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UniProtKB - P34971 (ADRB1_MOUSE)
Protein
Beta-1 adrenergic receptor
Gene
Adrb1
Organism
Mus musculus (Mouse)
Status
Functioni
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity).
Involved in the regulation of sleep/wake behaviors (PubMed:31473062).
By similarity1 PublicationGO - Molecular functioni
- alpha-2A adrenergic receptor binding Source: MGI
- amine binding Source: MGI
- beta1-adrenergic receptor activity Source: MGI
- G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential Source: SynGO
- G protein-coupled receptor activity Source: GO_Central
- guanyl-nucleotide exchange factor activity Source: UniProtKB
- PDZ domain binding Source: MGI
- protein heterodimerization activity Source: MGI
GO - Biological processi
- adenylate cyclase-activating adrenergic receptor signaling pathway Source: UniProtKB
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: MGI
- apoptotic process Source: MGI
- brown fat cell differentiation Source: MGI
- diet induced thermogenesis Source: MGI
- fear response Source: MGI
- glycogen catabolic process Source: MGI
- G protein-coupled receptor signaling pathway Source: MGI
- heat generation Source: MGI
- inhibitory postsynaptic potential Source: MGI
- lipid homeostasis Source: MGI
- memory Source: MGI
- negative regulation of multicellular organism growth Source: MGI
- negative regulation of smooth muscle contraction Source: MGI
- negative regulation of urine volume Source: MGI
- norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure Source: MGI
- positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: MGI
- positive regulation of adenylate cyclase activity Source: MGI
- positive regulation of apoptotic process Source: MGI
- positive regulation of calcium ion import across plasma membrane Source: MGI
- positive regulation of cation channel activity Source: MGI
- positive regulation of cell growth involved in cardiac muscle cell development Source: MGI
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of GTPase activity Source: UniProtKB
- positive regulation of heart rate Source: MGI
- positive regulation of heart rate by epinephrine-norepinephrine Source: MGI
- positive regulation of long-term synaptic potentiation Source: MGI
- positive regulation of renin secretion into blood stream Source: MGI
- positive regulation of saliva secretion Source: MGI
- positive regulation of systemic arterial blood pressure Source: MGI
- positive regulation of the force of heart contraction by epinephrine-norepinephrine Source: MGI
- positive regulation of the force of heart contraction by norepinephrine Source: MGI
- protein localization to organelle Source: MGI
- regulation of calcium ion transport Source: MGI
- regulation of cardiac muscle cell contraction Source: MGI
- regulation of circadian sleep/wake cycle, sleep Source: UniProtKB
- response to cold Source: MGI
- Rho protein signal transduction Source: MGI
- sensory perception of pain Source: MGI
- wound healing Source: MGI
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-390696, Adrenoceptors R-MMU-418555, G alpha (s) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Beta-1 adrenergic receptorAlternative name(s): Beta-1 adrenoreceptor Short name: Beta-1 adrenoceptor |
Gene namesi | Name:Adrb1 Synonyms:Adrb1r |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:87937, Adrb1 |
VEuPathDBi | HostDB:ENSMUSG00000035283 |
Subcellular locationi
Endosome
- Early endosome By similarity
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Note: Colocalizes with RAPGEF2 at the plasma membrane. Found in the Golgi upon GOPC overexpression (By similarity).By similarity
Endosome
- early endosome Source: UniProtKB
Nucleus
- nucleus Source: MGI
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: MGI
- intracellular membrane-bounded organelle Source: MGI
- membrane Source: MGI
- postsynapse Source: GOC
- Schaffer collateral - CA1 synapse Source: SynGO
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 55 | ExtracellularBy similarityAdd BLAST | 55 | |
Transmembranei | 56 – 84 | Helical; Name=1By similarityAdd BLAST | 29 | |
Topological domaini | 85 – 93 | CytoplasmicBy similarity | 9 | |
Transmembranei | 94 – 120 | Helical; Name=2By similarityAdd BLAST | 27 | |
Topological domaini | 121 – 132 | ExtracellularBy similarityAdd BLAST | 12 | |
Transmembranei | 133 – 154 | Helical; Name=3By similarityAdd BLAST | 22 | |
Topological domaini | 155 – 172 | CytoplasmicBy similarityAdd BLAST | 18 | |
Transmembranei | 173 – 196 | Helical; Name=4By similarityAdd BLAST | 24 | |
Topological domaini | 197 – 222 | ExtracellularBy similarityAdd BLAST | 26 | |
Transmembranei | 223 – 248 | Helical; Name=5By similarityAdd BLAST | 26 | |
Topological domaini | 249 – 308 | CytoplasmicBy similarityAdd BLAST | 60 | |
Transmembranei | 309 – 338 | Helical; Name=6By similarityAdd BLAST | 30 | |
Topological domaini | 339 – 343 | ExtracellularBy similarity | 5 | |
Transmembranei | 344 – 366 | Helical; Name=7By similarityAdd BLAST | 23 | |
Topological domaini | 367 – 466 | CytoplasmicBy similarityAdd BLAST | 100 |
Keywords - Cellular componenti
Cell membrane, Endosome, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 187 | A → V in knockin mouse model, decreases protein levels. Mice exhibit a short sleep phenotype. Changes the electrophysiological properties of dorsal pons neurons. 1 Publication | 1 |
Chemistry databases
ChEMBLi | CHEMBL3440 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069122 | 1 – 466 | Beta-1 adrenergic receptorAdd BLAST | 466 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 15 | N-linked (GlcNAc...) asparagineCurated | 1 | |
Disulfide bondi | 131 ↔ 216 | PROSITE-ProRule annotation | ||
Disulfide bondi | 209 ↔ 215 | PROSITE-ProRule annotation | ||
Modified residuei | 296 | Phosphoserine; by PKASequence analysis | 1 | |
Modified residuei | 301 | Phosphoserine; by PKASequence analysis | 1 | |
Lipidationi | 381 | S-palmitoyl cysteineBy similarity | 1 | |
Modified residuei | 401 | Phosphoserine; by PKASequence analysis | 1 | |
Modified residuei | 417 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
PaxDbi | P34971 |
PRIDEi | P34971 |
ProteomicsDBi | 296186 |
PTM databases
GlyGeni | P34971, 1 site |
iPTMneti | P34971 |
PhosphoSitePlusi | P34971 |
Expressioni
Tissue specificityi
In brain, expressed by glutamatergic and GABAergic neurons of the dorsal pons (at protein level).1 Publication
Gene expression databases
Bgeei | ENSMUSG00000035283, Expressed in pineal body and 199 other tissues |
Genevisiblei | P34971, MM |
Interactioni
Subunit structurei
Interacts (via C-terminus PDZ motif) with RAPGEF2; the interaction is direct.
Interacts with GOPC, MAGI3 and DLG4 (By similarity).
By similarityBinary interactionsi
GO - Molecular functioni
- alpha-2A adrenergic receptor binding Source: MGI
- PDZ domain binding Source: MGI
- protein heterodimerization activity Source: MGI
Protein-protein interaction databases
DIPi | DIP-59567N |
IntActi | P34971, 6 interactors |
MINTi | P34971 |
STRINGi | 10090.ENSMUSP00000040847 |
Chemistry databases
BindingDBi | P34971 |
Miscellaneous databases
RNActi | P34971, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 264 – 302 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 398 – 466 | DisorderedSequence analysisAdd BLAST | 69 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 463 – 466 | PDZ-BindingBy similarity | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 270 – 286 | Pro residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 438 – 466 | Polar residuesSequence analysisAdd BLAST | 29 |
Domaini
The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor.By similarity
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000161953 |
HOGENOMi | CLU_009579_11_0_1 |
InParanoidi | P34971 |
OMAi | CEFWISV |
OrthoDBi | 750855at2759 |
PhylomeDBi | P34971 |
TreeFami | TF316350 |
Family and domain databases
InterProi | View protein in InterPro IPR002233, ADR_fam IPR000507, ADRB1_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01103, ADRENERGICR PR00561, ADRENRGCB1AR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P34971-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGAGALALGA SEPCNLSSAA PLPDGAATAA RLLVLASPPA SLLPPASEGS
60 70 80 90 100
APLSQQWTAG MGLLLALIVL LIVVGNVLVI VAIAKTPRLQ TLTNLFIMSL
110 120 130 140 150
ASADLVMGLL VVPFGATIVV WGRWEYGSFF CELWTSVDVL CVTASIETLC
160 170 180 190 200
VIALDRYLAI TSPFRYQSLL TRARARALVC TVWAISALVS FLPILMHWWR
210 220 230 240 250
AESDEARRCY NDPKCCDFVT NRAYAIASSV VSFYVPLCIM AFVYLRVFRE
260 270 280 290 300
AQKQVKKIDS CERRFLGGPA RPPSPEPSPS PGPPRPADSL ANGRSSKRRP
310 320 330 340 350
SRLVALREQK ALKTLGIIMG VFTLCWLPFF LANVVKAFHR DLVPDRLFVF
360 370 380 390 400
FNWLGYANSA FNPIIYCRSP DFRKAFQRLL CCARRAACRR RAAHGDRPRA
410 420 430 440 450
SGCLARAGPP PSPGAPSDDD DDDAGTTPPA RLLEPWTGCN GGTTTVDSDS
460
SLDEPGRQGF SSESKV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 65 | L → V in AAA02929 (PubMed:8395893).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L10084 Genomic DNA Translation: AAA02929.1 CH466585 Genomic DNA Translation: EDL01765.1 BC140970 mRNA Translation: AAI40971.1 BC147435 mRNA Translation: AAI47436.1 |
CCDSi | CCDS29919.1 |
PIRi | S36794 |
RefSeqi | NP_031445.2, NM_007419.2 |
Genome annotation databases
Ensembli | ENSMUST00000038949; ENSMUSP00000040847; ENSMUSG00000035283 |
GeneIDi | 11554 |
KEGGi | mmu:11554 |
UCSCi | uc008hze.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L10084 Genomic DNA Translation: AAA02929.1 CH466585 Genomic DNA Translation: EDL01765.1 BC140970 mRNA Translation: AAI40971.1 BC147435 mRNA Translation: AAI47436.1 |
CCDSi | CCDS29919.1 |
PIRi | S36794 |
RefSeqi | NP_031445.2, NM_007419.2 |
3D structure databases
SMRi | P34971 |
ModBasei | Search... |
Protein-protein interaction databases
DIPi | DIP-59567N |
IntActi | P34971, 6 interactors |
MINTi | P34971 |
STRINGi | 10090.ENSMUSP00000040847 |
Chemistry databases
BindingDBi | P34971 |
ChEMBLi | CHEMBL3440 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P34971, 1 site |
iPTMneti | P34971 |
PhosphoSitePlusi | P34971 |
Proteomic databases
PaxDbi | P34971 |
PRIDEi | P34971 |
ProteomicsDBi | 296186 |
Protocols and materials databases
Antibodypediai | 31906, 279 antibodies from 37 providers |
DNASUi | 11554 |
Genome annotation databases
Ensembli | ENSMUST00000038949; ENSMUSP00000040847; ENSMUSG00000035283 |
GeneIDi | 11554 |
KEGGi | mmu:11554 |
UCSCi | uc008hze.2, mouse |
Organism-specific databases
CTDi | 153 |
MGIi | MGI:87937, Adrb1 |
VEuPathDBi | HostDB:ENSMUSG00000035283 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000161953 |
HOGENOMi | CLU_009579_11_0_1 |
InParanoidi | P34971 |
OMAi | CEFWISV |
OrthoDBi | 750855at2759 |
PhylomeDBi | P34971 |
TreeFami | TF316350 |
Enzyme and pathway databases
Reactomei | R-MMU-390696, Adrenoceptors R-MMU-418555, G alpha (s) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 11554, 1 hit in 66 CRISPR screens |
PROi | PR:P34971 |
RNActi | P34971, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000035283, Expressed in pineal body and 199 other tissues |
Genevisiblei | P34971, MM |
Family and domain databases
InterProi | View protein in InterPro IPR002233, ADR_fam IPR000507, ADRB1_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01103, ADRENERGICR PR00561, ADRENRGCB1AR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ADRB1_MOUSE | |
Accessioni | P34971Primary (citable) accession number: P34971 Secondary accession number(s): B2RVY4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 23, 2022 | |
This is version 181 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families