UniProtKB - P34928 (APOC1_MOUSE)
Protein
Apolipoprotein C-I
Gene
Apoc1
Organism
Mus musculus (Mouse)
Status
Functioni
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein (By similarity). Binds free fatty acids and reduces their intracellular esterification.By similarity1 Publication
GO - Molecular functioni
- fatty acid binding Source: GO_Central
- phospholipase inhibitor activity Source: GO_Central
GO - Biological processi
- cholesterol efflux Source: Ensembl
- cholesterol metabolic process Source: MGI
- chylomicron remnant clearance Source: Ensembl
- lipoprotein metabolic process Source: InterPro
- negative regulation of cholesterol transport Source: GO_Central
- negative regulation of fatty acid biosynthetic process Source: Ensembl
- negative regulation of lipid catabolic process Source: GO_Central
- negative regulation of lipoprotein lipase activity Source: GO_Central
- negative regulation of phosphatidylcholine catabolic process Source: Ensembl
- negative regulation of receptor-mediated endocytosis Source: Ensembl
- negative regulation of very-low-density lipoprotein particle clearance Source: GO_Central
- phospholipid efflux Source: Ensembl
- plasma lipoprotein particle remodeling Source: Ensembl
- triglyceride metabolic process Source: MGI
- very-low-density lipoprotein particle clearance Source: GO_Central
Keywordsi
Biological process | Lipid transport, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-8866423, VLDL assembly R-MMU-8964046, VLDL clearance |
Names & Taxonomyi
Protein namesi | Recommended name: Apolipoprotein C-IShort name: Apo-CI Short name: ApoC-I Alternative name(s): Apolipoprotein C1 Cleaved into the following chain: |
Gene namesi | Name:Apoc1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88053, Apoc1 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: Ensembl
Extracellular region or secreted
- extracellular region Source: Reactome
- high-density lipoprotein particle Source: GO_Central
- very-low-density lipoprotein particle Source: GO_Central
Keywords - Cellular componenti
Secreted, VLDLPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | By similarityAdd BLAST | 26 | |
ChainiPRO_0000002015 | 27 – 88 | Apolipoprotein C-IAdd BLAST | 62 | |
ChainiPRO_0000391844 | 29 – 88 | Truncated apolipoprotein C-IBy similarityAdd BLAST | 60 |
Proteomic databases
jPOSTi | P34928 |
MaxQBi | P34928 |
PaxDbi | P34928 |
PeptideAtlasi | P34928 |
PRIDEi | P34928 |
PTM databases
iPTMneti | P34928 |
PhosphoSitePlusi | P34928 |
Expressioni
Tissue specificityi
Adult and fetal liver.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000040564, Expressed in left lobe of liver and 186 other tissues |
Genevisiblei | P34928, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000104091 |
Miscellaneous databases
RNActi | P34928, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the apolipoprotein C1 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502SEU4, Eukaryota |
GeneTreei | ENSGT00390000011584 |
HOGENOMi | CLU_160094_1_0_1 |
InParanoidi | P34928 |
OMAi | RSWFSET |
OrthoDBi | 1558708at2759 |
PhylomeDBi | P34928 |
TreeFami | TF330940 |
Family and domain databases
Gene3Di | 4.10.260.30, 1 hit |
InterProi | View protein in InterPro IPR043081, ApoC-1_sf IPR006781, ApoC-I |
PANTHERi | PTHR16565, PTHR16565, 1 hit |
Pfami | View protein in Pfam PF04691, ApoC-I, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P34928-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLFIALPVL IVVVAMTLEG PAPAQAAPDL SGTLESIPDK LKEFGNTLED
60 70 80
KARAAIEHIK QKEILTKTRA WFSEAFGKVK EKLKTTFS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A140LIY8 | A0A140LIY8_MOUSE | Apolipoprotein C-I | Apoc1 | 29 | Annotation score: |
Mass spectrometryi
Molecular mass is 6993±0.707 Da. Determined by ESI. Strain C57BL/6. Without methionine sulfoxide.1 Publication
Molecular mass is 6825.6±0.495 Da. Determined by ESI. Strain C57BL/6. Without methionine sulfoxide.1 Publication
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z22661, Z22660 Genomic DNA Translation: CAA80375.1 AK011358 mRNA Translation: BAB27566.1 BC019398 mRNA Translation: AAH19398.1 BC094638 mRNA Translation: AAH94638.1 |
CCDSi | CCDS39802.1 |
PIRi | I48251 |
RefSeqi | NP_001103479.1, NM_001110009.2 NP_031495.1, NM_007469.5 |
Genome annotation databases
Ensembli | ENSMUST00000045035; ENSMUSP00000045571; ENSMUSG00000040564 ENSMUST00000108451; ENSMUSP00000104091; ENSMUSG00000040564 |
GeneIDi | 11812 |
KEGGi | mmu:11812 |
UCSCi | uc009fmv.3, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z22661, Z22660 Genomic DNA Translation: CAA80375.1 AK011358 mRNA Translation: BAB27566.1 BC019398 mRNA Translation: AAH19398.1 BC094638 mRNA Translation: AAH94638.1 |
CCDSi | CCDS39802.1 |
PIRi | I48251 |
RefSeqi | NP_001103479.1, NM_001110009.2 NP_031495.1, NM_007469.5 |
3D structure databases
SMRi | P34928 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000104091 |
PTM databases
iPTMneti | P34928 |
PhosphoSitePlusi | P34928 |
Proteomic databases
jPOSTi | P34928 |
MaxQBi | P34928 |
PaxDbi | P34928 |
PeptideAtlasi | P34928 |
PRIDEi | P34928 |
Protocols and materials databases
Antibodypediai | 17780, 355 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000045035; ENSMUSP00000045571; ENSMUSG00000040564 ENSMUST00000108451; ENSMUSP00000104091; ENSMUSG00000040564 |
GeneIDi | 11812 |
KEGGi | mmu:11812 |
UCSCi | uc009fmv.3, mouse |
Organism-specific databases
CTDi | 341 |
MGIi | MGI:88053, Apoc1 |
Phylogenomic databases
eggNOGi | ENOG502SEU4, Eukaryota |
GeneTreei | ENSGT00390000011584 |
HOGENOMi | CLU_160094_1_0_1 |
InParanoidi | P34928 |
OMAi | RSWFSET |
OrthoDBi | 1558708at2759 |
PhylomeDBi | P34928 |
TreeFami | TF330940 |
Enzyme and pathway databases
Reactomei | R-MMU-8866423, VLDL assembly R-MMU-8964046, VLDL clearance |
Miscellaneous databases
BioGRID-ORCSi | 11812, 2 hits in 17 CRISPR screens |
ChiTaRSi | Apoc1, mouse |
PROi | PR:P34928 |
RNActi | P34928, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000040564, Expressed in left lobe of liver and 186 other tissues |
Genevisiblei | P34928, MM |
Family and domain databases
Gene3Di | 4.10.260.30, 1 hit |
InterProi | View protein in InterPro IPR043081, ApoC-1_sf IPR006781, ApoC-I |
PANTHERi | PTHR16565, PTHR16565, 1 hit |
Pfami | View protein in Pfam PF04691, ApoC-I, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | APOC1_MOUSE | |
Accessioni | P34928Primary (citable) accession number: P34928 Secondary accession number(s): Q505B2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | February 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families