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Entry version 182 (16 Oct 2019)
Sequence version 3 (21 Sep 2011)
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Protein

1-phosphatidylinositol 3-phosphate 5-kinase FAB1

Gene

FAB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. The product of the reaction it catalyzes functions as an important regulator of vacuole homeostasis perhaps by controlling membrane flux to and/or from the vacuole. Hyperosmotic shock-induced increase in the levels of PtdIns(3,5)P2 requires the presence of VAC7, VAC14, and/or FIG4.2 Publications

Miscellaneous

Present with 149 molecules/cell in log phase SD medium.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+, Mn2+

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by VAC14 and VAC7. VAC14 acts as a specific osmotic response regulator.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri240 – 299FYVE-typePROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:YFR019W-MONOMER
YEAST:YFR019W-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.1.150 984

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000854

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
1-phosphatidylinositol 3-phosphate 5-kinase FAB1 (EC:2.7.1.150)
Short name:
Phosphatidylinositol 3-phosphate 5-kinase
Alternative name(s):
Type III PIP kinase
Short name:
PIPkin-III
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAB1
Ordered Locus Names:YFR019W
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VI

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YFR019W

Saccharomyces Genome Database

More...
SGDi
S000001915 FAB1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane, Vacuole

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi262C → S: Cells show growth at 38 degrees Celsius. Failure to localize to the vacuole membrane. 1 Publication1
Mutagenesisi864G → E: Loss of interaction with VAC14. Failure to localize to the vacuole membrane. 1 Publication1
Mutagenesisi1017T → I: Cells are defective for growth at 38 degrees Celsius. 1 Publication1
Mutagenesisi1243C → A: Cells are defective for growth at 38 degrees Celsius and show single-lobed, enlarged vacuoles. 1 Publication1
Mutagenesisi2134D → R: Cells are defective for growth at 38 degrees Celsius. PtdIns(3,5)P2 levels are severely reduced. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001854512 – 22781-phosphatidylinositol 3-phosphate 5-kinase FAB1Add BLAST2277

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei186PhosphoserineCombined sources1
Modified residuei1627PhosphoserineCombined sources1
Modified residuei1630PhosphoserineCombined sources1
Modified residuei1938PhosphoserineCombined sources1
Modified residuei1953PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P34756

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P34756

PRoteomics IDEntifications database

More...
PRIDEi
P34756

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P34756

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P34756

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the PI(3,5)P2 regulatory complex, composed of ATG18, FIG4, FAB1, VAC14 and VAC7. VAC14 nucleates the assembly of the complex and serves as a scaffold.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
31172, 386 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3088 PAS complex

Database of interacting proteins

More...
DIPi
DIP-6784N

Protein interaction database and analysis system

More...
IntActi
P34756, 9 interactors

Molecular INTeraction database

More...
MINTi
P34756

STRING: functional protein association networks

More...
STRINGi
4932.YFR019W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P34756

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1932 – 2266PIPKPROSITE-ProRule annotationAdd BLAST335

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 676Required for localization to the vacuole membraneAdd BLAST675
Regioni800 – 1500Mediates interaction with VAC14 and FIG4Add BLAST701

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi393 – 397Poly-Pro5
Compositional biasi571 – 590Poly-AsnAdd BLAST20
Compositional biasi1808 – 1811Poly-Thr4
Compositional biasi1891 – 1897Poly-Gln7

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri240 – 299FYVE-typePROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

Zinc-finger

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000141935

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P34756

KEGG Orthology (KO)

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KOi
K00921

Identification of Orthologs from Complete Genome Data

More...
OMAi
TCGQIFD

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit
3.30.800.10, 1 hit
3.50.7.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR002498 PInositol-4-P-5-kinase_core
IPR027484 PInositol-4-P-5-kinase_N
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PF01363 FYVE, 1 hit
PF01504 PIP5K, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00064 FYVE, 1 hit
SM00330 PIPKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52029 SSF52029, 1 hit
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51455 PIPK, 1 hit
PS50178 ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P34756-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSEEPHASI SFPDGSHVRS SSTGTSSVNT IDATLSRPNY IKKPSLHIMS
60 70 80 90 100
TSTTSTTTDL VTNPILSNIS VPKISPPTSS SIATATSTSH VTGTASHSNI
110 120 130 140 150
KANANTSTSV NKKNLPPTTS GRIPSSTIKR YPSRYKPSHS LQLPIKNDSN
160 170 180 190 200
FKRSSIYASK STVTAIPIRN NRPISMQNSY ARTPDSDHDD VGDEVSSIKS
210 220 230 240 250
ASSSLTASLS KSFLFAFYNN RKKDKTSNNG VLSKEYWMKD ESSKECFSCG
260 270 280 290 300
KTFNTFRRKH HCRICGQIFC SSCTLLIDGD RFGCHAKMRV CYNCYEHADT
310 320 330 340 350
YEDSSDEEND STMQLNEPRS RSRSRSSNTN PYSHSHSHLH LISQDNHNGT
360 370 380 390 400
DLHDPVAATD NPQQQNEVYL LNDDDVQSIM TSGEDSKLFI STPPPPPKMA
410 420 430 440 450
IPATKQGGSL EISFDSENDR ALHYQDDNPG RHHHLDSVPT RYTIRDMDNI
460 470 480 490 500
SHYDTNSNST LRPHYNTNNS TITINNLNNT TSNNSNYNNT NSNSNINNPA
510 520 530 540 550
HSLRRSIFHY VSSNSVNKDS NNSSATPASS AQSSSILDPA NRIIGNYAHR
560 570 580 590 600
NYKFKFNYNS KGPSQQNDTA NGNNDNNNNN NNNNNNNNNN SASGIADNNN
610 620 630 640 650
IPSNDNGTTF TLDKKKRNPL TKSKSTSAYL EYPLNEEDSS EDEGSMSIYS
660 670 680 690 700
VLNDDHKTDN PIRSMRNSTK SFQRAQASLQ RMRFRRKSKS KHFPNNSKSS
710 720 730 740 750
IYRDLNFLTN STPNLLSVVS DDNLYDDSSP LQDKASSSAA SRLTDRKFSN
760 770 780 790 800
SSGSNNNSNS NSNINTDPWK RIASISGFKL KKEKKRELNE VSLLHMHALL
810 820 830 840 850
KQLLNDQEIS NLQEWITLLD GALRKVLRTI LNARDLNTLD FRQTYVKIKR
860 870 880 890 900
ISGGSPQNSE YIDGVVFSKA LPSKTMPRHL KNPRILLIMF PLEYQKNNNH
910 920 930 940 950
FLSIESVFRQ EREYLDKLVS RLKSLHPDII YVGANVSGYA LELLNDSGIV
960 970 980 990 1000
VQFNMKPQVI ERIAKLTEAD IAISVDKLAT NIKMGECETF EVKSYIYGNI
1010 1020 1030 1040 1050
SKTYTFLRGC NPELGGTILL RGDSLENLRK IKQVSEFMVY AIFSLKLESS
1060 1070 1080 1090 1100
FFNDNFIQLS TDVYLKRAES KKLQVFEGYF ADFLIKFNNR ILTVSPTVDF
1110 1120 1130 1140 1150
PIPFLLEKAR GLEKKLIERI NQYESESDLD RQTQLNMLQG LESTITKKHL
1160 1170 1180 1190 1200
GNLIKFLHEM EIENLELEFQ KRSRQWEVSY SSSQNLLGTG SHQSITVLYS
1210 1220 1230 1240 1250
MVSTKTATPC VGPQIVTIDY FWDSDISIGQ FIENVVGTAR YPCQQGCNGL
1260 1270 1280 1290 1300
YLDHYRSYVH GSGKVDVLIE KFQTRLPKLK DIILTWSYCK KCGTSTPILQ
1310 1320 1330 1340 1350
ISEKTWNHSF GKYLEVMFWS YKDSVTGIGK CPHDFTKDHV KYFGYNDLVV
1360 1370 1380 1390 1400
RLEYSDLEVH ELITPPRKIK WKPHIDIKLK VELYYKILEK INNFYGSVLS
1410 1420 1430 1440 1450
RLERIKLDSM TKDKVLSGQA KIIELKSNAT EEQKLMLQDL DTFYADSPCD
1460 1470 1480 1490 1500
QHLPLNLVIK SLYDKAVNWN STFAIFAKSY LPSETDISRI TAKQLKKLFY
1510 1520 1530 1540 1550
DSSRKDSEDK KSLHDEKAKT RKPEKNELPL EGLKDVEKPK IDSKNTTENR
1560 1570 1580 1590 1600
DRTNEPQNAV TITTFKDDTP IIPTSGTSHL TVTPSASSVS SSLTPQTEER
1610 1620 1630 1640 1650
PPISRSGTGI SMTHDKSTRP NIRKMSSDSS LCGLASLANE YSKNNKVSKL
1660 1670 1680 1690 1700
ATFFDQMHFD ALSKEFELER ERERLQLNKD KYQAIRLQTS TPIVEIYKNV
1710 1720 1730 1740 1750
KDAVDEPLHS RSSGNNLSSA NVKTLEAPVG EHSRANNCNP PNLDQNLETE
1760 1770 1780 1790 1800
LENSISQWGE NILNPSGKTT ASTHLNSKPV VKETSENPKS IVRESDNSKS
1810 1820 1830 1840 1850
EPLPPVITTT TVNKVESTPQ PEKSLLMKTL SNFWADRSAY LWKPLVYPTC
1860 1870 1880 1890 1900
PSEHIFTDSD VIIREDEPSS LIAFCLSTSD YRNKMMNLNV QQQQQQQTAE
1910 1920 1930 1940 1950
AAPAKTGGNS GGTTQTGDPS VNISPSVSTT SHNKGRDSEI SSLVTTKEGL
1960 1970 1980 1990 2000
LNTPPIEGAR DRTPQESQTH SQANLDTLQE LEKIMTKKTA THLRYQFEEG
2010 2020 2030 2040 2050
LTVMSCKIFF TEHFDVFRKI CDCQENFIQS LSRCVKWDSN GGKSGSGFLK
2060 2070 2080 2090 2100
TLDDRFIIKE LSHAELEAFI KFAPSYFEYM AQAMFHDLPT TLAKVFGFYQ
2110 2120 2130 2140 2150
IQVKSSISSS KSYKMDVIIM ENLFYEKKTT RIFDLKGSMR NRHVEQTGKA
2160 2170 2180 2190 2200
NEVLLDENMV EYIYESPIHV REYDKKLLRA SVWNDTLFLA KMNVMDYSLV
2210 2220 2230 2240 2250
IGIDNEGYTL TVGIIDFIRT FTWDKKLESW VKEKGLVGGA SVIKQPTVVT
2260 2270
PRQYKKRFRE AMERYILMVP DPWYREGN
Length:2,278
Mass (Da):257,420
Last modified:September 21, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A0A30E13165DE41
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2275R → W in BAA09258 (PubMed:7670463).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U01017 Genomic DNA Translation: AAA81360.1
D50617 Genomic DNA Translation: BAA09258.1
BK006940 Genomic DNA Translation: DAA12460.2

Protein sequence database of the Protein Information Resource

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PIRi
S56274

NCBI Reference Sequences

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RefSeqi
NP_116674.2, NM_001179984.2

Genome annotation databases

Ensembl fungal genome annotation project

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EnsemblFungii
YFR019W_mRNA; YFR019W; YFR019W

Database of genes from NCBI RefSeq genomes

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GeneIDi
850574

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
sce:YFR019W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01017 Genomic DNA Translation: AAA81360.1
D50617 Genomic DNA Translation: BAA09258.1
BK006940 Genomic DNA Translation: DAA12460.2
PIRiS56274
RefSeqiNP_116674.2, NM_001179984.2

3D structure databases

SMRiP34756
ModBaseiSearch...

Protein-protein interaction databases

BioGridi31172, 386 interactors
ComplexPortaliCPX-3088 PAS complex
DIPiDIP-6784N
IntActiP34756, 9 interactors
MINTiP34756
STRINGi4932.YFR019W

Chemistry databases

SwissLipidsiSLP:000000854

PTM databases

CarbonylDBiP34756
iPTMnetiP34756

Proteomic databases

MaxQBiP34756
PaxDbiP34756
PRIDEiP34756

Genome annotation databases

EnsemblFungiiYFR019W_mRNA; YFR019W; YFR019W
GeneIDi850574
KEGGisce:YFR019W

Organism-specific databases

EuPathDBiFungiDB:YFR019W
SGDiS000001915 FAB1

Phylogenomic databases

HOGENOMiHOG000141935
InParanoidiP34756
KOiK00921
OMAiTCGQIFD

Enzyme and pathway databases

BioCyciMetaCyc:YFR019W-MONOMER
YEAST:YFR019W-MONOMER
BRENDAi2.7.1.150 984

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FAB1 yeast

Protein Ontology

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PROi
PR:P34756

Family and domain databases

Gene3Di3.30.40.10, 1 hit
3.30.800.10, 1 hit
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR002498 PInositol-4-P-5-kinase_core
IPR027484 PInositol-4-P-5-kinase_N
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PF01363 FYVE, 1 hit
PF01504 PIP5K, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SM00330 PIPKc, 1 hit
SUPFAMiSSF52029 SSF52029, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51455 PIPK, 1 hit
PS50178 ZF_FYVE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFAB1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34756
Secondary accession number(s): D6VTQ0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: September 21, 2011
Last modified: October 16, 2019
This is version 182 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names
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