Beta-1 adrenergic receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• alpha-2A adrenergic receptor binding Source: MGI
• amine binding Source: MGI
• beta1-adrenergic receptor activity Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Regulation of the uncoupling protein gene (Ucp) by beta 1, beta 2, and beta 3-adrenergic receptor subtypes in immortalized brown adipose cell lines."
    Rohlfs E.M., Daniel K.W., Premont R.T., Kozak L.P., Collins S.
    J Biol Chem 270:10723-10732(1995) [PubMed] [Europe PMC] [Abstract]
  • "Differential regulation by tumor necrosis factor-alpha of beta1-, beta2-, and beta3-adrenoreceptor gene expression in 3T3-F442A adipocytes."
    Hadri K.E., Courtalon A., Gauthereau X., Chambaut-Guerin A.M., Pairault J., Feve B.
    J Biol Chem 272:24514-24521(1997) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential Source: SynGO <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "ERK plays a regulatory role in induction of LTP by theta frequency stimulation and its modulation by beta-adrenergic receptors."
    Winder D.G., Martin K.C., Muzzio I.A., Rohrer D., Chruscinski A., Kobilka B., Kandel E.R.
    Neuron 24:715-726(1999) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• guanyl-nucleotide exchange factor activity Source: UniProtKB
• PDZ domain binding Source: MGI
• protein heterodimerization activity Source: MGI

GO - Biological processⁱ

• adenylate cyclase-activating adrenergic receptor signaling pathway Source: UniProtKB
• adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: MGIInferred from mutant phenotypeⁱ
  • "Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects."
    Rohrer D.K., Desai K.H., Jasper J.R., Stevens M.E., Regula D.P. Jr., Barsh G.S., Bernstein D., Kobilka B.K.
    Proc Natl Acad Sci U S A 93:7375-7380(1996) [PubMed] [Europe PMC] [Abstract]
• apoptotic process Source: MGI
• brown fat cell differentiation Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting."
    Jimenez M., Leger B., Canola K., Lehr L., Arboit P., Seydoux J., Russell A.P., Giacobino J.P., Muzzin P., Preitner F.
    FEBS Lett 530:37-40(2002) [PubMed] [Europe PMC] [Abstract]
• diet induced thermogenesis Source: MGIInferred from genetic interactionⁱ
  • "betaAR signaling required for diet-induced thermogenesis and obesity resistance."
    Bachman E.S., Dhillon H., Zhang C.Y., Cinti S., Bianco A.C., Kobilka B.K., Lowell B.B.
    Science 297:843-845(2002) [PubMed] [Europe PMC] [Abstract]
• fear response Source: MGIInferred from mutant phenotypeⁱ
  • "A distinct role for norepinephrine in memory retrieval."
    Murchison C.F., Zhang X.Y., Zhang W.P., Ouyang M., Lee A., Thomas S.A.
    Cell 117:131-143(2004) [PubMed] [Europe PMC] [Abstract]
• glycogen catabolic process Source: MGI
• G protein-coupled receptor signaling pathway Source: MGI
• heat generation Source: MGIInferred from genetic interactionⁱ
  • "betaAR signaling required for diet-induced thermogenesis and obesity resistance."
    Bachman E.S., Dhillon H., Zhang C.Y., Cinti S., Bianco A.C., Kobilka B.K., Lowell B.B.
    Science 297:843-845(2002) [PubMed] [Europe PMC] [Abstract]
• inhibitory postsynaptic potential Source: MGI
• lipid homeostasis Source: MGI
• memory Source: MGI
• negative regulation of multicellular organism growth Source: MGIInferred from genetic interactionⁱ
  • "Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting."
    Jimenez M., Leger B., Canola K., Lehr L., Arboit P., Seydoux J., Russell A.P., Giacobino J.P., Muzzin P., Preitner F.
    FEBS Lett 530:37-40(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of smooth muscle contraction Source: MGI
• negative regulation of urine volume Source: MGI
• norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure Source: MGIInferred from mutant phenotypeⁱ
  • "Cardiovascular and metabolic alterations in mice lacking both beta1- and beta2-adrenergic receptors."
    Rohrer D.K., Chruscinski A., Schauble E.H., Bernstein D., Kobilka B.K.
    J Biol Chem 274:16701-16708(1999) [PubMed] [Europe PMC] [Abstract]
  • "Differential distribution of beta-adrenergic receptor subtypes in blood vessels of knockout mice lacking beta(1)- or beta(2)-adrenergic receptors."
    Chruscinski A., Brede M.E., Meinel L., Lohse M.J., Kobilka B.K., Hein L.
    Mol Pharmacol 60:955-962(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: MGI
• positive regulation of adenylate cyclase activity Source: MGI
• positive regulation of apoptotic process Source: MGI
• positive regulation of calcium ion import across plasma membrane Source: MGI
• positive regulation of cation channel activity Source: MGI
• positive regulation of cell growth involved in cardiac muscle cell development Source: MGI
• positive regulation of cold-induced thermogenesis Source: YuBioLabInferred from mutant phenotypeⁱ
  • "beta(1) Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice."
    Ueta C.B., Fernandes G.W., Capelo L.P., Fonseca T.L., Maculan F.D., Gouveia C.H., Brum P.C., Christoffolete M.A., Aoki M.S., Lancellotti C.L., Kim B., Bianco A.C., Ribeiro M.O.
    J Endocrinol 214:359-365(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of GTPase activity Source: UniProtKB
• positive regulation of heart rate Source: MGI
• positive regulation of heart rate by epinephrine-norepinephrine Source: MGIInferred from mutant phenotypeⁱ
  • "Cardiovascular and metabolic alterations in mice lacking both beta1- and beta2-adrenergic receptors."
    Rohrer D.K., Chruscinski A., Schauble E.H., Bernstein D., Kobilka B.K.
    J Biol Chem 274:16701-16708(1999) [PubMed] [Europe PMC] [Abstract]
  • "Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects."
    Rohrer D.K., Desai K.H., Jasper J.R., Stevens M.E., Regula D.P. Jr., Barsh G.S., Bernstein D., Kobilka B.K.
    Proc Natl Acad Sci U S A 93:7375-7380(1996) [PubMed] [Europe PMC] [Abstract]
• positive regulation of long-term synaptic potentiation Source: MGI
• positive regulation of renin secretion into blood stream Source: MGI
• positive regulation of saliva secretion Source: MGI
• positive regulation of systemic arterial blood pressure Source: MGI
• positive regulation of the force of heart contraction by epinephrine-norepinephrine Source: MGIInferred from direct assayⁱ
  • "Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor."
    Koch W.J., Rockman H.A., Samama P., Hamilton R.A., Bond R.A., Milano C.A., Lefkowitz R.J.
    Science 268:1350-1353(1995) [PubMed] [Europe PMC] [Abstract]
• positive regulation of the force of heart contraction by norepinephrine Source: MGI
• protein localization to organelle Source: MGI
• regulation of calcium ion transport Source: MGI
• regulation of cardiac muscle cell contraction Source: MGI
• regulation of circadian sleep/wake cycle, sleep Source: UniProtKBInferred from mutant phenotypeⁱ
  • "A novel BHLHE41 variant is associated with short sleep and resistance to sleep deprivation in humans."
    Pellegrino R., Kavakli I.H., Goel N., Cardinale C.J., Dinges D.F., Kuna S.T., Maislin G., Van Dongen H.P., Tufik S., Hogenesch J.B., Hakonarson H., Pack A.I.
    Sleep 37:1327-1336(2014) [PubMed] [Europe PMC] [Abstract]
• response to cold Source: MGIInferred from genetic interactionⁱ
  • "betaAR signaling required for diet-induced thermogenesis and obesity resistance."
    Bachman E.S., Dhillon H., Zhang C.Y., Cinti S., Bianco A.C., Kobilka B.K., Lowell B.B.
    Science 297:843-845(2002) [PubMed] [Europe PMC] [Abstract]
  • "Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting."
    Jimenez M., Leger B., Canola K., Lehr L., Arboit P., Seydoux J., Russell A.P., Giacobino J.P., Muzzin P., Preitner F.
    FEBS Lett 530:37-40(2002) [PubMed] [Europe PMC] [Abstract]
• Rho protein signal transduction Source: MGI
• sensory perception of pain Source: MGI
• wound healing Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• alpha-2A adrenergic receptor binding Source: MGI
• PDZ domain binding Source: MGI
• protein heterodimerization activity Source: MGI

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MGAGALALGA SEPCNLSSAA PLPDGAATAA RLLVLASPPA SLLPPASEGS 
        60         70         80         90        100
APLSQQWTAG MGLLLALIVL LIVVGNVLVI VAIAKTPRLQ TLTNLFIMSL 
       110        120        130        140        150
ASADLVMGLL VVPFGATIVV WGRWEYGSFF CELWTSVDVL CVTASIETLC 
       160        170        180        190        200
VIALDRYLAI TSPFRYQSLL TRARARALVC TVWAISALVS FLPILMHWWR 
       210        220        230        240        250
AESDEARRCY NDPKCCDFVT NRAYAIASSV VSFYVPLCIM AFVYLRVFRE 
       260        270        280        290        300
AQKQVKKIDS CERRFLGGPA RPPSPEPSPS PGPPRPADSL ANGRSSKRRP 
       310        320        330        340        350
SRLVALREQK ALKTLGIIMG VFTLCWLPFF LANVVKAFHR DLVPDRLFVF 
       360        370        380        390        400
FNWLGYANSA FNPIIYCRSP DFRKAFQRLL CCARRAACRR RAAHGDRPRA 
       410        420        430        440        450
SGCLARAGPP PSPGAPSDDD DDDAGTTPPA RLLEPWTGCN GGTTTVDSDS 
       460 
SLDEPGRQGF SSESKV                                      

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
3. SIMILARITY comments
   Index of protein domains and families