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Protein

Protein EVI2B

Gene

EVI2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells.1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein EVI2BCurated
Alternative name(s):
Ecotropic viral integration site 2B protein homolog
Short name:
EVI-2B1 Publication
CD_antigen: CD361
Gene namesi
Name:EVI2B1 PublicationImported
Synonyms:EVDBImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000185862.6
HGNCiHGNC:3500 EVI2B
MIMi158381 gene
neXtProtiNX_P34910

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 202ExtracellularSequence analysisAdd BLAST181
Transmembranei203 – 226HelicalSequence analysisAdd BLAST24
Topological domaini227 – 448CytoplasmicSequence analysisAdd BLAST222

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi2124
OpenTargetsiENSG00000185862
PharmGKBiPA27914

Polymorphism and mutation databases

BioMutaiEVI2B
DMDMi281185464

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002121322 – 448Protein EVI2BAdd BLAST427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi16N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei249PhosphothreonineBy similarity1
Modified residuei268PhosphoserineCombined sources1
Modified residuei271PhosphoserineCombined sources1
Modified residuei278PhosphoserineBy similarity1
Modified residuei294PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP34910
MaxQBiP34910
PaxDbiP34910
PeptideAtlasiP34910
PRIDEiP34910
ProteomicsDBi54952

PTM databases

iPTMnetiP34910
PhosphoSitePlusiP34910
SwissPalmiP34910

Expressioni

Tissue specificityi

Bone marrow, peripheral blood mononuclear cells, fibroblasts and Epstein-Barr virus-transformed lymphoblastoid cell lines. Strongly expressed in granulocytic cells, and weakly on lymphocytes cells.1 Publication

Inductioni

Up-regulated by full-length CEBPA.1 Publication

Gene expression databases

BgeeiENSG00000185862 Expressed in 199 organ(s), highest expression level in bone marrow
CleanExiHS_EVI2B
GenevisibleiP34910 HS

Organism-specific databases

HPAiHPA007436

Interactioni

Protein-protein interaction databases

IntActiP34910, 26 interactors
STRINGi9606.ENSP00000333779

Structurei

3D structure databases

ProteinModelPortaliP34910
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVU1 Eukaryota
ENOG41118NF LUCA
GeneTreeiENSGT00390000009142
HOGENOMiHOG000285986
HOVERGENiHBG051514
InParanoidiP34910
KOiK16854
OMAiMDPKYFI
OrthoDBiEOG091G0GGD
PhylomeDBiP34910
TreeFamiTF336167

Family and domain databases

InterProiView protein in InterPro
IPR033239 EVI2B
PANTHERiPTHR15384 PTHR15384, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD140898 PD140898, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P34910-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPKYFILIL FCGHLNNTFF SKTETITTEK QSQPTLFTSS MSQVLANSQN
60 70 80 90 100
TTGNPLGQPT QFSDTFSGQS ISPAKVTAGQ PTPAVYTSSE KPEAHTSAGQ
110 120 130 140 150
PLAYNTKQPT PIANTSSQQA VFTSARQLPS ARTSTTQPPK SFVYTFTQQS
160 170 180 190 200
SSVQIPSRKQ ITVHNPSTQP TSTVKNSPRS TPGFILDTTS NKQTPQKNNY
210 220 230 240 250
NSIAAILIGV LLTSMLVAII IIVLWKCLRK PVLNDQNWAG RSPFADGETP
260 270 280 290 300
DICMDNIREN EISTKRTSII SLTPWKPSKS TLLADDLEIK LFESSENIED
310 320 330 340 350
SNNPKTEKIK DQVNGTSEDS ADGSTVGTAV SSSDDADLPP PPPLLDLEGQ
360 370 380 390 400
ESNQSDKPTM TIVSPLPNDS TSLPPSLDCL NQDCGDHKSE IIQSFPPLDS
410 420 430 440
LNLPLPPVDF MKNQEDSNLE IQCQEFSIPP NSDQDLNESL PPPPAELL
Length:448
Mass (Da):48,666
Last modified:December 15, 2009 - v2
Checksum:i5BF2DC46798577E3
GO
Isoform 2 (identifier: P34910-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLFRYAEKITRKYSEM

Note: No experimental confirmation available.
Show »
Length:463
Mass (Da):50,584
Checksum:i0BAC6993B9427827
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37F → Y in AAA35816 (PubMed:1903357).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05687153G → R. Corresponds to variant dbSNP:rs9903564EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0564611M → MLFRYAEKITRKYSEM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60830 Genomic DNA Translation: AAA35816.1
AK297087 mRNA Translation: BAH12493.1
AC134669 Genomic DNA No translation available.
CCDSiCCDS11266.1 [P34910-1]
PIRiA38445
RefSeqiNP_006486.3, NM_006495.3 [P34910-1]
XP_005258003.1, XM_005257946.3 [P34910-2]
UniGeneiHs.5509

Genome annotation databases

EnsembliENST00000330927; ENSP00000333779; ENSG00000185862 [P34910-1]
ENST00000577894; ENSP00000462682; ENSG00000185862 [P34910-1]
GeneIDi2124
KEGGihsa:2124
UCSCiuc002hgk.3 human [P34910-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60830 Genomic DNA Translation: AAA35816.1
AK297087 mRNA Translation: BAH12493.1
AC134669 Genomic DNA No translation available.
CCDSiCCDS11266.1 [P34910-1]
PIRiA38445
RefSeqiNP_006486.3, NM_006495.3 [P34910-1]
XP_005258003.1, XM_005257946.3 [P34910-2]
UniGeneiHs.5509

3D structure databases

ProteinModelPortaliP34910
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP34910, 26 interactors
STRINGi9606.ENSP00000333779

PTM databases

iPTMnetiP34910
PhosphoSitePlusiP34910
SwissPalmiP34910

Polymorphism and mutation databases

BioMutaiEVI2B
DMDMi281185464

Proteomic databases

EPDiP34910
MaxQBiP34910
PaxDbiP34910
PeptideAtlasiP34910
PRIDEiP34910
ProteomicsDBi54952

Protocols and materials databases

DNASUi2124
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330927; ENSP00000333779; ENSG00000185862 [P34910-1]
ENST00000577894; ENSP00000462682; ENSG00000185862 [P34910-1]
GeneIDi2124
KEGGihsa:2124
UCSCiuc002hgk.3 human [P34910-1]

Organism-specific databases

CTDi2124
DisGeNETi2124
EuPathDBiHostDB:ENSG00000185862.6
GeneCardsiEVI2B
H-InvDBiHIX0013696
HGNCiHGNC:3500 EVI2B
HPAiHPA007436
MIMi158381 gene
neXtProtiNX_P34910
OpenTargetsiENSG00000185862
PharmGKBiPA27914
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVU1 Eukaryota
ENOG41118NF LUCA
GeneTreeiENSGT00390000009142
HOGENOMiHOG000285986
HOVERGENiHBG051514
InParanoidiP34910
KOiK16854
OMAiMDPKYFI
OrthoDBiEOG091G0GGD
PhylomeDBiP34910
TreeFamiTF336167

Miscellaneous databases

GeneWikiiEVI2B
GenomeRNAii2124
PROiPR:P34910
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185862 Expressed in 199 organ(s), highest expression level in bone marrow
CleanExiHS_EVI2B
GenevisibleiP34910 HS

Family and domain databases

InterProiView protein in InterPro
IPR033239 EVI2B
PANTHERiPTHR15384 PTHR15384, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD140898 PD140898, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEVI2B_HUMAN
AccessioniPrimary (citable) accession number: P34910
Secondary accession number(s): B7Z4A7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: December 15, 2009
Last modified: September 12, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  5. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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