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Protein

Probable aromatic-L-amino-acid decarboxylase

Gene

hdl-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.

Catalytic activityi

L-dopa = dopamine + CO2.
5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2.

Cofactori

Pathwayi: dopamine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes dopamine from L-tyrosine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tyrosine 3-monooxygenase (cat-2)
  2. Probable aromatic-L-amino-acid decarboxylase (hdl-1)
This subpathway is part of the pathway dopamine biosynthesis, which is itself part of Catecholamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dopamine from L-tyrosine, the pathway dopamine biosynthesis and in Catecholamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei492Pyridoxal phosphateBy similarity1
Binding sitei591Pyridoxal phosphate; via carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processCatecholamine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-CEL-70921 Histidine catabolism
UniPathwayi
UPA00747;UER00734

Names & Taxonomyi

Protein namesi
Recommended name:
Probable aromatic-L-amino-acid decarboxylase (EC:4.1.1.28)
Short name:
AADC
Alternative name(s):
DOPA decarboxylase
Short name:
DDC
Gene namesi
Name:hdl-1
Synonyms:aad-1
ORF Names:ZK829.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiZK829.2 ; CE40593 ; WBGene00001839 ; hdl-1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001469431 – 905Probable aromatic-L-amino-acid decarboxylaseAdd BLAST905

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei648N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiP34751

Expressioni

Gene expression databases

BgeeiWBGene00001839 Expressed in 3 organ(s), highest expression level in material anatomical entity

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi6239.ZK829.2

Structurei

3D structure databases

ProteinModelPortaliP34751
SMRiP34751
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG0628 Eukaryota
COG0076 LUCA
GeneTreeiENSGT00760000119205
HOGENOMiHOG000017914
InParanoidiP34751
KOiK01593
OMAiGVACWFS
OrthoDBiEOG091G03KI
PhylomeDBiP34751

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR010977 Aromatic_deC
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
PRINTSiPR00800 YHDCRBOXLASE
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

P34751-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEKGETLIE DTAEIEFEQT VDKTQQWGRL KNAAAFSLFR DLHMNESLQR
60 70 80 90 100
KHARSDYKVY DLNNRVIFHV INTTAMPITK DGPFCLKVMN KDKKSVAKFL
110 120 130 140 150
RNEPKRSYKQ TGLASLFGCC SDTEDTMEVL DDNGLIIATS FLHHDQFRGI
160 170 180 190 200
LITMKDPAGK VLIGIQASRD QKDVFAVSGP DNRYLGEIRQ KIISSGNSTD
210 220 230 240 250
NYKGVACWFS TEVSLNVKVF FMAAAFLIEI DYFSETKSRQ APFRTPEADY
260 270 280 290 300
LNPIIKTPPH NERVPKMKTN ISKTRKKKGK VSDASKDSRP SETKKETLMM
310 320 330 340 350
PEIHHTKHFD SIGGEEQAFA KKEKVEEFKP TEAVKEEVDV NGMSRDQFRN
360 370 380 390 400
AAKKVVDYLM KQDESIRAAR CSPALKPGYL KALLPPKAPQ KAEDIDDILE
410 420 430 440 450
DYHKLIVPGL SHSSHPNFHS FYPAGNSFHC LLADLLGGHI GDAGFYWTSN
460 470 480 490 500
PALTELEVLM MDWLGEMMAL PKEFLLFPEA SRGGGCMQRS DTESNFLVLV
510 520 530 540 550
AARTDMIRRM KQRDKRLRSS DILARLVAYT SSDARRSIKM KMAAEVAMVK
560 570 580 590 600
MRVLPTDQNF ILRGDTLHAA IMADIERGLI PFFVGANFGT SGPCSFDHLH
610 620 630 640 650
ELGPVCREHG TWLHVDAAYA GTALICPEIR GLMRGIDWAD SFCTTPSKLI
660 670 680 690 700
IAVCDVCCLW VRDRHKLQHA SLENHPDLPF KGLPTSQRVG ALKIWFMIRS
710 720 730 740 750
FGVENLQNQI REHIRLGQVM TKILQKDLRF EVCNKVVMGL ICFRAKSNDM
760 770 780 790 800
FNKALLYRCN ETGNVSLASC VLQNKFVIRM CINSPKCSEE DLDSAYKLIC
810 820 830 840 850
NEYDILKPFQ YRIEVMNQAE LETFIRDPAK IHSSAEVSRR FPVVNPLEPC
860 870 880 890 900
RSLAQISSQM HTAEYADPPG KSNKSPQVAA KGELPSAAPP SSRTPNSDIS

EKSDR
Length:905
Mass (Da):102,004
Last modified:July 10, 2007 - v3
Checksum:i47F6151DBB422CB0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti415 – 422HPNFHSFY → SSKFSFIL in CAA77663 (PubMed:8382340).Curated8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73899 Genomic DNA Translation: CAA98072.2
Z11576 mRNA Translation: CAA77663.1
PIRiT28020
RefSeqiNP_502265.2, NM_069864.4
UniGeneiCel.11575

Genome annotation databases

EnsemblMetazoaiZK829.2; ZK829.2; WBGene00001839
GeneIDi178129
KEGGicel:CELE_ZK829.2
UCSCiZK829.2 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73899 Genomic DNA Translation: CAA98072.2
Z11576 mRNA Translation: CAA77663.1
PIRiT28020
RefSeqiNP_502265.2, NM_069864.4
UniGeneiCel.11575

3D structure databases

ProteinModelPortaliP34751
SMRiP34751
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.ZK829.2

Proteomic databases

PaxDbiP34751

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK829.2; ZK829.2; WBGene00001839
GeneIDi178129
KEGGicel:CELE_ZK829.2
UCSCiZK829.2 c. elegans

Organism-specific databases

CTDi178129
WormBaseiZK829.2 ; CE40593 ; WBGene00001839 ; hdl-1

Phylogenomic databases

eggNOGiKOG0628 Eukaryota
COG0076 LUCA
GeneTreeiENSGT00760000119205
HOGENOMiHOG000017914
InParanoidiP34751
KOiK01593
OMAiGVACWFS
OrthoDBiEOG091G03KI
PhylomeDBiP34751

Enzyme and pathway databases

UniPathwayi
UPA00747;UER00734

ReactomeiR-CEL-70921 Histidine catabolism

Miscellaneous databases

PROiPR:P34751

Gene expression databases

BgeeiWBGene00001839 Expressed in 3 organ(s), highest expression level in material anatomical entity

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR010977 Aromatic_deC
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
PRINTSiPR00800 YHDCRBOXLASE
SUPFAMiSSF53383 SSF53383, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDDC_CAEEL
AccessioniPrimary (citable) accession number: P34751
Secondary accession number(s): Q23619
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: July 10, 2007
Last modified: November 7, 2018
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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