEIRSSA HHCLAHWKKC VRGLGSEAKE EAPRSSVTET EADGKITPWP
360
DSRDLDLSDC
Length:360
Mass (Da):39,681
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA7ECF68C16E7514B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti173T → A in AAH95545 (PubMed:15489334).Curated1
Sequence conflicti307R → H in AAH69722 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05431063Q → R High incidence in Japanese depressed subjects. 2 PublicationsCorresponds to variant dbSNP:rs2501432Ensembl.1
Natural variantiVAR_029209316H → Y3 PublicationsCorresponds to variant dbSNP:rs2229579Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X74328 mRNA Translation: CAA52376.1
EU517121 mRNA Translation: ACD31539.1
AJ430063 mRNA Translation: CAD22548.1
AJ430064 Genomic DNA Translation: CAD22549.1
AY242132 Genomic DNA Translation: AAO92299.1
AM156854 mRNA Translation: CAJ42137.1
AM156855 mRNA Translation: CAJ42138.1
AM156856 mRNA Translation: CAJ42139.1
AL590609 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW95099.1
BC069722 mRNA Translation: AAH69722.1
BC074767 mRNA Translation: AAH74767.1
BC095545 mRNA Translation: AAH95545.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS245.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S36750

NCBI Reference Sequences

More...
RefSeqi
NP_001832.1, NM_001841.2
XP_011538931.1, XM_011540629.2
XP_016855750.1, XM_017000261.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000374472; ENSP00000363596; ENSG00000188822

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1269

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1269

UCSC genome browser

More...
UCSCi
uc001bif.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74328 mRNA Translation: CAA52376.1
EU517121 mRNA Translation: ACD31539.1
AJ430063 mRNA Translation: CAD22548.1
AJ430064 Genomic DNA Translation: CAD22549.1
AY242132 Genomic DNA Translation: AAO92299.1
AM156854 mRNA Translation: CAJ42137.1
AM156855 mRNA Translation: CAJ42138.1
AM156856 mRNA Translation: CAJ42139.1
AL590609 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW95099.1
BC069722 mRNA Translation: AAH69722.1
BC074767 mRNA Translation: AAH74767.1
BC095545 mRNA Translation: AAH95545.1
CCDSiCCDS245.1
PIRiS36750
RefSeqiNP_001832.1, NM_001841.2
XP_011538931.1, XM_011540629.2
XP_016855750.1, XM_017000261.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KI9NMR-A240-272[»]
5ZTYX-ray2.80A21-222[»]
A235-325[»]
SMRiP34972
ModBaseiSearch...

Protein-protein interaction databases

IntActiP34972, 23 interactors
STRINGi9606.ENSP00000363596

Chemistry databases

BindingDBiP34972
ChEMBLiCHEMBL253
DrugBankiDB00470 Dronabinol
DB00486 Nabilone
GuidetoPHARMACOLOGYi57
SwissLipidsiSLP:000001608

Protein family/group databases

TCDBi9.A.14.2.6 the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiP34972
PhosphoSitePlusiP34972

Polymorphism and mutation databases

BioMutaiCNR2
DMDMi461697

Proteomic databases

MaxQBiP34972
PaxDbiP34972
PeptideAtlasiP34972
PRIDEiP34972
ProteomicsDBi54964

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1269
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374472; ENSP00000363596; ENSG00000188822
GeneIDi1269
KEGGihsa:1269
UCSCiuc001bif.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1269
DisGeNETi1269

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CNR2
HGNCiHGNC:2160 CNR2
HPAiCAB009719
MIMi605051 gene
neXtProtiNX_P34972
OpenTargetsiENSG00000188822
PharmGKBiPA26682

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00960000186614
HOGENOMiHOG000049272
InParanoidiP34972
KOiK04278
OMAiVNFHVFH
OrthoDBi822074at2759
PhylomeDBiP34972
TreeFamiTF330052

Enzyme and pathway databases

ReactomeiR-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-418594 G alpha (i) signalling events
SIGNORiP34972

Miscellaneous databases

EvolutionaryTraceiP34972

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Cannabinoid_receptor_type_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1269

Protein Ontology

More...
PROi
PR:P34972

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000188822 Expressed in 36 organ(s), highest expression level in spleen
ExpressionAtlasiP34972 baseline and differential
GenevisibleiP34972 HS

Family and domain databases

CDDicd15341 7tmA_CB2, 1 hit
InterProiView protein in InterPro
IPR001551 Canbinoid_rcpt_2
IPR002230 Cnbnoid_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR22750:SF10 PTHR22750:SF10, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00523 CANABINOID2R
PR00362 CANNABINOIDR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNR2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34972
Secondary accession number(s): C6ES44
, Q4VBK8, Q5JRH7, Q6B0G7, Q6NSY0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 31, 2019
This is version 173 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again