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UniProtKB - P34969 (5HT7R_HUMAN)
Protein
5-hydroxytryptamine receptor 7
Gene
HTR7
Organism
Homo sapiens (Human)
Status
Functioni
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
GO - Molecular functioni
- G protein-coupled serotonin receptor activity Source: GO_Central
- neurotransmitter receptor activity Source: GO_Central
GO - Biological processi
- blood circulation Source: ProtInc
- chemical synaptic transmission Source: GO_Central
- circadian rhythm Source: ProtInc
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
- smooth muscle contraction Source: InterPro
- vasoconstriction Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P34969 |
Reactomei | R-HSA-390666, Serotonin receptors R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production R-HSA-9706019, RHOBTB3 ATPase cycle [P34969-2] |
SignaLinki | P34969 |
SIGNORi | P34969 |
Names & Taxonomyi
Protein namesi | Recommended name: 5-hydroxytryptamine receptor 7Short name: 5-HT-7 Short name: 5-HT7 Alternative name(s): 5-HT-X Serotonin receptor 7 |
Gene namesi | Name:HTR7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5302, HTR7 |
MIMi | 182137, gene |
neXtProti | NX_P34969 |
VEuPathDBi | HostDB:ENSG00000148680 |
Subcellular locationi
Plasma membrane
Golgi apparatus
- trans-Golgi network membrane Source: Reactome
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 83 | ExtracellularBy similarityAdd BLAST | 83 | |
Transmembranei | 84 – 104 | Helical; Name=1By similarityAdd BLAST | 21 | |
Topological domaini | 105 – 117 | CytoplasmicBy similarityAdd BLAST | 13 | |
Transmembranei | 118 – 138 | Helical; Name=2By similarityAdd BLAST | 21 | |
Topological domaini | 139 – 157 | ExtracellularBy similarityAdd BLAST | 19 | |
Transmembranei | 158 – 178 | Helical; Name=3By similarityAdd BLAST | 21 | |
Topological domaini | 179 – 201 | CytoplasmicBy similarityAdd BLAST | 23 | |
Transmembranei | 202 – 222 | Helical; Name=4By similarityAdd BLAST | 21 | |
Topological domaini | 223 – 236 | ExtracellularBy similarityAdd BLAST | 14 | |
Transmembranei | 237 – 257 | Helical; Name=5By similarityAdd BLAST | 21 | |
Topological domaini | 258 – 325 | CytoplasmicBy similarityAdd BLAST | 68 | |
Transmembranei | 326 – 346 | Helical; Name=6By similarityAdd BLAST | 21 | |
Topological domaini | 347 – 367 | ExtracellularBy similarityAdd BLAST | 21 | |
Transmembranei | 368 – 388 | Helical; Name=7By similarityAdd BLAST | 21 | |
Topological domaini | 389 – 479 | CytoplasmicBy similarityAdd BLAST | 91 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 3363 |
OpenTargetsi | ENSG00000148680 |
PharmGKBi | PA29561 |
Miscellaneous databases
Pharosi | P34969, Tclin |
Chemistry databases
ChEMBLi | CHEMBL3155 |
DrugBanki | DB06288, Amisulpride DB00321, Amitriptyline DB00543, Amoxapine DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB06216, Asenapine DB01200, Bromocriptine DB00248, Cabergoline DB00477, Chlorpromazine DB01239, Chlorprothixene DB00363, Clozapine DB00924, Cyclobenzaprine DB00434, Cyproheptadine DB11273, Dihydroergocornine DB13345, Dihydroergocristine DB00988, Dopamine DB00751, Epinastine DB01049, Ergoloid mesylate DB12141, Gilteritinib DB00502, Haloperidol DB04946, Iloperidone DB00458, Imipramine DB00589, Lisuride DB04948, Lofexidine DB00408, Loxapine DB08815, Lurasidone DB00934, Maprotiline DB00247, Methysergide DB06148, Mianserin DB01267, Paliperidone DB00715, Paroxetine DB01224, Quetiapine DB00734, Risperidone DB13988, SB-269970 DB09304, Setiptiline DB13025, Tiapride DB09068, Vortioxetine DB00246, Ziprasidone DB00315, Zolmitriptan DB09225, Zotepine |
DrugCentrali | P34969 |
GuidetoPHARMACOLOGYi | 12 |
Genetic variation databases
BioMutai | HTR7 |
DMDMi | 8488960 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068979 | 1 – 479 | 5-hydroxytryptamine receptor 7Add BLAST | 479 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 66 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 155 ↔ 231 | PROSITE-ProRule annotation | ||
Lipidationi | 401 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | P34969 |
PeptideAtlasi | P34969 |
PRIDEi | P34969 |
ProteomicsDBi | 54961 [P34969-1] 54962 [P34969-2] 54963 [P34969-3] |
PTM databases
GlyGeni | P34969, 2 sites |
iPTMneti | P34969 |
PhosphoSitePlusi | P34969 |
Expressioni
Tissue specificityi
Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels. Isoform D is a minor isoform in terms of expression.1 Publication
Gene expression databases
Bgeei | ENSG00000148680, Expressed in amniotic fluid and 158 other tissues |
Genevisiblei | P34969, HS |
Organism-specific databases
HPAi | ENSG00000148680, Group enriched (brain, parathyroid gland, testis) |
Interactioni
Binary interactionsi
P34969
With | #Exp. | IntAct |
---|---|---|
MATR3 [P43243] | 2 | EBI-2625020,EBI-352602 |
Protein-protein interaction databases
BioGRIDi | 109595, 5 interactors |
IntActi | P34969, 76 interactors |
STRINGi | 9606.ENSP00000337949 |
Chemistry databases
BindingDBi | P34969 |
Miscellaneous databases
RNActi | P34969, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222287 |
HOGENOMi | CLU_009579_11_6_1 |
InParanoidi | P34969 |
OMAi | GCWEQIN |
OrthoDBi | 1327781at2759 |
PhylomeDBi | P34969 |
TreeFami | TF331895 |
Family and domain databases
InterProi | View protein in InterPro IPR001069, 5HT_7_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00652, 5HT7RECEPTR PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketNote: Isoform A and isoform B appear to be expressed at higher levels.
Isoform D (identifier: P34969-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMDVNSSGRP DLYGHLRSFL LPEVGRGLPD LSPDGGADPV AGSWAPHLLS
60 70 80 90 100
EVTASPAPTW DAPPDNASGC GEQINYGRVE KVVIGSILTL ITLLTIAGNC
110 120 130 140 150
LVVISVCFVK KLRQPSNYLI VSLALADLSV AVAVMPFVSV TDLIGGKWIF
160 170 180 190 200
GHFFCNVFIA MDVMCCTASI MTLCVISIDR YLGITRPLTY PVRQNGKCMA
210 220 230 240 250
KMILSVWLLS ASITLPPLFG WAQNVNDDKV CLISQDFGYT IYSTAVAFYI
260 270 280 290 300
PMSVMLFMYY QIYKAARKSA AKHKFPGFPR VEPDSVIALN GIVKLQKEVE
310 320 330 340 350
ECANLSRLLK HERKNISIFK REQKAATTLG IIVGAFTVCW LPFFLLSTAR
360 370 380 390 400
PFICGTSCSC IPLWVERTFL WLGYANSLIN PFIYAFFNRD LRTTYRSLLQ
410 420 430 440 450
CQYRNINRKL SAAGMHEALK LAERPERPEF VLRACTRRVL LRPEKRPPVS
460 470
VWVLQSPDHH NWLADKMLTT VEKKVMIHD
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_012995 | 92 | T → K1 PublicationCorresponds to variant dbSNP:rs1379762209Ensembl. | 1 | |
Natural variantiVAR_012996 | 279 | P → L1 PublicationCorresponds to variant dbSNP:rs114969659Ensembl. | 1 | |
Natural variantiVAR_049365 | 448 | P → Q. Corresponds to variant dbSNP:rs33954285Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001857 | 433 – 479 | RACTR…VMIHD → QNADYCRKKGHDS in isoform A. 2 PublicationsAdd BLAST | 47 | |
Alternative sequenceiVSP_001856 | 433 – 479 | Missing in isoform B. 2 PublicationsAdd BLAST | 47 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U68487 mRNA Translation: AAB48393.1 U68488 mRNA Translation: AAB48394.1 U68492 Genomic DNA Translation: AAF07218.1 U68493, U68492 Genomic DNA Translation: AAF07217.1 U68493, U68492 Genomic DNA Translation: AAB48397.2 L21195 mRNA Translation: AAC37538.1 AY493988 mRNA Translation: AAR87480.1 AK292606 mRNA Translation: BAF85295.1 AB451482 mRNA Translation: BAG70296.1 AL360011 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW50118.1 CH471066 Genomic DNA Translation: EAW50119.1 CH471066 Genomic DNA Translation: EAW50120.1 BC047526 mRNA Translation: AAH47526.1 |
CCDSi | CCDS7408.1 [P34969-1] CCDS7409.1 [P34969-2] CCDS7410.1 [P34969-3] |
PIRi | A48881 |
RefSeqi | NP_000863.1, NM_000872.4 [P34969-2] NP_062873.1, NM_019859.3 [P34969-1] NP_062874.1, NM_019860.3 [P34969-3] |
Genome annotation databases
Ensembli | ENST00000277874; ENSP00000277874; ENSG00000148680 [P34969-2] ENST00000336152; ENSP00000337949; ENSG00000148680 ENST00000371719; ENSP00000360784; ENSG00000148680 [P34969-3] |
GeneIDi | 3363 |
KEGGi | hsa:3363 |
MANE-Selecti | ENST00000336152.8; ENSP00000337949.3; NM_019859.4; NP_062873.1 |
UCSCi | uc001kgz.4, human [P34969-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U68487 mRNA Translation: AAB48393.1 U68488 mRNA Translation: AAB48394.1 U68492 Genomic DNA Translation: AAF07218.1 U68493, U68492 Genomic DNA Translation: AAF07217.1 U68493, U68492 Genomic DNA Translation: AAB48397.2 L21195 mRNA Translation: AAC37538.1 AY493988 mRNA Translation: AAR87480.1 AK292606 mRNA Translation: BAF85295.1 AB451482 mRNA Translation: BAG70296.1 AL360011 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW50118.1 CH471066 Genomic DNA Translation: EAW50119.1 CH471066 Genomic DNA Translation: EAW50120.1 BC047526 mRNA Translation: AAH47526.1 |
CCDSi | CCDS7408.1 [P34969-1] CCDS7409.1 [P34969-2] CCDS7410.1 [P34969-3] |
PIRi | A48881 |
RefSeqi | NP_000863.1, NM_000872.4 [P34969-2] NP_062873.1, NM_019859.3 [P34969-1] NP_062874.1, NM_019860.3 [P34969-3] |
3D structure databases
SMRi | P34969 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109595, 5 interactors |
IntActi | P34969, 76 interactors |
STRINGi | 9606.ENSP00000337949 |
Chemistry databases
BindingDBi | P34969 |
ChEMBLi | CHEMBL3155 |
DrugBanki | DB06288, Amisulpride DB00321, Amitriptyline DB00543, Amoxapine DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB06216, Asenapine DB01200, Bromocriptine DB00248, Cabergoline DB00477, Chlorpromazine DB01239, Chlorprothixene DB00363, Clozapine DB00924, Cyclobenzaprine DB00434, Cyproheptadine DB11273, Dihydroergocornine DB13345, Dihydroergocristine DB00988, Dopamine DB00751, Epinastine DB01049, Ergoloid mesylate DB12141, Gilteritinib DB00502, Haloperidol DB04946, Iloperidone DB00458, Imipramine DB00589, Lisuride DB04948, Lofexidine DB00408, Loxapine DB08815, Lurasidone DB00934, Maprotiline DB00247, Methysergide DB06148, Mianserin DB01267, Paliperidone DB00715, Paroxetine DB01224, Quetiapine DB00734, Risperidone DB13988, SB-269970 DB09304, Setiptiline DB13025, Tiapride DB09068, Vortioxetine DB00246, Ziprasidone DB00315, Zolmitriptan DB09225, Zotepine |
DrugCentrali | P34969 |
GuidetoPHARMACOLOGYi | 12 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P34969, 2 sites |
iPTMneti | P34969 |
PhosphoSitePlusi | P34969 |
Genetic variation databases
BioMutai | HTR7 |
DMDMi | 8488960 |
Proteomic databases
PaxDbi | P34969 |
PeptideAtlasi | P34969 |
PRIDEi | P34969 |
ProteomicsDBi | 54961 [P34969-1] 54962 [P34969-2] 54963 [P34969-3] |
Protocols and materials databases
Antibodypediai | 16324, 429 antibodies from 36 providers |
DNASUi | 3363 |
Genome annotation databases
Ensembli | ENST00000277874; ENSP00000277874; ENSG00000148680 [P34969-2] ENST00000336152; ENSP00000337949; ENSG00000148680 ENST00000371719; ENSP00000360784; ENSG00000148680 [P34969-3] |
GeneIDi | 3363 |
KEGGi | hsa:3363 |
MANE-Selecti | ENST00000336152.8; ENSP00000337949.3; NM_019859.4; NP_062873.1 |
UCSCi | uc001kgz.4, human [P34969-1] |
Organism-specific databases
CTDi | 3363 |
DisGeNETi | 3363 |
GeneCardsi | HTR7 |
HGNCi | HGNC:5302, HTR7 |
HPAi | ENSG00000148680, Group enriched (brain, parathyroid gland, testis) |
MIMi | 182137, gene |
neXtProti | NX_P34969 |
OpenTargetsi | ENSG00000148680 |
PharmGKBi | PA29561 |
VEuPathDBi | HostDB:ENSG00000148680 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222287 |
HOGENOMi | CLU_009579_11_6_1 |
InParanoidi | P34969 |
OMAi | GCWEQIN |
OrthoDBi | 1327781at2759 |
PhylomeDBi | P34969 |
TreeFami | TF331895 |
Enzyme and pathway databases
PathwayCommonsi | P34969 |
Reactomei | R-HSA-390666, Serotonin receptors R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production R-HSA-9706019, RHOBTB3 ATPase cycle [P34969-2] |
SignaLinki | P34969 |
SIGNORi | P34969 |
Miscellaneous databases
BioGRID-ORCSi | 3363, 7 hits in 1035 CRISPR screens |
GeneWikii | 5-HT7_receptor |
GenomeRNAii | 3363 |
Pharosi | P34969, Tclin |
PROi | PR:P34969 |
RNActi | P34969, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000148680, Expressed in amniotic fluid and 158 other tissues |
Genevisiblei | P34969, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001069, 5HT_7_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00652, 5HT7RECEPTR PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | 5HT7R_HUMAN | |
Accessioni | P34969Primary (citable) accession number: P34969 Secondary accession number(s): B5BUP6 Q5VX03 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | May 30, 2000 | |
Last modified: | February 23, 2022 | |
This is version 192 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families