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Entry version 149 (12 Aug 2020)
Sequence version 1 (01 Feb 1994)
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Protein

Quinol oxidase subunit 1

Gene

qoxB

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Major component for energy conversion during vegetative growth (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi102Iron (heme A axial ligand)By similarity1
Metal bindingi280Copper BBy similarity1
Metal bindingi284Copper BBy similarity1
Metal bindingi329Copper BBy similarity1
Metal bindingi330Copper BBy similarity1
Metal bindingi415Iron (heme A3 axial ligand)By similarity1
Metal bindingi417Iron (heme A axial ligand)By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport
LigandCopper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BSUB:BSU38160-MONOMER
MetaCyc:BSU38160-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00705

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Quinol oxidase subunit 1 (EC:1.10.3.-)
Alternative name(s):
Oxidase aa(3)-600 subunit 1
Quinol oxidase aa3-600, subunit QoxB
Quinol oxidase polypeptide I
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:qoxB
Ordered Locus Names:BSU38160
ORF Names:ipa-38d
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus subtilis (strain 168)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224308 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 15ExtracellularSequence analysisAdd BLAST15
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei16 – 34HelicalSequence analysisAdd BLAST19
Topological domaini35 – 56CytoplasmicSequence analysisAdd BLAST22
Transmembranei57 – 75HelicalSequence analysisAdd BLAST19
Topological domaini76 – 97ExtracellularSequence analysisAdd BLAST22
Transmembranei98 – 117HelicalSequence analysisAdd BLAST20
Topological domaini118 – 139CytoplasmicSequence analysisAdd BLAST22
Transmembranei140 – 157HelicalSequence analysisAdd BLAST18
Topological domaini158 – 190ExtracellularSequence analysisAdd BLAST33
Transmembranei191 – 209HelicalSequence analysisAdd BLAST19
Topological domaini210 – 227CytoplasmicSequence analysisAdd BLAST18
Transmembranei228 – 246HelicalSequence analysisAdd BLAST19
Topological domaini247 – 272ExtracellularSequence analysisAdd BLAST26
Transmembranei273 – 292HelicalSequence analysisAdd BLAST20
Topological domaini293 – 315CytoplasmicSequence analysisAdd BLAST23
Transmembranei316 – 335HelicalSequence analysisAdd BLAST20
Topological domaini336 – 343ExtracellularSequence analysis8
Transmembranei344 – 362HelicalSequence analysisAdd BLAST19
Topological domaini363 – 377CytoplasmicSequence analysisAdd BLAST15
Transmembranei378 – 397HelicalSequence analysisAdd BLAST20
Topological domaini398 – 405ExtracellularSequence analysis8
Transmembranei406 – 425HelicalSequence analysisAdd BLAST20
Topological domaini426 – 452CytoplasmicSequence analysisAdd BLAST27
Transmembranei453 – 472HelicalSequence analysisAdd BLAST20
Topological domaini473 – 490ExtracellularSequence analysisAdd BLAST18
Transmembranei491 – 510HelicalSequence analysisAdd BLAST20
Topological domaini511 – 584CytoplasmicSequence analysisAdd BLAST74
Transmembranei585 – 604HelicalSequence analysisAdd BLAST20
Topological domaini605 – 610ExtracellularSequence analysis6
Transmembranei611 – 631HelicalSequence analysisAdd BLAST21
Topological domaini632 – 649CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001834741 – 649Quinol oxidase subunit 1Add BLAST649

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki280 ↔ 2841'-histidyl-3'-tyrosine (His-Tyr)By similarity

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P34956

PRoteomics IDEntifications database

More...
PRIDEi
P34956

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
224308.BSU38160

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P34956

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0843, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P34956

KEGG Orthology (KO)

More...
KOi
K02827

Identification of Orthologs from Complete Genome Data

More...
OMAi
YSGKKEP

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P34956

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.210.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023616, Cyt_c_oxase-like_su1_dom
IPR036927, Cyt_c_oxase-like_su1_sf
IPR000883, Cyt_C_Oxase_1
IPR023615, Cyt_c_Oxase_su1_BS
IPR014233, QoxB

The PANTHER Classification System

More...
PANTHERi
PTHR10422, PTHR10422, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00115, COX1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01165, CYCOXIDASEI

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81442, SSF81442, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02882, QoxB, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50855, COX1, 1 hit
PS00077, COX1_CUB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P34956-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFKWDEFFV TGDPLILGAQ VSIALSTIAI IFVLTYFKKW KWLWSEWITT
60 70 80 90 100
VDHKKLGIMY IISAVIMLFR GGVDGLMMRA QLALPNNSFL DSNHYNEIFT
110 120 130 140 150
THGTIMIIFM AMPFLIGLIN VVVPLQIGAR DVAFPYLNNL SFWTFFVGAM
160 170 180 190 200
LFNISFVIGG SPNAGWTSYM PLASNDMSPG PGENYYLLGL QIAGIGTLMT
210 220 230 240 250
GINFMVTILK MRTKGMTLMR MPMFTWTTLI TMVIIVFAFP VLTVALALLS
260 270 280 290 300
FDRLFGAHFF TLEAGGMPML WANLFWIWGH PEVYIVILPA FGIFSEIISS
310 320 330 340 350
FARKQLFGYK AMVGSIIAIS VLSFLVWTHH FFTMGNSASV NSFFSITTMA
360 370 380 390 400
ISIPTGVKIF NWLFTMYKGR ISFTTPMLWA LAFIPNFVIG GVTGVMLAMA
410 420 430 440 450
AADYQYHNTY FLVSHFHYVL IAGTVFACFA GFIFWYPKMF GHKLNERIGK
460 470 480 490 500
WFFWIFMIGF NICFFPQYFL GLQGMPRRIY TYGPNDGWTT LNFISTVGAF
510 520 530 540 550
MMGVGFLILC YNIYYSFRYS TREISGDSWG VGRTLDWATS SAIPPHYNFA
560 570 580 590 600
VLPEVKSQDA FLHMKEEKTE LYPESKFKKI HMPSNSGRPF FMSVAFGLAG
610 620 630 640
FGLVFEWYWM GVVGLIGVLL CMVLRSFEYD NGYYISVDEI KETERKISE
Length:649
Mass (Da):73,838
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5D77F58ED64CBFCC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M86548 Genomic DNA Translation: AAA22687.1
X73124 Genomic DNA Translation: CAA51594.1
AL009126 Genomic DNA Translation: CAB15842.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B38129

NCBI Reference Sequences

More...
RefSeqi
NP_391695.1, NC_000964.3
WP_003227407.1, NZ_JNCM01000034.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAB15842; CAB15842; BSU38160

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51994166
937303

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bsu:BSU38160

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|224308.179.peg.4130

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86548 Genomic DNA Translation: AAA22687.1
X73124 Genomic DNA Translation: CAA51594.1
AL009126 Genomic DNA Translation: CAB15842.1
PIRiB38129
RefSeqiNP_391695.1, NC_000964.3
WP_003227407.1, NZ_JNCM01000034.1

3D structure databases

SMRiP34956
ModBaseiSearch...

Protein-protein interaction databases

STRINGi224308.BSU38160

Proteomic databases

PaxDbiP34956
PRIDEiP34956

Genome annotation databases

EnsemblBacteriaiCAB15842; CAB15842; BSU38160
GeneIDi51994166
937303
KEGGibsu:BSU38160
PATRICifig|224308.179.peg.4130

Phylogenomic databases

eggNOGiCOG0843, Bacteria
InParanoidiP34956
KOiK02827
OMAiYSGKKEP
PhylomeDBiP34956

Enzyme and pathway databases

UniPathwayiUPA00705
BioCyciBSUB:BSU38160-MONOMER
MetaCyc:BSU38160-MONOMER

Family and domain databases

Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616, Cyt_c_oxase-like_su1_dom
IPR036927, Cyt_c_oxase-like_su1_sf
IPR000883, Cyt_C_Oxase_1
IPR023615, Cyt_c_Oxase_su1_BS
IPR014233, QoxB
PANTHERiPTHR10422, PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115, COX1, 1 hit
PRINTSiPR01165, CYCOXIDASEI
SUPFAMiSSF81442, SSF81442, 1 hit
TIGRFAMsiTIGR02882, QoxB, 1 hit
PROSITEiView protein in PROSITE
PS50855, COX1, 1 hit
PS00077, COX1_CUB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQOX1_BACSU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34956
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: August 12, 2020
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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