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Entry version 201 (18 Sep 2019)
Sequence version 1 (01 Feb 1994)
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Protein

Serine hydroxymethyltransferase, cytosolic

Gene

SHMT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Interconversion of serine and glycine (PubMed:8505317, PubMed:24698160).2 Publications

Miscellaneous

In eukaryotes there are two forms of the enzymes: a cytosolic one and a mitochondrial one.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pyridoxal 5'-phosphate3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by tetrahydrofolate concentrations above 40 µM.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.18 mM for L-serine1 Publication
  2. KM=5.2 µM for tetrahydrofolate1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: tetrahydrofolate interconversion

    This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.1 Publication
    View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionTransferase
    Biological processOne-carbon metabolism
    LigandPyridoxal phosphate

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS11114-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.1.2.1 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-196757 Metabolism of folate and pterines
    R-HSA-71262 Carnitine synthesis

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P34896

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00193

    Protein family/group databases

    MoonProt database of moonlighting proteins

    More...
    MoonProti
    P34896

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Serine hydroxymethyltransferase, cytosolic (EC:2.1.2.12 Publications)
    Short name:
    SHMT
    Alternative name(s):
    Glycine hydroxymethyltransferase
    Serine methylase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SHMT1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:10850 SHMT1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    182144 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P34896

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    6470

    Open Targets

    More...
    OpenTargetsi
    ENSG00000176974

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA35753

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL1772927

    Drug and drug target database

    More...
    DrugBanki
    DB02800 5-Hydroxymethylene-6-Hydrofolic Acid
    DB00145 Glycine
    DB01055 Mimosine
    DB02824 N-Pyridoxyl-Glycine-5-Monophosphate
    DB00114 Pyridoxal phosphate
    DB00116 Tetrahydrofolic acid
    DB02067 Triglu-5-Formyl-Tetrahydrofolate

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    SHMT1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    462184

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001135041 – 483Serine hydroxymethyltransferase, cytosolicAdd BLAST483

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei257N6-(pyridoxal phosphate)lysineCombined sources1 Publication1
    Isoform 2 (identifier: P34896-2)
    Modified residuei271N6-acetyllysineCombined sources1

    Keywords - PTMi

    Acetylation

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P34896

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P34896

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    P34896

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P34896

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P34896

    PeptideAtlas

    More...
    PeptideAtlasi
    P34896

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P34896

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    4797
    54945 [P34896-1]
    54946 [P34896-2]
    54947 [P34896-3]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P34896

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P34896

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    P34896

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000176974 Expressed in 214 organ(s), highest expression level in right lobe of liver

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P34896 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P34896 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA023314

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homotetramer (PubMed:24698160, PubMed:25619277, PubMed:9753690). Identified in complex with ABRAXAS2 and the other subunits of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1 (PubMed:24075985).

    4 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    112366, 51 interactors

    CORUM comprehensive resource of mammalian protein complexes

    More...
    CORUMi
    P34896

    Protein interaction database and analysis system

    More...
    IntActi
    P34896, 18 interactors

    Molecular INTeraction database

    More...
    MINTi
    P34896

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000318868

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P34896

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1483
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P34896

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P34896

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the SHMT family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2467 Eukaryota
    COG0112 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000002762

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000239405

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P34896

    KEGG Orthology (KO)

    More...
    KOi
    K00600

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    PLEHIIA

    Database of Orthologous Groups

    More...
    OrthoDBi
    372408at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P34896

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF314667

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00378 SHMT, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.640.10, 1 hit
    3.90.1150.10, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_00051 SHMT, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR015424 PyrdxlP-dep_Trfase
    IPR015422 PyrdxlP-dep_Trfase_dom1
    IPR015421 PyrdxlP-dep_Trfase_major
    IPR001085 Ser_HO-MeTrfase
    IPR019798 Ser_HO-MeTrfase_PLP_BS
    IPR039429 SHMT-like_dom

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11680 PTHR11680, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00464 SHMT, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000412 SHMT, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53383 SSF53383, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00096 SHMT, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: P34896-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MTMPVNGAHK DADLWSSHDK MLAQPLKDSD VEVYNIIKKE SNRQRVGLEL
    60 70 80 90 100
    IASENFASRA VLEALGSCLN NKYSEGYPGQ RYYGGTEFID ELETLCQKRA
    110 120 130 140 150
    LQAYKLDPQC WGVNVQPYSG SPANFAVYTA LVEPHGRIMG LDLPDGGHLT
    160 170 180 190 200
    HGFMTDKKKI SATSIFFESM PYKVNPDTGY INYDQLEENA RLFHPKLIIA
    210 220 230 240 250
    GTSCYSRNLE YARLRKIADE NGAYLMADMA HISGLVAAGV VPSPFEHCHV
    260 270 280 290 300
    VTTTTHKTLR GCRAGMIFYR KGVKSVDPKT GKEILYNLES LINSAVFPGL
    310 320 330 340 350
    QGGPHNHAIA GVAVALKQAM TLEFKVYQHQ VVANCRALSE ALTELGYKIV
    360 370 380 390 400
    TGGSDNHLIL VDLRSKGTDG GRAEKVLEAC SIACNKNTCP GDRSALRPSG
    410 420 430 440 450
    LRLGTPALTS RGLLEKDFQK VAHFIHRGIE LTLQIQSDTG VRATLKEFKE
    460 470 480
    RLAGDKYQAA VQALREEVES FASLFPLPGL PDF
    Length:483
    Mass (Da):53,083
    Last modified:February 1, 1994 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6CDD6CA06D017C19
    GO
    Isoform 2 (identifier: P34896-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         274-312: Missing.

    Show »
    Length:444
    Mass (Da):49,028
    Checksum:i92091DCEB64B65D1
    GO
    Isoform 3 (identifier: P34896-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         273-352: Missing.

    Show »
    Length:403
    Mass (Da):44,552
    Checksum:i9CE930DFA6FC1FF7
    GO
    Isoform 4 (identifier: P34896-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-138: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:345
    Mass (Da):37,672
    Checksum:iDD683D88B3A1D1FA
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    J3KRZ5J3KRZ5_HUMAN
    Serine hydroxymethyltransferase, cy...
    SHMT1
    167Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3KRK5J3KRK5_HUMAN
    Serine hydroxymethyltransferase, cy...
    SHMT1
    128Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A087WTD8A0A087WTD8_HUMAN
    Serine hydroxymethyltransferase, cy...
    SHMT1
    125Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059795340E → Q. Corresponds to variant dbSNP:rs7215148Ensembl.1
    Natural variantiVAR_022010474L → F2 PublicationsCorresponds to variant dbSNP:rs1979277EnsemblClinVar.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0546101 – 138Missing in isoform 4. 1 PublicationAdd BLAST138
    Alternative sequenceiVSP_006096273 – 352Missing in isoform 3. CuratedAdd BLAST80
    Alternative sequenceiVSP_006095274 – 312Missing in isoform 2. 1 PublicationAdd BLAST39

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    L11931 mRNA Translation: AAA63257.1
    L23928 mRNA Translation: AAA36020.1
    L23928 mRNA Translation: AAA36019.1
    L23928 mRNA Translation: AAA36018.1
    Y14485 mRNA Translation: CAB54838.1
    Y14486 mRNA Translation: CAB54839.1
    Y14487 mRNA Translation: CAB54840.1
    AK298415 mRNA Translation: BAG60641.1
    AC127537 Genomic DNA No translation available.
    AL353997 Genomic DNA No translation available.
    CH471196 Genomic DNA Translation: EAW55637.1
    CH471196 Genomic DNA Translation: EAW55640.1
    CH471196 Genomic DNA Translation: EAW55641.1
    BC007979 mRNA Translation: AAH07979.1
    BC022874 mRNA Translation: AAH22874.1
    BC038598 mRNA Translation: AAH38598.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS11196.1 [P34896-1]
    CCDS11197.1 [P34896-2]
    CCDS62112.1 [P34896-4]

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A46746

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001268715.1, NM_001281786.1 [P34896-4]
    NP_004160.3, NM_004169.4 [P34896-1]
    NP_683718.1, NM_148918.2 [P34896-2]
    XP_005256824.1, XM_005256767.3 [P34896-1]
    XP_011522294.1, XM_011523992.2 [P34896-3]
    XP_016880446.1, XM_017024957.1 [P34896-1]
    XP_016880447.1, XM_017024958.1 [P34896-2]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000316694; ENSP00000318868; ENSG00000176974 [P34896-1]
    ENST00000352886; ENSP00000345881; ENSG00000176974 [P34896-4]
    ENST00000354098; ENSP00000318805; ENSG00000176974 [P34896-2]

    Database of genes from NCBI RefSeq genomes

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    GeneIDi
    6470

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:6470

    UCSC genome browser

    More...
    UCSCi
    uc002gta.5 human [P34896-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    L11931 mRNA Translation: AAA63257.1
    L23928 mRNA Translation: AAA36020.1
    L23928 mRNA Translation: AAA36019.1
    L23928 mRNA Translation: AAA36018.1
    Y14485 mRNA Translation: CAB54838.1
    Y14486 mRNA Translation: CAB54839.1
    Y14487 mRNA Translation: CAB54840.1
    AK298415 mRNA Translation: BAG60641.1
    AC127537 Genomic DNA No translation available.
    AL353997 Genomic DNA No translation available.
    CH471196 Genomic DNA Translation: EAW55637.1
    CH471196 Genomic DNA Translation: EAW55640.1
    CH471196 Genomic DNA Translation: EAW55641.1
    BC007979 mRNA Translation: AAH07979.1
    BC022874 mRNA Translation: AAH22874.1
    BC038598 mRNA Translation: AAH38598.1
    CCDSiCCDS11196.1 [P34896-1]
    CCDS11197.1 [P34896-2]
    CCDS62112.1 [P34896-4]
    PIRiA46746
    RefSeqiNP_001268715.1, NM_001281786.1 [P34896-4]
    NP_004160.3, NM_004169.4 [P34896-1]
    NP_683718.1, NM_148918.2 [P34896-2]
    XP_005256824.1, XM_005256767.3 [P34896-1]
    XP_011522294.1, XM_011523992.2 [P34896-3]
    XP_016880446.1, XM_017024957.1 [P34896-1]
    XP_016880447.1, XM_017024958.1 [P34896-2]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1BJ4X-ray2.65A11-480[»]
    6FL5X-ray3.60A/D/G/J11-481[»]
    SMRiP34896
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi112366, 51 interactors
    CORUMiP34896
    IntActiP34896, 18 interactors
    MINTiP34896
    STRINGi9606.ENSP00000318868

    Chemistry databases

    BindingDBiP34896
    ChEMBLiCHEMBL1772927
    DrugBankiDB02800 5-Hydroxymethylene-6-Hydrofolic Acid
    DB00145 Glycine
    DB01055 Mimosine
    DB02824 N-Pyridoxyl-Glycine-5-Monophosphate
    DB00114 Pyridoxal phosphate
    DB00116 Tetrahydrofolic acid
    DB02067 Triglu-5-Formyl-Tetrahydrofolate

    DrugCentral

    More...
    DrugCentrali
    P34896

    Protein family/group databases

    MoonProtiP34896

    PTM databases

    iPTMnetiP34896
    PhosphoSitePlusiP34896
    SwissPalmiP34896

    Polymorphism and mutation databases

    BioMutaiSHMT1
    DMDMi462184

    Proteomic databases

    EPDiP34896
    jPOSTiP34896
    MassIVEiP34896
    MaxQBiP34896
    PaxDbiP34896
    PeptideAtlasiP34896
    PRIDEiP34896
    ProteomicsDBi4797
    54945 [P34896-1]
    54946 [P34896-2]
    54947 [P34896-3]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    6470
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000316694; ENSP00000318868; ENSG00000176974 [P34896-1]
    ENST00000352886; ENSP00000345881; ENSG00000176974 [P34896-4]
    ENST00000354098; ENSP00000318805; ENSG00000176974 [P34896-2]
    GeneIDi6470
    KEGGihsa:6470
    UCSCiuc002gta.5 human [P34896-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    6470
    DisGeNETi6470

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    SHMT1
    HGNCiHGNC:10850 SHMT1
    HPAiHPA023314
    MIMi182144 gene
    neXtProtiNX_P34896
    OpenTargetsiENSG00000176974
    PharmGKBiPA35753

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG2467 Eukaryota
    COG0112 LUCA
    GeneTreeiENSGT00390000002762
    HOGENOMiHOG000239405
    InParanoidiP34896
    KOiK00600
    OMAiPLEHIIA
    OrthoDBi372408at2759
    PhylomeDBiP34896
    TreeFamiTF314667

    Enzyme and pathway databases

    UniPathwayiUPA00193
    BioCyciMetaCyc:HS11114-MONOMER
    BRENDAi2.1.2.1 2681
    ReactomeiR-HSA-196757 Metabolism of folate and pterines
    R-HSA-71262 Carnitine synthesis
    SABIO-RKiP34896

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    SHMT1 human
    EvolutionaryTraceiP34896

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    6470

    Pharos

    More...
    Pharosi
    P34896

    Protein Ontology

    More...
    PROi
    PR:P34896

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000176974 Expressed in 214 organ(s), highest expression level in right lobe of liver
    ExpressionAtlasiP34896 baseline and differential
    GenevisibleiP34896 HS

    Family and domain databases

    CDDicd00378 SHMT, 1 hit
    Gene3Di3.40.640.10, 1 hit
    3.90.1150.10, 1 hit
    HAMAPiMF_00051 SHMT, 1 hit
    InterProiView protein in InterPro
    IPR015424 PyrdxlP-dep_Trfase
    IPR015422 PyrdxlP-dep_Trfase_dom1
    IPR015421 PyrdxlP-dep_Trfase_major
    IPR001085 Ser_HO-MeTrfase
    IPR019798 Ser_HO-MeTrfase_PLP_BS
    IPR039429 SHMT-like_dom
    PANTHERiPTHR11680 PTHR11680, 1 hit
    PfamiView protein in Pfam
    PF00464 SHMT, 1 hit
    PIRSFiPIRSF000412 SHMT, 1 hit
    SUPFAMiSSF53383 SSF53383, 1 hit
    PROSITEiView protein in PROSITE
    PS00096 SHMT, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLYC_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34896
    Secondary accession number(s): B4DPM9
    , D3DXD0, Q96HY0, Q9UMD1, Q9UMD2
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: September 18, 2019
    This is version 201 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    7. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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