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Protein

Macrophage metalloelastase

Gene

Mmp12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3 (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin. EC:3.4.24.65

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:
  • Ca2+By similarityNote: Binds 4 Ca2+ ions per subunit.By similarity
  • Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi96Zinc 2; in inhibited formBy similarity1
Metal bindingi128Calcium 1By similarity1
Metal bindingi162Calcium 2By similarity1
Metal bindingi172Zinc 1By similarity1
Metal bindingi174Zinc 1By similarity1
Metal bindingi179Calcium 3By similarity1
Metal bindingi180Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi182Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi184Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi187Zinc 1By similarity1
Metal bindingi194Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi198Calcium 2By similarity1
Metal bindingi200Zinc 1By similarity1
Metal bindingi202Calcium 3By similarity1
Metal bindingi203Calcium 1By similarity1
Metal bindingi205Calcium 1By similarity1
Metal bindingi205Calcium 3By similarity1
Metal bindingi222Zinc 2; catalyticBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei223PROSITE-ProRule annotation1
Metal bindingi226Zinc 2; catalyticBy similarity1
Metal bindingi232Zinc 2; catalyticBy similarity1
Metal bindingi293Calcium 4; via carbonyl oxygenBy similarity1
Metal bindingi385Calcium 4; via carbonyl oxygenBy similarity1
Metal bindingi434Calcium 4; via carbonyl oxygenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1442490 Collagen degradation
R-MMU-1474228 Degradation of the extracellular matrix

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M10.009

MoonProt database of moonlighting proteins

More...
MoonProti
P34960

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Macrophage metalloelastase (EC:3.4.24.65)
Short name:
MME
Alternative name(s):
Matrix metalloproteinase-12
Short name:
MMP-12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mmp12
Synonyms:Mme, Mmel
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:97005 Mmp12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2594

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28CuratedAdd BLAST28
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002877829 – 109Activation peptide1 PublicationAdd BLAST81
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000028779110 – 473Macrophage metalloelastaseAdd BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi32N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi286 ↔ 473By similarity
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P34960

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P34960

PRoteomics IDEntifications database

More...
PRIDEi
P34960

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P34960

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P34960

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000049723 Expressed in 65 organ(s), highest expression level in camera-type eye

CleanEx database of gene expression profiles

More...
CleanExi
MM_MME
MM_MMP12

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P34960 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P34960 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000005950

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P34960

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P34960

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P34960

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati289 – 332Hemopexin 1Add BLAST44
Repeati333 – 379Hemopexin 2Add BLAST47
Repeati381 – 429Hemopexin 3Add BLAST49
Repeati430 – 473Hemopexin 4Add BLAST44

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi94 – 101Cysteine switchBy similarity8

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M10A family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1565 Eukaryota
ENOG410XQ5D LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162085

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052484

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P34960

KEGG Orthology (KO)

More...
KOi
K01413

Identification of Orthologs from Complete Genome Data

More...
OMAi
KDDKYWL

Database of Orthologous Groups

More...
OrthoDBi
EOG091G03DP

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P34960

TreeFam database of animal gene trees

More...
TreeFami
TF315428

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00094 HX, 1 hit
cd04278 ZnMc_MMP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.110.10.10, 1 hit
3.40.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR033739 M10A_MMP
IPR024079 MetalloPept_cat_dom_sf
IPR028718 MMP12
IPR001818 Pept_M10_metallopeptidase
IPR021190 Pept_M10A
IPR021158 Pept_M10A_Zn_BS
IPR006026 Peptidase_Metallo
IPR002477 Peptidoglycan-bd-like
IPR036365 PGBD-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10201:SF32 PTHR10201:SF32, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00045 Hemopexin, 4 hits
PF00413 Peptidase_M10, 1 hit
PF01471 PG_binding_1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001191 Peptidase_M10A_matrix, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00138 MATRIXIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00120 HX, 4 hits
SM00235 ZnMc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47090 SSF47090, 1 hit
SSF50923 SSF50923, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00546 CYSTEINE_SWITCH, 1 hit
PS00024 HEMOPEXIN, 1 hit
PS51642 HEMOPEXIN_2, 4 hits
PS00142 ZINC_PROTEASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P34960-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSCTLLKGVC TMKFLMMIVF LQVSACGAAP MNDSEFAEWY LSRFYDYGKD
60 70 80 90 100
RIPMTKTKTN RNFLKEKLQE MQQFFGLEAT GQLDNSTLAI MHIPRCGVPD
110 120 130 140 150
VQHLRAVPQR SRWMKRYLTY RIYNYTPDMK REDVDYIFQK AFQVWSDVTP
160 170 180 190 200
LRFRKLHKDE ADIMILFAFG AHGDFNYFDG KGGTLAHAFY PGPGIQGDAH
210 220 230 240 250
FDEAETWTKS FQGTNLFLVA VHELGHSLGL QHSNNPKSIM YPTYRYLNPS
260 270 280 290 300
TFRLSADDIR NIQSLYGAPV KPPSLTKPSS PPSTFCHQSL SFDAVTTVGE
310 320 330 340 350
KIFFFKDWFF WWKLPGSPAT NITSISSIWP SIPSGIQAAY EIESRNQLFL
360 370 380 390 400
FKDEKYWLIN NLVPEPHYPR SIYSLGFSAS VKKVDAAVFD PLRQKVYFFV
410 420 430 440 450
DKHYWRYDVR QELMDPAYPK LISTHFPGIK PKIDAVLYFK RHYYIFQGAY
460 470
QLEYDPLFRR VTKTLKSTSW FGC
Length:473
Mass (Da):54,971
Last modified:July 10, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD377250610BA249E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3TCW6Q3TCW6_MOUSE
Macrophage metalloelastase
Mmp12
403Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8BJC0Q8BJC0_MOUSE
Macrophage metalloelastase
Mmp12
339Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z705D3Z705_MOUSE
Macrophage metalloelastase
Mmp12
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RJI9D6RJI9_MOUSE
Macrophage metalloelastase
Mmp12
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA39526 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC40889 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti65K → E in AAH19135 (PubMed:15489334).Curated1
Sequence conflicti65K → E in CAJ18584 (Ref. 4) Curated1
Sequence conflicti78E → V in BAE30809 (PubMed:16141072).Curated1
Sequence conflicti78E → V in BAE30260 (PubMed:16141072).Curated1
Sequence conflicti78E → V in BAE30039 (PubMed:16141072).Curated1
Sequence conflicti78E → V in BAE29689 (PubMed:16141072).Curated1
Sequence conflicti80T → N in BAE33415 (PubMed:16141072).Curated1
Sequence conflicti87T → A in BAE42486 (PubMed:16141072).Curated1
Sequence conflicti172H → N in BAE42198 (PubMed:16141072).Curated1
Sequence conflicti188A → V in AAA39526 (PubMed:1537850).Curated1
Sequence conflicti199A → T in BAC40836 (PubMed:16141072).Curated1
Sequence conflicti241Y → D in AAH19135 (PubMed:15489334).Curated1
Sequence conflicti241Y → D in CAJ18584 (Ref. 4) Curated1
Sequence conflicti247L → F in BAE33072 (PubMed:16141072).Curated1
Sequence conflicti250S → N in AAH19135 (PubMed:15489334).Curated1
Sequence conflicti250S → N in CAJ18584 (Ref. 4) Curated1
Sequence conflicti268A → P in BAC40846 (PubMed:16141072).Curated1
Sequence conflicti272P → T in AAH19135 (PubMed:15489334).Curated1
Sequence conflicti272P → T in CAJ18584 (Ref. 4) Curated1
Sequence conflicti303F → L in AAA39526 (PubMed:1537850).Curated1
Sequence conflicti303F → Y in BAC40889 (PubMed:16141072).Curated1
Sequence conflicti303F → Y in BAC40913 (PubMed:16141072).Curated1
Sequence conflicti319A → D in BAE33415 (PubMed:16141072).Curated1
Sequence conflicti323T → I in AAH19135 (PubMed:15489334).Curated1
Sequence conflicti323T → I in CAJ18584 (Ref. 4) Curated1
Sequence conflicti328I → T in BAE41743 (PubMed:16141072).Curated1
Sequence conflicti335G → A in AAA39526 (PubMed:1537850).Curated1
Sequence conflicti403H → Q in AAH19135 (PubMed:15489334).Curated1
Sequence conflicti403H → Q in CAJ18584 (Ref. 4) Curated1
Sequence conflicti432K → R in BAC40836 (PubMed:16141072).Curated1
Sequence conflicti467S → G in BAE42201 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M82831 mRNA Translation: AAA39526.1 Different initiation.
AK089309 mRNA Translation: BAC40836.1
AK089335 mRNA Translation: BAC40846.1
AK089452 mRNA Translation: BAC40889.1 Different initiation.
AK089523 mRNA Translation: BAC40913.1
AK090051 mRNA Translation: BAC41067.1
AK150596 mRNA Translation: BAE29689.1
AK151021 mRNA Translation: BAE30039.1
AK151273 mRNA Translation: BAE30260.1
AK151933 mRNA Translation: BAE30809.1
AK155139 mRNA Translation: BAE33072.1
AK155743 mRNA Translation: BAE33411.1
AK155747 mRNA Translation: BAE33414.1
AK155748 mRNA Translation: BAE33415.1
AK155865 mRNA Translation: BAE33469.1
AK170360 mRNA Translation: BAE41743.1
AK170364 mRNA Translation: BAE41746.1
AK170798 mRNA Translation: BAE42035.1
AK170804 mRNA Translation: BAE42039.1
AK170976 mRNA Translation: BAE42154.1
AK171006 mRNA Translation: BAE42177.1
AK171032 mRNA Translation: BAE42198.1
AK171036 mRNA Translation: BAE42201.1
AK171176 mRNA Translation: BAE42294.1
AK171428 mRNA Translation: BAE42446.1
AK171447 mRNA Translation: BAE42457.1
AK171448 mRNA Translation: BAE42458.1
AK171449 mRNA Translation: BAE42459.1
AK171450 mRNA Translation: BAE42460.1
AK171466 mRNA Translation: BAE42472.1
AK171468 mRNA Translation: BAE42474.1
AK171470 mRNA Translation: BAE42476.1
AK171472 mRNA Translation: BAE42478.1
AK171485 mRNA Translation: BAE42486.1
AK171518 mRNA Translation: BAE42502.1
AK171542 mRNA Translation: BAE42516.1
AK171570 mRNA Translation: BAE42531.1
BC019135 mRNA Translation: AAH19135.2
CT010377 mRNA Translation: CAJ18584.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS22804.1

Protein sequence database of the Protein Information Resource

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PIRi
A42401

NCBI Reference Sequences

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RefSeqi
NP_001307005.1, NM_001320076.1
NP_001307006.1, NM_001320077.1
NP_032631.3, NM_008605.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.2055

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000005950; ENSMUSP00000005950; ENSMUSG00000049723

Database of genes from NCBI RefSeq genomes

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GeneIDi
17381

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:17381

UCSC genome browser

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UCSCi
uc009och.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M82831 mRNA Translation: AAA39526.1 Different initiation.
AK089309 mRNA Translation: BAC40836.1
AK089335 mRNA Translation: BAC40846.1
AK089452 mRNA Translation: BAC40889.1 Different initiation.
AK089523 mRNA Translation: BAC40913.1
AK090051 mRNA Translation: BAC41067.1
AK150596 mRNA Translation: BAE29689.1
AK151021 mRNA Translation: BAE30039.1
AK151273 mRNA Translation: BAE30260.1
AK151933 mRNA Translation: BAE30809.1
AK155139 mRNA Translation: BAE33072.1
AK155743 mRNA Translation: BAE33411.1
AK155747 mRNA Translation: BAE33414.1
AK155748 mRNA Translation: BAE33415.1
AK155865 mRNA Translation: BAE33469.1
AK170360 mRNA Translation: BAE41743.1
AK170364 mRNA Translation: BAE41746.1
AK170798 mRNA Translation: BAE42035.1
AK170804 mRNA Translation: BAE42039.1
AK170976 mRNA Translation: BAE42154.1
AK171006 mRNA Translation: BAE42177.1
AK171032 mRNA Translation: BAE42198.1
AK171036 mRNA Translation: BAE42201.1
AK171176 mRNA Translation: BAE42294.1
AK171428 mRNA Translation: BAE42446.1
AK171447 mRNA Translation: BAE42457.1
AK171448 mRNA Translation: BAE42458.1
AK171449 mRNA Translation: BAE42459.1
AK171450 mRNA Translation: BAE42460.1
AK171466 mRNA Translation: BAE42472.1
AK171468 mRNA Translation: BAE42474.1
AK171470 mRNA Translation: BAE42476.1
AK171472 mRNA Translation: BAE42478.1
AK171485 mRNA Translation: BAE42486.1
AK171518 mRNA Translation: BAE42502.1
AK171542 mRNA Translation: BAE42516.1
AK171570 mRNA Translation: BAE42531.1
BC019135 mRNA Translation: AAH19135.2
CT010377 mRNA Translation: CAJ18584.1
CCDSiCCDS22804.1
PIRiA42401
RefSeqiNP_001307005.1, NM_001320076.1
NP_001307006.1, NM_001320077.1
NP_032631.3, NM_008605.3
UniGeneiMm.2055

3D structure databases

ProteinModelPortaliP34960
SMRiP34960
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005950

Chemistry databases

BindingDBiP34960
ChEMBLiCHEMBL2594

Protein family/group databases

MEROPSiM10.009
MoonProtiP34960

PTM databases

iPTMnetiP34960
PhosphoSitePlusiP34960

Proteomic databases

MaxQBiP34960
PaxDbiP34960
PRIDEiP34960

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005950; ENSMUSP00000005950; ENSMUSG00000049723
GeneIDi17381
KEGGimmu:17381
UCSCiuc009och.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4321
MGIiMGI:97005 Mmp12

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
GeneTreeiENSGT00940000162085
HOVERGENiHBG052484
InParanoidiP34960
KOiK01413
OMAiKDDKYWL
OrthoDBiEOG091G03DP
PhylomeDBiP34960
TreeFamiTF315428

Enzyme and pathway databases

ReactomeiR-MMU-1442490 Collagen degradation
R-MMU-1474228 Degradation of the extracellular matrix

Miscellaneous databases

Protein Ontology

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PROi
PR:P34960

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000049723 Expressed in 65 organ(s), highest expression level in camera-type eye
CleanExiMM_MME
MM_MMP12
ExpressionAtlasiP34960 baseline and differential
GenevisibleiP34960 MM

Family and domain databases

CDDicd00094 HX, 1 hit
cd04278 ZnMc_MMP, 1 hit
Gene3Di2.110.10.10, 1 hit
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR033739 M10A_MMP
IPR024079 MetalloPept_cat_dom_sf
IPR028718 MMP12
IPR001818 Pept_M10_metallopeptidase
IPR021190 Pept_M10A
IPR021158 Pept_M10A_Zn_BS
IPR006026 Peptidase_Metallo
IPR002477 Peptidoglycan-bd-like
IPR036365 PGBD-like_sf
PANTHERiPTHR10201:SF32 PTHR10201:SF32, 1 hit
PfamiView protein in Pfam
PF00045 Hemopexin, 4 hits
PF00413 Peptidase_M10, 1 hit
PF01471 PG_binding_1, 1 hit
PIRSFiPIRSF001191 Peptidase_M10A_matrix, 1 hit
PRINTSiPR00138 MATRIXIN
SMARTiView protein in SMART
SM00120 HX, 4 hits
SM00235 ZnMc, 1 hit
SUPFAMiSSF47090 SSF47090, 1 hit
SSF50923 SSF50923, 1 hit
PROSITEiView protein in PROSITE
PS00546 CYSTEINE_SWITCH, 1 hit
PS00024 HEMOPEXIN, 1 hit
PS51642 HEMOPEXIN_2, 4 hits
PS00142 ZINC_PROTEASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMMP12_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34960
Secondary accession number(s): Q3TB28
, Q3TBV6, Q3TBV9, Q3TD61, Q3U1S8, Q3U1S9, Q3U2R8, Q3UBC5, Q4FJM7, Q8BJ92, Q8BJB3, Q8BJB6, Q8BJB8, Q8BJB9, Q8VED6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: July 10, 2007
Last modified: December 5, 2018
This is version 172 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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