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Entry version 79 (11 Dec 2019)
Sequence version 1 (01 Feb 1994)
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Protein

NADH-ubiquinone oxidoreductase chain 2

Gene

ND2

Organism
Apis mellifera ligustica (Common honeybee) (Italian honeybee)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 2 (EC:7.1.1.2)
Alternative name(s):
NADH dehydrogenase subunit 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ND2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniMitochondrion
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiApis mellifera ligustica (Common honeybee) (Italian honeybee)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7469 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataApoideaApidaeApis

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001175501 – 333NADH-ubiquinone oxidoreductase chain 2Add BLAST333

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complex I subunit 2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P34849-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFFMNFKYHW FIYFLITIFV LMMNSNNIFI QWMLMEFGTI ISISLINIKS
60 70 80 90 100
TNKTPSLIYY SVSVISSIFL FFMIIVYLSS ISFTKTDTFN FMVQMMFFLK
110 120 130 140 150
IGTFPFHFWM IYSYEMMNWK QIFLMSTLIK FIPIYMMVSM TKINSWTLYF
160 170 180 190 200
LITNSLYISF YANKFYTLKK LLACSTIFNS FYFIFILELN KNMFIAMIIL
210 220 230 240 250
YSFNYFLLIS FLNKFNIQNF NFMFYNKYQM YTFLTLMFNY SMYPIFLSFV
260 270 280 290 300
IKWNLIFMMV SVKAYNWILF LLMISSMLMI WNYIIILKRV FLKMNFYKNN
310 320 330
FIDDKDNKYM YHSYFALTLL SFNISFFITL NFL
Length:333
Mass (Da):40,879
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i866969F11529907F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti14F → L in strain: ssp. adansonii, ssp. capensis, ssp. carnica, ssp. iberica, ssp. intermissa, ssp. lamarckii, ssp. macedonica, ssp. meda, ssp. monticola, ssp. sahariensis, ssp. scutellata and ssp. sicula. 1
Natural varianti62V → M in haplotype 9. 1
Natural varianti84T → I in haplotypes 3, 5, 6, 7 and 10. 1
Natural varianti138V → I in haplotype 4, MELLI1 and MELLI2. 1
Natural varianti142K → S in strain: ssp. lamarckii. 1
Natural varianti158I → T in strain: MELLI1. 1
Natural varianti203F → L in strain: ssp. carnica. 1
Natural varianti262V → D in haplotype 6. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L06178 Genomic DNA Translation: AAB96798.1
U35743 Genomic DNA Translation: AAB38223.1
U35744 Genomic DNA Translation: AAB38224.1
U35745 Genomic DNA Translation: AAB38225.1
U35746 Genomic DNA Translation: AAB38226.1
U35747 Genomic DNA Translation: AAB38227.1
U35748 Genomic DNA Translation: AAD12744.1
U35749 Genomic DNA Translation: AAD12745.1
U35750 Genomic DNA Translation: AAB38228.1
U35751 Genomic DNA Translation: AAB38229.1
U35752 Genomic DNA Translation: AAB38230.1
U35753 Genomic DNA Translation: AAB38231.1
U35754 Genomic DNA Translation: AAB38232.1
U35755 Genomic DNA Translation: AAB38233.1
U35756 Genomic DNA Translation: AAB38234.1
U35757 Genomic DNA Translation: AAB38235.1
U35758 Genomic DNA Translation: AAB38236.1
U35759 Genomic DNA Translation: AAB38237.1
U35760 Genomic DNA Translation: AAB38238.1
U35761 Genomic DNA Translation: AAB38239.1
U35762 Genomic DNA Translation: AAB38241.1
U35763 Genomic DNA Translation: AAB38242.1
U35764 Genomic DNA Translation: AAB38243.1
U35765 Genomic DNA Translation: AAB38244.1
U72279 Genomic DNA Translation: AAB41177.1
U72280 Genomic DNA Translation: AAB41178.1
U72281 Genomic DNA Translation: AAB41179.1
U72282 Genomic DNA Translation: AAB41180.1
U72283 Genomic DNA Translation: AAB41181.1
U72284 Genomic DNA Translation: AAB41182.1
U72285 Genomic DNA Translation: AAB41183.1
U72286 Genomic DNA Translation: AAB41184.1
U72287 Genomic DNA Translation: AAB41185.1
U72288 Genomic DNA Translation: AAB41186.1
U72289 Genomic DNA Translation: AAB41187.1

NCBI Reference Sequences

More...
RefSeqi
NP_008082.1, NC_001566.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
807701

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06178 Genomic DNA Translation: AAB96798.1
U35743 Genomic DNA Translation: AAB38223.1
U35744 Genomic DNA Translation: AAB38224.1
U35745 Genomic DNA Translation: AAB38225.1
U35746 Genomic DNA Translation: AAB38226.1
U35747 Genomic DNA Translation: AAB38227.1
U35748 Genomic DNA Translation: AAD12744.1
U35749 Genomic DNA Translation: AAD12745.1
U35750 Genomic DNA Translation: AAB38228.1
U35751 Genomic DNA Translation: AAB38229.1
U35752 Genomic DNA Translation: AAB38230.1
U35753 Genomic DNA Translation: AAB38231.1
U35754 Genomic DNA Translation: AAB38232.1
U35755 Genomic DNA Translation: AAB38233.1
U35756 Genomic DNA Translation: AAB38234.1
U35757 Genomic DNA Translation: AAB38235.1
U35758 Genomic DNA Translation: AAB38236.1
U35759 Genomic DNA Translation: AAB38237.1
U35760 Genomic DNA Translation: AAB38238.1
U35761 Genomic DNA Translation: AAB38239.1
U35762 Genomic DNA Translation: AAB38241.1
U35763 Genomic DNA Translation: AAB38242.1
U35764 Genomic DNA Translation: AAB38243.1
U35765 Genomic DNA Translation: AAB38244.1
U72279 Genomic DNA Translation: AAB41177.1
U72280 Genomic DNA Translation: AAB41178.1
U72281 Genomic DNA Translation: AAB41179.1
U72282 Genomic DNA Translation: AAB41180.1
U72283 Genomic DNA Translation: AAB41181.1
U72284 Genomic DNA Translation: AAB41182.1
U72285 Genomic DNA Translation: AAB41183.1
U72286 Genomic DNA Translation: AAB41184.1
U72287 Genomic DNA Translation: AAB41185.1
U72288 Genomic DNA Translation: AAB41186.1
U72289 Genomic DNA Translation: AAB41187.1
RefSeqiNP_008082.1, NC_001566.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi807701

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4536

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNU2M_APILI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34849
Secondary accession number(s): P92496
, P92497, P92502, P92886, P92907, Q33785, Q33786, Q33787, Q33788, Q36885
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: December 11, 2019
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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