HTR7

Functionⁱ

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

GO - Molecular functionⁱ

G protein-coupled receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled serotonin receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neurotransmitter receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blood circulation
Source: ProtInc
Traceable author statementⁱ
- 8226867
chemical synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
circadian rhythm
Source: ProtInc
Traceable author statementⁱ
- 8398139
G protein-coupled receptor signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
smooth muscle contraction Source: InterPro
vasoconstriction Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390666 Serotonin receptors R-HSA-418555 G alpha (s) signalling events

Reactomeⁱ

R-HSA-390666 Serotonin receptors
R-HSA-418555 G alpha (s) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 5-hydroxytryptamine receptor 7 Short name: 5-HT-7 Short name: 5-HT7 Alternative name(s): 5-HT-X Serotonin receptor 7
Gene namesⁱ	Name:HTR7
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000148680.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5302 HTR7
MIMⁱ	182137 gene
neXtProtⁱ	NX_P34969

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 83	ExtracellularBy similarityAdd BLAST	83
Transmembraneⁱ	84 – 104	Helical; Name=1By similarityAdd BLAST	21
Topological domainⁱ	105 – 117	CytoplasmicBy similarityAdd BLAST	13
Transmembraneⁱ	118 – 138	Helical; Name=2By similarityAdd BLAST	21
Topological domainⁱ	139 – 157	ExtracellularBy similarityAdd BLAST	19
Transmembraneⁱ	158 – 178	Helical; Name=3By similarityAdd BLAST	21
Topological domainⁱ	179 – 201	CytoplasmicBy similarityAdd BLAST	23
Transmembraneⁱ	202 – 222	Helical; Name=4By similarityAdd BLAST	21
Topological domainⁱ	223 – 236	ExtracellularBy similarityAdd BLAST	14
Transmembraneⁱ	237 – 257	Helical; Name=5By similarityAdd BLAST	21
Topological domainⁱ	258 – 325	CytoplasmicBy similarityAdd BLAST	68
Transmembraneⁱ	326 – 346	Helical; Name=6By similarityAdd BLAST	21
Topological domainⁱ	347 – 367	ExtracellularBy similarityAdd BLAST	21
Transmembraneⁱ	368 – 388	Helical; Name=7By similarityAdd BLAST	21
Topological domainⁱ	389 – 479	CytoplasmicBy similarityAdd BLAST	91

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3363
Open Targets More...OpenTargetsⁱ	ENSG00000148680
PharmGKBⁱ	PA29561

Chemistry databases

ChEMBLⁱ	CHEMBL3155
Drug and drug target database More...DrugBankⁱ	DB06288 Amisulpride DB00321 Amitriptyline DB00543 Amoxapine DB01238 Aripiprazole DB06216 Asenapine DB01200 Bromocriptine DB00248 Cabergoline DB00477 Chlorpromazine DB00363 Clozapine DB00988 Dopamine DB00216 Eletriptan DB00751 Epinastine DB01049 Ergoloid mesylate DB04946 Iloperidone DB00458 Imipramine DB00408 Loxapine DB08815 Lurasidone DB00934 Maprotiline DB00247 Methysergide DB06148 Mianserin DB00370 Mirtazapine DB00334 Olanzapine DB01224 Quetiapine DB13025 Tiapride DB09068 Vortioxetine DB00246 Ziprasidone
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	12

Polymorphism and mutation databases

BioMutaⁱ	HTR7
DMDMⁱ	8488960

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000068979	1 – 479	5-hydroxytryptamine receptor 7Add BLAST		479

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	5	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	66	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	155 ↔ 231	PROSITE-ProRule annotation
Lipidationⁱ	401	S-palmitoyl cysteineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbⁱ	P34969
PRIDEⁱ	P34969
ProteomicsDBⁱ	54961 54962 [P34969-2] 54963 [P34969-3]

PTM databases

iPTMnetⁱ	P34969
PhosphoSitePlusⁱ	P34969

Expressionⁱ

Tissue specificityⁱ

Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels. Isoform D is a minor isoform in terms of expression.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000148680 Expressed in 137 organ(s), highest expression level in testis
CleanExⁱ	HS_HTR7
Genevisibleⁱ	P34969 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB022708 HPA073617

HPAⁱ

CAB022708
HPA073617

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	109595, 4 interactors
IntActⁱ	P34969, 77 interactors
STRINGⁱ	9606.ENSP00000337949

Chemistry databases

BindingDBⁱ

P34969

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P34969
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118795
HOVERGENⁱ	HBG106962
InParanoidⁱ	P34969
KEGG Orthology (KO) More...KOⁱ	K04163
OMAⁱ	QCRYRNI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P34969
TreeFamⁱ	TF331895

Family and domain databases

InterProⁱ	View protein in InterPro IPR001069 5HT_7_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00652 5HT7RECEPTR PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Isoform A and isoform B appear to be expressed at higher levels.

Isoform D (identifier: P34969-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMDVNSSGRP DLYGHLRSFL LPEVGRGLPD LSPDGGADPV AGSWAPHLLS 
        60         70         80         90        100
EVTASPAPTW DAPPDNASGC GEQINYGRVE KVVIGSILTL ITLLTIAGNC 
       110        120        130        140        150
LVVISVCFVK KLRQPSNYLI VSLALADLSV AVAVMPFVSV TDLIGGKWIF 
       160        170        180        190        200
GHFFCNVFIA MDVMCCTASI MTLCVISIDR YLGITRPLTY PVRQNGKCMA 
       210        220        230        240        250
KMILSVWLLS ASITLPPLFG WAQNVNDDKV CLISQDFGYT IYSTAVAFYI 
       260        270        280        290        300
PMSVMLFMYY QIYKAARKSA AKHKFPGFPR VEPDSVIALN GIVKLQKEVE 
       310        320        330        340        350
ECANLSRLLK HERKNISIFK REQKAATTLG IIVGAFTVCW LPFFLLSTAR 
       360        370        380        390        400
PFICGTSCSC IPLWVERTFL WLGYANSLIN PFIYAFFNRD LRTTYRSLLQ 
       410        420        430        440        450
CQYRNINRKL SAAGMHEALK LAERPERPEF VLRACTRRVL LRPEKRPPVS 
       460        470 
VWVLQSPDHH NWLADKMLTT VEKKVMIHD

Length:479

Mass (Da):53,555

Last modified:May 30, 2000 - v2

Checksum:ⁱ1F62E985EADE1F23

GO

Isoform A (identifier: P34969-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
433-479: RACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD → QNADYCRKKGHDS

« Hide

        10         20         30         40         50
MMDVNSSGRP DLYGHLRSFL LPEVGRGLPD LSPDGGADPV AGSWAPHLLS 
        60         70         80         90        100
EVTASPAPTW DAPPDNASGC GEQINYGRVE KVVIGSILTL ITLLTIAGNC 
       110        120        130        140        150
LVVISVCFVK KLRQPSNYLI VSLALADLSV AVAVMPFVSV TDLIGGKWIF 
       160        170        180        190        200
GHFFCNVFIA MDVMCCTASI MTLCVISIDR YLGITRPLTY PVRQNGKCMA 
       210        220        230        240        250
KMILSVWLLS ASITLPPLFG WAQNVNDDKV CLISQDFGYT IYSTAVAFYI 
       260        270        280        290        300
PMSVMLFMYY QIYKAARKSA AKHKFPGFPR VEPDSVIALN GIVKLQKEVE 
       310        320        330        340        350
ECANLSRLLK HERKNISIFK REQKAATTLG IIVGAFTVCW LPFFLLSTAR 
       360        370        380        390        400
PFICGTSCSC IPLWVERTFL WLGYANSLIN PFIYAFFNRD LRTTYRSLLQ 
       410        420        430        440 
CQYRNINRKL SAAGMHEALK LAERPERPEF VLQNADYCRK KGHDS

Show »

Length:445

Mass (Da):49,488

Checksum:ⁱA09BE5E3CBCAB232

GO

Isoform B (identifier: P34969-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
433-479: Missing.

« Hide

        10         20         30         40         50
MMDVNSSGRP DLYGHLRSFL LPEVGRGLPD LSPDGGADPV AGSWAPHLLS 
        60         70         80         90        100
EVTASPAPTW DAPPDNASGC GEQINYGRVE KVVIGSILTL ITLLTIAGNC 
       110        120        130        140        150
LVVISVCFVK KLRQPSNYLI VSLALADLSV AVAVMPFVSV TDLIGGKWIF 
       160        170        180        190        200
GHFFCNVFIA MDVMCCTASI MTLCVISIDR YLGITRPLTY PVRQNGKCMA 
       210        220        230        240        250
KMILSVWLLS ASITLPPLFG WAQNVNDDKV CLISQDFGYT IYSTAVAFYI 
       260        270        280        290        300
PMSVMLFMYY QIYKAARKSA AKHKFPGFPR VEPDSVIALN GIVKLQKEVE 
       310        320        330        340        350
ECANLSRLLK HERKNISIFK REQKAATTLG IIVGAFTVCW LPFFLLSTAR 
       360        370        380        390        400
PFICGTSCSC IPLWVERTFL WLGYANSLIN PFIYAFFNRD LRTTYRSLLQ 
       410        420        430 
CQYRNINRKL SAAGMHEALK LAERPERPEF VL

Show »

Length:432

Mass (Da):47,984

Checksum:ⁱD6202D8C921D627E

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_012995	92	T → K1 Publication	1
Natural variantⁱVAR_012996	279	P → L1 PublicationCorresponds to variant dbSNP:rs114969659Ensembl.	1
Natural variantⁱVAR_049365	448	P → Q. Corresponds to variant dbSNP:rs33954285Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_001857	433 – 479	RACTR…VMIHD → QNADYCRKKGHDS in isoform A. 2 PublicationsAdd BLAST		47
Alternative sequenceⁱVSP_001856	433 – 479	Missing in isoform B. 2 PublicationsAdd BLAST		47

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U68487 mRNA Translation: AAB48393.1 U68488 mRNA Translation: AAB48394.1 U68492 Genomic DNA Translation: AAF07218.1 U68493, U68492 Genomic DNA Translation: AAF07217.1 U68493, U68492 Genomic DNA Translation: AAB48397.2 L21195 mRNA Translation: AAC37538.1 AY493988 mRNA Translation: AAR87480.1 AK292606 mRNA Translation: BAF85295.1 AB451482 mRNA Translation: BAG70296.1 AL360011 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW50118.1 CH471066 Genomic DNA Translation: EAW50119.1 CH471066 Genomic DNA Translation: EAW50120.1 BC047526 mRNA Translation: AAH47526.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7408.1 [P34969-1] CCDS7409.1 [P34969-2] CCDS7410.1 [P34969-3]
PIRⁱ	A48881
NCBI Reference Sequences More...RefSeqⁱ	NP_000863.1, NM_000872.4 [P34969-2] NP_062873.1, NM_019859.3 [P34969-1] NP_062874.1, NM_019860.3 [P34969-3]
UniGeneⁱ	Hs.73739

Genome annotation databases

Ensemblⁱ	ENST00000277874; ENSP00000277874; ENSG00000148680 [P34969-2] ENST00000336152; ENSP00000337949; ENSG00000148680 [P34969-1] ENST00000371719; ENSP00000360784; ENSG00000148680 [P34969-3]
GeneIDⁱ	3363
KEGGⁱ	hsa:3363
UCSC genome browser More...UCSCⁱ	uc001kgz.4 human [P34969-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P34969-2	5-hydroxytryptamine (Serotonin) receptor 7 (Adenylate cyclase-coupled)		PANTR		445	UniRef100_P34969-2
Uncharacterized protein		PANPA		445
Uncharacterized protein		NOMLE		290
P34969-3	5-hydroxytryptamine receptor 7		PANTR		492	UniRef100_P34969-3
Uncharacterized protein		PANPA		480
HTR7 isoform 2 (Fragment)		PANTR		480
HTR7 isoform 1		PANTR		432

Protein	Similar proteins		Species	Score	Length	Source
P34969	Uncharacterized protein		CALJA		480	UniRef90_P34969
Uncharacterized protein		AOTNA		480
Uncharacterized protein		Cebus capucinus imitator		300
5-hydroxytryptamine receptor 7		SAIBB		479
5-hydroxytryptamine receptor 7		MOUSE		470
+25
P34969-2	5-hydroxytryptamine receptor 7		RAT		448	UniRef90_P32305
5-hydroxytryptamine receptor 7		MOUSE		448
5-hydroxytryptamine receptor 7		CAVPO		446
Uncharacterized protein		PROCO		465
HTR7 isoform 2		PONAB		460
+142
P34969-3	5-hydroxytryptamine receptor 7		PANTR		492	UniRef90_P34969-3
Uncharacterized protein		PANPA		480
Uncharacterized protein		MACFA		480
Uncharacterized protein		CERAT		480
Uncharacterized protein		MACNE		480
+17

Protein	Similar proteins		Species	Score	Length	Source
P34969	5-hydroxytryptamine receptor 7		RAT		448	UniRef50_P32305
5-hydroxytryptamine receptor 7		MOUSE		448
5-hydroxytryptamine receptor 7		CAVPO		446
Uncharacterized protein		PROCO		465
HTR7 isoform 2		PONAB		460
+507

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U68487 mRNA Translation: AAB48393.1 U68488 mRNA Translation: AAB48394.1 U68492 Genomic DNA Translation: AAF07218.1 U68493, U68492 Genomic DNA Translation: AAF07217.1 U68493, U68492 Genomic DNA Translation: AAB48397.2 L21195 mRNA Translation: AAC37538.1 AY493988 mRNA Translation: AAR87480.1 AK292606 mRNA Translation: BAF85295.1 AB451482 mRNA Translation: BAG70296.1 AL360011 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW50118.1 CH471066 Genomic DNA Translation: EAW50119.1 CH471066 Genomic DNA Translation: EAW50120.1 BC047526 mRNA Translation: AAH47526.1
CCDSⁱ	CCDS7408.1 [P34969-1] CCDS7409.1 [P34969-2] CCDS7410.1 [P34969-3]
PIRⁱ	A48881
RefSeqⁱ	NP_000863.1, NM_000872.4 [P34969-2] NP_062873.1, NM_019859.3 [P34969-1] NP_062874.1, NM_019860.3 [P34969-3]
UniGeneⁱ	Hs.73739

3D structure databases

ProteinModelPortalⁱ	P34969
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109595, 4 interactors
IntActⁱ	P34969, 77 interactors
STRINGⁱ	9606.ENSP00000337949

Chemistry databases

BindingDBⁱ	P34969
ChEMBLⁱ	CHEMBL3155
DrugBankⁱ	DB06288 Amisulpride DB00321 Amitriptyline DB00543 Amoxapine DB01238 Aripiprazole DB06216 Asenapine DB01200 Bromocriptine DB00248 Cabergoline DB00477 Chlorpromazine DB00363 Clozapine DB00988 Dopamine DB00216 Eletriptan DB00751 Epinastine DB01049 Ergoloid mesylate DB04946 Iloperidone DB00458 Imipramine DB00408 Loxapine DB08815 Lurasidone DB00934 Maprotiline DB00247 Methysergide DB06148 Mianserin DB00370 Mirtazapine DB00334 Olanzapine DB01224 Quetiapine DB13025 Tiapride DB09068 Vortioxetine DB00246 Ziprasidone
GuidetoPHARMACOLOGYⁱ	12

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	P34969
PhosphoSitePlusⁱ	P34969

Polymorphism and mutation databases

BioMutaⁱ	HTR7
DMDMⁱ	8488960

Proteomic databases

PaxDbⁱ	P34969
PRIDEⁱ	P34969
ProteomicsDBⁱ	54961 54962 [P34969-2] 54963 [P34969-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000277874; ENSP00000277874; ENSG00000148680 [P34969-2] ENST00000336152; ENSP00000337949; ENSG00000148680 [P34969-1] ENST00000371719; ENSP00000360784; ENSG00000148680 [P34969-3]
GeneIDⁱ	3363
KEGGⁱ	hsa:3363
UCSCⁱ	uc001kgz.4 human [P34969-1]

Organism-specific databases

CTDⁱ	3363
DisGeNETⁱ	3363
EuPathDBⁱ	HostDB:ENSG00000148680.15
GeneCardsⁱ	HTR7
HGNCⁱ	HGNC:5302 HTR7
HPAⁱ	CAB022708 HPA073617
MIMⁱ	182137 gene
neXtProtⁱ	NX_P34969
OpenTargetsⁱ	ENSG00000148680
PharmGKBⁱ	PA29561
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00760000118795
HOVERGENⁱ	HBG106962
InParanoidⁱ	P34969
KOⁱ	K04163
OMAⁱ	QCRYRNI
OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P34969
TreeFamⁱ	TF331895

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390666 Serotonin receptors R-HSA-418555 G alpha (s) signalling events

Reactomeⁱ

R-HSA-390666 Serotonin receptors
R-HSA-418555 G alpha (s) signalling events

Miscellaneous databases

GeneWikiⁱ	5-HT7_receptor
GenomeRNAiⁱ	3363
Protein Ontology More...PROⁱ	PR:P34969
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000148680 Expressed in 137 organ(s), highest expression level in testis
CleanExⁱ	HS_HTR7
Genevisibleⁱ	P34969 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001069 5HT_7_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00652 5HT7RECEPTR PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	5HT7R_HUMAN
Accessionⁱ	P34969Primary (citable) accession number: P34969 Secondary accession number(s): B5BUP6 Q5VX03
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
	Last sequence update:	May 30, 2000
	Last modified:	November 7, 2018
	This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

UniProtKB

UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - P34969 (5HT7R_HUMAN)

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5-hydroxytryptamine receptor 7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ