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Protein

Dorsalin-1

Gene

DSL1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Appears to regulate cell differentiation within the neural tube. May regulate the differentiation of cell types along the dorsoventral axis of the neural tube, acting in conjunction with distinct ventralizing signals from the notochord and floor plate. Controls the cell differentiation in the neural tube in several ways: (1) promotes the differentiation of cell types that derive from the dorsal neural tube. (2) ensures that the dorsal neural tube is refractory to ventralizing species from the notochord. (3) can diffuse and influence the fate of cells in more ventral regions of the neural tube.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor

Enzyme and pathway databases

ReactomeiR-GGA-201451 Signaling by BMP

Names & Taxonomyi

Protein namesi
Recommended name:
Dorsalin-1
Short name:
DSL-1
Gene namesi
Name:DSL1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000003390621 – 3181 PublicationAdd BLAST298
ChainiPRO_0000033907319 – 427Dorsalin-1Add BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi265N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi292N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi325 ↔ 391By similarity
Disulfide bondi354 ↔ 424By similarity
Disulfide bondi358 ↔ 426By similarity
Disulfide bondi390InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP34822
PRIDEiP34822

Expressioni

Tissue specificityi

Expressed selectively in the dorsal neural tube. Lower levels seen in kidney and myotomal cells.

Developmental stagei

Is not expressed in neural cells at stages before neural tube closure. Is expressed at high levels in the dorsal third of the neural tube, beginning at the time of neural tube closure, but not by ventral neural cells or by nonneural cells. Dorsal restriction persists in the spinal cord at stages after the onset of neuronal differentiation. At later stages of spinal development, is restricted to the dorsomedial region of the spinal cord, including but not confined to the roof plate.

Gene expression databases

BgeeiENSGALG00000005981

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000009606

Structurei

3D structure databases

ProteinModelPortaliP34822
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00760000118883
HOGENOMiHOG000249477
HOVERGENiHBG106648
InParanoidiP34822
KOiK05503
OMAiILYKDDM
OrthoDBiEOG091G075U
PhylomeDBiP34822
TreeFamiTF316134

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34822-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHYFGVLAAL SVFNIIACLT RGKPLENWKK LPVMEESDAF FHDPGEVEHD
60 70 80 90 100
THFDFKSFLE NMKTDLLRSL NLSRVPSQVK TKEEPPQFMI DLYNRYTADK
110 120 130 140 150
SSIPASNIVR SFSTEDVVSL ISPEEHSFQK HILLFNISIP RYEEVTRAEL
160 170 180 190 200
RIFISCHKEV GSPSRLEGNM VIYDVLDGDH WENKESTKSL LVSHSIQDCG
210 220 230 240 250
WEMFEVSSAV KRWVKADKMK TKNKLEVVIE SKDLSGFPCG KLDITVTHDT
260 270 280 290 300
KNLPLLIVFS NDRSNGTKET KVELREMIVH EQESVLNKLG KNDSSSEEEQ
310 320 330 340 350
REEKAIARPR QHSSRSKRSI GANHCRRTSL HVNFKEIGWD SWIIAPKDYE
360 370 380 390 400
AFECKGGCFF PLTDNVTPTK HAIVQTLVHL QNPKKASKAC CVPTKLDAIS
410 420
ILYKDDAGVP TLIYNYEGMK VAECGCR
Length:427
Mass (Da):48,626
Last modified:February 1, 1994 - v1
Checksum:i23AA42DC7085FABC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12032 mRNA Translation: AAA48752.1
PIRiA40735
RefSeqiNP_990763.1, NM_205432.1
UniGeneiGga.811

Genome annotation databases

EnsembliENSGALT00000009620; ENSGALP00000009606; ENSGALG00000005981
GeneIDi396412
KEGGigga:396412

Similar proteinsi

Entry informationi

Entry nameiDSL1_CHICK
AccessioniPrimary (citable) accession number: P34822
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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