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Protein

Bone morphogenetic protein 8B

Gene

BMP8B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Developmental protein, Growth factor
Biological processChondrogenesis, Differentiation, Osteogenesis

Enzyme and pathway databases

SignaLinkiP34820

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 8B
Short name:
BMP-8
Short name:
BMP-8B
Alternative name(s):
Osteogenic protein 2
Short name:
OP-2
Gene namesi
Name:BMP8B
Synonyms:BMP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116985.10
HGNCiHGNC:1075 BMP8B
MIMi602284 gene
neXtProtiNX_P34820

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi656
OpenTargetsiENSG00000116985
PharmGKBiPA25385

Polymorphism and mutation databases

BioMutaiBMP8B
DMDMi90110010

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000003388220 – 263Sequence analysisAdd BLAST244
ChainiPRO_0000033883264 – 402Bone morphogenetic protein 8BAdd BLAST139

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi301 ↔ 367By similarity
Disulfide bondi330 ↔ 399By similarity
Disulfide bondi334 ↔ 401By similarity
Glycosylationi343N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi366InterchainBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP34820
PeptideAtlasiP34820
PRIDEiP34820
ProteomicsDBi54944

PTM databases

iPTMnetiP34820
PhosphoSitePlusiP34820

Expressioni

Gene expression databases

BgeeiENSG00000116985
CleanExiHS_BMP8B
GenevisibleiP34820 HS

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107124, 7 interactors
IntActiP34820, 4 interactors
MINTiP34820
STRINGi9606.ENSP00000361915

Structurei

3D structure databases

ProteinModelPortaliP34820
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00760000118883
HOGENOMiHOG000249476
HOVERGENiHBG004860
InParanoidiP34820
KOiK16622
OMAiMKPEAVP
OrthoDBiEOG091G0K7Z
PhylomeDBiP34820
TreeFamiTF316134

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P34820-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTALPGPLWL LGLALCALGG GGPGLRPPPG CPQRRLGARE RRDVQREILA
60 70 80 90 100
VLGLPGRPRP RAPPAASRLP ASAPLFMLDL YHAMAGDDDE DGAPAERRLG
110 120 130 140 150
RADLVMSFVN MVERDRALGH QEPHWKEFRF DLTQIPAGEA VTAAEFRIYK
160 170 180 190 200
VPSIHLLNRT LHVSMFQVVQ EQSNRESDLF FLDLQTLRAG DEGWLVLDVT
210 220 230 240 250
AASDCWLLKR HKDLGLRLYV ETEDGHSVDP GLAGLLGQRA PRSQQPFVVT
260 270 280 290 300
FFRASPSPIR TPRAVRPLRR RQPKKSNELP QANRLPGIFD DVHGSHGRQV
310 320 330 340 350
CRRHELYVSF QDLGWLDWVI APQGYSAYYC EGECSFPLDS CMNATNHAIL
360 370 380 390 400
QSLVHLMMPD AVPKACCAPT KLSATSVLYY DSSNNVILRK HRNMVVKACG

CH
Length:402
Mass (Da):44,768
Last modified:March 21, 2006 - v2
Checksum:iAE2330F1547E83A7
GO
Isoform 2 (identifier: P34820-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     226-253: HSVDPGLAGLLGQRAPRSQQPFVVTFFR → ETWTGWGWTK...LLCLLQGHCP
     317-402: DWVIAPQGYS...NMVVKACGCH → VIADSSCF

Note: No experimental confirmation available.Curated
Show »
Length:349
Mass (Da):39,151
Checksum:i3065C85AA8CF5020
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti358 – 360MPD → KPN in AAB01360 (PubMed:1460021).Curated3
Isoform 2 (identifier: P34820-2)
Sequence conflicti347S → P in AAI08679 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014474293H → R1 PublicationCorresponds to variant dbSNP:rs6525Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056842226 – 253HSVDP…VTFFR → ETWTGWGWTKDSRLQMWKLR LSRTPWVLSLHAPGPAQAPA ERPLLCLLQGHCP in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_056843317 – 402DWVIA…ACGCH → VIADSSCF in isoform 2. 1 PublicationAdd BLAST86

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97016 mRNA Translation: AAB01360.1
AY303955 mRNA Translation: AAP74560.1
AL033527 Genomic DNA No translation available.
AL049824 Genomic DNA No translation available.
BC108678 mRNA Translation: AAI08679.1
CCDSiCCDS444.1 [P34820-1]
PIRiA45056
RefSeqiNP_001711.2, NM_001720.4 [P34820-1]
UniGeneiHs.734367

Genome annotation databases

EnsembliENST00000372827; ENSP00000361915; ENSG00000116985 [P34820-1]
GeneIDi656
KEGGihsa:656
UCSCiuc001cdz.2 human [P34820-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBMP8B_HUMAN
AccessioniPrimary (citable) accession number: P34820
Secondary accession number(s): E7EMY8
, Q32NE5, Q53ZM7, Q9NUF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: March 21, 2006
Last modified: June 20, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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