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UniProtKB - P34969 (5HT7R_HUMAN)

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Protein

5-hydroxytryptamine receptor 7

Gene

HTR7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: GO_Central
  • blood circulation Source: ProtInc
  • chemical synaptic transmission Source: ProtInc
  • circadian rhythm Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: Reactome
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  • smooth muscle contraction Source: InterPro
  • vasoconstriction Source: InterPro
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-390666 Serotonin receptors
R-HSA-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 7
Short name:
5-HT-7
Short name:
5-HT7
Alternative name(s):
5-HT-X
Serotonin receptor 7
Gene namesi
Name:HTR7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000148680.15
HGNCiHGNC:5302 HTR7
MIMi182137 gene
neXtProtiNX_P34969

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 83ExtracellularBy similarityAdd BLAST83
Transmembranei84 – 104Helical; Name=1By similarityAdd BLAST21
Topological domaini105 – 117CytoplasmicBy similarityAdd BLAST13
Transmembranei118 – 138Helical; Name=2By similarityAdd BLAST21
Topological domaini139 – 157ExtracellularBy similarityAdd BLAST19
Transmembranei158 – 178Helical; Name=3By similarityAdd BLAST21
Topological domaini179 – 201CytoplasmicBy similarityAdd BLAST23
Transmembranei202 – 222Helical; Name=4By similarityAdd BLAST21
Topological domaini223 – 236ExtracellularBy similarityAdd BLAST14
Transmembranei237 – 257Helical; Name=5By similarityAdd BLAST21
Topological domaini258 – 325CytoplasmicBy similarityAdd BLAST68
Transmembranei326 – 346Helical; Name=6By similarityAdd BLAST21
Topological domaini347 – 367ExtracellularBy similarityAdd BLAST21
Transmembranei368 – 388Helical; Name=7By similarityAdd BLAST21
Topological domaini389 – 479CytoplasmicBy similarityAdd BLAST91

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3363
OpenTargetsiENSG00000148680
PharmGKBiPA29561

Chemistry databases

ChEMBLiCHEMBL3155
DrugBankiDB06288 Amisulpride
DB00321 Amitriptyline
DB00543 Amoxapine
DB01238 Aripiprazole
DB06216 Asenapine
DB01200 Bromocriptine
DB00248 Cabergoline
DB00477 Chlorpromazine
DB00363 Clozapine
DB00988 Dopamine
DB00216 Eletriptan
DB00751 Epinastine
DB01049 Ergoloid mesylate
DB04946 Iloperidone
DB00458 Imipramine
DB00408 Loxapine
DB08815 Lurasidone
DB00934 Maprotiline
DB00247 Methysergide
DB06148 Mianserin
DB00370 Mirtazapine
DB00334 Olanzapine
DB01224 Quetiapine
DB13025 Tiapride
DB09068 Vortioxetine
DB00246 Ziprasidone
GuidetoPHARMACOLOGYi12

Polymorphism and mutation databases

BioMutaiHTR7
DMDMi8488960

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689791 – 4795-hydroxytryptamine receptor 7Add BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi66N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi155 ↔ 231PROSITE-ProRule annotation
Lipidationi401S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP34969
PRIDEiP34969
ProteomicsDBi54961
54962 [P34969-2]
54963 [P34969-3]

PTM databases

iPTMnetiP34969
PhosphoSitePlusiP34969

Expressioni

Tissue specificityi

Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels. Isoform D is a minor isoform in term of expression.1 Publication

Gene expression databases

BgeeiENSG00000148680
CleanExiHS_HTR7
GenevisibleiP34969 HS

Organism-specific databases

HPAiCAB022708
HPA073617

Interactioni

Protein-protein interaction databases

BioGridi109595, 4 interactors
IntActiP34969, 77 interactors
STRINGi9606.ENSP00000337949

Chemistry databases

BindingDBiP34969

Structurei

3D structure databases

ProteinModelPortaliP34969
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118795
HOVERGENiHBG106962
InParanoidiP34969
KOiK04163
OMAiSCSCIPL
OrthoDBiEOG091G06VI
PhylomeDBiP34969
TreeFamiTF331895

Family and domain databases

InterProiView protein in InterPro
IPR001069 5HT_7_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00652 5HT7RECEPTR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Isoform A and isoform B appear to be expressed at higher levels.
Isoform D (identifier: P34969-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMDVNSSGRP DLYGHLRSFL LPEVGRGLPD LSPDGGADPV AGSWAPHLLS 
        60         70         80         90        100
EVTASPAPTW DAPPDNASGC GEQINYGRVE KVVIGSILTL ITLLTIAGNC 
       110        120        130        140        150
LVVISVCFVK KLRQPSNYLI VSLALADLSV AVAVMPFVSV TDLIGGKWIF 
       160        170        180        190        200
GHFFCNVFIA MDVMCCTASI MTLCVISIDR YLGITRPLTY PVRQNGKCMA 
       210        220        230        240        250
KMILSVWLLS ASITLPPLFG WAQNVNDDKV CLISQDFGYT IYSTAVAFYI 
       260        270        280        290        300
PMSVMLFMYY QIYKAARKSA AKHKFPGFPR VEPDSVIALN GIVKLQKEVE 
       310        320        330        340        350
ECANLSRLLK HERKNISIFK REQKAATTLG IIVGAFTVCW LPFFLLSTAR 
       360        370        380        390        400
PFICGTSCSC IPLWVERTFL WLGYANSLIN PFIYAFFNRD LRTTYRSLLQ 
       410        420        430        440        450
CQYRNINRKL SAAGMHEALK LAERPERPEF VLRACTRRVL LRPEKRPPVS 
       460        470 
VWVLQSPDHH NWLADKMLTT VEKKVMIHD
Length:479
Mass (Da):53,555
Last modified:May 30, 2000 - v2
Checksum:i1F62E985EADE1F23
GO
Isoform A (identifier: P34969-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     433-479: RACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD → QNADYCRKKGHDS

Show »
Length:445
Mass (Da):49,488
Checksum:iA09BE5E3CBCAB232
GO
Isoform B (identifier: P34969-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     433-479: Missing.

Show »
Length:432
Mass (Da):47,984
Checksum:iD6202D8C921D627E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01299592T → K1 Publication1
Natural variantiVAR_012996279P → L1 PublicationCorresponds to variant dbSNP:rs114969659Ensembl.1
Natural variantiVAR_049365448P → Q. Corresponds to variant dbSNP:rs33954285Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001857433 – 479RACTR…VMIHD → QNADYCRKKGHDS in isoform A. 2 PublicationsAdd BLAST47
Alternative sequenceiVSP_001856433 – 479Missing in isoform B. 2 PublicationsAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68487 mRNA Translation: AAB48393.1
U68488 mRNA Translation: AAB48394.1
U68492 Genomic DNA Translation: AAF07218.1
U68493, U68492 Genomic DNA Translation: AAF07217.1
U68493, U68492 Genomic DNA Translation: AAB48397.2
L21195 mRNA Translation: AAC37538.1
AY493988 mRNA Translation: AAR87480.1
AK292606 mRNA Translation: BAF85295.1
AB451482 mRNA Translation: BAG70296.1
AL360011 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50118.1
CH471066 Genomic DNA Translation: EAW50119.1
CH471066 Genomic DNA Translation: EAW50120.1
BC047526 mRNA Translation: AAH47526.1
CCDSiCCDS7408.1 [P34969-1]
CCDS7409.1 [P34969-2]
CCDS7410.1 [P34969-3]
PIRiA48881
RefSeqiNP_000863.1, NM_000872.4 [P34969-2]
NP_062873.1, NM_019859.3 [P34969-1]
NP_062874.1, NM_019860.3 [P34969-3]
UniGeneiHs.73739

Genome annotation databases

EnsembliENST00000277874; ENSP00000277874; ENSG00000148680 [P34969-2]
ENST00000336152; ENSP00000337949; ENSG00000148680 [P34969-1]
ENST00000371719; ENSP00000360784; ENSG00000148680 [P34969-3]
GeneIDi3363
KEGGihsa:3363
UCSCiuc001kgz.4 human [P34969-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry namei5HT7R_HUMAN
AccessioniPrimary (citable) accession number: P34969
Secondary accession number(s): B5BUP6
, P78336, P78372, P78516, Q5VX01, Q5VX02, Q5VX03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 30, 2000
Last modified: June 20, 2018
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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